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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DNAJC16 |
 Gene summary |
| Gene information | Gene symbol | DNAJC16 | Gene ID | 23341 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C16 | |
| Synonyms | - | |
| Cytomap | 1p36.21 | |
| Type of gene | protein-coding | |
| Description | dnaJ homolog subfamily C member 16DnaJ (Hsp40) homolog, subfamily C, member 16novel DnaJ domain-containing protein | |
| Modification date | 20180519 | |
| UniProtAcc | Q9Y2G8 | |
| Context | PubMed: DNAJC16 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DNAJC16 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DNAJC16 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DNAJC16 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_1685 | 1 | 15853307:15853453:15855582:15855767:15860731:15860798 | 15855582:15855767 | ENSG00000116138.8 | ENST00000375847.3,ENST00000375849.1,ENST00000475133.1 |
| exon_skip_1686 | 1 | 15870893:15871078:15873261:15873366:15874764:15874923 | 15873261:15873366 | ENSG00000116138.8 | ENST00000375838.1,ENST00000375847.3,ENST00000375849.1,ENST00000475133.1 |
| exon_skip_1687 | 1 | 15873261:15873366:15874764:15874923:15886020:15886151 | 15874764:15874923 | ENSG00000116138.8 | ENST00000375838.1,ENST00000375847.3,ENST00000375849.1,ENST00000475133.1 |
| exon_skip_1689 | 1 | 15886102:15886151:15888636:15888820:15890423:15890606 | 15888636:15888820 | ENSG00000116138.8 | ENST00000375838.1,ENST00000375847.3,ENST00000375849.1,ENST00000475133.1 |
| exon_skip_1690 | 1 | 15890777:15890854:15891676:15891948:15892413:15892494 | 15891676:15891948 | ENSG00000116138.8 | ENST00000483270.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DNAJC16 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_1685 | 1 | 15853307:15853453:15855582:15855767:15860731:15860798 | 15855582:15855767 | ENSG00000116138.8 | ENST00000375847.3,ENST00000475133.1,ENST00000375849.1 |
| exon_skip_1686 | 1 | 15870893:15871078:15873261:15873366:15874764:15874923 | 15873261:15873366 | ENSG00000116138.8 | ENST00000375838.1,ENST00000375847.3,ENST00000475133.1,ENST00000375849.1 |
| exon_skip_1687 | 1 | 15873261:15873366:15874764:15874923:15886020:15886151 | 15874764:15874923 | ENSG00000116138.8 | ENST00000375838.1,ENST00000375847.3,ENST00000475133.1,ENST00000375849.1 |
| exon_skip_1689 | 1 | 15886102:15886151:15888636:15888820:15890423:15890606 | 15888636:15888820 | ENSG00000116138.8 | ENST00000375838.1,ENST00000375847.3,ENST00000475133.1,ENST00000375849.1 |
| exon_skip_1690 | 1 | 15890777:15890854:15891676:15891948:15892413:15892494 | 15891676:15891948 | ENSG00000116138.8 | ENST00000483270.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DNAJC16 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000375847 | 15855582 | 15855767 | 5CDS-5UTR |
| ENST00000375847 | 15888636 | 15888820 | Frame-shift |
| ENST00000375847 | 15873261 | 15873366 | In-frame |
| ENST00000375847 | 15874764 | 15874923 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000375847 | 15855582 | 15855767 | 5CDS-5UTR |
| ENST00000375847 | 15888636 | 15888820 | Frame-shift |
| ENST00000375847 | 15873261 | 15873366 | In-frame |
| ENST00000375847 | 15874764 | 15874923 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DNAJC16 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000375847 | 6086 | 782 | 15873261 | 15873366 | 924 | 1028 | 253 | 288 |
| ENST00000375847 | 6086 | 782 | 15874764 | 15874923 | 1029 | 1187 | 288 | 341 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000375847 | 6086 | 782 | 15873261 | 15873366 | 924 | 1028 | 253 | 288 |
| ENST00000375847 | 6086 | 782 | 15874764 | 15874923 | 1029 | 1187 | 288 | 341 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y2G8 | 253 | 288 | 1 | 312 | Alternative sequence | ID=VSP_018583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y2G8 | 253 | 288 | 26 | 782 | Chain | ID=PRO_0000236683;Note=DnaJ homolog subfamily C member 16 |
| Q9Y2G8 | 253 | 288 | 26 | 535 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9Y2G8 | 288 | 341 | 1 | 312 | Alternative sequence | ID=VSP_018583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y2G8 | 288 | 341 | 26 | 782 | Chain | ID=PRO_0000236683;Note=DnaJ homolog subfamily C member 16 |
| Q9Y2G8 | 288 | 341 | 26 | 535 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y2G8 | 253 | 288 | 1 | 312 | Alternative sequence | ID=VSP_018583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y2G8 | 253 | 288 | 26 | 782 | Chain | ID=PRO_0000236683;Note=DnaJ homolog subfamily C member 16 |
| Q9Y2G8 | 253 | 288 | 26 | 535 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9Y2G8 | 288 | 341 | 1 | 312 | Alternative sequence | ID=VSP_018583;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y2G8 | 288 | 341 | 26 | 782 | Chain | ID=PRO_0000236683;Note=DnaJ homolog subfamily C member 16 |
| Q9Y2G8 | 288 | 341 | 26 | 535 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for DNAJC16 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_1686 | 15873262 | 15873366 | 15873320 | 15873321 | Frame_Shift_Del | AT | - | p.273_273del |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_1686 | 15873262 | 15873366 | 15873320 | 15873321 | Frame_Shift_Del | AT | - | p.H273fs |
| THYM | TCGA-ZB-A96E-01 | exon_skip_1689 | 15888637 | 15888820 | 15888722 | 15888722 | Nonsense_Mutation | C | T | p.Q414X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| TOV21G_OVARY | 15855583 | 15855767 | 15855761 | 15855761 | Missense_Mutation | G | A | p.R54Q |
| NCIH2342_LUNG | 15873262 | 15873366 | 15873293 | 15873293 | Missense_Mutation | C | G | p.S264C |
| MDAPCA2B_PROSTATE | 15873262 | 15873366 | 15873341 | 15873341 | Missense_Mutation | C | T | p.T280M |
| NCIH2066_LUNG | 15874765 | 15874923 | 15874767 | 15874767 | Missense_Mutation | G | C | p.L289F |
| HCT116_LARGE_INTESTINE | 15874765 | 15874923 | 15874849 | 15874849 | Missense_Mutation | T | C | p.Y317H |
| TE8_OESOPHAGUS | 15888637 | 15888820 | 15888676 | 15888676 | Missense_Mutation | G | C | p.L398F |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15888637 | 15888820 | 15888662 | 15888662 | Nonsense_Mutation | G | T | p.E394* |
| SW48_LARGE_INTESTINE | 15888637 | 15888820 | 15888764 | 15888764 | Nonsense_Mutation | C | T | p.Q428* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DNAJC16 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DNAJC16 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DNAJC16 |
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RelatedDrugs for DNAJC16 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJC16 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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