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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ARHGAP26 |
 Gene summary |
| Gene information | Gene symbol | ARHGAP26 | Gene ID | 23092 |
| Gene name | Rho GTPase activating protein 26 | |
| Synonyms | GRAF|GRAF1|OPHN1L|OPHN1L1 | |
| Cytomap | 5q31.3 | |
| Type of gene | protein-coding | |
| Description | rho GTPase-activating protein 26GTPase regulator associated with focal adhesion kinase pp125(FAK)oligophrenin-1-like protein | |
| Modification date | 20180523 | |
| UniProtAcc | Q9UNA1 | |
| Context | PubMed: ARHGAP26 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ARHGAP26 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ARHGAP26 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ARHGAP26 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_438364 | 5 | 142258938:142259010:142264862:142264964:142273802:142273900 | 142264862:142264964 | ENSG00000145819.11 | ENST00000274498.4,ENST00000475287.1,ENST00000378004.3,ENST00000378013.2 |
| exon_skip_438366 | 5 | 142264862:142264964:142273802:142273913:142281499:142281578 | 142273802:142273913 | ENSG00000145819.11 | ENST00000274498.4,ENST00000475287.1,ENST00000378004.3 |
| exon_skip_438367 | 5 | 142273802:142273913:142281499:142281604:142283104:142283234 | 142281499:142281604 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3 |
| exon_skip_438368 | 5 | 142281499:142281604:142283104:142283234:142287268:142287369 | 142283104:142283234 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3 |
| exon_skip_438371 | 5 | 142292763:142292858:142295106:142295249:142311611:142311690 | 142295106:142295249 | ENSG00000145819.11 | ENST00000461314.1 |
| exon_skip_438374 | 5 | 142311611:142311690:142393644:142393681:142416760:142416788 | 142393644:142393681 | ENSG00000145819.11 | ENST00000469131.1,ENST00000274498.4,ENST00000451259.1,ENST00000469396.1,ENST00000378004.3 |
| exon_skip_438377 | 5 | 142393644:142393681:142416760:142416826:142421380:142421455 | 142416760:142416826 | ENSG00000145819.11 | ENST00000469131.1,ENST00000274498.4,ENST00000469396.1,ENST00000378004.3 |
| exon_skip_438380 | 5 | 142513549:142513670:142526795:142526946:142586762:142586873 | 142526795:142526946 | ENSG00000145819.11 | ENST00000274498.4,ENST00000443674.1,ENST00000378004.3 |
| exon_skip_438381 | 5 | 142513549:142513670:142526795:142526946:142593561:142593653 | 142526795:142526946 | ENSG00000145819.11 | ENST00000418236.1 |
| exon_skip_438384 | 5 | 142526795:142526946:142545591:142545662:142552523:142552585 | 142545591:142545662 | ENSG00000145819.11 | ENST00000424007.1 |
| exon_skip_438392 | 5 | 142526795:142526946:142586762:142586873:142593561:142593653 | 142586762:142586873 | ENSG00000145819.11 | ENST00000378004.3 |
| exon_skip_438393 | 5 | 142526795:142526946:142586762:142587038:142593561:142593653 | 142586762:142587038 | ENSG00000145819.11 | ENST00000274498.4 |
| exon_skip_438394 | 5 | 142526795:142526946:142586947:142587038:142593561:142593653 | 142586947:142587038 | ENSG00000145819.11 | ENST00000419676.1 |
| exon_skip_438395 | 5 | 142526795:142526946:142593561:142593653:142601922:142601978 | 142593561:142593653 | ENSG00000145819.11 | ENST00000418236.1 |
| exon_skip_438406 | 5 | 142586764:142586873:142587008:142587038:142593561:142593653 | 142587008:142587038 | ENSG00000145819.11 | ENST00000443674.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ARHGAP26 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_438364 | 5 | 142258938:142259010:142264862:142264964:142273802:142273900 | 142264862:142264964 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3,ENST00000378013.2,ENST00000475287.1 |
| exon_skip_438366 | 5 | 142264862:142264964:142273802:142273913:142281499:142281578 | 142273802:142273913 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3,ENST00000475287.1 |
| exon_skip_438367 | 5 | 142273802:142273913:142281499:142281604:142283104:142283234 | 142281499:142281604 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3 |
| exon_skip_438368 | 5 | 142281499:142281604:142283104:142283234:142287268:142287369 | 142283104:142283234 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3 |
| exon_skip_438371 | 5 | 142292763:142292858:142295106:142295249:142311611:142311690 | 142295106:142295249 | ENSG00000145819.11 | ENST00000461314.1 |
| exon_skip_438374 | 5 | 142311611:142311690:142393644:142393681:142416760:142416788 | 142393644:142393681 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3,ENST00000451259.1,ENST00000469131.1,ENST00000469396.1 |
| exon_skip_438377 | 5 | 142393644:142393681:142416760:142416826:142421380:142421455 | 142416760:142416826 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3,ENST00000469131.1,ENST00000469396.1 |
| exon_skip_438380 | 5 | 142513549:142513670:142526795:142526946:142586762:142586873 | 142526795:142526946 | ENSG00000145819.11 | ENST00000274498.4,ENST00000378004.3,ENST00000443674.1 |
| exon_skip_438381 | 5 | 142513549:142513670:142526795:142526946:142593561:142593653 | 142526795:142526946 | ENSG00000145819.11 | ENST00000418236.1 |
| exon_skip_438384 | 5 | 142526795:142526946:142545591:142545662:142552523:142552585 | 142545591:142545662 | ENSG00000145819.11 | ENST00000424007.1 |
| exon_skip_438392 | 5 | 142526795:142526946:142586762:142586873:142593561:142593653 | 142586762:142586873 | ENSG00000145819.11 | ENST00000378004.3 |
| exon_skip_438393 | 5 | 142526795:142526946:142586762:142587038:142593561:142593653 | 142586762:142587038 | ENSG00000145819.11 | ENST00000274498.4 |
| exon_skip_438394 | 5 | 142526795:142526946:142586947:142587038:142593561:142593653 | 142586947:142587038 | ENSG00000145819.11 | ENST00000419676.1 |
| exon_skip_438395 | 5 | 142526795:142526946:142593561:142593653:142601922:142601978 | 142593561:142593653 | ENSG00000145819.11 | ENST00000418236.1 |
| exon_skip_438406 | 5 | 142586764:142586873:142587008:142587038:142593561:142593653 | 142587008:142587038 | ENSG00000145819.11 | ENST00000443674.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ARHGAP26 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000274498 | 142283104 | 142283234 | Frame-shift |
| ENST00000378004 | 142283104 | 142283234 | Frame-shift |
| ENST00000274498 | 142393644 | 142393681 | Frame-shift |
| ENST00000378004 | 142393644 | 142393681 | Frame-shift |
| ENST00000274498 | 142526795 | 142526946 | Frame-shift |
| ENST00000378004 | 142526795 | 142526946 | Frame-shift |
| ENST00000274498 | 142264862 | 142264964 | In-frame |
| ENST00000378004 | 142264862 | 142264964 | In-frame |
| ENST00000274498 | 142273802 | 142273913 | In-frame |
| ENST00000378004 | 142273802 | 142273913 | In-frame |
| ENST00000274498 | 142281499 | 142281604 | In-frame |
| ENST00000378004 | 142281499 | 142281604 | In-frame |
| ENST00000274498 | 142416760 | 142416826 | In-frame |
| ENST00000378004 | 142416760 | 142416826 | In-frame |
| ENST00000274498 | 142586762 | 142587038 | In-frame |
| ENST00000378004 | 142586762 | 142586873 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000274498 | 142283104 | 142283234 | Frame-shift |
| ENST00000378004 | 142283104 | 142283234 | Frame-shift |
| ENST00000274498 | 142393644 | 142393681 | Frame-shift |
| ENST00000378004 | 142393644 | 142393681 | Frame-shift |
| ENST00000274498 | 142526795 | 142526946 | Frame-shift |
| ENST00000378004 | 142526795 | 142526946 | Frame-shift |
| ENST00000274498 | 142264862 | 142264964 | In-frame |
| ENST00000378004 | 142264862 | 142264964 | In-frame |
| ENST00000274498 | 142273802 | 142273913 | In-frame |
| ENST00000378004 | 142273802 | 142273913 | In-frame |
| ENST00000274498 | 142281499 | 142281604 | In-frame |
| ENST00000378004 | 142281499 | 142281604 | In-frame |
| ENST00000274498 | 142416760 | 142416826 | In-frame |
| ENST00000378004 | 142416760 | 142416826 | In-frame |
| ENST00000274498 | 142586762 | 142587038 | In-frame |
| ENST00000378004 | 142586762 | 142586873 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ARHGAP26 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000274498 | 6879 | 814 | 142264862 | 142264964 | 763 | 864 | 128 | 162 |
| ENST00000378004 | 9217 | 814 | 142264862 | 142264964 | 740 | 841 | 128 | 162 |
| ENST00000274498 | 6879 | 814 | 142273802 | 142273913 | 865 | 975 | 162 | 199 |
| ENST00000378004 | 9217 | 814 | 142273802 | 142273913 | 842 | 952 | 162 | 199 |
| ENST00000274498 | 6879 | 814 | 142281499 | 142281604 | 976 | 1080 | 199 | 234 |
| ENST00000378004 | 9217 | 814 | 142281499 | 142281604 | 953 | 1057 | 199 | 234 |
| ENST00000274498 | 6879 | 814 | 142416760 | 142416826 | 1523 | 1588 | 381 | 403 |
| ENST00000378004 | 9217 | 814 | 142416760 | 142416826 | 1500 | 1565 | 381 | 403 |
| ENST00000274498 | 6879 | 814 | 142586762 | 142587038 | 2367 | 2642 | 663 | 754 |
| ENST00000378004 | 9217 | 814 | 142586762 | 142586873 | 2344 | 2454 | 663 | 699 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000274498 | 6879 | 814 | 142264862 | 142264964 | 763 | 864 | 128 | 162 |
| ENST00000378004 | 9217 | 814 | 142264862 | 142264964 | 740 | 841 | 128 | 162 |
| ENST00000274498 | 6879 | 814 | 142273802 | 142273913 | 865 | 975 | 162 | 199 |
| ENST00000378004 | 9217 | 814 | 142273802 | 142273913 | 842 | 952 | 162 | 199 |
| ENST00000274498 | 6879 | 814 | 142281499 | 142281604 | 976 | 1080 | 199 | 234 |
| ENST00000378004 | 9217 | 814 | 142281499 | 142281604 | 953 | 1057 | 199 | 234 |
| ENST00000274498 | 6879 | 814 | 142416760 | 142416826 | 1523 | 1588 | 381 | 403 |
| ENST00000378004 | 9217 | 814 | 142416760 | 142416826 | 1500 | 1565 | 381 | 403 |
| ENST00000274498 | 6879 | 814 | 142586762 | 142587038 | 2367 | 2642 | 663 | 754 |
| ENST00000378004 | 9217 | 814 | 142586762 | 142586873 | 2344 | 2454 | 663 | 699 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UNA1 | 128 | 162 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 128 | 162 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 162 | 199 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 162 | 199 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 199 | 234 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 199 | 234 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 381 | 403 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 381 | 403 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 381 | 403 | 383 | 568 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q9UNA1 | 381 | 403 | 383 | 568 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q9UNA1 | 663 | 754 | 700 | 754 | Alternative sequence | ID=VSP_001659;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9UNA1 | 663 | 754 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 663 | 699 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 663 | 754 | 584 | 701 | Compositional bias | Note=Ser-rich |
| Q9UNA1 | 663 | 699 | 584 | 701 | Compositional bias | Note=Ser-rich |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UNA1 | 128 | 162 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 128 | 162 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 162 | 199 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 162 | 199 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 199 | 234 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 199 | 234 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 381 | 403 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 381 | 403 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 381 | 403 | 383 | 568 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q9UNA1 | 381 | 403 | 383 | 568 | Domain | Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00172 |
| Q9UNA1 | 663 | 754 | 700 | 754 | Alternative sequence | ID=VSP_001659;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9UNA1 | 663 | 754 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 663 | 699 | 1 | 814 | Chain | ID=PRO_0000056718;Note=Rho GTPase-activating protein 26 |
| Q9UNA1 | 663 | 754 | 584 | 701 | Compositional bias | Note=Ser-rich |
| Q9UNA1 | 663 | 699 | 584 | 701 | Compositional bias | Note=Ser-rich |
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SNVs in the skipped exons for ARHGAP26 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
ARHGAP26_UCEC_exon_skip_438393_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_438364 | 142264863 | 142264964 | 142264915 | 142264915 | Frame_Shift_Del | A | - | p.E146fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_438364 | 142264863 | 142264964 | 142264915 | 142264915 | Frame_Shift_Del | A | - | p.E146fs |
| KIRC | TCGA-B8-A54D-01 | exon_skip_438364 | 142264863 | 142264964 | 142264938 | 142264941 | Frame_Shift_Del | AAAA | - | p.153_154del |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_438366 | 142273803 | 142273913 | 142273896 | 142273896 | Frame_Shift_Del | T | - | p.F194fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_438366 | 142273803 | 142273913 | 142273902 | 142273902 | Frame_Shift_Del | T | - | p.F196fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_438368 | 142283105 | 142283234 | 142283153 | 142283153 | Frame_Shift_Del | A | - | p.K252fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_438368 | 142283105 | 142283234 | 142283153 | 142283153 | Frame_Shift_Del | A | - | p.K252fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_438368 | 142283105 | 142283234 | 142283153 | 142283153 | Frame_Shift_Del | A | - | p.K252fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_438392 | 142586763 | 142586873 | 142586787 | 142586788 | Frame_Shift_Ins | - | C | p.SP671fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_438393 | 142586763 | 142587038 | 142586787 | 142586788 | Frame_Shift_Ins | - | C | p.SP671fs |
| LGG | TCGA-DU-6392-01 | 142281500 | 142281604 | 142281518 | 142281518 | Nonsense_Mutation | G | T | p.G206* | |
| HNSC | TCGA-BA-5152-01 | exon_skip_438368 | 142283105 | 142283234 | 142283207 | 142283207 | Nonsense_Mutation | G | T | p.E269* |
| UCEC | TCGA-B5-A0K2-01 | exon_skip_438392 | 142586763 | 142586873 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| UCEC | TCGA-B5-A0K2-01 | exon_skip_438393 | 142586763 | 142587038 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| UCEC | TCGA-B5-A0K9-01 | exon_skip_438392 | 142586763 | 142586873 | 142586762 | 142586762 | Splice_Site | G | A | p.L663_splice |
| UCEC | TCGA-B5-A0K9-01 | exon_skip_438393 | 142586763 | 142587038 | 142586762 | 142586762 | Splice_Site | G | A | p.L663_splice |
| UCEC | TCGA-BG-A0M3-01 | exon_skip_438392 | 142586763 | 142586873 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| UCEC | TCGA-BG-A0M3-01 | exon_skip_438393 | 142586763 | 142587038 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| UCEC | TCGA-BG-A0M7-01 | exon_skip_438392 | 142586763 | 142586873 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| UCEC | TCGA-BG-A0M7-01 | exon_skip_438393 | 142586763 | 142587038 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| UCEC | TCGA-BG-A0M9-01 | exon_skip_438392 | 142586763 | 142586873 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| UCEC | TCGA-BG-A0M9-01 | exon_skip_438393 | 142586763 | 142587038 | 142586762 | 142586763 | Splice_Site | - | C | p.L663_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-B5-A0K9-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_438392 | |
| Skipped exon start: 142586763 | |
| Skipped exon end: 142586873 | |
| Mutation start: 142586762 | |
| Mutation end: 142586762 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.L663_splice | |
| Sample: TCGA-B5-A0K9-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_438393 | |
| Skipped exon start: 142586763 | |
| Skipped exon end: 142587038 | |
| Mutation start: 142586762 | |
| Mutation end: 142586762 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.L663_splice | |
exon_skip_101656_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_25134_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_295913_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_301201_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_319638_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_321422_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_321423_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_321427_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_32745_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_382168_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_420494_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_421737_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_438393_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_468121_UCEC_TCGA-B5-A0K9-01.png | |
exon_skip_54935_UCEC_TCGA-B5-A0K9-01.png | |
 | Sample: TCGA-BC-A112-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_438392 | |
| Skipped exon start: 142586763 | |
| Skipped exon end: 142586873 | |
| Mutation start: 142586787 | |
| Mutation end: 142586788 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.SP671fs | |
| Sample: TCGA-BC-A112-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_438393 | |
| Skipped exon start: 142586763 | |
| Skipped exon end: 142587038 | |
| Mutation start: 142586787 | |
| Mutation end: 142586788 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.SP671fs | |
exon_skip_114200_LIHC_TCGA-BC-A112-01.png | |
exon_skip_131894_LIHC_TCGA-BC-A112-01.png | |
exon_skip_135820_LIHC_TCGA-BC-A112-01.png | |
exon_skip_138911_LIHC_TCGA-BC-A112-01.png | |
exon_skip_141587_LIHC_TCGA-BC-A112-01.png | |
exon_skip_142606_LIHC_TCGA-BC-A112-01.png | |
exon_skip_146695_LIHC_TCGA-BC-A112-01.png | |
exon_skip_146697_LIHC_TCGA-BC-A112-01.png | |
exon_skip_152962_LIHC_TCGA-BC-A112-01.png | |
exon_skip_155765_LIHC_TCGA-BC-A112-01.png | |
exon_skip_1757_LIHC_TCGA-BC-A112-01.png | |
exon_skip_1879_LIHC_TCGA-BC-A112-01.png | |
exon_skip_1881_LIHC_TCGA-BC-A112-01.png | |
exon_skip_266_LIHC_TCGA-BC-A112-01.png | |
exon_skip_284527_LIHC_TCGA-BC-A112-01.png | |
exon_skip_286998_LIHC_TCGA-BC-A112-01.png | |
exon_skip_293546_LIHC_TCGA-BC-A112-01.png | |
exon_skip_293549_LIHC_TCGA-BC-A112-01.png | |
exon_skip_306900_LIHC_TCGA-BC-A112-01.png | |
exon_skip_311841_LIHC_TCGA-BC-A112-01.png | |
exon_skip_325884_LIHC_TCGA-BC-A112-01.png | |
exon_skip_326432_LIHC_TCGA-BC-A112-01.png | |
exon_skip_32825_LIHC_TCGA-BC-A112-01.png | |
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exon_skip_337747_LIHC_TCGA-BC-A112-01.png | |
exon_skip_339045_LIHC_TCGA-BC-A112-01.png | |
exon_skip_344031_LIHC_TCGA-BC-A112-01.png | |
exon_skip_35548_LIHC_TCGA-BC-A112-01.png | |
exon_skip_35556_LIHC_TCGA-BC-A112-01.png | |
exon_skip_359720_LIHC_TCGA-BC-A112-01.png | |
exon_skip_37056_LIHC_TCGA-BC-A112-01.png | |
exon_skip_37483_LIHC_TCGA-BC-A112-01.png | |
exon_skip_37491_LIHC_TCGA-BC-A112-01.png | |
exon_skip_375724_LIHC_TCGA-BC-A112-01.png | |
exon_skip_378789_LIHC_TCGA-BC-A112-01.png | |
exon_skip_386291_LIHC_TCGA-BC-A112-01.png | |
exon_skip_41850_LIHC_TCGA-BC-A112-01.png | |
exon_skip_435931_LIHC_TCGA-BC-A112-01.png | |
exon_skip_436296_LIHC_TCGA-BC-A112-01.png | |
exon_skip_438393_LIHC_TCGA-BC-A112-01.png | |
exon_skip_443977_LIHC_TCGA-BC-A112-01.png | |
exon_skip_444190_LIHC_TCGA-BC-A112-01.png | |
exon_skip_44538_LIHC_TCGA-BC-A112-01.png | |
exon_skip_449944_LIHC_TCGA-BC-A112-01.png | |
exon_skip_458520_LIHC_TCGA-BC-A112-01.png | |
exon_skip_460075_LIHC_TCGA-BC-A112-01.png | |
exon_skip_472635_LIHC_TCGA-BC-A112-01.png | |
exon_skip_489149_LIHC_TCGA-BC-A112-01.png | |
exon_skip_492152_LIHC_TCGA-BC-A112-01.png | |
exon_skip_49506_LIHC_TCGA-BC-A112-01.png | |
exon_skip_5044_LIHC_TCGA-BC-A112-01.png | |
exon_skip_512559_LIHC_TCGA-BC-A112-01.png | |
exon_skip_514460_LIHC_TCGA-BC-A112-01.png | |
exon_skip_514990_LIHC_TCGA-BC-A112-01.png | |
exon_skip_55171_LIHC_TCGA-BC-A112-01.png | |
exon_skip_55175_LIHC_TCGA-BC-A112-01.png | |
exon_skip_56847_LIHC_TCGA-BC-A112-01.png | |
exon_skip_57586_LIHC_TCGA-BC-A112-01.png | |
exon_skip_57892_LIHC_TCGA-BC-A112-01.png | |
exon_skip_58035_LIHC_TCGA-BC-A112-01.png | |
exon_skip_6399_LIHC_TCGA-BC-A112-01.png | |
exon_skip_77132_LIHC_TCGA-BC-A112-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC151_ENDOMETRIUM | 142264863 | 142264964 | 142264878 | 142264878 | Missense_Mutation | T | C | p.Y134H |
| NTERA2CLD1_TESTIS | 142273803 | 142273913 | 142273856 | 142273856 | Missense_Mutation | A | C | p.E180D |
| SNU1040_LARGE_INTESTINE | 142281500 | 142281604 | 142281566 | 142281566 | Missense_Mutation | G | A | p.G222R |
| LU65_LUNG | 142283105 | 142283234 | 142283160 | 142283160 | Missense_Mutation | T | C | p.M253T |
| HEC108_ENDOMETRIUM | 142283105 | 142283234 | 142283205 | 142283205 | Missense_Mutation | T | C | p.M268T |
| SNU1040_LARGE_INTESTINE | 142283105 | 142283234 | 142283222 | 142283222 | Missense_Mutation | G | A | p.V274M |
| SKCO1_LARGE_INTESTINE | 142526796 | 142526946 | 142526858 | 142526858 | Missense_Mutation | A | G | p.I634V |
| CW2_LARGE_INTESTINE | 142526796 | 142526946 | 142526912 | 142526912 | Missense_Mutation | C | A | p.L652M |
| EN_ENDOMETRIUM | 142586763 | 142586873 | 142586779 | 142586779 | Missense_Mutation | C | A | p.P669T |
| EN_ENDOMETRIUM | 142586763 | 142587038 | 142586779 | 142586779 | Missense_Mutation | C | A | p.P669T |
| WM88_SKIN | 142586763 | 142586873 | 142586795 | 142586795 | Missense_Mutation | C | T | p.S674L |
| WM88_SKIN | 142586763 | 142587038 | 142586795 | 142586795 | Missense_Mutation | C | T | p.S674L |
| 639V_URINARY_TRACT | 142586763 | 142587038 | 142586885 | 142586885 | Missense_Mutation | G | T | p.G704V |
| SNU175_LARGE_INTESTINE | 142586763 | 142587038 | 142586927 | 142586927 | Missense_Mutation | C | T | p.A718V |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 142586763 | 142587038 | 142586929 | 142586929 | Missense_Mutation | C | T | p.R719W |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142586763 | 142587038 | 142586929 | 142586929 | Missense_Mutation | C | T | p.R719W |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142586763 | 142587038 | 142586929 | 142586929 | Missense_Mutation | C | T | p.R719W |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 142586948 | 142587038 | 142587026 | 142587026 | Missense_Mutation | A | G | p.H751R |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 142586763 | 142587038 | 142587026 | 142587026 | Missense_Mutation | A | G | p.H751R |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 142587009 | 142587038 | 142587026 | 142587026 | Missense_Mutation | A | G | p.H751R |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142586948 | 142587038 | 142587026 | 142587026 | Missense_Mutation | A | G | p.H751R |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142586763 | 142587038 | 142587026 | 142587026 | Missense_Mutation | A | G | p.H751R |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142587009 | 142587038 | 142587026 | 142587026 | Missense_Mutation | A | G | p.H751R |
| CW2_LARGE_INTESTINE | 142526796 | 142526946 | 142526946 | 142526946 | Splice_Site | T | C | p.L663P |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARHGAP26 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARHGAP26 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARHGAP26 |
Top |
RelatedDrugs for ARHGAP26 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ARHGAP26 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ARHGAP26 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| ARHGAP26 | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human;HPO;UNIPROT |
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