ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for KDM4C

Gene summary

Gene information	Gene symbol	KDM4C
	Gene ID	23081
	Gene name	lysine demethylase 4C
	Synonyms	GASC1\|JHDM3C\|JMJD2C\|TDRD14C
	Cytomap	9p24.1
	Type of gene	protein-coding
	Description	lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
	Modification date	20180523
	UniProtAcc	Q9H3R0
	Context	PubMed: KDM4C [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
KDM4C	GO:0006357	regulation of transcription by RNA polymerase II	17277772
KDM4C	GO:0033169	histone H3-K9 demethylation	18066052\|21914792
KDM4C	GO:0070544	histone H3-K36 demethylation	21914792

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Exon skipping events across known transcript of Ensembl for KDM4C from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for KDM4C

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for KDM4C

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_495049	9	6758117:6758203:6792971:6793132:6805598:6805774	6792971:6793132	ENSG00000107077.13	ENST00000489243.1,ENST00000536108.1,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3,ENST00000401787.3
exon_skip_495050	9	6792971:6793132:6805598:6805774:6814630:6814745	6805598:6805774	ENSG00000107077.13	ENST00000535193.1,ENST00000489243.1,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3,ENST00000401787.3
exon_skip_495052	9	6805616:6805774:6814630:6814745:6849506:6849700	6814630:6814745	ENSG00000107077.13	ENST00000535193.1,ENST00000489243.1,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3
exon_skip_495056	9	6814630:6814745:6849506:6849700:6880011:6880061	6849506:6849700	ENSG00000107077.13	ENST00000535193.1,ENST00000489243.1,ENST00000438023.1,ENST00000442236.2,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENSG00000107077.13	ENST00000438023.1
exon_skip_495067	9	6984280:6984404:6986343:6986666:6990415:6990524	6986343:6986666	ENSG00000107077.13	ENST00000535193.1,ENST00000536108.1,ENST00000428870.2,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENSG00000107077.13	ENST00000536108.1
exon_skip_495076	9	7046861:7046917:7049091:7049200:7076433:7077262	7049091:7049200	ENSG00000107077.13	ENST00000535193.1,ENST00000543771.1
exon_skip_495077	9	7046861:7046917:7049091:7049200:7103684:7103870	7049091:7049200	ENSG00000107077.13	ENST00000428870.2,ENST00000442236.2,ENST00000420847.1,ENST00000381309.3,ENST00000381306.3
exon_skip_495079	9	7049191:7049200:7103684:7103870:7128065:7128236	7103684:7103870	ENSG00000107077.13	ENST00000428870.2,ENST00000442236.2,ENST00000381309.3,ENST00000381306.3
exon_skip_495080	9	7103684:7103870:7105401:7105500:7128065:7128236	7105401:7105500	ENSG00000107077.13	ENST00000420847.1
exon_skip_495083	9	7103684:7103870:7128065:7128236:7165237:7165355	7128065:7128236	ENSG00000107077.13	ENST00000536108.1,ENST00000428870.2,ENST00000442236.2,ENST00000381309.3,ENST00000381306.3
exon_skip_495085	9	7105401:7105500:7128065:7128236:7165237:7165355	7128065:7128236	ENSG00000107077.13	ENST00000420847.1
exon_skip_495087	9	7128065:7128236:7165237:7165357:7169797:7169829	7165237:7165357	ENSG00000107077.13	ENST00000490806.1,ENST00000428870.2,ENST00000466673.1,ENST00000442236.2,ENST00000420847.1,ENST00000381309.3,ENST00000381306.3

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for KDM4C

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_495049	9	6758117:6758203:6792971:6793132:6805598:6805774	6792971:6793132	ENSG00000107077.13	ENST00000438023.1,ENST00000543771.1,ENST00000401787.3,ENST00000381306.3,ENST00000381309.3,ENST00000489243.1,ENST00000536108.1
exon_skip_495050	9	6792971:6793132:6805598:6805774:6814630:6814745	6805598:6805774	ENSG00000107077.13	ENST00000535193.1,ENST00000438023.1,ENST00000543771.1,ENST00000401787.3,ENST00000381306.3,ENST00000381309.3,ENST00000489243.1
exon_skip_495052	9	6805616:6805774:6814630:6814745:6849506:6849700	6814630:6814745	ENSG00000107077.13	ENST00000535193.1,ENST00000438023.1,ENST00000543771.1,ENST00000381306.3,ENST00000381309.3,ENST00000489243.1
exon_skip_495056	9	6814630:6814745:6849506:6849700:6880011:6880061	6849506:6849700	ENSG00000107077.13	ENST00000535193.1,ENST00000438023.1,ENST00000543771.1,ENST00000381306.3,ENST00000381309.3,ENST00000442236.2,ENST00000489243.1
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENSG00000107077.13	ENST00000438023.1
exon_skip_495067	9	6984280:6984404:6986343:6986666:6990415:6990524	6986343:6986666	ENSG00000107077.13	ENST00000535193.1,ENST00000438023.1,ENST00000543771.1,ENST00000381306.3,ENST00000381309.3,ENST00000536108.1,ENST00000428870.2
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENSG00000107077.13	ENST00000536108.1
exon_skip_495076	9	7046861:7046917:7049091:7049200:7076433:7077262	7049091:7049200	ENSG00000107077.13	ENST00000535193.1,ENST00000543771.1
exon_skip_495077	9	7046861:7046917:7049091:7049200:7103684:7103870	7049091:7049200	ENSG00000107077.13	ENST00000381306.3,ENST00000381309.3,ENST00000442236.2,ENST00000428870.2,ENST00000420847.1
exon_skip_495079	9	7049191:7049200:7103684:7103870:7128065:7128236	7103684:7103870	ENSG00000107077.13	ENST00000381306.3,ENST00000381309.3,ENST00000442236.2,ENST00000428870.2
exon_skip_495080	9	7103684:7103870:7105401:7105500:7128065:7128236	7105401:7105500	ENSG00000107077.13	ENST00000420847.1
exon_skip_495083	9	7103684:7103870:7128065:7128236:7165237:7165355	7128065:7128236	ENSG00000107077.13	ENST00000381306.3,ENST00000381309.3,ENST00000442236.2,ENST00000536108.1,ENST00000428870.2
exon_skip_495085	9	7105401:7105500:7128065:7128236:7165237:7165355	7128065:7128236	ENSG00000107077.13	ENST00000420847.1
exon_skip_495087	9	7128065:7128236:7165237:7165357:7169797:7169829	7165237:7165357	ENSG00000107077.13	ENST00000381306.3,ENST00000381309.3,ENST00000442236.2,ENST00000428870.2,ENST00000420847.1,ENST00000490806.1,ENST00000466673.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for KDM4C

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000381309	6792971	6793132	5CDS-5UTR
ENST00000381309	6805598	6805774	Frame-shift
ENST00000381309	6814630	6814745	Frame-shift
ENST00000381309	6849506	6849700	Frame-shift
ENST00000381309	6986343	6986666	Frame-shift
ENST00000381309	7049091	7049200	Frame-shift
ENST00000381309	7103684	7103870	In-frame
ENST00000381309	7128065	7128236	In-frame
ENST00000381309	7165237	7165357	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000381309	6792971	6793132	5CDS-5UTR
ENST00000381309	6805598	6805774	Frame-shift
ENST00000381309	6814630	6814745	Frame-shift
ENST00000381309	6849506	6849700	Frame-shift
ENST00000381309	6986343	6986666	Frame-shift
ENST00000381309	7049091	7049200	Frame-shift
ENST00000381309	7103684	7103870	In-frame
ENST00000381309	7128065	7128236	In-frame
ENST00000381309	7165237	7165357	In-frame

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Infer the effects of exon skipping event on protein functional features for KDM4C

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000381309	4672	1056	7103684	7103870	2990	3175	808	870
ENST00000381309	4672	1056	7128065	7128236	3176	3346	870	927
ENST00000381309	4672	1056	7165237	7165357	3347	3466	927	967

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000381309	4672	1056	7103684	7103870	2990	3175	808	870
ENST00000381309	4672	1056	7128065	7128236	3176	3346	870	927
ENST00000381309	4672	1056	7165237	7165357	3347	3466	927	967

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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SNVs in the skipped exons for KDM4C

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

KDM4C_LIHC_exon_skip_495073_psi_boxplot.png
boxplot

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A39Y-01	exon_skip_495050	6805599	6805774	6805725	6805725	Frame_Shift_Del	A	-	p.K92fs
LIHC	TCGA-DD-A39Y-01	exon_skip_495050	6805599	6805774	6805725	6805725	Frame_Shift_Del	A	-	p.Q112fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_495050	6805599	6805774	6805725	6805725	Frame_Shift_Del	A	-	p.K92fs
LIHC	TCGA-DD-A39Y-01	exon_skip_495056	6849507	6849700	6849546	6849546	Frame_Shift_Del	T	-	p.L159fs
LIHC	TCGA-DD-A1EG-01	exon_skip_495056	6849507	6849700	6849608	6849608	Frame_Shift_Del	T	-	p.Y179fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_495067	6986344	6986666	6986447	6986447	Frame_Shift_Del	T	-	p.D486fs
LIHC	TCGA-DD-A39Y-01	exon_skip_495067	6986344	6986666	6986613	6986613	Frame_Shift_Del	G	-	p.G542fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_495067	6986344	6986666	6986621	6986621	Frame_Shift_Del	C	-	p.I544fs
LIHC	TCGA-DD-A39Y-01	exon_skip_495073	7046862	7046917	7046879	7046879	Frame_Shift_Del	T	-	p.N759fs
STAD	TCGA-D7-A6EY-01	exon_skip_495079	7103685	7103870	7103861	7103861	Frame_Shift_Del	C	-	p.N867fs
LGG	TCGA-CS-4944-01	exon_skip_495085 exon_skip_495083	7128066	7128236	7128074	7128075	Frame_Shift_Del	GG	-	p.873_873del
LGG	TCGA-CS-4944-01	exon_skip_495085 exon_skip_495083	7128066	7128236	7128074	7128075	Frame_Shift_Del	GG	-	p.KA873fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_495087	7165238	7165357	7165261	7165261	Frame_Shift_Del	C	-	p.G935fs
LIHC	TCGA-DD-A1EG-01	exon_skip_495087	7165238	7165357	7165321	7165321	Frame_Shift_Del	A	-	p.A955fs
LGG	TCGA-DB-A64R-01	exon_skip_495050	6805599	6805774	6805637	6805637	Nonsense_Mutation	T	G	p.Y61*
LGG	TCGA-DB-A64R-01	exon_skip_495050	6805599	6805774	6805637	6805637	Nonsense_Mutation	T	G	p.Y83X
UCEC	TCGA-AX-A05Z-01	exon_skip_495076 exon_skip_495077	7049092	7049200	7049132	7049132	Nonsense_Mutation	C	T	p.R786*
SKCM	TCGA-D9-A6EC-06	exon_skip_495056	6849507	6849700	6849702	6849702	Splice_Site	C	T	.
LIHC	TCGA-UB-A7MB-01	exon_skip_495073	7046862	7046917	7046860	7046860	Splice_Site	A	T	.

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons	Mutation description
	Sample: TCGA-UB-A7MB-01
	Cancer type: LIHC
	ESID: exon_skip_495073
	Skipped exon start: 7046862
	Skipped exon end: 7046917
	Mutation start: 7046860
	Mutation end: 7046860
	Mutation type: Splice_Site
	Reference seq: A
	Mutation seq: T
	AAchange: .
exon_skip_124728_LIHC_TCGA-UB-A7MB-01.png
exon_skip_128735_LIHC_TCGA-UB-A7MB-01.png
exon_skip_136487_LIHC_TCGA-UB-A7MB-01.png
exon_skip_32461_LIHC_TCGA-UB-A7MB-01.png
exon_skip_495073_LIHC_TCGA-UB-A7MB-01.png
exon_skip_85286_LIHC_TCGA-UB-A7MB-01.png

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
SNU1040_LARGE_INTESTINE	6792972	6793132	6792992	6792992	Missense_Mutation	G	A	p.E2K
KNS62_LUNG	6792972	6793132	6792999	6792999	Missense_Mutation	C	A	p.A4D
JSC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	6792972	6793132	6793011	6793011	Missense_Mutation	G	T	p.S8I
H4_CENTRAL_NERVOUS_SYSTEM	6805599	6805774	6805609	6805609	Missense_Mutation	C	A	p.P52H
NCIH2286_LUNG	6805599	6805774	6805679	6805679	Missense_Mutation	G	T	p.Q75H
HCC1195_LUNG	6805599	6805774	6805694	6805694	Missense_Mutation	G	T	p.Q80H
HEC251_ENDOMETRIUM	6805599	6805774	6805732	6805732	Missense_Mutation	C	T	p.A93V
LN443_CENTRAL_NERVOUS_SYSTEM	6805599	6805774	6805743	6805743	Missense_Mutation	A	C	p.K97Q
KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	6814631	6814745	6814671	6814671	Missense_Mutation	C	T	p.R121C
A427_LUNG	6814631	6814745	6814713	6814713	Missense_Mutation	G	C	p.G135R
SNU175_LARGE_INTESTINE	6849507	6849700	6849510	6849510	Missense_Mutation	G	A	p.V147M
JHUEM7_ENDOMETRIUM	6849507	6849700	6849532	6849532	Missense_Mutation	G	A	p.R154H
SNU478_BILIARY_TRACT	6986344	6986666	6986373	6986373	Missense_Mutation	G	A	p.E462K
LN382_CENTRAL_NERVOUS_SYSTEM	6986344	6986666	6986377	6986377	Missense_Mutation	A	T	p.D463V
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM	6986344	6986666	6986503	6986503	Missense_Mutation	T	G	p.L505R
MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	6986344	6986666	6986541	6986541	Missense_Mutation	G	T	p.A518S
NCIH1792_LUNG	6986344	6986666	6986571	6986571	Missense_Mutation	G	A	p.E528K
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	6986344	6986666	6986644	6986644	Missense_Mutation	G	A	p.R552K
OVK18_OVARY	7049092	7049200	7049117	7049117	Missense_Mutation	G	A	p.A781T
HUCCT1_BILIARY_TRACT	7049092	7049200	7049117	7049117	Missense_Mutation	G	T	p.A781S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	7049092	7049200	7049172	7049172	Missense_Mutation	G	A	p.G799D
BICR18_UPPER_AERODIGESTIVE_TRACT	7049092	7049200	7049172	7049172	Missense_Mutation	G	A	p.G799D
CPCN_LUNG	7103685	7103870	7103716	7103716	Missense_Mutation	G	T	p.R819M
NCIH740_LUNG	7103685	7103870	7103717	7103717	Missense_Mutation	G	T	p.R819S
KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	7103685	7103870	7103758	7103758	Missense_Mutation	C	T	p.P833L
BCPAP_THYROID	7103685	7103870	7103796	7103796	Missense_Mutation	G	A	p.V846I
GP2D_LARGE_INTESTINE	7103685	7103870	7103797	7103797	Missense_Mutation	T	C	p.V846A
IGROV1_OVARY	7128066	7128236	7128081	7128081	Missense_Mutation	G	A	p.E876K
HAL01_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	7128066	7128236	7128094	7128094	Missense_Mutation	C	G	p.S880C
HS578T_BREAST	7128066	7128236	7128132	7128132	Missense_Mutation	C	T	p.R893W
TK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	7128066	7128236	7128132	7128132	Missense_Mutation	C	T	p.R893W
SNU1040_LARGE_INTESTINE	7128066	7128236	7128162	7128162	Missense_Mutation	A	G	p.T903A
JHUEM1_ENDOMETRIUM	7165238	7165357	7165259	7165259	Missense_Mutation	G	A	p.G935S
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	7165238	7165357	7165283	7165283	Missense_Mutation	G	A	p.V943I
OSRC2_KIDNEY	7165238	7165357	7165319	7165319	Missense_Mutation	G	A	p.A955T
TUHR10TKB_KIDNEY	7165238	7165357	7165320	7165320	Missense_Mutation	C	T	p.A955V
NCIH1770_LUNG	7165238	7165357	7165331	7165331	Missense_Mutation	G	A	p.G959R
NCIH2106_LUNG	7165238	7165357	7165331	7165331	Missense_Mutation	G	A	p.G959R
LS411N_LARGE_INTESTINE	6849507	6849700	6849638	6849638	Nonsense_Mutation	G	A	p.W189*
COLO792_SKIN	7049092	7049200	7049132	7049132	Nonsense_Mutation	C	T	p.R786*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KDM4C

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENST00000536108.1	LGG	rs1407856	chr9:7046901	C/G	7.36e-04
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENST00000536108.1	KIRC	rs1407856	chr9:7046901	C/G	2.23e-05
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENST00000536108.1	KIRC	rs1417290	chr9:7046917	A/G	9.36e-04
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENST00000536108.1	PRAD	rs1407856	chr9:7046901	C/G	6.46e-05
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENST00000536108.1	THYM	rs1407856	chr9:7046901	C/G	2.71e-04
exon_skip_495073	9	7015852:7015929:7046861:7046917:7103684:7103870	7046861:7046917	ENST00000536108.1	THCA	rs1407856	chr9:7046901	C/G	9.68e-05
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENST00000438023.1	BRCA	rs818911	chr9:6982099	G/A	5.29e-05
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENST00000438023.1	BRCA	rs818911	chr9:6982099	G/A	9.82e-05
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENST00000438023.1	KIRC	rs818911	chr9:6982099	G/A	1.36e-04
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENST00000438023.1	LUAD	rs818911	chr9:6982099	G/A	2.47e-03
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENST00000438023.1	TGCT	rs818911	chr9:6982099	G/A	3.20e-04
exon_skip_495063	9	6980924:6981118:6981841:6982765:6984165:6984404	6981841:6982765	ENST00000438023.1	THCA	rs818911	chr9:6982099	G/A	3.12e-08
exon_skip_495067	9	6984280:6984404:6986343:6986666:6990415:6990524	6986343:6986666	ENST00000535193.1,ENST00000536108.1,ENST00000428870.2,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3	ESCA	rs35826653	chr9:6986464	G/C	2.88e-04
exon_skip_495067	9	6984280:6984404:6986343:6986666:6990415:6990524	6986343:6986666	ENST00000535193.1,ENST00000536108.1,ENST00000428870.2,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3	PRAD	rs35826653	chr9:6986464	G/C	7.44e-04
exon_skip_495067	9	6984280:6984404:6986343:6986666:6990415:6990524	6986343:6986666	ENST00000535193.1,ENST00000536108.1,ENST00000428870.2,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3	PRAD	rs35826653	chr9:6986464	G/C	1.19e-03
exon_skip_495067	9	6984280:6984404:6986343:6986666:6990415:6990524	6986343:6986666	ENST00000535193.1,ENST00000536108.1,ENST00000428870.2,ENST00000438023.1,ENST00000381309.3,ENST00000543771.1,ENST00000381306.3	TGCT	rs35826653	chr9:6986464	G/C	4.71e-06

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KDM4C

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KDM4C

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RelatedDrugs for KDM4C

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for KDM4C

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
KDM4C	C0025149	Medulloblastoma	1	CTD_human
KDM4C	C0236663	Alcohol withdrawal syndrome	1	PSYGENET

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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