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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FOSB |
 Gene summary |
| Gene information | Gene symbol | FOSB | Gene ID | 2354 |
| Gene name | FosB proto-oncogene, AP-1 transcription factor subunit | |
| Synonyms | AP-1|G0S3|GOS3|GOSB | |
| Cytomap | 19q13.32 | |
| Type of gene | protein-coding | |
| Description | protein fosBFBJ murine osteosarcoma viral oncogene homolog BFosB proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 3activator protein 1 | |
| Modification date | 20180523 | |
| UniProtAcc | P53539 | |
| Context | PubMed: FOSB [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for FOSB from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FOSB |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FOSB |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_308388 | 19 | 45971692:45971970:45973886:45974207:45975808:45975811 | 45973886:45974207 | ENSG00000125740.9 | ENST00000417353.2 |
| exon_skip_308395 | 19 | 45974003:45974207:45974451:45974559:45975808:45975811 | 45974451:45974559 | ENSG00000125740.9 | ENST00000591858.1,ENST00000592436.1,ENST00000586615.1,ENST00000592811.1,ENST00000353609.3,ENST00000589593.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FOSB |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_308388 | 19 | 45971692:45971970:45973886:45974207:45975808:45975811 | 45973886:45974207 | ENSG00000125740.9 | ENST00000417353.2 |
| exon_skip_308395 | 19 | 45974003:45974207:45974451:45974559:45975808:45975811 | 45974451:45974559 | ENSG00000125740.9 | ENST00000353609.3,ENST00000591858.1,ENST00000592436.1,ENST00000592811.1,ENST00000586615.1,ENST00000589593.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FOSB |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353609 | 45974451 | 45974559 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353609 | 45974451 | 45974559 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FOSB |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000353609 | 3792 | 338 | 45974451 | 45974559 | 1040 | 1147 | 149 | 185 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000353609 | 3792 | 338 | 45974451 | 45974559 | 1040 | 1147 | 149 | 185 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for FOSB |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SARC | TCGA-DX-A6YQ-01 | exon_skip_308388 | 45973887 | 45974207 | 45974168 | 45974168 | Frame_Shift_Del | C | - | p.P137fs |
| UCEC | TCGA-BS-A0UF-01 | exon_skip_308395 | 45974452 | 45974559 | 45974503 | 45974503 | Frame_Shift_Del | C | - | p.L167fs |
| HNSC | TCGA-CV-5977-01 | exon_skip_308388 | 45973887 | 45974207 | 45974012 | 45974013 | Frame_Shift_Ins | - | C | p.A85fs |
| UCEC | TCGA-D1-A103-01 | exon_skip_308388 | 45973887 | 45974207 | 45973967 | 45973967 | Nonsense_Mutation | G | A | p.W69* |
| LUAD | TCGA-73-4658-01 | exon_skip_308388 | 45973887 | 45974207 | 45973886 | 45973886 | Splice_Site | G | A | p.E43_splice |
| LIHC | TCGA-DD-AAEE-01 | exon_skip_308395 | 45974452 | 45974559 | 45974560 | 45974560 | Splice_Site | G | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NUDUL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45973887 | 45974207 | 45973896 | 45973896 | Missense_Mutation | G | T | p.G46C |
| HEC59_ENDOMETRIUM | 45973887 | 45974207 | 45973972 | 45973972 | Missense_Mutation | T | C | p.V71A |
| KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45973887 | 45974207 | 45974035 | 45974035 | Missense_Mutation | C | T | p.P92L |
| NCIH187_LUNG | 45973887 | 45974207 | 45974062 | 45974062 | Missense_Mutation | G | A | p.G101E |
| SW684_SOFT_TISSUE | 45973887 | 45974207 | 45974064 | 45974064 | Missense_Mutation | A | G | p.T102A |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45973887 | 45974207 | 45974110 | 45974110 | Missense_Mutation | C | T | p.A117V |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45973887 | 45974207 | 45974149 | 45974149 | Missense_Mutation | G | A | p.S130N |
| HS698T_FIBROBLAST | 45973887 | 45974207 | 45974179 | 45974179 | Missense_Mutation | C | G | p.A140G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FOSB |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FOSB |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FOSB |
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RelatedDrugs for FOSB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FOSB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FOSB | C0236736 | Cocaine-Related Disorders | 4 | CTD_human |
| FOSB | C0009241 | Cognition Disorders | 1 | CTD_human |
| FOSB | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
| FOSB | C0014544 | Epilepsy | 1 | CTD_human |
| FOSB | C0021122 | Disruptive, Impulse Control, and Conduct Disorders | 1 | CTD_human |
| FOSB | C0023903 | Liver neoplasms | 1 | CTD_human |
| FOSB | C0026650 | Movement Disorders | 1 | CTD_human |
| FOSB | C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
| FOSB | C0525045 | Mood Disorders | 1 | PSYGENET |
| FOSB | C3495559 | Juvenile arthritis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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