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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CLASP2 |
 Gene summary |
| Gene information | Gene symbol | CLASP2 | Gene ID | 23122 |
| Gene name | cytoplasmic linker associated protein 2 | |
| Synonyms | - | |
| Cytomap | 3p22.3 | |
| Type of gene | protein-coding | |
| Description | CLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2 | |
| Modification date | 20180522 | |
| UniProtAcc | O75122 | |
| Context | PubMed: CLASP2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for CLASP2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CLASP2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CLASP2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_382283 | 3 | 33540075:33540209:33543143:33543260:33552049:33552256 | 33543143:33543260 | ENSG00000163539.11 | ENST00000480013.1,ENST00000476251.1,ENST00000468888.2,ENST00000461133.3,ENST00000359576.5,ENST00000399362.4,ENST00000539981.1,ENST00000307312.7 |
| exon_skip_382284 | 3 | 33540075:33540209:33543143:33543260:33557514:33557643 | 33543143:33543260 | ENSG00000163539.11 | ENST00000487553.1 |
| exon_skip_382288 | 3 | 33543143:33543260:33552049:33552256:33557514:33557643 | 33552049:33552256 | ENSG00000163539.11 | ENST00000480013.1,ENST00000468888.2,ENST00000461133.3,ENST00000359576.5,ENST00000399362.4,ENST00000539981.1,ENST00000307312.7 |
| exon_skip_382289 | 3 | 33552049:33552256:33556071:33556171:33557514:33557643 | 33556071:33556171 | ENSG00000163539.11 | ENST00000476251.1 |
| exon_skip_382291 | 3 | 33557514:33557643:33558472:33558666:33576724:33576858 | 33558472:33558666 | ENSG00000163539.11 | ENST00000480013.1,ENST00000476251.1,ENST00000468888.2,ENST00000461133.3,ENST00000487553.1,ENST00000359576.5,ENST00000399362.4,ENST00000539981.1,ENST00000307312.7 |
| exon_skip_382292 | 3 | 33558472:33558666:33576724:33576953:33580280:33580434 | 33576724:33576953 | ENSG00000163539.11 | ENST00000480013.1,ENST00000468888.2,ENST00000461133.3,ENST00000359576.5,ENST00000399362.4,ENST00000539981.1,ENST00000307312.7 |
| exon_skip_382295 | 3 | 33592743:33592887:33600616:33600667:33600798:33600833 | 33600616:33600667 | ENSG00000163539.11 | ENST00000480385.1 |
| exon_skip_382297 | 3 | 33602299:33602463:33605455:33605458:33612218:33612282 | 33605455:33605458 | ENSG00000163539.11 | ENST00000461133.3 |
| exon_skip_382298 | 3 | 33602299:33602463:33612181:33612184:33612218:33612282 | 33612181:33612184 | ENSG00000163539.11 | ENST00000307312.7 |
| exon_skip_382300 | 3 | 33614661:33614846:33615964:33615988:33617660:33617767 | 33615964:33615988 | ENSG00000163539.11 | ENST00000468888.2,ENST00000475576.1,ENST00000399362.4 |
| exon_skip_382301 | 3 | 33617660:33617767:33618693:33618756:33623312:33623420 | 33618693:33618756 | ENSG00000163539.11 | ENST00000480013.1,ENST00000475576.1 |
| exon_skip_382303 | 3 | 33617660:33617767:33623312:33623420:33626241:33626290 | 33623312:33623420 | ENSG00000163539.11 | ENST00000468888.2,ENST00000461133.3,ENST00000359576.5,ENST00000399362.4,ENST00000539981.1,ENST00000307312.7 |
| exon_skip_382304 | 3 | 33626241:33626412:33630196:33630223:33633704:33633731 | 33630196:33630223 | ENSG00000163539.11 | ENST00000539981.1 |
| exon_skip_382308 | 3 | 33633886:33633988:33636442:33636460:33638202:33638226 | 33636442:33636460 | ENSG00000163539.11 | ENST00000480013.1,ENST00000468888.2,ENST00000461133.3,ENST00000359576.5,ENST00000399362.4,ENST00000307312.7 |
| exon_skip_382314 | 3 | 33636442:33636460:33638202:33638226:33644443:33644617 | 33638202:33638226 | ENSG00000163539.11 | ENST00000480013.1,ENST00000468888.2,ENST00000461133.3,ENST00000359576.5,ENST00000399362.4,ENST00000307312.7 |
| exon_skip_382315 | 3 | 33650058:33650118:33653492:33653563:33661094:33661230 | 33653492:33653563 | ENSG00000163539.11 | ENST00000480013.1,ENST00000313350.6,ENST00000468888.2,ENST00000461133.3,ENST00000487200.1,ENST00000333778.6,ENST00000359576.5,ENST00000399362.4,ENST00000539981.1,ENST00000307312.7 |
| exon_skip_382316 | 3 | 33686248:33686395:33700465:33700501:33700998:33701094 | 33700465:33700501 | ENSG00000163539.11 | ENST00000498331.1 |
| exon_skip_382317 | 3 | 33686248:33686395:33704936:33705007:33725850:33725948 | 33704936:33705007 | ENSG00000163539.11 | ENST00000468888.2,ENST00000359576.5,ENST00000399362.4,ENST00000307312.7 |
| exon_skip_382318 | 3 | 33704936:33705007:33725850:33725948:33728551:33728627 | 33725850:33725948 | ENSG00000163539.11 | ENST00000468888.2,ENST00000359576.5,ENST00000399362.4,ENST00000307312.7 |
| exon_skip_382319 | 3 | 33731320:33731424:33738346:33738425:33759299:33759502 | 33738346:33738425 | ENSG00000163539.11 | ENST00000468888.2,ENST00000467956.1,ENST00000359576.5,ENST00000399362.4,ENST00000307312.7 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CLASP2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_382283 | 3 | 33540075:33540209:33543143:33543260:33552049:33552256 | 33543143:33543260 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000539981.1,ENST00000480013.1,ENST00000461133.3,ENST00000476251.1 |
| exon_skip_382284 | 3 | 33540075:33540209:33543143:33543260:33557514:33557643 | 33543143:33543260 | ENSG00000163539.11 | ENST00000487553.1 |
| exon_skip_382288 | 3 | 33543143:33543260:33552049:33552256:33557514:33557643 | 33552049:33552256 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000539981.1,ENST00000480013.1,ENST00000461133.3 |
| exon_skip_382289 | 3 | 33552049:33552256:33556071:33556171:33557514:33557643 | 33556071:33556171 | ENSG00000163539.11 | ENST00000476251.1 |
| exon_skip_382291 | 3 | 33557514:33557643:33558472:33558666:33576724:33576858 | 33558472:33558666 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000539981.1,ENST00000480013.1,ENST00000461133.3,ENST00000487553.1,ENST00000476251.1 |
| exon_skip_382292 | 3 | 33558472:33558666:33576724:33576953:33580280:33580434 | 33576724:33576953 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000539981.1,ENST00000480013.1,ENST00000461133.3 |
| exon_skip_382295 | 3 | 33592743:33592887:33600616:33600667:33600798:33600833 | 33600616:33600667 | ENSG00000163539.11 | ENST00000480385.1 |
| exon_skip_382297 | 3 | 33602299:33602463:33605455:33605458:33612218:33612282 | 33605455:33605458 | ENSG00000163539.11 | ENST00000461133.3 |
| exon_skip_382300 | 3 | 33614661:33614846:33615964:33615988:33617660:33617767 | 33615964:33615988 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000475576.1 |
| exon_skip_382301 | 3 | 33617660:33617767:33618693:33618756:33623312:33623420 | 33618693:33618756 | ENSG00000163539.11 | ENST00000480013.1,ENST00000475576.1 |
| exon_skip_382303 | 3 | 33617660:33617767:33623312:33623420:33626241:33626290 | 33623312:33623420 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000539981.1,ENST00000461133.3 |
| exon_skip_382304 | 3 | 33626241:33626412:33630196:33630223:33633704:33633731 | 33630196:33630223 | ENSG00000163539.11 | ENST00000539981.1 |
| exon_skip_382308 | 3 | 33633886:33633988:33636442:33636460:33638202:33638226 | 33636442:33636460 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000480013.1,ENST00000461133.3 |
| exon_skip_382314 | 3 | 33636442:33636460:33638202:33638226:33644443:33644617 | 33638202:33638226 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000480013.1,ENST00000461133.3 |
| exon_skip_382315 | 3 | 33650058:33650118:33653492:33653563:33661094:33661230 | 33653492:33653563 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000539981.1,ENST00000480013.1,ENST00000461133.3,ENST00000313350.6,ENST00000487200.1,ENST00000333778.6 |
| exon_skip_382316 | 3 | 33686248:33686395:33700465:33700501:33700998:33701094 | 33700465:33700501 | ENSG00000163539.11 | ENST00000498331.1 |
| exon_skip_382317 | 3 | 33686248:33686395:33704936:33705007:33725850:33725948 | 33704936:33705007 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7 |
| exon_skip_382318 | 3 | 33704936:33705007:33725850:33725948:33728551:33728627 | 33725850:33725948 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7 |
| exon_skip_382319 | 3 | 33731320:33731424:33738346:33738425:33759299:33759502 | 33738346:33738425 | ENSG00000163539.11 | ENST00000468888.2,ENST00000399362.4,ENST00000359576.5,ENST00000307312.7,ENST00000467956.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CLASP2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for CLASP2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CLASP2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_382318 | 33725851 | 33725948 | 33725892 | 33725892 | Frame_Shift_Del | T | - | p.K201fs |
| BLCA | TCGA-ZF-A9RC-01 | exon_skip_382288 | 33552050 | 33552256 | 33552169 | 33552169 | Nonsense_Mutation | G | A | p.Q1407* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| GOTO_AUTONOMIC_GANGLIA | 33558473 | 33558666 | 33558540 | 33558543 | Frame_Shift_Del | AAAG | - | p.SF1312fs |
| MDAMB157_BREAST | 33543144 | 33543260 | 33543149 | 33543149 | Missense_Mutation | T | C | p.S1485G |
| NCIBL1395_MATCHED_NORMAL_TISSUE | 33543144 | 33543260 | 33543149 | 33543149 | Missense_Mutation | T | A | p.S1485C |
| NCIH1395_LUNG | 33543144 | 33543260 | 33543149 | 33543149 | Missense_Mutation | T | A | p.S1485C |
| SNUC2A_LARGE_INTESTINE | 33543144 | 33543260 | 33543232 | 33543232 | Missense_Mutation | C | T | p.R1457Q |
| SNUC2B_LARGE_INTESTINE | 33543144 | 33543260 | 33543232 | 33543232 | Missense_Mutation | C | T | p.R1457Q |
| YD10B_UPPER_AERODIGESTIVE_TRACT | 33552050 | 33552256 | 33552075 | 33552075 | Missense_Mutation | G | A | p.P1439L |
| SNU175_LARGE_INTESTINE | 33552050 | 33552256 | 33552105 | 33552105 | Missense_Mutation | A | G | p.V1429A |
| SCABER_URINARY_TRACT | 33576725 | 33576953 | 33576791 | 33576791 | Missense_Mutation | T | G | p.S1249R |
| TE125T_FIBROBLAST | 33576725 | 33576953 | 33576933 | 33576933 | Missense_Mutation | C | T | p.M1201I |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 33618694 | 33618756 | 33618705 | 33618705 | Missense_Mutation | T | C | p.Y567C |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 33618694 | 33618756 | 33618705 | 33618705 | Missense_Mutation | T | C | p.Y567C |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 33618694 | 33618756 | 33618705 | 33618705 | Missense_Mutation | T | C | p.Y567C |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 33618694 | 33618756 | 33618710 | 33618710 | Missense_Mutation | T | A | p.E565D |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 33618694 | 33618756 | 33618710 | 33618710 | Missense_Mutation | T | A | p.E565D |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 33618694 | 33618756 | 33618710 | 33618710 | Missense_Mutation | T | A | p.E565D |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 33623313 | 33623420 | 33623354 | 33623354 | Missense_Mutation | C | T | p.S770N |
| NCIH2347_LUNG | 33623313 | 33623420 | 33623403 | 33623403 | Missense_Mutation | G | T | p.P754T |
| NCIH1435_LUNG | 33700466 | 33700501 | 33700478 | 33700478 | Missense_Mutation | C | G | p.A2P |
| SNU1040_LARGE_INTESTINE | 33704937 | 33705007 | 33704991 | 33704991 | Missense_Mutation | C | T | p.A221T |
| KYAE1_OESOPHAGUS | 33725851 | 33725948 | 33725933 | 33725933 | Missense_Mutation | T | C | p.I188V |
| NCIH1688_LUNG | 33576725 | 33576953 | 33576725 | 33576725 | Splice_Site | C | A | p.D1271Y |
| HEY_OVARY | 33725851 | 33725948 | 33725948 | 33725948 | Splice_Site | C | G | p.V183L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLASP2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLASP2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLASP2 |
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RelatedDrugs for CLASP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLASP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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