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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FOS |
 Gene summary |
| Gene information | Gene symbol | FOS | Gene ID | 2353 |
| Gene name | Fos proto-oncogene, AP-1 transcription factor subunit | |
| Synonyms | AP-1|C-FOS|p55 | |
| Cytomap | 14q24.3 | |
| Type of gene | protein-coding | |
| Description | proto-oncogene c-FosFBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFos proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 7activator protein 1cellular o | |
| Modification date | 20180523 | |
| UniProtAcc | P01100 | |
| Context | PubMed: FOS [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FOS | GO:0007179 | transforming growth factor beta receptor signaling pathway | 9732876 |
| FOS | GO:0034614 | cellular response to reactive oxygen species | 17217916 |
| FOS | GO:0045893 | positive regulation of transcription, DNA-templated | 9732876 |
| FOS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10508860 |
| FOS | GO:0060395 | SMAD protein signal transduction | 9732876 |
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Exon skipping events across known transcript of Ensembl for FOS from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FOS |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FOS |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_108284 | 14 | 75745679:75745826:75746579:75746831:75747262:75747310 | 75746579:75746831 | ENSG00000170345.5 | ENST00000555242.1 |
| exon_skip_108285 | 14 | 75745530:75745826:75746608:75746831:75747262:75747310 | 75746608:75746831 | ENSG00000170345.5 | ENST00000554212.1 |
| exon_skip_108287 | 14 | 75746761:75746831:75747262:75747370:75747485:75747860 | 75747262:75747370 | ENSG00000170345.5 | ENST00000555686.1,ENST00000303562.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FOS |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_108284 | 14 | 75745679:75745826:75746579:75746831:75747262:75747310 | 75746579:75746831 | ENSG00000170345.5 | ENST00000555242.1 |
| exon_skip_108285 | 14 | 75745530:75745826:75746608:75746831:75747262:75747310 | 75746608:75746831 | ENSG00000170345.5 | ENST00000554212.1 |
| exon_skip_108287 | 14 | 75746761:75746831:75747262:75747370:75747485:75747860 | 75747262:75747370 | ENSG00000170345.5 | ENST00000303562.4,ENST00000555686.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FOS |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000303562 | 75747262 | 75747370 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000303562 | 75747262 | 75747370 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FOS |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000303562 | 2175 | 380 | 75747262 | 75747370 | 603 | 710 | 131 | 167 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000303562 | 2175 | 380 | 75747262 | 75747370 | 603 | 710 | 131 | 167 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P01100 | 131 | 167 | 132 | 167 | Alternative sequence | ID=VSP_055561;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P01100 | 131 | 167 | 1 | 380 | Chain | ID=PRO_0000076465;Note=Proto-oncogene c-Fos |
| P01100 | 131 | 167 | 137 | 200 | Domain | Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P01100 | 131 | 167 | 141 | 191 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A02 |
| P01100 | 131 | 167 | 139 | 159 | Region | Note=Basic motif%3B required for the activation of phospholipid synthesis%2C but not for CDS1-binding |
| P01100 | 131 | 167 | 165 | 193 | Region | Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P01100 | 131 | 167 | 133 | 144 | Sequence conflict | Note=SPEEEEKRRIRR->ISRRRREKENPK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P01100 | 131 | 167 | 132 | 167 | Alternative sequence | ID=VSP_055561;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P01100 | 131 | 167 | 1 | 380 | Chain | ID=PRO_0000076465;Note=Proto-oncogene c-Fos |
| P01100 | 131 | 167 | 137 | 200 | Domain | Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P01100 | 131 | 167 | 141 | 191 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1A02 |
| P01100 | 131 | 167 | 139 | 159 | Region | Note=Basic motif%3B required for the activation of phospholipid synthesis%2C but not for CDS1-binding |
| P01100 | 131 | 167 | 165 | 193 | Region | Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P01100 | 131 | 167 | 133 | 144 | Sequence conflict | Note=SPEEEEKRRIRR->ISRRRREKENPK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for FOS |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_108284 | 75746580 | 75746831 | 75746737 | 75746737 | Frame_Shift_Del | C | - | p.A100fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_108285 | 75746609 | 75746831 | 75746737 | 75746737 | Frame_Shift_Del | C | - | p.A100fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_108284 | 75746580 | 75746831 | 75746815 | 75746815 | Frame_Shift_Del | G | - | p.R126fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_108285 | 75746609 | 75746831 | 75746815 | 75746815 | Frame_Shift_Del | G | - | p.R126fs |
| COAD | TCGA-AZ-6598-01 | exon_skip_108287 | 75747263 | 75747370 | 75747284 | 75747284 | Frame_Shift_Del | A | - | p.E138fs |
| COAD | TCGA-A6-6781-01 | exon_skip_108287 | 75747263 | 75747370 | 75747303 | 75747303 | Frame_Shift_Del | A | - | p.E145fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_108287 | 75747263 | 75747370 | 75747345 | 75747345 | Frame_Shift_Del | G | - | p.R159fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LS180_LARGE_INTESTINE | 75746609 | 75746831 | 75746736 | 75746737 | Frame_Shift_Ins | - | C | p.A100fs |
| LS180_LARGE_INTESTINE | 75746580 | 75746831 | 75746736 | 75746737 | Frame_Shift_Ins | - | C | p.A100fs |
| HEC251_ENDOMETRIUM | 75746609 | 75746831 | 75746629 | 75746629 | Missense_Mutation | T | G | p.V64G |
| HEC251_ENDOMETRIUM | 75746580 | 75746831 | 75746629 | 75746629 | Missense_Mutation | T | G | p.V64G |
| DL40_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 75746609 | 75746831 | 75746680 | 75746680 | Missense_Mutation | T | G | p.L81R |
| DL40_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 75746580 | 75746831 | 75746680 | 75746680 | Missense_Mutation | T | G | p.L81R |
| CAL27_UPPER_AERODIGESTIVE_TRACT | 75747263 | 75747370 | 75747278 | 75747278 | Missense_Mutation | G | A | p.E137K |
| RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 75747263 | 75747370 | 75747318 | 75747318 | Missense_Mutation | C | T | p.A150V |
| HCT116_LARGE_INTESTINE | 75747263 | 75747370 | 75747369 | 75747369 | Splice_Site | C | T | p.A167V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FOS |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FOS |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FOS |
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RelatedDrugs for FOS |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P01100 | DB08813 | Nadroparin | Proto-oncogene c-Fos | small molecule | approved|investigational |
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RelatedDiseases for FOS |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FOS | C0036572 | Seizures | 4 | CTD_human |
| FOS | C0038220 | Status Epilepticus | 4 | CTD_human |
| FOS | C0038587 | Substance Withdrawal Syndrome | 3 | CTD_human |
| FOS | C0236736 | Cocaine-Related Disorders | 3 | CTD_human |
| FOS | C0020538 | Hypertensive disease | 2 | CTD_human |
| FOS | C0003469 | Anxiety Disorders | 1 | CTD_human |
| FOS | C0011570 | Mental Depression | 1 | PSYGENET |
| FOS | C0011581 | Depressive disorder | 1 | PSYGENET |
| FOS | C0014175 | Endometriosis | 1 | CTD_human |
| FOS | C0014544 | Epilepsy | 1 | CTD_human |
| FOS | C0016063 | Osteitis Fibrosa Disseminata | 1 | CTD_human |
| FOS | C0018843 | Heat Stroke | 1 | CTD_human |
| FOS | C0019080 | Hemorrhage | 1 | CTD_human |
| FOS | C0020429 | Hyperalgesia | 1 | CTD_human |
| FOS | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| FOS | C0024121 | Lung Neoplasms | 1 | CTD_human |
| FOS | C0027765 | nervous system disorder | 1 | CTD_human |
| FOS | C0035126 | Reperfusion Injury | 1 | CTD_human |
| FOS | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
| FOS | C0041696 | Unipolar Depression | 1 | PSYGENET |
| FOS | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
| FOS | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| FOS | C0270458 | Severe major depression with psychotic features | 1 | PSYGENET |
| FOS | C0424295 | Hyperactive behavior | 1 | CTD_human |
| FOS | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
| FOS | C0743072 | Depression, psychotic | 1 | PSYGENET |
| FOS | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| FOS | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| FOS | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
| FOS | C2239176 | Liver carcinoma | 1 | CTD_human |
| FOS | C3495559 | Juvenile arthritis | 1 | CTD_human |
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