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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FCGR2B |
 Gene summary |
| Gene information | Gene symbol | FCGR2B | Gene ID | 2213 |
| Gene name | Fc fragment of IgG receptor IIb | |
| Synonyms | CD32|CD32B|FCG2|FCGR2|IGFR2 | |
| Cytomap | 1q23.3 | |
| Type of gene | protein-coding | |
| Description | low affinity immunoglobulin gamma Fc region receptor II-bCDw32Fc fragment of IgG, low affinity II, receptor for (CD32)Fc fragment of IgG, low affinity IIb, receptor (CD32)Fc fragment of IgG, low affinity IIb, receptor for (CD32)Fc gamma RIIbFc gamma | |
| Modification date | 20180527 | |
| UniProtAcc | P31994 | |
| Context | PubMed: FCGR2B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FCGR2B | GO:0006898 | receptor-mediated endocytosis | 2142460 |
| FCGR2B | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 2142460 |
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Exon skipping events across known transcript of Ensembl for FCGR2B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FCGR2B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FCGR2B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_13373 | 1 | 161632988:161633143:161640041:161640062:161641181:161641439 | 161640041:161640062 | ENSG00000072694.14 | ENST00000358671.5,ENST00000485778.1,ENST00000480308.1,ENST00000236937.9 |
| exon_skip_13375 | 1 | 161642764:161643019:161643253:161643338:161643749:161643863 | 161643253:161643338 | ENSG00000072694.14 | ENST00000428605.2 |
| exon_skip_13377 | 1 | 161643749:161643863:161645046:161645103:161647117:161647155 | 161645046:161645103 | ENSG00000072694.14 | ENST00000358671.5,ENST00000367962.4,ENST00000367961.4,ENST00000367960.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FCGR2B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_13373 | 1 | 161632988:161633143:161640041:161640062:161641181:161641439 | 161640041:161640062 | ENSG00000072694.14 | ENST00000236937.9,ENST00000358671.5,ENST00000480308.1,ENST00000485778.1 |
| exon_skip_13375 | 1 | 161642764:161643019:161643253:161643338:161643749:161643863 | 161643253:161643338 | ENSG00000072694.14 | ENST00000428605.2 |
| exon_skip_13377 | 1 | 161643749:161643863:161645046:161645103:161647117:161647155 | 161645046:161645103 | ENSG00000072694.14 | ENST00000367962.4,ENST00000367960.5,ENST00000367961.4,ENST00000358671.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FCGR2B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358671 | 161640041 | 161640062 | In-frame |
| ENST00000358671 | 161645046 | 161645103 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358671 | 161640041 | 161640062 | In-frame |
| ENST00000358671 | 161645046 | 161645103 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FCGR2B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358671 | 2132 | 310 | 161645046 | 161645103 | 842 | 898 | 253 | 272 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358671 | 2132 | 310 | 161645046 | 161645103 | 842 | 898 | 253 | 272 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P31994 | 253 | 272 | 254 | 272 | Alternative sequence | ID=VSP_002643;Note=In isoform IIB2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2142460,ECO:0000303|PubMed:2529342,ECO:0000303|PubMed:2 |
| P31994 | 253 | 272 | 43 | 310 | Chain | ID=PRO_0000015147;Note=Low affinity immunoglobulin gamma Fc region receptor II-b |
| P31994 | 253 | 272 | 258 | 258 | Natural variant | ID=VAR_008798;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8466861;Dbxref=dbSNP:rs148534844,PMID:8466861 |
| P31994 | 253 | 272 | 241 | 310 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P31994 | 253 | 272 | 254 | 272 | Alternative sequence | ID=VSP_002643;Note=In isoform IIB2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2142460,ECO:0000303|PubMed:2529342,ECO:0000303|PubMed:2 |
| P31994 | 253 | 272 | 43 | 310 | Chain | ID=PRO_0000015147;Note=Low affinity immunoglobulin gamma Fc region receptor II-b |
| P31994 | 253 | 272 | 258 | 258 | Natural variant | ID=VAR_008798;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8466861;Dbxref=dbSNP:rs148534844,PMID:8466861 |
| P31994 | 253 | 272 | 241 | 310 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for FCGR2B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HUPT4_PANCREAS | 161645047 | 161645103 | 161645077 | 161645077 | Missense_Mutation | T | A | p.M264K |
| NCIH128_LUNG | 161645047 | 161645103 | 161645080 | 161645080 | Missense_Mutation | G | A | p.G265E |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCGR2B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCGR2B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCGR2B |
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RelatedDrugs for FCGR2B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P31994 | DB00002 | Cetuximab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved | |
| P31994 | DB00054 | Abciximab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved | |
| P31994 | DB00098 | Antithymocyte immunoglobulin (rabbit) | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved | |
| P31994 | DB00005 | Etanercept | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00056 | Gemtuzumab ozogamicin | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00072 | Trastuzumab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00074 | Basiliximab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00075 | Muromonab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00078 | Ibritumomab tiuxetan | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00081 | Tositumomab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00087 | Alemtuzumab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00095 | Efalizumab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00108 | Natalizumab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00110 | Palivizumab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00112 | Bevacizumab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB11767 | Sarilumab | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational | |
| P31994 | DB00092 | Alefacept | Low affinity immunoglobulin gamma Fc region receptor II-b | biotech | approved|investigational|withdrawn |
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RelatedDiseases for FCGR2B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FCGR2B | C0004364 | Autoimmune Diseases | 1 | CTD_human |
| FCGR2B | C0027947 | Neutropenia | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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