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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FGR |
 Gene summary |
| Gene information | Gene symbol | FGR | Gene ID | 2268 |
| Gene name | FGR proto-oncogene, Src family tyrosine kinase | |
| Synonyms | SRC2|c-fgr|c-src2|p55-Fgr|p55c-fgr|p58-Fgr|p58c-fgr | |
| Cytomap | 1p35.3 | |
| Type of gene | protein-coding | |
| Description | tyrosine-protein kinase FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologc-fgr protooncogenec-src-2 proto-oncogenefeline Gardner-Rasheed sarcoma viral oncogene homologp55-c-fgr proteinproto-oncogene c-Fgrproto-oncogene tyrosine-prote | |
| Modification date | 20180523 | |
| UniProtAcc | P09769 | |
| Context | PubMed: FGR [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FGR | GO:0018108 | peptidyl-tyrosine phosphorylation | 7519620|8327512 |
| FGR | GO:0046777 | protein autophosphorylation | 2181286|8327512 |
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Exon skipping events across known transcript of Ensembl for FGR from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FGR |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FGR |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_23659 | 1 | 27939729:27939861:27940940:27941094:27941360:27941433 | 27940940:27941094 | ENSG00000000938.8 | ENST00000374005.3,ENST00000374004.1,ENST00000399173.1,ENST00000545953.1,ENST00000374003.3 |
| exon_skip_23661 | 1 | 27943367:27943517:27943703:27943807:27948069:27948168 | 27943703:27943807 | ENSG00000000938.8 | ENST00000374005.3,ENST00000374004.1,ENST00000399173.1,ENST00000374003.3,ENST00000457296.1 |
| exon_skip_23663 | 1 | 27943703:27943807:27948069:27948168:27949552:27949655 | 27948069:27948168 | ENSG00000000938.8 | ENST00000374005.3,ENST00000374004.1,ENST00000399173.1,ENST00000374003.3,ENST00000457296.1 |
| exon_skip_23668 | 1 | 27948163:27948168:27949552:27949655:27950201:27950440 | 27949552:27949655 | ENSG00000000938.8 | ENST00000374005.3,ENST00000374004.1,ENST00000399173.1,ENST00000545953.1,ENST00000374003.3,ENST00000457296.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FGR |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_23659 | 1 | 27939729:27939861:27940940:27941094:27941360:27941433 | 27940940:27941094 | ENSG00000000938.8 | ENST00000374005.3,ENST00000545953.1,ENST00000399173.1,ENST00000374004.1,ENST00000374003.3 |
| exon_skip_23661 | 1 | 27943367:27943517:27943703:27943807:27948069:27948168 | 27943703:27943807 | ENSG00000000938.8 | ENST00000374005.3,ENST00000399173.1,ENST00000374004.1,ENST00000374003.3,ENST00000457296.1 |
| exon_skip_23663 | 1 | 27943703:27943807:27948069:27948168:27949552:27949655 | 27948069:27948168 | ENSG00000000938.8 | ENST00000374005.3,ENST00000399173.1,ENST00000374004.1,ENST00000374003.3,ENST00000457296.1 |
| exon_skip_23668 | 1 | 27948163:27948168:27949552:27949655:27950201:27950440 | 27949552:27949655 | ENSG00000000938.8 | ENST00000374005.3,ENST00000545953.1,ENST00000399173.1,ENST00000374004.1,ENST00000374003.3,ENST00000457296.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FGR |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374004 | 27940940 | 27941094 | Frame-shift |
| ENST00000374005 | 27940940 | 27941094 | Frame-shift |
| ENST00000399173 | 27940940 | 27941094 | Frame-shift |
| ENST00000374004 | 27943703 | 27943807 | Frame-shift |
| ENST00000374005 | 27943703 | 27943807 | Frame-shift |
| ENST00000399173 | 27943703 | 27943807 | Frame-shift |
| ENST00000374004 | 27949552 | 27949655 | Frame-shift |
| ENST00000374005 | 27949552 | 27949655 | Frame-shift |
| ENST00000399173 | 27949552 | 27949655 | Frame-shift |
| ENST00000374004 | 27948069 | 27948168 | In-frame |
| ENST00000374005 | 27948069 | 27948168 | In-frame |
| ENST00000399173 | 27948069 | 27948168 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374004 | 27940940 | 27941094 | Frame-shift |
| ENST00000374005 | 27940940 | 27941094 | Frame-shift |
| ENST00000399173 | 27940940 | 27941094 | Frame-shift |
| ENST00000374004 | 27943703 | 27943807 | Frame-shift |
| ENST00000374005 | 27943703 | 27943807 | Frame-shift |
| ENST00000399173 | 27943703 | 27943807 | Frame-shift |
| ENST00000374004 | 27949552 | 27949655 | Frame-shift |
| ENST00000374005 | 27949552 | 27949655 | Frame-shift |
| ENST00000399173 | 27949552 | 27949655 | Frame-shift |
| ENST00000374004 | 27948069 | 27948168 | In-frame |
| ENST00000374005 | 27948069 | 27948168 | In-frame |
| ENST00000399173 | 27948069 | 27948168 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FGR |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374004 | 2367 | 529 | 27948069 | 27948168 | 476 | 574 | 110 | 142 |
| ENST00000374005 | 2746 | 529 | 27948069 | 27948168 | 619 | 717 | 110 | 142 |
| ENST00000399173 | 2500 | 529 | 27948069 | 27948168 | 601 | 699 | 110 | 142 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374004 | 2367 | 529 | 27948069 | 27948168 | 476 | 574 | 110 | 142 |
| ENST00000374005 | 2746 | 529 | 27948069 | 27948168 | 619 | 717 | 110 | 142 |
| ENST00000399173 | 2500 | 529 | 27948069 | 27948168 | 601 | 699 | 110 | 142 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P09769 | 110 | 142 | 2 | 529 | Chain | ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr |
| P09769 | 110 | 142 | 2 | 529 | Chain | ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr |
| P09769 | 110 | 142 | 2 | 529 | Chain | ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr |
| P09769 | 110 | 142 | 77 | 138 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P09769 | 110 | 142 | 77 | 138 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P09769 | 110 | 142 | 77 | 138 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P09769 | 110 | 142 | 110 | 110 | Natural variant | ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846 |
| P09769 | 110 | 142 | 110 | 110 | Natural variant | ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846 |
| P09769 | 110 | 142 | 110 | 110 | Natural variant | ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846 |
| P09769 | 110 | 142 | 130 | 130 | Natural variant | ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846 |
| P09769 | 110 | 142 | 130 | 130 | Natural variant | ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846 |
| P09769 | 110 | 142 | 130 | 130 | Natural variant | ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P09769 | 110 | 142 | 2 | 529 | Chain | ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr |
| P09769 | 110 | 142 | 2 | 529 | Chain | ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr |
| P09769 | 110 | 142 | 2 | 529 | Chain | ID=PRO_0000088091;Note=Tyrosine-protein kinase Fgr |
| P09769 | 110 | 142 | 77 | 138 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P09769 | 110 | 142 | 77 | 138 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P09769 | 110 | 142 | 77 | 138 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P09769 | 110 | 142 | 110 | 110 | Natural variant | ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846 |
| P09769 | 110 | 142 | 110 | 110 | Natural variant | ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846 |
| P09769 | 110 | 142 | 110 | 110 | Natural variant | ID=VAR_041700;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34597831,PMID:17344846 |
| P09769 | 110 | 142 | 130 | 130 | Natural variant | ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846 |
| P09769 | 110 | 142 | 130 | 130 | Natural variant | ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846 |
| P09769 | 110 | 142 | 130 | 130 | Natural variant | ID=VAR_041701;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35334091,PMID:17344846 |
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SNVs in the skipped exons for FGR |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_23668 | 27949553 | 27949655 | 27949629 | 27949629 | Frame_Shift_Del | G | - | p.L85fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_23668 | 27949553 | 27949655 | 27949641 | 27949641 | Frame_Shift_Del | G | - | p.L81fs |
| LIHC | TCGA-K7-A5RF-01 | exon_skip_23661 | 27943704 | 27943807 | 27943782 | 27943782 | Nonsense_Mutation | T | A | p.K152* |
| STAD | TCGA-CG-4306-01 | exon_skip_23668 | 27949553 | 27949655 | 27949552 | 27949552 | Splice_Site | C | T | . |
| STAD | TCGA-CG-4306-01 | exon_skip_23668 | 27949553 | 27949655 | 27949552 | 27949552 | Splice_Site | C | T | p.T110_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| 639V_URINARY_TRACT | 27940941 | 27941094 | 27940979 | 27940979 | Missense_Mutation | G | A | p.A404V |
| LU65_LUNG | 27940941 | 27941094 | 27941049 | 27941049 | Missense_Mutation | G | T | p.R381S |
| MCC26_SKIN | 27948070 | 27948168 | 27948115 | 27948115 | Missense_Mutation | A | T | p.I128N |
| HT115_LARGE_INTESTINE | 27948070 | 27948168 | 27948165 | 27948165 | Missense_Mutation | T | G | p.E111D |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 27949553 | 27949655 | 27949572 | 27949572 | Missense_Mutation | A | G | p.F104L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FGR |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FGR |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FGR |
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RelatedDrugs for FGR |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P09769 | DB01254 | Dasatinib | Tyrosine-protein kinase Fgr | small molecule | approved|investigational | |
| P09769 | DB12010 | Fostamatinib | Tyrosine-protein kinase Fgr | small molecule | approved|investigational |
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RelatedDiseases for FGR |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FGR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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