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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZC3H3 |
 Gene summary |
| Gene information | Gene symbol | ZC3H3 | Gene ID | 23144 |
| Gene name | zinc finger CCCH-type containing 3 | |
| Synonyms | ZC3HDC3 | |
| Cytomap | 8q24.3 | |
| Type of gene | protein-coding | |
| Description | zinc finger CCCH domain-containing protein 3smad-interacting CPSF-like factorzinc finger CCCH-type domain containing 3 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8IXZ2 | |
| Context | PubMed: ZC3H3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZC3H3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZC3H3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZC3H3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_493273 | 8 | 144523105:144523290:144547886:144548018:144550378:144550448 | 144547886:144548018 | ENSG00000014164.6 | ENST00000262577.5 |
| exon_skip_493274 | 8 | 144550551:144550710:144550786:144550829:144557567:144557755 | 144550786:144550829 | ENSG00000014164.6 | ENST00000262577.5 |
| exon_skip_493277 | 8 | 144557567:144557755:144589915:144590069:144618426:144618623 | 144589915:144590069 | ENSG00000014164.6 | ENST00000262577.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZC3H3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_493273 | 8 | 144523105:144523290:144547886:144548018:144550378:144550448 | 144547886:144548018 | ENSG00000014164.6 | ENST00000262577.5 |
| exon_skip_493274 | 8 | 144550551:144550710:144550786:144550829:144557567:144557755 | 144550786:144550829 | ENSG00000014164.6 | ENST00000262577.5 |
| exon_skip_493277 | 8 | 144557567:144557755:144589915:144590069:144618426:144618623 | 144589915:144590069 | ENSG00000014164.6 | ENST00000262577.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZC3H3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ZC3H3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZC3H3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_493273 | 144547887 | 144548018 | 144547898 | 144547898 | Frame_Shift_Del | G | - | p.L766fs |
| HNSC | TCGA-CN-5369-01 | exon_skip_493273 | 144547887 | 144548018 | 144548019 | 144548019 | Splice_Site | C | T | p.M726_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HDLM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 144547887 | 144548018 | 144547897 | 144547906 | Frame_Shift_Del | AGGGGGCAGT | - | p.YCPL763fs |
| COLO792_SKIN | 144547887 | 144548018 | 144547916 | 144547916 | Missense_Mutation | G | A | p.L760F |
| COLO792_SKIN | 144547887 | 144548018 | 144547916 | 144547917 | Missense_Mutation | GG | AA | p.L760F |
| D566MG_CENTRAL_NERVOUS_SYSTEM | 144550787 | 144550829 | 144550791 | 144550791 | Missense_Mutation | C | T | p.A648T |
| SUM229PE_BREAST | 144550787 | 144550829 | 144550799 | 144550799 | Missense_Mutation | C | T | p.R645H |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 144550787 | 144550829 | 144550812 | 144550812 | Missense_Mutation | C | A | p.G641C |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 144589916 | 144590069 | 144590009 | 144590009 | Missense_Mutation | C | T | p.R541H |
| LS180_LARGE_INTESTINE | 144547887 | 144548018 | 144547968 | 144547968 | Nonsense_Mutation | A | T | p.C742* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZC3H3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZC3H3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZC3H3 |
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RelatedDrugs for ZC3H3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZC3H3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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