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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SBNO2 |
 Gene summary |
| Gene information | Gene symbol | SBNO2 | Gene ID | 22904 |
| Gene name | strawberry notch homolog 2 | |
| Synonyms | KIAA0963|SNO|STNO | |
| Cytomap | 19p13.3 | |
| Type of gene | protein-coding | |
| Description | protein strawberry notch homolog 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9Y2G9 | |
| Context | PubMed: SBNO2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SBNO2 | GO:0071354 | cellular response to interleukin-6 | 25903009 |
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Exon skipping events across known transcript of Ensembl for SBNO2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SBNO2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SBNO2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_312499 | 19 | 1108781:1108968:1109133:1109210:1109290:1109422 | 1109133:1109210 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3 |
| exon_skip_312501 | 19 | 1109133:1109210:1109290:1109422:1109504:1109597 | 1109290:1109422 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3 |
| exon_skip_312505 | 19 | 1109290:1109422:1109504:1109597:1109681:1109776 | 1109504:1109597 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3 |
| exon_skip_312507 | 19 | 1109504:1109597:1109681:1109776:1110743:1110887 | 1109681:1109776 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3,ENST00000587673.1 |
| exon_skip_312510 | 19 | 1110743:1110887:1111017:1111092:1111504:1111613 | 1111017:1111092 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3,ENST00000587673.1 |
| exon_skip_312513 | 19 | 1111994:1112066:1112187:1112300:1112400:1112536 | 1112187:1112300 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3 |
| exon_skip_312516 | 19 | 1112816:1112948:1113533:1113703:1114229:1114421 | 1113533:1113703 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3 |
| exon_skip_312517 | 19 | 1113533:1113703:1114229:1114421:1116019:1116102 | 1114229:1114421 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000361757.3 |
| exon_skip_312525 | 19 | 1116019:1116102:1116827:1116925:1117321:1117468 | 1116827:1116925 | ENSG00000064932.11 | ENST00000587024.1,ENST00000438103.2,ENST00000592222.1,ENST00000361757.3 |
| exon_skip_312530 | 19 | 1127708:1127764:1147307:1147419:1149367:1149441 | 1147307:1147419 | ENSG00000064932.11 | ENST00000587024.1,ENST00000361757.3,ENST00000590998.1,ENST00000590176.1,ENST00000587655.1 |
| exon_skip_312532 | 19 | 1149367:1149441:1154182:1154401:1174170:1174255 | 1154182:1154401 | ENSG00000064932.11 | ENST00000587024.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SBNO2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_312499 | 19 | 1108781:1108968:1109133:1109210:1109290:1109422 | 1109133:1109210 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2 |
| exon_skip_312501 | 19 | 1109133:1109210:1109290:1109422:1109504:1109597 | 1109290:1109422 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2 |
| exon_skip_312505 | 19 | 1109290:1109422:1109504:1109597:1109681:1109776 | 1109504:1109597 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2 |
| exon_skip_312507 | 19 | 1109504:1109597:1109681:1109776:1110743:1110887 | 1109681:1109776 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2,ENST00000587673.1 |
| exon_skip_312510 | 19 | 1110743:1110887:1111017:1111092:1111504:1111613 | 1111017:1111092 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2,ENST00000587673.1 |
| exon_skip_312513 | 19 | 1111994:1112066:1112187:1112300:1112400:1112536 | 1112187:1112300 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2 |
| exon_skip_312516 | 19 | 1112816:1112948:1113533:1113703:1114229:1114421 | 1113533:1113703 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2 |
| exon_skip_312517 | 19 | 1113533:1113703:1114229:1114421:1116019:1116102 | 1114229:1114421 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2 |
| exon_skip_312525 | 19 | 1116019:1116102:1116827:1116925:1117321:1117468 | 1116827:1116925 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000438103.2,ENST00000592222.1 |
| exon_skip_312530 | 19 | 1127708:1127764:1147307:1147419:1149367:1149441 | 1147307:1147419 | ENSG00000064932.11 | ENST00000361757.3,ENST00000587024.1,ENST00000590998.1,ENST00000590176.1,ENST00000587655.1 |
| exon_skip_312532 | 19 | 1149367:1149441:1154182:1154401:1174170:1174255 | 1154182:1154401 | ENSG00000064932.11 | ENST00000587024.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SBNO2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for SBNO2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SBNO2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-QB-AA9O-06 | exon_skip_312499 | 1109134 | 1109210 | 1109180 | 1109180 | Frame_Shift_Del | C | - | p.E1127fs |
| HNSC | TCGA-HD-A4C1-01 | exon_skip_312501 | 1109291 | 1109422 | 1109414 | 1109420 | Frame_Shift_Del | ACCGCGG | - | p.VRG1073fs |
| THYM | TCGA-ZB-A966-01 | exon_skip_312510 | 1111018 | 1111092 | 1111067 | 1111068 | Frame_Shift_Del | CA | - | p.V945fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_312516 | 1113534 | 1113703 | 1113650 | 1113650 | Frame_Shift_Del | C | - | p.V711fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_312516 | 1113534 | 1113703 | 1113698 | 1113698 | Frame_Shift_Del | G | - | p.L695fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_312517 | 1114230 | 1114421 | 1114287 | 1114287 | Frame_Shift_Del | G | - | p.L674fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_312517 | 1114230 | 1114421 | 1114325 | 1114325 | Frame_Shift_Del | G | - | p.P661fs |
| PRAD | TCGA-HC-8260-01 | exon_skip_312517 | 1114230 | 1114421 | 1114389 | 1114389 | Frame_Shift_Del | G | - | p.R640fs |
| LIHC | TCGA-CC-5261-01 | exon_skip_312516 | 1113534 | 1113703 | 1113608 | 1113609 | Frame_Shift_Ins | - | C | p.L725fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_312532 | 1154183 | 1154401 | 1154260 | 1154261 | Frame_Shift_Ins | - | C | p.R6fs |
| HNSC | TCGA-CV-7427-01 | exon_skip_312507 | 1109682 | 1109776 | 1109708 | 1109708 | Nonsense_Mutation | G | A | p.Q1033* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1111018 | 1111092 | 1111067 | 1111068 | Frame_Shift_Del | CA | - | p.V945fs |
| SNU1040_LARGE_INTESTINE | 1147308 | 1147419 | 1147356 | 1147356 | Frame_Shift_Del | G | - | p.P77fs |
| HEC6_ENDOMETRIUM | 1109134 | 1109210 | 1109195 | 1109197 | In_Frame_Del | CCT | - | p.E1121del |
| HEC59_ENDOMETRIUM | 1109682 | 1109776 | 1109754 | 1109756 | In_Frame_Del | CTC | - | p.E1017del |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1109134 | 1109210 | 1109183 | 1109183 | Missense_Mutation | A | G | p.W1126R |
| HEC6_ENDOMETRIUM | 1109291 | 1109422 | 1109379 | 1109379 | Missense_Mutation | C | T | p.R1087H |
| SNGM_ENDOMETRIUM | 1109291 | 1109422 | 1109416 | 1109416 | Missense_Mutation | C | T | p.G1075S |
| GEO_LARGE_INTESTINE | 1109505 | 1109597 | 1109551 | 1109551 | Missense_Mutation | G | A | p.S1057L |
| OCUBM_BREAST | 1109682 | 1109776 | 1109698 | 1109698 | Missense_Mutation | T | C | p.Q1036R |
| SCC9_UPPER_AERODIGESTIVE_TRACT | 1112188 | 1112300 | 1112237 | 1112237 | Missense_Mutation | G | A | p.A860V |
| CORL32_LUNG | 1113534 | 1113703 | 1113574 | 1113574 | Missense_Mutation | T | A | p.E736V |
| SNB75_CENTRAL_NERVOUS_SYSTEM | 1113534 | 1113703 | 1113576 | 1113576 | Missense_Mutation | G | C | p.D735E |
| SNU1066_UPPER_AERODIGESTIVE_TRACT | 1113534 | 1113703 | 1113581 | 1113581 | Missense_Mutation | G | C | p.L734V |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1113534 | 1113703 | 1113674 | 1113674 | Missense_Mutation | G | A | p.H703Y |
| EN_ENDOMETRIUM | 1114230 | 1114421 | 1114254 | 1114254 | Missense_Mutation | C | T | p.V685I |
| KMS34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1114230 | 1114421 | 1114304 | 1114304 | Missense_Mutation | T | C | p.N668S |
| HEC50B_ENDOMETRIUM | 1114230 | 1114421 | 1114388 | 1114388 | Missense_Mutation | C | T | p.R640Q |
| LU65_LUNG | 1114230 | 1114421 | 1114413 | 1114413 | Missense_Mutation | G | A | p.R632W |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1114230 | 1114421 | 1114418 | 1114418 | Missense_Mutation | C | T | p.R630Q |
| HT144_SKIN | 1116828 | 1116925 | 1116909 | 1116909 | Missense_Mutation | A | G | p.L574P |
| MFE319_ENDOMETRIUM | 1147308 | 1147419 | 1147369 | 1147369 | Missense_Mutation | G | A | p.T73I |
| C80_LARGE_INTESTINE | 1147308 | 1147419 | 1147400 | 1147400 | Missense_Mutation | A | G | p.S63P |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1147308 | 1147419 | 1147403 | 1147403 | Missense_Mutation | C | G | p.A62P |
| CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1154183 | 1154401 | 1154196 | 1154196 | Missense_Mutation | G | A | p.P27L |
| GP2D_LARGE_INTESTINE | 1154183 | 1154401 | 1154214 | 1154214 | Missense_Mutation | C | T | p.G21D |
| RO82W1_THYROID | 1154183 | 1154401 | 1154228 | 1154228 | Missense_Mutation | T | G | p.E16D |
| BE13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1154183 | 1154401 | 1154238 | 1154238 | Missense_Mutation | G | A | p.P13L |
| PEER_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1154183 | 1154401 | 1154238 | 1154238 | Missense_Mutation | G | A | p.P13L |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1154183 | 1154401 | 1154250 | 1154250 | Missense_Mutation | T | A | p.D9V |
| SNGM_ENDOMETRIUM | 1113534 | 1113703 | 1113534 | 1113534 | Splice_Site | C | A | p.E749D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SBNO2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SBNO2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SBNO2 |
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RelatedDrugs for SBNO2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SBNO2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SBNO2 | C0036341 | Schizophrenia | 1 | PSYGENET |
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