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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DTX4 |
 Gene summary |
| Gene information | Gene symbol | DTX4 | Gene ID | 23220 |
| Gene name | deltex E3 ubiquitin ligase 4 | |
| Synonyms | RNF155 | |
| Cytomap | 11q12.1 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase DTX4RING finger protein 155RING-type E3 ubiquitin transferase DTX4deltex 4 homologdeltex 4, E3 ubiquitin ligasedeltex homolog 4deltex4protein deltex-4 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9Y2E6 | |
| Context | PubMed: DTX4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DTX4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DTX4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DTX4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_59593 | 11 | 58956634:58956796:58958586:58958648:58959570:58959723 | 58958586:58958648 | ENSG00000110042.3 | ENST00000531902.1,ENST00000532982.1,ENST00000227451.3 |
| exon_skip_59598 | 11 | 58962680:58962842:58967156:58967246:58972148:58972231 | 58967156:58967246 | ENSG00000110042.3 | ENST00000532982.1,ENST00000527475.1,ENST00000227451.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DTX4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_59593 | 11 | 58956634:58956796:58958586:58958648:58959570:58959723 | 58958586:58958648 | ENSG00000110042.3 | ENST00000532982.1,ENST00000227451.3,ENST00000531902.1 |
| exon_skip_59598 | 11 | 58962680:58962842:58967156:58967246:58972148:58972231 | 58967156:58967246 | ENSG00000110042.3 | ENST00000532982.1,ENST00000227451.3,ENST00000527475.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DTX4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000227451 | 58958586 | 58958648 | Frame-shift |
| ENST00000227451 | 58967156 | 58967246 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000227451 | 58958586 | 58958648 | Frame-shift |
| ENST00000227451 | 58967156 | 58967246 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DTX4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000227451 | 5659 | 619 | 58967156 | 58967246 | 1641 | 1730 | 512 | 542 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000227451 | 5659 | 619 | 58967156 | 58967246 | 1641 | 1730 | 512 | 542 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y2E6 | 512 | 542 | 1 | 619 | Chain | ID=PRO_0000280555;Note=E3 ubiquitin-protein ligase DTX4 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y2E6 | 512 | 542 | 1 | 619 | Chain | ID=PRO_0000280555;Note=E3 ubiquitin-protein ligase DTX4 |
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SNVs in the skipped exons for DTX4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-AD-6964-01 | exon_skip_59593 | 58958587 | 58958648 | 58958609 | 58958609 | Frame_Shift_Del | A | - | p.L394fs |
| COAD | TCGA-D5-6540-01 | exon_skip_59593 | 58958587 | 58958648 | 58958609 | 58958609 | Frame_Shift_Del | A | - | p.L394fs |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_59593 | 58958587 | 58958648 | 58958609 | 58958609 | Frame_Shift_Del | A | - | p.L394fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| IGROV1_OVARY | 58958587 | 58958648 | 58958609 | 58958609 | Frame_Shift_Del | A | - | p.L394fs |
| SW48_LARGE_INTESTINE | 58958587 | 58958648 | 58958609 | 58958609 | Frame_Shift_Del | A | - | p.L394fs |
| LIM1215_LARGE_INTESTINE | 58958587 | 58958648 | 58958609 | 58958609 | Frame_Shift_Del | A | - | p.L394fs |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 58958587 | 58958648 | 58958609 | 58958609 | Frame_Shift_Del | A | - | p.L394fs |
| DBTRG05MG_CENTRAL_NERVOUS_SYSTEM | 58958587 | 58958648 | 58958616 | 58958616 | Frame_Shift_Del | T | - | p.Y397fs |
| CW2_LARGE_INTESTINE | 58967157 | 58967246 | 58967194 | 58967194 | Missense_Mutation | C | T | p.A525V |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 58967157 | 58967246 | 58967208 | 58967208 | Nonsense_Mutation | C | T | p.R530* |
| C33A_CERVIX | 58967157 | 58967246 | 58967245 | 58967248 | Splice_Site | AAGT | - | p.K542fs |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DTX4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DTX4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DTX4 |
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RelatedDrugs for DTX4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DTX4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DTX4 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| DTX4 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
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