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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FGG |
 Gene summary |
| Gene information | Gene symbol | FGG | Gene ID | 2266 |
| Gene name | fibrinogen gamma chain | |
| Synonyms | - | |
| Cytomap | 4q32.1 | |
| Type of gene | protein-coding | |
| Description | fibrinogen gamma chainfibrinogen, gamma polypeptidetesticular tissue protein Li 70 | |
| Modification date | 20180519 | |
| UniProtAcc | P02679 | |
| Context | PubMed: FGG [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FGG | GO:0007160 | cell-matrix adhesion | 10903502 |
| FGG | GO:0031639 | plasminogen activation | 16846481 |
| FGG | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 |
| FGG | GO:0034622 | cellular protein-containing complex assembly | 8910396 |
| FGG | GO:0042730 | fibrinolysis | 16846481 |
| FGG | GO:0045907 | positive regulation of vasoconstriction | 15739255 |
| FGG | GO:0045921 | positive regulation of exocytosis | 19193866 |
| FGG | GO:0050714 | positive regulation of protein secretion | 19193866 |
| FGG | GO:0051592 | response to calcium ion | 6777381 |
| FGG | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502|19193866 |
| FGG | GO:0070527 | platelet aggregation | 6281794 |
| FGG | GO:0072378 | blood coagulation, fibrin clot formation | 16846481 |
| FGG | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 |
| FGG | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 |
| FGG | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
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Exon skipping events across known transcript of Ensembl for FGG from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FGG |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FGG |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_432732 | 4 | 155525324:155525506:155526048:155526218:155527856:155527974 | 155526048:155526218 | ENSG00000171557.12 | ENST00000404648.3,ENST00000405164.1,ENST00000492082.1 |
| exon_skip_432747 | 4 | 155528109:155528134:155529617:155529802:155530781:155530906 | 155529617:155529802 | ENSG00000171557.12 | ENST00000404648.3,ENST00000465913.1,ENST00000407946.1,ENST00000405164.1,ENST00000336098.3,ENST00000492082.1 |
| exon_skip_432751 | 4 | 155530781:155530915:155531218:155531349:155532956:155533050 | 155531218:155531349 | ENSG00000171557.12 | ENST00000443553.1,ENST00000404648.3,ENST00000336098.3,ENST00000393846.2 |
| exon_skip_432752 | 4 | 155532956:155533050:155533169:155533319:155533542:155533587 | 155533169:155533319 | ENSG00000171557.12 | ENST00000443553.1 |
| exon_skip_432754 | 4 | 155532956:155533050:155533169:155533353:155533542:155533587 | 155533169:155533353 | ENSG00000171557.12 | ENST00000473393.1,ENST00000404648.3,ENST00000407946.1,ENST00000405164.1,ENST00000336098.3,ENST00000393846.2,ENST00000464532.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FGG |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_432732 | 4 | 155525324:155525506:155526048:155526218:155527856:155527974 | 155526048:155526218 | ENSG00000171557.12 | ENST00000404648.3,ENST00000492082.1,ENST00000405164.1 |
| exon_skip_432747 | 4 | 155528109:155528134:155529617:155529802:155530781:155530906 | 155529617:155529802 | ENSG00000171557.12 | ENST00000404648.3,ENST00000492082.1,ENST00000465913.1,ENST00000405164.1,ENST00000336098.3,ENST00000407946.1 |
| exon_skip_432751 | 4 | 155530781:155530915:155531218:155531349:155532956:155533050 | 155531218:155531349 | ENSG00000171557.12 | ENST00000404648.3,ENST00000336098.3,ENST00000443553.1,ENST00000393846.2 |
| exon_skip_432752 | 4 | 155532956:155533050:155533169:155533319:155533542:155533587 | 155533169:155533319 | ENSG00000171557.12 | ENST00000443553.1 |
| exon_skip_432754 | 4 | 155532956:155533050:155533169:155533353:155533542:155533587 | 155533169:155533353 | ENSG00000171557.12 | ENST00000404648.3,ENST00000405164.1,ENST00000336098.3,ENST00000407946.1,ENST00000393846.2,ENST00000464532.1,ENST00000473393.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FGG |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000336098 | 155529617 | 155529802 | Frame-shift |
| ENST00000336098 | 155531218 | 155531349 | Frame-shift |
| ENST00000336098 | 155533169 | 155533353 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000336098 | 155529617 | 155529802 | Frame-shift |
| ENST00000336098 | 155531218 | 155531349 | Frame-shift |
| ENST00000336098 | 155533169 | 155533353 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for FGG |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for FGG |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-CV-A45W-01 | exon_skip_432732 | 155526049 | 155526218 | 155526059 | 155526059 | Frame_Shift_Del | C | - | p.G430fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_432732 | 155526049 | 155526218 | 155526154 | 155526154 | Frame_Shift_Del | C | - | p.W398fs |
| STAD | TCGA-BR-8591-01 | exon_skip_432732 | 155526049 | 155526218 | 155526202 | 155526202 | Frame_Shift_Del | T | - | p.A383fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_432747 | 155529618 | 155529802 | 155529702 | 155529702 | Frame_Shift_Del | T | - | p.N256fs |
| LUAD | TCGA-44-2656-01 | exon_skip_432732 | 155526049 | 155526218 | 155526058 | 155526059 | Frame_Shift_Ins | - | C | p.G430fs |
| UCEC | TCGA-B5-A0K2-01 | exon_skip_432732 | 155526049 | 155526218 | 155526058 | 155526059 | Frame_Shift_Ins | - | C | p.G430fs |
| UCEC | TCGA-BG-A0M3-01 | exon_skip_432732 | 155526049 | 155526218 | 155526058 | 155526059 | Frame_Shift_Ins | - | C | p.G430fs |
| UCEC | TCGA-BG-A0M9-01 | exon_skip_432732 | 155526049 | 155526218 | 155526058 | 155526059 | Frame_Shift_Ins | - | C | p.G430fs |
| SARC | TCGA-DX-A8BG-01 | exon_skip_432732 | 155526049 | 155526218 | 155526181 | 155526181 | Nonsense_Mutation | A | C | p.Y389* |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_432751 | 155531219 | 155531349 | 155531339 | 155531339 | Nonsense_Mutation | C | A | p.E138* |
| BRCA | TCGA-E9-A295-01 | exon_skip_432752 | 155533170 | 155533319 | 155533233 | 155533233 | Nonsense_Mutation | C | A | p.E82* |
| BRCA | TCGA-E9-A295-01 | exon_skip_432754 | 155533170 | 155533353 | 155533233 | 155533233 | Nonsense_Mutation | C | A | p.E82* |
| BRCA | TCGA-E9-A1N5-01 | exon_skip_432752 | 155533170 | 155533319 | 155533321 | 155533321 | Splice_Site | T | A | e1-2 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NUGC3_STOMACH | 155526049 | 155526218 | 155526190 | 155526192 | In_Frame_Del | AGG | - | p.P386del |
| HCC202_BREAST | 155526049 | 155526218 | 155526090 | 155526090 | Missense_Mutation | T | C | p.I420V |
| HEC1A_ENDOMETRIUM | 155526049 | 155526218 | 155526147 | 155526147 | Missense_Mutation | G | A | p.R401W |
| HEC1_ENDOMETRIUM | 155526049 | 155526218 | 155526147 | 155526147 | Missense_Mutation | G | A | p.R401W |
| NCIH630_LARGE_INTESTINE | 155526049 | 155526218 | 155526147 | 155526147 | Missense_Mutation | G | A | p.R401W |
| MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 155526049 | 155526218 | 155526185 | 155526185 | Missense_Mutation | C | T | p.G388D |
| MJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 155526049 | 155526218 | 155526201 | 155526201 | Missense_Mutation | C | G | p.A383P |
| COLO684_ENDOMETRIUM | 155526049 | 155526218 | 155526213 | 155526213 | Missense_Mutation | T | C | p.T379A |
| 253J_URINARY_TRACT | 155529618 | 155529802 | 155529683 | 155529683 | Missense_Mutation | T | C | p.I262M |
| 253JBV_URINARY_TRACT | 155529618 | 155529802 | 155529683 | 155529683 | Missense_Mutation | T | C | p.I262M |
| CESS_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 155529618 | 155529802 | 155529699 | 155529699 | Missense_Mutation | T | G | p.E257A |
| FEPD_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 155529618 | 155529802 | 155529700 | 155529700 | Missense_Mutation | C | T | p.E257K |
| DU145_PROSTATE | 155529618 | 155529802 | 155529740 | 155529740 | Missense_Mutation | A | T | p.H243Q |
| LN215_CENTRAL_NERVOUS_SYSTEM | 155529618 | 155529802 | 155529760 | 155529760 | Missense_Mutation | A | G | p.Y237H |
| KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 155531219 | 155531349 | 155531224 | 155531224 | Missense_Mutation | C | T | p.G176E |
| SNU81_LARGE_INTESTINE | 155531219 | 155531349 | 155531252 | 155531252 | Missense_Mutation | C | A | p.D167Y |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 155531219 | 155531349 | 155531300 | 155531300 | Missense_Mutation | T | G | p.K151Q |
| HEC251_ENDOMETRIUM | 155531219 | 155531349 | 155531311 | 155531311 | Missense_Mutation | A | G | p.I147T |
| MDAMB330_BREAST | 155531219 | 155531349 | 155531326 | 155531326 | Missense_Mutation | G | A | p.S142L |
| NK92MI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 155531219 | 155531349 | 155531347 | 155531347 | Missense_Mutation | T | C | p.Y135C |
| RCCJW_KIDNEY | 155533170 | 155533353 | 155533230 | 155533230 | Missense_Mutation | C | A | p.V83F |
| RCCJW_KIDNEY | 155533170 | 155533319 | 155533230 | 155533230 | Missense_Mutation | C | A | p.V83F |
| HCC2998_LARGE_INTESTINE | 155533170 | 155533353 | 155533290 | 155533290 | Missense_Mutation | C | G | p.D63H |
| HCC2998_LARGE_INTESTINE | 155533170 | 155533319 | 155533290 | 155533290 | Missense_Mutation | C | G | p.D63H |
| LU134A_LUNG | 155529618 | 155529802 | 155529802 | 155529802 | Splice_Site | T | A | p.R223* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FGG |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FGG |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FGG |
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RelatedDrugs for FGG |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P02679 | DB00364 | Sucralfate | Fibrinogen gamma chain | small molecule | approved | |
| P02679 | DB11300 | Thrombin | Fibrinogen gamma chain | biotech | approved|investigational |
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RelatedDiseases for FGG |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FGG | C0272350 | Dysfibrinogenemia, Congenital | 7 | ORPHANET;UNIPROT |
| FGG | C0022548 | Keloid | 1 | CTD_human |
| FGG | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| FGG | C2584774 | Congenital hypofibrinogenemia | 1 | ORPHANET;UNIPROT |
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