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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FBXO21 |
 Gene summary |
| Gene information | Gene symbol | FBXO21 | Gene ID | 23014 |
| Gene name | F-box protein 21 | |
| Synonyms | FBX21 | |
| Cytomap | 12q24.22 | |
| Type of gene | protein-coding | |
| Description | F-box only protein 21 | |
| Modification date | 20180519 | |
| UniProtAcc | O94952 | |
| Context | PubMed: FBXO21 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for FBXO21 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FBXO21 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FBXO21 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_97088 | 12 | 117593595:117593753:117595677:117595868:117603289:117603422 | 117595677:117595868 | ENSG00000135108.10 | ENST00000550180.1,ENST00000427718.2 |
| exon_skip_97090 | 12 | 117593595:117593753:117595677:117595889:117603289:117603422 | 117595677:117595889 | ENSG00000135108.10 | ENST00000330622.5,ENST00000548840.1 |
| exon_skip_97092 | 12 | 117603289:117603422:117604702:117604882:117610275:117610412 | 117604702:117604882 | ENSG00000135108.10 | ENST00000330622.5,ENST00000427718.2 |
| exon_skip_97093 | 12 | 117604702:117604882:117610275:117610412:117612009:117612146 | 117610275:117610412 | ENSG00000135108.10 | ENST00000330622.5,ENST00000427718.2 |
| exon_skip_97094 | 12 | 117615324:117615446:117624281:117624376:117627031:117627167 | 117624281:117624376 | ENSG00000135108.10 | ENST00000550180.1,ENST00000330622.5,ENST00000427718.2 |
| exon_skip_97096 | 12 | 117624307:117624376:117626563:117626598:117627031:117627167 | 117626563:117626598 | ENSG00000135108.10 | ENST00000551458.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FBXO21 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_97088 | 12 | 117593595:117593753:117595677:117595868:117603289:117603422 | 117595677:117595868 | ENSG00000135108.10 | ENST00000427718.2,ENST00000550180.1 |
| exon_skip_97090 | 12 | 117593595:117593753:117595677:117595889:117603289:117603422 | 117595677:117595889 | ENSG00000135108.10 | ENST00000330622.5,ENST00000548840.1 |
| exon_skip_97092 | 12 | 117603289:117603422:117604702:117604882:117610275:117610412 | 117604702:117604882 | ENSG00000135108.10 | ENST00000427718.2,ENST00000330622.5 |
| exon_skip_97093 | 12 | 117604702:117604882:117610275:117610412:117612009:117612146 | 117610275:117610412 | ENSG00000135108.10 | ENST00000427718.2,ENST00000330622.5 |
| exon_skip_97094 | 12 | 117615324:117615446:117624281:117624376:117627031:117627167 | 117624281:117624376 | ENSG00000135108.10 | ENST00000427718.2,ENST00000550180.1,ENST00000330622.5 |
| exon_skip_97096 | 12 | 117624307:117624376:117626563:117626598:117627031:117627167 | 117626563:117626598 | ENSG00000135108.10 | ENST00000551458.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FBXO21 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for FBXO21 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for FBXO21 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A1-01 | exon_skip_97093 | 117610276 | 117610412 | 117610363 | 117610363 | Frame_Shift_Del | A | - | p.L309fs |
| LIHC | TCGA-BC-A10S-01 | exon_skip_97094 | 117624282 | 117624376 | 117624320 | 117624320 | Frame_Shift_Del | A | - | p.F144fs |
| LIHC | TCGA-DD-A116-01 | exon_skip_97094 | 117624282 | 117624376 | 117624320 | 117624320 | Frame_Shift_Del | A | - | p.F144fs |
| STAD | TCGA-BR-4201-01 | exon_skip_97094 | 117624282 | 117624376 | 117624320 | 117624320 | Frame_Shift_Del | A | - | p.E145fs |
| STAD | TCGA-BR-4256-01 | exon_skip_97094 | 117624282 | 117624376 | 117624320 | 117624320 | Frame_Shift_Del | A | - | p.E145fs |
| STAD | TCGA-BR-4257-01 | exon_skip_97094 | 117624282 | 117624376 | 117624320 | 117624320 | Frame_Shift_Del | A | - | p.E145fs |
| STAD | TCGA-BR-8591-01 | exon_skip_97094 | 117624282 | 117624376 | 117624320 | 117624320 | Frame_Shift_Del | A | - | p.E145fs |
| UCEC | TCGA-A5-A0VQ-01 | exon_skip_97094 | 117624282 | 117624376 | 117624319 | 117624320 | Frame_Shift_Ins | - | A | p.F144fs |
| KICH | TCGA-KN-8425-01 | exon_skip_97094 | 117624282 | 117624376 | 117624289 | 117624289 | Nonsense_Mutation | C | A | p.E155* |
| KICH | TCGA-KN-8425-01 | exon_skip_97094 | 117624282 | 117624376 | 117624289 | 117624289 | Nonsense_Mutation | C | A | p.E155X |
| COAD | TCGA-A6-5661-01 | exon_skip_97094 | 117624282 | 117624376 | 117624319 | 117624320 | Nonsense_Mutation | - | A | p.E145_D146delinsX |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| AN3CA_ENDOMETRIUM | 117624282 | 117624376 | 117624320 | 117624320 | Frame_Shift_Del | A | - | p.F144fs |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 117595678 | 117595868 | 117595816 | 117595816 | Missense_Mutation | G | A | p.A467V |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 117595678 | 117595889 | 117595816 | 117595816 | Missense_Mutation | G | A | p.A467V |
| KYSE50_OESOPHAGUS | 117604703 | 117604882 | 117604715 | 117604715 | Missense_Mutation | C | T | p.S394N |
| SW1783_CENTRAL_NERVOUS_SYSTEM | 117610276 | 117610412 | 117610283 | 117610283 | Missense_Mutation | C | T | p.A336T |
| HCC461_LUNG | 117610276 | 117610412 | 117610321 | 117610321 | Missense_Mutation | T | C | p.N323S |
| TGBC24TKB_BILIARY_TRACT | 117610276 | 117610412 | 117610352 | 117610352 | Missense_Mutation | G | A | p.R313W |
| KE39_STOMACH | 117624282 | 117624376 | 117624328 | 117624328 | Missense_Mutation | T | C | p.I142V |
| SNU1040_LARGE_INTESTINE | 117624282 | 117624376 | 117624354 | 117624354 | Missense_Mutation | T | C | p.D133G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FBXO21 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FBXO21 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FBXO21 |
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RelatedDrugs for FBXO21 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXO21 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FBXO21 | C0043094 | Weight Gain | 1 | CTD_human |
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