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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MGRN1 |
 Gene summary |
| Gene information | Gene symbol | MGRN1 | Gene ID | 23295 |
| Gene name | mahogunin ring finger 1 | |
| Synonyms | RNF156 | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase MGRN1RING finger protein 156RING-type E3 ubiquitin transferase MGRN1mahogunin RING finger protein 1mahogunin ring finger 1, E3 ubiquitin protein ligaseprobable E3 ubiquitin-protein ligase MGRN1 | |
| Modification date | 20180519 | |
| UniProtAcc | O60291 | |
| Context | PubMed: MGRN1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MGRN1 | GO:0043951 | negative regulation of cAMP-mediated signaling | 19737927 |
| MGRN1 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway | 19737927 |
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Exon skipping events across known transcript of Ensembl for MGRN1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MGRN1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MGRN1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_133105 | 16 | 4700400:4700484:4701963:4702052:4702678:4702825 | 4701963:4702052 | ENSG00000102858.8 | ENST00000591895.1,ENST00000399577.5,ENST00000536343.1,ENST00000415496.1,ENST00000586183.1,ENST00000262370.7,ENST00000590790.1,ENST00000587747.1,ENST00000593224.1,ENST00000588994.1 |
| exon_skip_133107 | 16 | 4702678:4702825:4707246:4707364:4714709:4714776 | 4707246:4707364 | ENSG00000102858.8 | ENST00000399577.5,ENST00000536343.1,ENST00000415496.1,ENST00000586183.1,ENST00000262370.7,ENST00000590790.1,ENST00000587747.1,ENST00000588994.1 |
| exon_skip_133110 | 16 | 4715102:4715152:4718265:4718313:4721391:4721460 | 4718265:4718313 | ENSG00000102858.8 | ENST00000399577.5,ENST00000536343.1,ENST00000415496.1,ENST00000586183.1,ENST00000262370.7,ENST00000590790.1,ENST00000587747.1,ENST00000587145.1,ENST00000590457.1,ENST00000588994.1 |
| exon_skip_133112 | 16 | 4718297:4718313:4721391:4721460:4723498:4723523 | 4721391:4721460 | ENSG00000102858.8 | ENST00000399577.5,ENST00000588015.1,ENST00000536343.1,ENST00000415496.1,ENST00000586183.1,ENST00000262370.7,ENST00000590790.1,ENST00000587145.1,ENST00000590457.1,ENST00000588994.1 |
| exon_skip_133114 | 16 | 4721405:4721460:4722400:4722517:4723498:4723523 | 4722400:4722517 | ENSG00000102858.8 | ENST00000587747.1 |
| exon_skip_133116 | 16 | 4723498:4723658:4727463:4727573:4730032:4730068 | 4727463:4727573 | ENSG00000102858.8 | ENST00000399577.5,ENST00000262370.7,ENST00000590790.1,ENST00000587747.1,ENST00000591673.1 |
| exon_skip_133117 | 16 | 4723498:4723658:4727463:4727573:4731550:4731581 | 4727463:4727573 | ENSG00000102858.8 | ENST00000415496.1,ENST00000586183.1,ENST00000588994.1 |
| exon_skip_133119 | 16 | 4727463:4727573:4730032:4730098:4731550:4731581 | 4730032:4730098 | ENSG00000102858.8 | ENST00000399577.5,ENST00000262370.7,ENST00000587747.1,ENST00000591673.1 |
| exon_skip_133122 | 16 | 4731550:4731777:4732823:4732947:4733224:4733270 | 4732823:4732947 | ENSG00000102858.8 | ENST00000399577.5,ENST00000536343.1,ENST00000415496.1,ENST00000586183.1,ENST00000585676.1,ENST00000592256.1,ENST00000262370.7,ENST00000587747.1,ENST00000588994.1 |
| exon_skip_133123 | 16 | 4732823:4732947:4733224:4733270:4733843:4733873 | 4733224:4733270 | ENSG00000102858.8 | ENST00000399577.5,ENST00000536343.1,ENST00000415496.1,ENST00000586183.1,ENST00000585676.1,ENST00000592256.1,ENST00000262370.7,ENST00000587747.1,ENST00000588994.1 |
| exon_skip_133126 | 16 | 4733855:4733933:4736259:4736304:4738796:4738810 | 4736259:4736304 | ENSG00000102858.8 | ENST00000586183.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MGRN1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_133105 | 16 | 4700400:4700484:4701963:4702052:4702678:4702825 | 4701963:4702052 | ENSG00000102858.8 | ENST00000591895.1,ENST00000262370.7,ENST00000415496.1,ENST00000536343.1,ENST00000587747.1,ENST00000399577.5,ENST00000588994.1,ENST00000586183.1,ENST00000590790.1,ENST00000593224.1 |
| exon_skip_133107 | 16 | 4702678:4702825:4707246:4707364:4714709:4714776 | 4707246:4707364 | ENSG00000102858.8 | ENST00000262370.7,ENST00000415496.1,ENST00000536343.1,ENST00000587747.1,ENST00000399577.5,ENST00000588994.1,ENST00000586183.1,ENST00000590790.1 |
| exon_skip_133110 | 16 | 4715102:4715152:4718265:4718313:4721391:4721460 | 4718265:4718313 | ENSG00000102858.8 | ENST00000262370.7,ENST00000415496.1,ENST00000536343.1,ENST00000587747.1,ENST00000399577.5,ENST00000588994.1,ENST00000586183.1,ENST00000590790.1,ENST00000587145.1,ENST00000590457.1 |
| exon_skip_133112 | 16 | 4718297:4718313:4721391:4721460:4723498:4723523 | 4721391:4721460 | ENSG00000102858.8 | ENST00000262370.7,ENST00000415496.1,ENST00000536343.1,ENST00000399577.5,ENST00000588994.1,ENST00000586183.1,ENST00000590790.1,ENST00000587145.1,ENST00000590457.1,ENST00000588015.1 |
| exon_skip_133114 | 16 | 4721405:4721460:4722400:4722517:4723498:4723523 | 4722400:4722517 | ENSG00000102858.8 | ENST00000587747.1 |
| exon_skip_133116 | 16 | 4723498:4723658:4727463:4727573:4730032:4730068 | 4727463:4727573 | ENSG00000102858.8 | ENST00000262370.7,ENST00000587747.1,ENST00000399577.5,ENST00000590790.1,ENST00000591673.1 |
| exon_skip_133117 | 16 | 4723498:4723658:4727463:4727573:4731550:4731581 | 4727463:4727573 | ENSG00000102858.8 | ENST00000415496.1,ENST00000588994.1,ENST00000586183.1 |
| exon_skip_133119 | 16 | 4727463:4727573:4730032:4730098:4731550:4731581 | 4730032:4730098 | ENSG00000102858.8 | ENST00000262370.7,ENST00000587747.1,ENST00000399577.5,ENST00000591673.1 |
| exon_skip_133122 | 16 | 4731550:4731777:4732823:4732947:4733224:4733270 | 4732823:4732947 | ENSG00000102858.8 | ENST00000262370.7,ENST00000415496.1,ENST00000536343.1,ENST00000587747.1,ENST00000399577.5,ENST00000588994.1,ENST00000586183.1,ENST00000592256.1,ENST00000585676.1 |
| exon_skip_133123 | 16 | 4732823:4732947:4733224:4733270:4733843:4733873 | 4733224:4733270 | ENSG00000102858.8 | ENST00000262370.7,ENST00000415496.1,ENST00000536343.1,ENST00000587747.1,ENST00000399577.5,ENST00000588994.1,ENST00000586183.1,ENST00000592256.1,ENST00000585676.1 |
| exon_skip_133126 | 16 | 4733855:4733933:4736259:4736304:4738796:4738810 | 4736259:4736304 | ENSG00000102858.8 | ENST00000586183.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MGRN1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000399577 | 4701963 | 4702052 | Frame-shift |
| ENST00000399577 | 4707246 | 4707364 | Frame-shift |
| ENST00000399577 | 4727463 | 4727573 | Frame-shift |
| ENST00000399577 | 4732823 | 4732947 | Frame-shift |
| ENST00000399577 | 4733224 | 4733270 | Frame-shift |
| ENST00000399577 | 4718265 | 4718313 | In-frame |
| ENST00000399577 | 4721391 | 4721460 | In-frame |
| ENST00000399577 | 4730032 | 4730098 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000399577 | 4701963 | 4702052 | Frame-shift |
| ENST00000399577 | 4707246 | 4707364 | Frame-shift |
| ENST00000399577 | 4727463 | 4727573 | Frame-shift |
| ENST00000399577 | 4732823 | 4732947 | Frame-shift |
| ENST00000399577 | 4733224 | 4733270 | Frame-shift |
| ENST00000399577 | 4718265 | 4718313 | In-frame |
| ENST00000399577 | 4721391 | 4721460 | In-frame |
| ENST00000399577 | 4730032 | 4730098 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MGRN1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000399577 | 6442 | 552 | 4718265 | 4718313 | 772 | 819 | 226 | 242 |
| ENST00000399577 | 6442 | 552 | 4721391 | 4721460 | 820 | 888 | 242 | 265 |
| ENST00000399577 | 6442 | 552 | 4730032 | 4730098 | 1159 | 1224 | 355 | 377 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000399577 | 6442 | 552 | 4718265 | 4718313 | 772 | 819 | 226 | 242 |
| ENST00000399577 | 6442 | 552 | 4721391 | 4721460 | 820 | 888 | 242 | 265 |
| ENST00000399577 | 6442 | 552 | 4730032 | 4730098 | 1159 | 1224 | 355 | 377 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60291 | 226 | 242 | 2 | 552 | Chain | ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1 |
| O60291 | 242 | 265 | 2 | 552 | Chain | ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1 |
| O60291 | 242 | 265 | 248 | 248 | Sequence conflict | Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| O60291 | 242 | 265 | 248 | 248 | Sequence conflict | Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| O60291 | 355 | 377 | 356 | 377 | Alternative sequence | ID=VSP_036462;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19737927;Dbxref=PMID:19737927 |
| O60291 | 355 | 377 | 2 | 552 | Chain | ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60291 | 226 | 242 | 2 | 552 | Chain | ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1 |
| O60291 | 242 | 265 | 2 | 552 | Chain | ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1 |
| O60291 | 242 | 265 | 248 | 248 | Sequence conflict | Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| O60291 | 242 | 265 | 248 | 248 | Sequence conflict | Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| O60291 | 355 | 377 | 356 | 377 | Alternative sequence | ID=VSP_036462;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19737927;Dbxref=PMID:19737927 |
| O60291 | 355 | 377 | 2 | 552 | Chain | ID=PRO_0000246687;Note=E3 ubiquitin-protein ligase MGRN1 |
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SNVs in the skipped exons for MGRN1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-BR-4363-01 | exon_skip_133105 | 4701964 | 4702052 | 4701983 | 4701983 | Frame_Shift_Del | C | - | p.A76fs |
| UCEC | TCGA-BG-A0M0-01 | exon_skip_133119 | 4730033 | 4730098 | 4730042 | 4730042 | Frame_Shift_Del | A | - | p.K359fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_133122 | 4732824 | 4732947 | 4732844 | 4732844 | Frame_Shift_Del | C | - | p.S460fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_133122 | 4732824 | 4732947 | 4732897 | 4732897 | Frame_Shift_Del | C | - | p.P479fs |
| COAD | TCGA-AZ-6601-01 | exon_skip_133105 | 4701964 | 4702052 | 4701982 | 4701983 | Frame_Shift_Ins | - | C | p.A76fs |
| HNSC | TCGA-CV-A45W-01 | exon_skip_133107 | 4707247 | 4707364 | 4707252 | 4707253 | Frame_Shift_Ins | - | C | p.T150fs |
| THYM | TCGA-4V-A9QT-01 | exon_skip_133123 | 4733225 | 4733270 | 4733256 | 4733256 | Nonsense_Mutation | C | A | p.S505X |
| CHOL | TCGA-W5-AA2Q-01 | exon_skip_133123 | 4733225 | 4733270 | 4733264 | 4733264 | Nonsense_Mutation | C | T | p.Q508X |
| UCEC | TCGA-B5-A11E-01 | exon_skip_133126 | 4736260 | 4736304 | 4736259 | 4736259 | Splice_Site | G | T | e17-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_133126 | |
| Skipped exon start: 4736260 | |
| Skipped exon end: 4736304 | |
| Mutation start: 4736259 | |
| Mutation end: 4736259 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: e17-1 | |
exon_skip_104037_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_106242_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_108777_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_108778_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_121584_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_121649_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_131821_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_133126_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_23327_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_27874_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_312611_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_312613_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_312641_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_313540_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_326446_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_326448_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_330038_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_340150_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_348004_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_348005_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_377858_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_380242_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_433438_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_489645_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_500396_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_62223_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_97620_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_97655_UCEC_TCGA-B5-A11E-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC1A_ENDOMETRIUM | 4730033 | 4730098 | 4730041 | 4730042 | Frame_Shift_Ins | - | A | p.K359fs |
| SCABER_URINARY_TRACT | 4701964 | 4702052 | 4701980 | 4701980 | Missense_Mutation | C | T | p.P75L |
| NCIH2110_LUNG | 4707247 | 4707364 | 4707300 | 4707300 | Missense_Mutation | G | T | p.G166V |
| BXPC3_PANCREAS | 4707247 | 4707364 | 4707326 | 4707326 | Missense_Mutation | T | C | p.S175P |
| HEC59_ENDOMETRIUM | 4718266 | 4718313 | 4718278 | 4718278 | Missense_Mutation | A | G | p.S231G |
| OCUBM_BREAST | 4721392 | 4721460 | 4721418 | 4721418 | Missense_Mutation | G | C | p.Q251H |
| SNU175_LARGE_INTESTINE | 4727464 | 4727573 | 4727491 | 4727491 | Missense_Mutation | C | T | p.A328V |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 4727464 | 4727573 | 4727491 | 4727491 | Missense_Mutation | C | T | p.A328V |
| 22RV1_PROSTATE | 4727464 | 4727573 | 4727567 | 4727567 | Missense_Mutation | G | T | p.E353D |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 4730033 | 4730098 | 4730054 | 4730054 | Missense_Mutation | C | T | p.P363S |
| HCT15_LARGE_INTESTINE | 4730033 | 4730098 | 4730066 | 4730066 | Missense_Mutation | T | G | p.S367A |
| LN215_CENTRAL_NERVOUS_SYSTEM | 4732824 | 4732947 | 4732847 | 4732847 | Missense_Mutation | C | T | p.P461L |
| EVSAT_BREAST | 4736260 | 4736304 | 4736268 | 4736268 | Missense_Mutation | C | T | p.P543S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MGRN1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MGRN1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MGRN1 |
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RelatedDrugs for MGRN1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MGRN1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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