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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FGL1 |
 Gene summary |
| Gene information | Gene symbol | FGL1 | Gene ID | 2267 |
| Gene name | fibrinogen like 1 | |
| Synonyms | HFREP1|HP-041|LFIRE-1|LFIRE1 | |
| Cytomap | 8p22 | |
| Type of gene | protein-coding | |
| Description | fibrinogen-like protein 1hepassocinhepatocellular carcinoma-related sequencehepatocyte-derived fibrinogen-related protein 1liver fibrinogen-related protein 1 | |
| Modification date | 20180519 | |
| UniProtAcc | Q08830 | |
| Context | PubMed: FGL1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for FGL1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FGL1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FGL1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_488454 | 8 | 17722166:17722260:17726056:17726244:17726424:17726510 | 17726056:17726244 | ENSG00000104760.12 | ENST00000518650.1,ENST00000398056.2,ENST00000427924.1,ENST00000522444.1,ENST00000398054.1,ENST00000381841.2,ENST00000522636.1,ENST00000381840.2 |
| exon_skip_488464 | 8 | 17726068:17726244:17726424:17726513:17731527:17731625 | 17726424:17726513 | ENSG00000104760.12 | ENST00000518650.1,ENST00000398056.2,ENST00000427924.1,ENST00000522444.1,ENST00000398054.1,ENST00000381841.2,ENST00000522636.1,ENST00000523097.1,ENST00000381840.2 |
| exon_skip_488468 | 8 | 17731527:17731625:17731870:17732030:17739507:17739674 | 17731870:17732030 | ENSG00000104760.12 | ENST00000518650.1,ENST00000398056.2,ENST00000427924.1,ENST00000522444.1,ENST00000398054.1,ENST00000381841.2,ENST00000523097.1,ENST00000381840.2 |
| exon_skip_488476 | 8 | 17739507:17739688:17743000:17743080:17749189:17749316 | 17743000:17743080 | ENSG00000104760.12 | ENST00000518650.1,ENST00000398054.1,ENST00000381841.2 |
| exon_skip_488477 | 8 | 17739507:17739688:17743000:17743080:17752733:17752770 | 17743000:17743080 | ENSG00000104760.12 | ENST00000381840.2 |
| exon_skip_488478 | 8 | 17739507:17739688:17743000:17743080:17752955:17753026 | 17743000:17743080 | ENSG00000104760.12 | ENST00000398056.2,ENST00000427924.1 |
| exon_skip_488521 | 8 | 17743028:17743080:17749189:17749316:17752733:17752770 | 17749189:17749316 | ENSG00000104760.12 | ENST00000398054.1 |
| exon_skip_488524 | 8 | 17743028:17743080:17749189:17749316:17752955:17753026 | 17749189:17749316 | ENSG00000104760.12 | ENST00000381841.2 |
| exon_skip_488525 | 8 | 17743028:17743080:17749189:17749338:17752733:17752770 | 17749189:17749338 | ENSG00000104760.12 | ENST00000518769.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FGL1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_488454 | 8 | 17722166:17722260:17726056:17726244:17726424:17726510 | 17726056:17726244 | ENSG00000104760.12 | ENST00000398056.2,ENST00000522444.1,ENST00000381841.2,ENST00000427924.1,ENST00000398054.1,ENST00000381840.2,ENST00000518650.1,ENST00000522636.1 |
| exon_skip_488464 | 8 | 17726068:17726244:17726424:17726513:17731527:17731625 | 17726424:17726513 | ENSG00000104760.12 | ENST00000398056.2,ENST00000522444.1,ENST00000381841.2,ENST00000427924.1,ENST00000398054.1,ENST00000381840.2,ENST00000518650.1,ENST00000522636.1,ENST00000523097.1 |
| exon_skip_488468 | 8 | 17731527:17731625:17731870:17732030:17739507:17739674 | 17731870:17732030 | ENSG00000104760.12 | ENST00000398056.2,ENST00000522444.1,ENST00000381841.2,ENST00000427924.1,ENST00000398054.1,ENST00000381840.2,ENST00000518650.1,ENST00000523097.1 |
| exon_skip_488476 | 8 | 17739507:17739688:17743000:17743080:17749189:17749316 | 17743000:17743080 | ENSG00000104760.12 | ENST00000381841.2,ENST00000398054.1,ENST00000518650.1 |
| exon_skip_488477 | 8 | 17739507:17739688:17743000:17743080:17752733:17752770 | 17743000:17743080 | ENSG00000104760.12 | ENST00000381840.2 |
| exon_skip_488478 | 8 | 17739507:17739688:17743000:17743080:17752955:17753026 | 17743000:17743080 | ENSG00000104760.12 | ENST00000398056.2,ENST00000427924.1 |
| exon_skip_488521 | 8 | 17743028:17743080:17749189:17749316:17752733:17752770 | 17749189:17749316 | ENSG00000104760.12 | ENST00000398054.1 |
| exon_skip_488524 | 8 | 17743028:17743080:17749189:17749316:17752955:17753026 | 17749189:17749316 | ENSG00000104760.12 | ENST00000381841.2 |
| exon_skip_488525 | 8 | 17743028:17743080:17749189:17749338:17752733:17752770 | 17749189:17749338 | ENSG00000104760.12 | ENST00000518769.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FGL1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381840 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000381841 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000398054 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000398056 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000427924 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000518650 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000381841 | 17749189 | 17749316 | 3UTR-3UTR |
| ENST00000398054 | 17749189 | 17749316 | 3UTR-3UTR |
| ENST00000381840 | 17726056 | 17726244 | Frame-shift |
| ENST00000381841 | 17726056 | 17726244 | Frame-shift |
| ENST00000398054 | 17726056 | 17726244 | Frame-shift |
| ENST00000398056 | 17726056 | 17726244 | Frame-shift |
| ENST00000427924 | 17726056 | 17726244 | Frame-shift |
| ENST00000518650 | 17726056 | 17726244 | Frame-shift |
| ENST00000522444 | 17726056 | 17726244 | Frame-shift |
| ENST00000381840 | 17726424 | 17726513 | Frame-shift |
| ENST00000381841 | 17726424 | 17726513 | Frame-shift |
| ENST00000398054 | 17726424 | 17726513 | Frame-shift |
| ENST00000398056 | 17726424 | 17726513 | Frame-shift |
| ENST00000427924 | 17726424 | 17726513 | Frame-shift |
| ENST00000518650 | 17726424 | 17726513 | Frame-shift |
| ENST00000522444 | 17726424 | 17726513 | Frame-shift |
| ENST00000381840 | 17731870 | 17732030 | Frame-shift |
| ENST00000381841 | 17731870 | 17732030 | Frame-shift |
| ENST00000398054 | 17731870 | 17732030 | Frame-shift |
| ENST00000398056 | 17731870 | 17732030 | Frame-shift |
| ENST00000427924 | 17731870 | 17732030 | Frame-shift |
| ENST00000518650 | 17731870 | 17732030 | Frame-shift |
| ENST00000522444 | 17731870 | 17732030 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381840 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000381841 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000398054 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000398056 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000427924 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000518650 | 17743000 | 17743080 | 3UTR-3CDS |
| ENST00000381841 | 17749189 | 17749316 | 3UTR-3UTR |
| ENST00000398054 | 17749189 | 17749316 | 3UTR-3UTR |
| ENST00000381840 | 17726056 | 17726244 | Frame-shift |
| ENST00000381841 | 17726056 | 17726244 | Frame-shift |
| ENST00000398054 | 17726056 | 17726244 | Frame-shift |
| ENST00000398056 | 17726056 | 17726244 | Frame-shift |
| ENST00000427924 | 17726056 | 17726244 | Frame-shift |
| ENST00000518650 | 17726056 | 17726244 | Frame-shift |
| ENST00000522444 | 17726056 | 17726244 | Frame-shift |
| ENST00000381840 | 17726424 | 17726513 | Frame-shift |
| ENST00000381841 | 17726424 | 17726513 | Frame-shift |
| ENST00000398054 | 17726424 | 17726513 | Frame-shift |
| ENST00000398056 | 17726424 | 17726513 | Frame-shift |
| ENST00000427924 | 17726424 | 17726513 | Frame-shift |
| ENST00000518650 | 17726424 | 17726513 | Frame-shift |
| ENST00000522444 | 17726424 | 17726513 | Frame-shift |
| ENST00000381840 | 17731870 | 17732030 | Frame-shift |
| ENST00000381841 | 17731870 | 17732030 | Frame-shift |
| ENST00000398054 | 17731870 | 17732030 | Frame-shift |
| ENST00000398056 | 17731870 | 17732030 | Frame-shift |
| ENST00000427924 | 17731870 | 17732030 | Frame-shift |
| ENST00000518650 | 17731870 | 17732030 | Frame-shift |
| ENST00000522444 | 17731870 | 17732030 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for FGL1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for FGL1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-FW-A3R5-06 | exon_skip_488454 | 17726057 | 17726244 | 17726125 | 17726125 | Nonsense_Mutation | C | T | p.W237* |
| SKCM | TCGA-FW-A3R5-06 | exon_skip_488454 | 17726057 | 17726244 | 17726125 | 17726125 | Nonsense_Mutation | C | T | p.W237X |
| UCEC | TCGA-AX-A060-01 | exon_skip_488454 | 17726057 | 17726244 | 17726161 | 17726161 | Nonsense_Mutation | C | T | p.W225* |
| UCEC | TCGA-AX-A060-01 | exon_skip_488454 | 17726057 | 17726244 | 17726161 | 17726161 | Nonsense_Mutation | C | T | p.W275* |
| UCEC | TCGA-AX-A0J0-01 | exon_skip_488468 | 17731871 | 17732030 | 17731884 | 17731884 | Nonsense_Mutation | C | A | p.E131* |
| BLCA | TCGA-ZF-AA4X-01 | exon_skip_488468 | 17731871 | 17732030 | 17731905 | 17731905 | Nonsense_Mutation | G | A | p.Q124* |
| SARC | TCGA-QC-A7B5-01 | exon_skip_488468 | 17731871 | 17732030 | 17731905 | 17731905 | Nonsense_Mutation | G | A | p.Q124* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JIMT1_BREAST | 17726057 | 17726244 | 17726091 | 17726091 | Missense_Mutation | C | A | p.A249S |
| UMUC5_URINARY_TRACT | 17726057 | 17726244 | 17726220 | 17726220 | Missense_Mutation | C | T | p.E206K |
| IGR1_SKIN | 17726425 | 17726513 | 17726478 | 17726478 | Missense_Mutation | C | T | p.E180K |
| SNU878_LIVER | 17731871 | 17732030 | 17731898 | 17731898 | Missense_Mutation | C | A | p.R126L |
| HCT15_LARGE_INTESTINE | 17731871 | 17732030 | 17731962 | 17731962 | Missense_Mutation | G | T | p.P105T |
| HUCCT1_BILIARY_TRACT | 17731871 | 17732030 | 17731983 | 17731983 | Missense_Mutation | T | C | p.K98E |
| HMVII_SKIN | 17731871 | 17732030 | 17732021 | 17732021 | Missense_Mutation | T | G | p.E85A |
| SW684_SOFT_TISSUE | 17743001 | 17743080 | 17743009 | 17743009 | Missense_Mutation | C | T | p.E19K |
| YD10B_UPPER_AERODIGESTIVE_TRACT | 17743001 | 17743080 | 17743060 | 17743060 | Missense_Mutation | C | T | p.A2T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FGL1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FGL1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FGL1 |
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RelatedDrugs for FGL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FGL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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