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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for LARP4B |
 Gene summary |
| Gene information | Gene symbol | LARP4B | Gene ID | 23185 |
| Gene name | La ribonucleoprotein domain family member 4B | |
| Synonyms | KIAA0217|LARP5 | |
| Cytomap | 10p15.3 | |
| Type of gene | protein-coding | |
| Description | la-related protein 4BLa ribonucleoprotein domain family, member 5la-related protein 5 | |
| Modification date | 20180519 | |
| UniProtAcc | Q92615 | |
| Context | PubMed: LARP4B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for LARP4B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for LARP4B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for LARP4B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_46679 | 10 | 858445:859153:860576:860790:860885:861010 | 860576:860790 | ENSG00000107929.10 | ENST00000448368.1 |
| exon_skip_46680 | 10 | 858445:859153:860681:860790:860885:861010 | 860681:860790 | ENSG00000107929.10 | ENST00000609318.1,ENST00000316157.3 |
| exon_skip_46684 | 10 | 860885:861010:863664:863829:866739:866785 | 863664:863829 | ENSG00000107929.10 | ENST00000448368.1,ENST00000316157.3 |
| exon_skip_46686 | 10 | 866739:866785:871004:871256:871703:871810 | 871004:871256 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46688 | 10 | 875620:875674:876806:876917:882342:882446 | 876806:876917 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46693 | 10 | 888871:889008:890916:890995:909682:909823 | 890916:890995 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46694 | 10 | 890916:890995:909682:909823:910062:910210 | 909682:909823 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46696 | 10 | 910180:910210:915948:916023:930386:930446 | 915948:916023 | ENSG00000107929.10 | ENST00000481118.1 |
| exon_skip_46697 | 10 | 910180:910210:915952:916023:930386:930446 | 915952:916023 | ENSG00000107929.10 | ENST00000476529.1 |
| exon_skip_46698 | 10 | 931580:931700:949147:949283:949369:949455 | 949147:949283 | ENSG00000107929.10 | ENST00000412411.1 |
| exon_skip_46700 | 10 | 931580:931700:970322:970373:977367:977564 | 970322:970373 | ENSG00000107929.10 | ENST00000406525.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for LARP4B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_46679 | 10 | 858445:859153:860576:860790:860885:861010 | 860576:860790 | ENSG00000107929.10 | ENST00000448368.1 |
| exon_skip_46680 | 10 | 858445:859153:860681:860790:860885:861010 | 860681:860790 | ENSG00000107929.10 | ENST00000316157.3,ENST00000609318.1 |
| exon_skip_46684 | 10 | 860885:861010:863664:863829:866739:866785 | 863664:863829 | ENSG00000107929.10 | ENST00000316157.3,ENST00000448368.1 |
| exon_skip_46686 | 10 | 866739:866785:871004:871256:871703:871810 | 871004:871256 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46688 | 10 | 875620:875674:876806:876917:882342:882446 | 876806:876917 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46693 | 10 | 888871:889008:890916:890995:909682:909823 | 890916:890995 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46694 | 10 | 890916:890995:909682:909823:910062:910210 | 909682:909823 | ENSG00000107929.10 | ENST00000316157.3 |
| exon_skip_46696 | 10 | 910180:910210:915948:916023:930386:930446 | 915948:916023 | ENSG00000107929.10 | ENST00000481118.1 |
| exon_skip_46697 | 10 | 910180:910210:915952:916023:930386:930446 | 915952:916023 | ENSG00000107929.10 | ENST00000476529.1 |
| exon_skip_46698 | 10 | 931580:931700:949147:949283:949369:949455 | 949147:949283 | ENSG00000107929.10 | ENST00000412411.1 |
| exon_skip_46700 | 10 | 931580:931700:970322:970373:977367:977564 | 970322:970373 | ENSG00000107929.10 | ENST00000406525.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for LARP4B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000316157 | 860681 | 860790 | Frame-shift |
| ENST00000316157 | 890916 | 890995 | Frame-shift |
| ENST00000316157 | 863664 | 863829 | In-frame |
| ENST00000316157 | 871004 | 871256 | In-frame |
| ENST00000316157 | 876806 | 876917 | In-frame |
| ENST00000316157 | 909682 | 909823 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000316157 | 860681 | 860790 | Frame-shift |
| ENST00000316157 | 890916 | 890995 | Frame-shift |
| ENST00000316157 | 863664 | 863829 | In-frame |
| ENST00000316157 | 871004 | 871256 | In-frame |
| ENST00000316157 | 876806 | 876917 | In-frame |
| ENST00000316157 | 909682 | 909823 | In-frame |
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Infer the effects of exon skipping event on protein functional features for LARP4B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000316157 | 5657 | 738 | 909682 | 909823 | 331 | 471 | 96 | 143 |
| ENST00000316157 | 5657 | 738 | 876806 | 876917 | 792 | 902 | 250 | 287 |
| ENST00000316157 | 5657 | 738 | 871004 | 871256 | 1274 | 1525 | 411 | 494 |
| ENST00000316157 | 5657 | 738 | 863664 | 863829 | 1572 | 1736 | 510 | 565 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000316157 | 5657 | 738 | 909682 | 909823 | 331 | 471 | 96 | 143 |
| ENST00000316157 | 5657 | 738 | 876806 | 876917 | 792 | 902 | 250 | 287 |
| ENST00000316157 | 5657 | 738 | 871004 | 871256 | 1274 | 1525 | 411 | 494 |
| ENST00000316157 | 5657 | 738 | 863664 | 863829 | 1572 | 1736 | 510 | 565 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92615 | 96 | 143 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 250 | 287 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 250 | 287 | 240 | 307 | Domain | Note=RRM |
| Q92615 | 411 | 494 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 411 | 494 | 419 | 419 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
| Q92615 | 411 | 494 | 424 | 424 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332 |
| Q92615 | 411 | 494 | 434 | 434 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648;Dbxref=PMID:16964243,PMID:18669648 |
| Q92615 | 411 | 494 | 451 | 451 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q92615 | 411 | 494 | 488 | 488 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q92615 | 411 | 494 | 493 | 493 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6A0A2 |
| Q92615 | 510 | 565 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 510 | 565 | 518 | 518 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
| Q92615 | 510 | 565 | 524 | 524 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163 |
| Q92615 | 510 | 565 | 556 | 556 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92615 | 96 | 143 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 250 | 287 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 250 | 287 | 240 | 307 | Domain | Note=RRM |
| Q92615 | 411 | 494 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 411 | 494 | 419 | 419 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315 |
| Q92615 | 411 | 494 | 424 | 424 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332 |
| Q92615 | 411 | 494 | 434 | 434 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648;Dbxref=PMID:16964243,PMID:18669648 |
| Q92615 | 411 | 494 | 451 | 451 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q92615 | 411 | 494 | 488 | 488 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q92615 | 411 | 494 | 493 | 493 | Modified residue | Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6A0A2 |
| Q92615 | 510 | 565 | 1 | 738 | Chain | ID=PRO_0000281139;Note=La-related protein 4B |
| Q92615 | 510 | 565 | 518 | 518 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
| Q92615 | 510 | 565 | 524 | 524 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163 |
| Q92615 | 510 | 565 | 556 | 556 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
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SNVs in the skipped exons for LARP4B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
LARP4B_KIRC_exon_skip_46686_psi_boxplot.png |
LARP4B_SKCM_exon_skip_46686_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SARC | TCGA-X6-A8C4-01 | exon_skip_46684 | 863665 | 863829 | 863681 | 863681 | Frame_Shift_Del | C | - | p.G560fs |
| TGCT | TCGA-VF-A8A8-01 | exon_skip_46686 | 871005 | 871256 | 871022 | 871031 | Frame_Shift_Del | AGGAGAGGAT | - | p.ESSP486fs |
| PRAD | TCGA-KK-A8I9-01 | exon_skip_46686 | 871005 | 871256 | 871034 | 871034 | Frame_Shift_Del | G | - | p.L485fs |
| TGCT | TCGA-VF-A8A8-01 | exon_skip_46686 | 871005 | 871256 | 871042 | 871045 | Frame_Shift_Del | CTGG | - | p.482_483del |
| KIRC | TCGA-CZ-5463-01 | exon_skip_46686 | 871005 | 871256 | 871057 | 871060 | Frame_Shift_Del | CAGG | - | p.477_478del |
| SKCM | TCGA-EE-A2GH-06 | exon_skip_46686 | 871005 | 871256 | 871151 | 871151 | Frame_Shift_Del | A | - | p.I446fs |
| SKCM | TCGA-EE-A2GH-06 | exon_skip_46686 | 871005 | 871256 | 871151 | 871151 | Frame_Shift_Del | A | - | p.N447fs |
| BRCA | TCGA-A8-A06O-01 | exon_skip_46688 | 876807 | 876917 | 876875 | 876875 | Frame_Shift_Del | T | - | p.I265fs |
| COAD | TCGA-AA-3663-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| COAD | TCGA-CM-5861-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| COAD | TCGA-D5-6930-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| COAD | TCGA-G4-6588-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| ESCA | TCGA-L5-A8NM-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-4184-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890940 | Frame_Shift_Del | TT | - | p.163_163del |
| STAD | TCGA-BR-4184-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890940 | Frame_Shift_Del | TT | - | p.T163fs |
| STAD | TCGA-BR-4257-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-4292-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-4363-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-4368-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-4370-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-6566-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-7707-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-8368-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-8372-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-BR-A4QL-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-CD-A4MG-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-CD-A4MI-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-CG-5721-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-CG-5728-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-CG-5733-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-F1-6874-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-HF-A5NB-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-HU-8602-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-HU-A4G8-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-HU-A4GN-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-HU-A4GT-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| STAD | TCGA-R5-A7ZI-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| UCEC | TCGA-AP-A0LE-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| UCEC | TCGA-AX-A05S-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| UCEC | TCGA-B5-A0K9-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| UCEC | TCGA-D1-A17R-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_46693 | 890917 | 890995 | 890957 | 890957 | Frame_Shift_Del | G | - | p.R157fs |
| STAD | TCGA-BR-4201-01 | exon_skip_46693 | 890917 | 890995 | 890938 | 890939 | Frame_Shift_Ins | - | T | p.T163fs |
| STAD | TCGA-BR-4201-01 | exon_skip_46693 | 890917 | 890995 | 890939 | 890940 | Frame_Shift_Ins | - | T | p.T163fs |
| READ | TCGA-AG-A002-01 | exon_skip_46684 | 863665 | 863829 | 863670 | 863670 | Nonsense_Mutation | C | A | p.E564X |
| HNSC | TCGA-CV-6948-01 | exon_skip_46684 | 863665 | 863829 | 863817 | 863817 | Nonsense_Mutation | G | A | p.Q515* |
| SKCM | TCGA-EE-A3JI-06 | exon_skip_46686 | 871005 | 871256 | 871159 | 871159 | Nonsense_Mutation | G | A | p.R444* |
| SKCM | TCGA-EE-A3JI-06 | exon_skip_46686 | 871005 | 871256 | 871159 | 871159 | Nonsense_Mutation | G | A | p.R444X |
| SKCM | TCGA-Z2-A8RT-06 | exon_skip_46686 | 871005 | 871256 | 871159 | 871159 | Nonsense_Mutation | G | A | p.R444* |
| COAD | TCGA-CM-4743-01 | exon_skip_46693 | 890917 | 890995 | 890957 | 890957 | Nonsense_Mutation | G | A | p.R157X |
| READ | TCGA-AG-A011-01 | exon_skip_46693 | 890917 | 890995 | 890957 | 890957 | Nonsense_Mutation | G | A | p.R157X |
| SKCM | TCGA-D3-A1Q4-06 | exon_skip_46693 | 890917 | 890995 | 890981 | 890981 | Nonsense_Mutation | G | A | p.Q149* |
| SKCM | TCGA-D3-A1Q4-06 | exon_skip_46693 | 890917 | 890995 | 890981 | 890981 | Nonsense_Mutation | G | A | p.Q149X |
| LUAD | TCGA-86-8279-01 | exon_skip_46694 | 909683 | 909823 | 909761 | 909761 | Nonsense_Mutation | C | A | p.E118* |
| CESC | TCGA-DG-A2KL-01 | exon_skip_46694 | 909683 | 909823 | 909788 | 909788 | Nonsense_Mutation | C | A | p.E109* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-Z2-A8RT-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_46686 | |
| Skipped exon start: 871005 | |
| Skipped exon end: 871256 | |
| Mutation start: 871159 | |
| Mutation end: 871159 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R444* | |
exon_skip_436327_SKCM_TCGA-Z2-A8RT-06.png | |
exon_skip_46686_SKCM_TCGA-Z2-A8RT-06.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DV90_LUNG | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| HEC108_ENDOMETRIUM | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| SNGM_ENDOMETRIUM | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| SNU324_PANCREAS | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| SNUC4_LARGE_INTESTINE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| TOV21G_OVARY | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| SNU1_STOMACH | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| LOVO_LARGE_INTESTINE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| MFE319_ENDOMETRIUM | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| SNU407_LARGE_INTESTINE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| SW48_LARGE_INTESTINE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| LIM1215_LARGE_INTESTINE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| TGBC11TKB_STOMACH | 890917 | 890995 | 890939 | 890939 | Frame_Shift_Del | T | - | p.T163fs |
| NCIH1155_LUNG | 890917 | 890995 | 890938 | 890939 | Frame_Shift_Ins | - | T | p.T163fs |
| NCIH2110_LUNG | 860577 | 860790 | 860686 | 860686 | Missense_Mutation | G | C | p.A642G |
| NCIH2110_LUNG | 860682 | 860790 | 860686 | 860686 | Missense_Mutation | G | C | p.A642G |
| SNU1040_LARGE_INTESTINE | 860577 | 860790 | 860723 | 860723 | Missense_Mutation | C | T | p.A630T |
| SNU1040_LARGE_INTESTINE | 860682 | 860790 | 860723 | 860723 | Missense_Mutation | C | T | p.A630T |
| NCIH596_LUNG | 860577 | 860790 | 860766 | 860766 | Missense_Mutation | C | G | p.Q615H |
| NCIH596_LUNG | 860682 | 860790 | 860766 | 860766 | Missense_Mutation | C | G | p.Q615H |
| CORL95_LUNG | 860577 | 860790 | 860776 | 860776 | Missense_Mutation | G | A | p.A612V |
| CORL95_LUNG | 860682 | 860790 | 860776 | 860776 | Missense_Mutation | G | A | p.A612V |
| EVSAT_BREAST | 863665 | 863829 | 863709 | 863709 | Missense_Mutation | C | G | p.E551Q |
| LS180_LARGE_INTESTINE | 863665 | 863829 | 863736 | 863736 | Missense_Mutation | C | T | p.G542S |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 863665 | 863829 | 863811 | 863811 | Missense_Mutation | G | A | p.P517S |
| MG63_BONE | 871005 | 871256 | 871010 | 871010 | Missense_Mutation | C | G | p.R493S |
| CW2_LARGE_INTESTINE | 871005 | 871256 | 871070 | 871070 | Missense_Mutation | T | A | p.R473S |
| SKLU1_LUNG | 871005 | 871256 | 871117 | 871117 | Missense_Mutation | C | A | p.G458C |
| SNU81_LARGE_INTESTINE | 871005 | 871256 | 871211 | 871211 | Missense_Mutation | C | A | p.E426D |
| JK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 871005 | 871256 | 871216 | 871216 | Missense_Mutation | C | T | p.A425T |
| MM426_SKIN | 871005 | 871256 | 871219 | 871219 | Missense_Mutation | T | A | p.S424C |
| SNU475_LIVER | 871005 | 871256 | 871230 | 871230 | Missense_Mutation | T | C | p.H420R |
| HT115_LARGE_INTESTINE | 876807 | 876917 | 876821 | 876821 | Missense_Mutation | C | T | p.A283T |
| HCC2998_LARGE_INTESTINE | 890917 | 890995 | 890964 | 890964 | Missense_Mutation | T | G | p.E154D |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 890917 | 890995 | 890973 | 890973 | Missense_Mutation | G | T | p.D151E |
| T47D_BREAST | 890917 | 890995 | 890987 | 890987 | Missense_Mutation | C | T | p.E147K |
| JHUEM1_ENDOMETRIUM | 909683 | 909823 | 909737 | 909737 | Missense_Mutation | C | T | p.A126T |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 860577 | 860790 | 860683 | 860683 | Splice_Site | G | A | p.T643M |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 860682 | 860790 | 860683 | 860683 | Splice_Site | G | A | p.T643M |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LARP4B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LARP4B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LARP4B |
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RelatedDrugs for LARP4B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LARP4B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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