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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DENND3 |
 Gene summary |
| Gene information | Gene symbol | DENND3 | Gene ID | 22898 |
| Gene name | DENN domain containing 3 | |
| Synonyms | - | |
| Cytomap | 8q24.3 | |
| Type of gene | protein-coding | |
| Description | DENN domain-containing protein 3DENN/MADD domain containing 3 | |
| Modification date | 20180519 | |
| UniProtAcc | A2RUS2 | |
| Context | PubMed: DENND3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DENND3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DENND3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DENND3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_486659 | 8 | 142146656:142146890:142148120:142148236:142160932:142160988 | 142148120:142148236 | ENSG00000105339.6 | ENST00000520986.1 |
| exon_skip_486663 | 8 | 142148120:142148236:142151301:142151423:142154246:142154358 | 142151301:142151423 | ENSG00000105339.6 | ENST00000523058.1,ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENSG00000105339.6 | ENST00000520986.1 |
| exon_skip_486671 | 8 | 142154265:142154358:142160384:142160447:142160932:142160988 | 142160384:142160447 | ENSG00000105339.6 | ENST00000523058.1 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENSG00000105339.6 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENSG00000105339.6 | ENST00000519811.1,ENST00000262585.2 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENSG00000105339.6 | ENST00000521477.1 |
| exon_skip_486680 | 8 | 142165992:142166069:142173431:142173528:142175284:142175388 | 142173431:142173528 | ENSG00000105339.6 | ENST00000424248.1,ENST00000518668.1 |
| exon_skip_486690 | 8 | 142170730:142170886:142173431:142173528:142175284:142175388 | 142173431:142173528 | ENSG00000105339.6 | ENST00000519811.1,ENST00000262585.2 |
| exon_skip_486692 | 8 | 142170730:142170886:142175284:142175388:142176288:142176332 | 142175284:142175388 | ENSG00000105339.6 | ENST00000521477.1 |
| exon_skip_486695 | 8 | 142176288:142176488:142178102:142178624:142185298:142185378 | 142178102:142178624 | ENSG00000105339.6 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000520482.1,ENST00000518668.1 |
| exon_skip_486700 | 8 | 142199084:142199245:142200382:142200516:142202429:142202548 | 142200382:142200516 | ENSG00000105339.6 | ENST00000517813.1,ENST00000424248.1,ENST00000523308.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DENND3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_486659 | 8 | 142146656:142146890:142148120:142148236:142160932:142160988 | 142148120:142148236 | ENSG00000105339.6 | ENST00000520986.1 |
| exon_skip_486663 | 8 | 142148120:142148236:142151301:142151423:142154246:142154358 | 142151301:142151423 | ENSG00000105339.6 | ENST00000262585.2,ENST00000424248.1,ENST00000519811.1,ENST00000523058.1,ENST00000518668.1 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENSG00000105339.6 | ENST00000520986.1 |
| exon_skip_486671 | 8 | 142154265:142154358:142160384:142160447:142160932:142160988 | 142160384:142160447 | ENSG00000105339.6 | ENST00000523058.1 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENSG00000105339.6 | ENST00000262585.2,ENST00000424248.1,ENST00000519811.1,ENST00000518668.1 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENSG00000105339.6 | ENST00000262585.2,ENST00000519811.1 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENSG00000105339.6 | ENST00000521477.1 |
| exon_skip_486680 | 8 | 142165992:142166069:142173431:142173528:142175284:142175388 | 142173431:142173528 | ENSG00000105339.6 | ENST00000424248.1,ENST00000518668.1 |
| exon_skip_486690 | 8 | 142170730:142170886:142173431:142173528:142175284:142175388 | 142173431:142173528 | ENSG00000105339.6 | ENST00000262585.2,ENST00000519811.1 |
| exon_skip_486692 | 8 | 142170730:142170886:142175284:142175388:142176288:142176332 | 142175284:142175388 | ENSG00000105339.6 | ENST00000521477.1 |
| exon_skip_486695 | 8 | 142176288:142176488:142178102:142178624:142185298:142185378 | 142178102:142178624 | ENSG00000105339.6 | ENST00000262585.2,ENST00000424248.1,ENST00000519811.1,ENST00000518668.1,ENST00000520482.1 |
| exon_skip_486700 | 8 | 142199084:142199245:142200382:142200516:142202429:142202548 | 142200382:142200516 | ENSG00000105339.6 | ENST00000262585.2,ENST00000424248.1,ENST00000519811.1,ENST00000518668.1,ENST00000517813.1,ENST00000523308.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DENND3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262585 | 142151301 | 142151423 | Frame-shift |
| ENST00000262585 | 142173431 | 142173528 | Frame-shift |
| ENST00000262585 | 142200382 | 142200516 | Frame-shift |
| ENST00000262585 | 142161717 | 142161936 | In-frame |
| ENST00000262585 | 142170730 | 142170886 | In-frame |
| ENST00000262585 | 142178102 | 142178624 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262585 | 142151301 | 142151423 | Frame-shift |
| ENST00000262585 | 142173431 | 142173528 | Frame-shift |
| ENST00000262585 | 142200382 | 142200516 | Frame-shift |
| ENST00000262585 | 142161717 | 142161936 | In-frame |
| ENST00000262585 | 142170730 | 142170886 | In-frame |
| ENST00000262585 | 142178102 | 142178624 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DENND3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262585 | 5455 | 1198 | 142161717 | 142161936 | 894 | 1112 | 205 | 278 |
| ENST00000262585 | 5455 | 1198 | 142170730 | 142170886 | 1235 | 1390 | 319 | 370 |
| ENST00000262585 | 5455 | 1198 | 142178102 | 142178624 | 1792 | 2313 | 504 | 678 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262585 | 5455 | 1198 | 142161717 | 142161936 | 894 | 1112 | 205 | 278 |
| ENST00000262585 | 5455 | 1198 | 142170730 | 142170886 | 1235 | 1390 | 319 | 370 |
| ENST00000262585 | 5455 | 1198 | 142178102 | 142178624 | 1792 | 2313 | 504 | 678 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| A2RUS2 | 205 | 278 | 1 | 950 | Alternative sequence | ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 205 | 278 | 129 | 1198 | Alternative sequence | ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 205 | 278 | 1 | 1198 | Chain | ID=PRO_0000304672;Note=DENN domain-containing protein 3 |
| A2RUS2 | 205 | 278 | 186 | 318 | Domain | Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
| A2RUS2 | 319 | 370 | 1 | 950 | Alternative sequence | ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 319 | 370 | 129 | 1198 | Alternative sequence | ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 319 | 370 | 319 | 370 | Alternative sequence | ID=VSP_028080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| A2RUS2 | 319 | 370 | 1 | 1198 | Chain | ID=PRO_0000304672;Note=DENN domain-containing protein 3 |
| A2RUS2 | 319 | 370 | 320 | 424 | Domain | Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
| A2RUS2 | 319 | 370 | 364 | 364 | Natural variant | ID=VAR_035054;Note=Q->R;Dbxref=dbSNP:rs11997191 |
| A2RUS2 | 504 | 678 | 1 | 950 | Alternative sequence | ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 504 | 678 | 129 | 1198 | Alternative sequence | ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 504 | 678 | 1 | 1198 | Chain | ID=PRO_0000304672;Note=DENN domain-containing protein 3 |
| A2RUS2 | 504 | 678 | 438 | 888 | Region | Note=Linker;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| A2RUS2 | 205 | 278 | 1 | 950 | Alternative sequence | ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 205 | 278 | 129 | 1198 | Alternative sequence | ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 205 | 278 | 1 | 1198 | Chain | ID=PRO_0000304672;Note=DENN domain-containing protein 3 |
| A2RUS2 | 205 | 278 | 186 | 318 | Domain | Note=cDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
| A2RUS2 | 319 | 370 | 1 | 950 | Alternative sequence | ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 319 | 370 | 129 | 1198 | Alternative sequence | ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 319 | 370 | 319 | 370 | Alternative sequence | ID=VSP_028080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| A2RUS2 | 319 | 370 | 1 | 1198 | Chain | ID=PRO_0000304672;Note=DENN domain-containing protein 3 |
| A2RUS2 | 319 | 370 | 320 | 424 | Domain | Note=dDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
| A2RUS2 | 319 | 370 | 364 | 364 | Natural variant | ID=VAR_035054;Note=Q->R;Dbxref=dbSNP:rs11997191 |
| A2RUS2 | 504 | 678 | 1 | 950 | Alternative sequence | ID=VSP_028075;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 504 | 678 | 129 | 1198 | Alternative sequence | ID=VSP_028078;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| A2RUS2 | 504 | 678 | 1 | 1198 | Chain | ID=PRO_0000304672;Note=DENN domain-containing protein 3 |
| A2RUS2 | 504 | 678 | 438 | 888 | Region | Note=Linker;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for DENND3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_486667 | 142160933 | 142161052 | 142160989 | 142160989 | Frame_Shift_Del | C | - | p.S264fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_486672 | 142161718 | 142161936 | 142161732 | 142161732 | Frame_Shift_Del | C | - | p.I290fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_486672 | 142161718 | 142161936 | 142161881 | 142161881 | Frame_Shift_Del | C | - | p.A340fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_486690 exon_skip_486680 | 142173432 | 142173528 | 142173505 | 142173505 | Frame_Shift_Del | G | - | p.G476fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_486695 | 142178103 | 142178624 | 142178333 | 142178333 | Frame_Shift_Del | A | - | p.N662fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_486695 | 142178103 | 142178624 | 142178416 | 142178416 | Frame_Shift_Del | G | - | p.E689fs |
| SKCM | TCGA-EE-A2GO-06 | exon_skip_486667 | 142160933 | 142161052 | 142160972 | 142160972 | Nonsense_Mutation | C | T | p.R179X |
| SKCM | TCGA-EE-A2GO-06 | exon_skip_486667 | 142160933 | 142161052 | 142160972 | 142160972 | Nonsense_Mutation | C | T | p.R259* |
| CHOL | TCGA-YR-A95A-01 | exon_skip_486667 | 142160933 | 142161052 | 142160984 | 142160984 | Nonsense_Mutation | G | T | p.E183X |
| SKCM | TCGA-EB-A3XF-01 | exon_skip_486700 | 142200383 | 142200516 | 142200425 | 142200425 | Nonsense_Mutation | G | A | p.W1096* |
| SKCM | TCGA-YD-A89C-06 | exon_skip_486700 | 142200383 | 142200516 | 142200441 | 142200441 | Nonsense_Mutation | C | T | p.Q1102* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ALLSIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142173432 | 142173528 | 142173463 | 142173464 | Frame_Shift_Del | AG | - | p.R382fs |
| MPP89_PLEURA | 142178103 | 142178624 | 142178331 | 142178337 | Frame_Shift_Del | AGAATCT | - | p.QNL581fs |
| MPP89_PLEURA | 142178103 | 142178624 | 142178342 | 142178354 | Frame_Shift_Del | AAAACAGACATAC | - | p.KTDIR585fs |
| SNU81_LARGE_INTESTINE | 142160933 | 142161052 | 142160949 | 142160949 | Missense_Mutation | C | T | p.S171L |
| NCIH1155_LUNG | 142161718 | 142161936 | 142161745 | 142161745 | Missense_Mutation | C | T | p.R215W |
| RL952_ENDOMETRIUM | 142161718 | 142161936 | 142161758 | 142161758 | Missense_Mutation | T | C | p.F219S |
| PACADD137_PANCREAS | 142161718 | 142161936 | 142161764 | 142161764 | Missense_Mutation | C | T | p.S221L |
| HEC251_ENDOMETRIUM | 142161718 | 142161936 | 142161794 | 142161794 | Missense_Mutation | A | C | p.E231A |
| RL952_ENDOMETRIUM | 142161718 | 142161936 | 142161902 | 142161902 | Missense_Mutation | G | A | p.G267D |
| GSS_STOMACH | 142161718 | 142161936 | 142161913 | 142161913 | Missense_Mutation | G | A | p.D271N |
| EFM19_BREAST | 142170731 | 142170886 | 142170768 | 142170768 | Missense_Mutation | G | A | p.A332T |
| CL34_LARGE_INTESTINE | 142170731 | 142170886 | 142170768 | 142170768 | Missense_Mutation | G | A | p.A332T |
| MFE319_ENDOMETRIUM | 142170731 | 142170886 | 142170777 | 142170777 | Missense_Mutation | C | A | p.L335I |
| U178_CENTRAL_NERVOUS_SYSTEM | 142170731 | 142170886 | 142170784 | 142170784 | Missense_Mutation | G | T | p.S337I |
| NCIH650_LUNG | 142170731 | 142170886 | 142170814 | 142170814 | Missense_Mutation | G | A | p.R347Q |
| CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142170731 | 142170886 | 142170847 | 142170847 | Missense_Mutation | T | G | p.I358R |
| A2780_OVARY | 142173432 | 142173528 | 142173502 | 142173502 | Missense_Mutation | C | T | p.P395S |
| EN_ENDOMETRIUM | 142173432 | 142173528 | 142173515 | 142173515 | Missense_Mutation | A | C | p.Q399P |
| LAN2_AUTONOMIC_GANGLIA | 142175285 | 142175388 | 142175300 | 142175300 | Missense_Mutation | A | G | p.M409V |
| STS0421_SOFT_TISSUE | 142175285 | 142175388 | 142175374 | 142175374 | Missense_Mutation | G | C | p.Q433H |
| TGBC24TKB_BILIARY_TRACT | 142175285 | 142175388 | 142175386 | 142175386 | Missense_Mutation | C | A | p.D437E |
| IM95_STOMACH | 142178103 | 142178624 | 142178115 | 142178115 | Missense_Mutation | C | T | p.T509M |
| KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142178103 | 142178624 | 142178160 | 142178160 | Missense_Mutation | C | T | p.P524L |
| YH13_CENTRAL_NERVOUS_SYSTEM | 142178103 | 142178624 | 142178183 | 142178183 | Missense_Mutation | G | C | p.A532P |
| CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142178103 | 142178624 | 142178345 | 142178345 | Missense_Mutation | A | C | p.T586P |
| OCILY7_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142178103 | 142178624 | 142178345 | 142178345 | Missense_Mutation | A | T | p.T586S |
| HEC59_ENDOMETRIUM | 142178103 | 142178624 | 142178354 | 142178354 | Missense_Mutation | C | T | p.R589W |
| SUDHL5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142178103 | 142178624 | 142178355 | 142178355 | Missense_Mutation | G | A | p.R589Q |
| HCC1569_BREAST | 142178103 | 142178624 | 142178357 | 142178357 | Missense_Mutation | A | C | p.I590L |
| COLO829_SKIN | 142178103 | 142178624 | 142178421 | 142178421 | Missense_Mutation | C | A | p.A611D |
| COLO829_MATCHED_NORMAL_TISSUE | 142178103 | 142178624 | 142178421 | 142178421 | Missense_Mutation | C | A | p.A611D |
| TE14_OESOPHAGUS | 142178103 | 142178624 | 142178472 | 142178472 | Missense_Mutation | C | T | p.P628L |
| HCT116_LARGE_INTESTINE | 142178103 | 142178624 | 142178475 | 142178475 | Missense_Mutation | A | G | p.H629R |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142178103 | 142178624 | 142178477 | 142178477 | Missense_Mutation | G | A | p.E630K |
| HEC251_ENDOMETRIUM | 142178103 | 142178624 | 142178508 | 142178508 | Missense_Mutation | A | C | p.K640T |
| HS834T_FIBROBLAST | 142200383 | 142200516 | 142200408 | 142200408 | Missense_Mutation | G | A | p.G1011S |
| KM12_LARGE_INTESTINE | 142200383 | 142200516 | 142200430 | 142200430 | Missense_Mutation | T | C | p.V1018A |
| NCIH1869_LUNG | 142200383 | 142200516 | 142200466 | 142200466 | Missense_Mutation | C | T | p.P1030L |
| SISO_CERVIX | 142200383 | 142200516 | 142200505 | 142200505 | Missense_Mutation | G | A | p.R1043H |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142200383 | 142200516 | 142200505 | 142200505 | Missense_Mutation | G | A | p.R1043H |
| NCIH1184_LUNG | 142148121 | 142148236 | 142148224 | 142148224 | Nonsense_Mutation | C | A | p.Y83* |
| RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 142151302 | 142151423 | 142151397 | 142151397 | Nonsense_Mutation | C | A | p.Y119* |
| PL4_PANCREAS | 142200383 | 142200516 | 142200468 | 142200468 | Nonsense_Mutation | C | T | p.R1031* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DENND3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | LGG | rs441914 | chr8:142161032 | A/C | 3.96e-05 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | LGG | rs441914 | chr8:142161032 | A/C | 2.92e-04 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | LGG | rs441914 | chr8:142161032 | A/C | 3.62e-03 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | LGG | rs441914 | chr8:142161032 | A/C | 3.62e-03 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | KIRC | rs441914 | chr8:142161032 | A/C | 9.03e-06 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | KIRC | rs441914 | chr8:142161032 | A/C | 1.26e-04 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | KIRC | rs441914 | chr8:142161032 | A/C | 3.48e-03 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | THCA | rs441914 | chr8:142161032 | A/C | 1.10e-04 |
| exon_skip_486667 | 8 | 142148120:142148236:142160932:142161052:142161717:142161936 | 142160932:142161052 | ENST00000520986.1 | THCA | rs441914 | chr8:142161032 | A/C | 2.21e-03 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | GBM | rs2289001 | chr8:142170884 | C/T | 7.87e-04 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | GBM | rs2289001 | chr8:142170884 | C/T | 7.87e-04 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | LAML | rs2289001 | chr8:142170884 | C/T | 1.55e-14 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | KIRP | rs2289001 | chr8:142170884 | C/T | 2.87e-05 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | LGG | rs2289001 | chr8:142170884 | C/T | 1.14e-08 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | LGG | rs2289001 | chr8:142170884 | C/T | 2.78e-03 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | LGG | rs2289001 | chr8:142170884 | C/T | 3.34e-03 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | KIRC | rs2289001 | chr8:142170884 | C/T | 7.00e-25 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | KIRC | rs2289001 | chr8:142170884 | C/T | 2.24e-04 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | KIRC | rs2289001 | chr8:142170884 | C/T | 2.24e-04 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | KIRC | rs2289001 | chr8:142170884 | C/T | 7.18e-04 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | KIRC | rs2289001 | chr8:142170884 | C/T | 2.35e-03 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | MESO | rs2289001 | chr8:142170884 | C/T | 2.35e-04 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | PAAD | rs2289001 | chr8:142170884 | C/T | 3.44e-12 |
| exon_skip_486676 | 8 | 142165992:142166069:142170730:142170886:142173431:142173528 | 142170730:142170886 | ENST00000519811.1,ENST00000262585.2 | STAD | rs2289001 | chr8:142170884 | C/T | 1.16e-17 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | GBM | rs2289001 | chr8:142170884 | C/T | 7.87e-04 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | GBM | rs2289001 | chr8:142170884 | C/T | 7.87e-04 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | LAML | rs2289001 | chr8:142170884 | C/T | 1.55e-14 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | KIRP | rs2289001 | chr8:142170884 | C/T | 2.87e-05 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | LGG | rs2289001 | chr8:142170884 | C/T | 1.14e-08 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | LGG | rs2289001 | chr8:142170884 | C/T | 2.78e-03 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | LGG | rs2289001 | chr8:142170884 | C/T | 3.34e-03 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | KIRC | rs2289001 | chr8:142170884 | C/T | 7.00e-25 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | KIRC | rs2289001 | chr8:142170884 | C/T | 2.24e-04 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | KIRC | rs2289001 | chr8:142170884 | C/T | 2.24e-04 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | KIRC | rs2289001 | chr8:142170884 | C/T | 7.18e-04 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | KIRC | rs2289001 | chr8:142170884 | C/T | 2.35e-03 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | MESO | rs2289001 | chr8:142170884 | C/T | 2.35e-04 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | PAAD | rs2289001 | chr8:142170884 | C/T | 3.44e-12 |
| exon_skip_486677 | 8 | 142165992:142166069:142170730:142170886:142175284:142175388 | 142170730:142170886 | ENST00000521477.1 | STAD | rs2289001 | chr8:142170884 | C/T | 1.16e-17 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRP | rs2304284 | chr8:142161873 | C/T | 1.22e-03 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRP | rs2304283 | chr8:142161888 | G/A | 1.22e-03 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LGG | rs2304284 | chr8:142161873 | C/T | 2.56e-05 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LGG | rs2304283 | chr8:142161888 | G/A | 2.56e-05 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LGG | rs2304284 | chr8:142161873 | C/T | 3.39e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LGG | rs2304283 | chr8:142161888 | G/A | 3.39e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRC | rs2304284 | chr8:142161873 | C/T | 1.18e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRC | rs2304283 | chr8:142161888 | G/A | 1.18e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRC | rs2304284 | chr8:142161873 | C/T | 6.28e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRC | rs2304283 | chr8:142161888 | G/A | 6.28e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRC | rs2304284 | chr8:142161873 | C/T | 2.13e-03 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | KIRC | rs2304283 | chr8:142161888 | G/A | 2.13e-03 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LUAD | rs2304284 | chr8:142161873 | C/T | 1.83e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LUAD | rs2304283 | chr8:142161888 | G/A | 1.83e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LUAD | rs2304284 | chr8:142161873 | C/T | 3.39e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LUAD | rs2304283 | chr8:142161888 | G/A | 3.39e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LUAD | rs2304284 | chr8:142161873 | C/T | 9.79e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | LUAD | rs2304283 | chr8:142161888 | G/A | 9.79e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | THCA | rs2304284 | chr8:142161873 | C/T | 6.34e-04 |
| exon_skip_486672 | 8 | 142160932:142161052:142161717:142161936:142165947:142166069 | 142161717:142161936 | ENST00000424248.1,ENST00000519811.1,ENST00000262585.2,ENST00000518668.1 | THCA | rs2304283 | chr8:142161888 | G/A | 6.34e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DENND3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DENND3 |
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RelatedDrugs for DENND3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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