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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for GPR161 |
 Gene summary |
| Gene information | Gene symbol | GPR161 | Gene ID | 23432 |
| Gene name | G protein-coupled receptor 161 | |
| Synonyms | RE2 | |
| Cytomap | 1q24.2 | |
| Type of gene | protein-coding | |
| Description | G-protein coupled receptor 161G-protein coupled receptor RE2 | |
| Modification date | 20180519 | |
| UniProtAcc | Q8N6U8 | |
| Context | PubMed: GPR161 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for GPR161 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for GPR161 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for GPR161 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_34375 | 1 | 168059801:168059906:168065745:168066470:168073714:168074132 | 168065745:168066470 | ENSG00000143147.10 | ENST00000361697.2,ENST00000537209.1,ENST00000271357.5,ENST00000367835.1,ENST00000367838.1,ENST00000493800.1 |
| exon_skip_34379 | 1 | 168065745:168066470:168073714:168074132:168104143:168104274 | 168073714:168074132 | ENSG00000143147.10 | ENST00000361697.2,ENST00000537209.1 |
| exon_skip_34389 | 1 | 168073714:168074132:168083693:168083787:168103113:168103159 | 168083693:168083787 | ENSG00000143147.10 | ENST00000367838.1 |
| exon_skip_34394 | 1 | 168073714:168074132:168083693:168083787:168106402:168106536 | 168083693:168083787 | ENSG00000143147.10 | ENST00000367835.1 |
| exon_skip_34410 | 1 | 168073714:168074132:168104143:168104274:168106402:168106536 | 168104143:168104274 | ENSG00000143147.10 | ENST00000361697.2,ENST00000537209.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for GPR161 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_34375 | 1 | 168059801:168059906:168065745:168066470:168073714:168074132 | 168065745:168066470 | ENSG00000143147.10 | ENST00000367838.1,ENST00000271357.5,ENST00000367835.1,ENST00000537209.1,ENST00000361697.2,ENST00000493800.1 |
| exon_skip_34389 | 1 | 168073714:168074132:168083693:168083787:168103113:168103159 | 168083693:168083787 | ENSG00000143147.10 | ENST00000367838.1 |
| exon_skip_34394 | 1 | 168073714:168074132:168083693:168083787:168106402:168106536 | 168083693:168083787 | ENSG00000143147.10 | ENST00000367835.1 |
| exon_skip_34410 | 1 | 168073714:168074132:168104143:168104274:168106402:168106536 | 168104143:168104274 | ENSG00000143147.10 | ENST00000537209.1,ENST00000361697.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for GPR161 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367835 | 168083693 | 168083787 | 3UTR-3UTR |
| ENST00000367838 | 168083693 | 168083787 | 3UTR-3UTR |
| ENST00000367835 | 168065745 | 168066470 | Frame-shift |
| ENST00000367838 | 168065745 | 168066470 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367835 | 168083693 | 168083787 | 3UTR-3UTR |
| ENST00000367838 | 168083693 | 168083787 | 3UTR-3UTR |
| ENST00000367835 | 168065745 | 168066470 | Frame-shift |
| ENST00000367838 | 168065745 | 168066470 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for GPR161 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for GPR161 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_34379 | 168073715 | 168074132 | 168073969 | 168073969 | Frame_Shift_Del | A | - | p.F40fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_34379 | 168073715 | 168074132 | 168073969 | 168073969 | Frame_Shift_Del | A | - | p.F40fs |
| HNSC | TCGA-CV-7418-01 | exon_skip_34379 | 168073715 | 168074132 | 168074064 | 168074068 | Frame_Shift_Del | AGCTG | - | p.L7fs |
| GBM | TCGA-06-0184-01 | exon_skip_34375 | 168065746 | 168066470 | 168065791 | 168065791 | Nonsense_Mutation | G | A | p.R372* |
| READ | TCGA-AG-A002-01 | exon_skip_34375 | 168065746 | 168066470 | 168065845 | 168065845 | Nonsense_Mutation | C | A | p.E334X |
| SKCM | TCGA-GN-A8LK-06 | exon_skip_34375 | 168065746 | 168066470 | 168066076 | 168066076 | Nonsense_Mutation | G | A | p.Q257* |
| SKCM | TCGA-FW-A3R5-06 | exon_skip_34375 | 168065746 | 168066470 | 168066390 | 168066390 | Nonsense_Mutation | C | T | p.W152* |
| SKCM | TCGA-FW-A3R5-06 | exon_skip_34375 | 168065746 | 168066470 | 168066390 | 168066390 | Nonsense_Mutation | C | T | p.W38X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH1092_LUNG | 168065746 | 168066470 | 168066432 | 168066432 | Frame_Shift_Del | T | - | p.K138fs |
| NCIH1651_LUNG | 168073715 | 168074132 | 168073827 | 168073827 | Frame_Shift_Del | A | - | p.S88fs |
| GP2D_LARGE_INTESTINE | 168065746 | 168066470 | 168065796 | 168065796 | Missense_Mutation | A | G | p.V350A |
| GP5D_LARGE_INTESTINE | 168065746 | 168066470 | 168065796 | 168065796 | Missense_Mutation | A | G | p.V350A |
| HUTU80_SMALL_INTESTINE | 168065746 | 168066470 | 168065808 | 168065808 | Missense_Mutation | C | T | p.R346Q |
| IMR5_AUTONOMIC_GANGLIA | 168065746 | 168066470 | 168065831 | 168065831 | Missense_Mutation | C | T | p.M338I |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 168065746 | 168066470 | 168065850 | 168065850 | Missense_Mutation | C | T | p.R332H |
| VAL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 168065746 | 168066470 | 168065856 | 168065856 | Missense_Mutation | G | A | p.T330I |
| SNU1040_LARGE_INTESTINE | 168065746 | 168066470 | 168065991 | 168065991 | Missense_Mutation | G | A | p.P285L |
| MFM223_BREAST | 168065746 | 168066470 | 168066149 | 168066149 | Missense_Mutation | C | G | p.E232D |
| SNU61_LARGE_INTESTINE | 168065746 | 168066470 | 168066183 | 168066183 | Missense_Mutation | T | C | p.K221R |
| SKUT1_SOFT_TISSUE | 168065746 | 168066470 | 168066207 | 168066207 | Missense_Mutation | C | T | p.R213H |
| MFE319_ENDOMETRIUM | 168065746 | 168066470 | 168066409 | 168066409 | Missense_Mutation | T | C | p.M146V |
| SNU308_BILIARY_TRACT | 168065746 | 168066470 | 168066442 | 168066442 | Missense_Mutation | A | G | p.Y135H |
| CW2_LARGE_INTESTINE | 168065746 | 168066470 | 168066457 | 168066457 | Missense_Mutation | G | T | p.L130M |
| HS445_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 168073715 | 168074132 | 168073820 | 168073820 | Missense_Mutation | C | A | p.R90L |
| MON_SOFT_TISSUE | 168073715 | 168074132 | 168073821 | 168073821 | Missense_Mutation | G | A | p.R90C |
| HEC6_ENDOMETRIUM | 168073715 | 168074132 | 168073821 | 168073821 | Missense_Mutation | G | T | p.R90S |
| CW2_LARGE_INTESTINE | 168073715 | 168074132 | 168073829 | 168073829 | Missense_Mutation | C | A | p.S87I |
| SNU1040_LARGE_INTESTINE | 168073715 | 168074132 | 168073944 | 168073944 | Missense_Mutation | C | T | p.V49M |
| SNU81_LARGE_INTESTINE | 168073715 | 168074132 | 168074079 | 168074079 | Missense_Mutation | T | G | p.N4H |
| HEC1A_ENDOMETRIUM | 168065746 | 168066470 | 168065912 | 168065912 | Nonsense_Mutation | C | T | p.W311* |
| HEC1_ENDOMETRIUM | 168065746 | 168066470 | 168065746 | 168065746 | Splice_Site | C | A | p.D367Y |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GPR161 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GPR161 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GPR161 |
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RelatedDrugs for GPR161 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPR161 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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