ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for FCGR2A

Gene summary

Gene information	Gene symbol	FCGR2A
	Gene ID	2212
	Gene name	Fc fragment of IgG receptor IIa
	Synonyms	CD32\|CD32A\|CDw32\|FCG2\|FCGR2\|FCGR2A1\|FcGR\|IGFR2
	Cytomap	1q23.3
	Type of gene	protein-coding
	Description	low affinity immunoglobulin gamma Fc region receptor II-aFc fragment of IgG, low affinity IIa, receptor (CD32)Immunoglobulin G Fc receptor IIfc-gamma-RIIafcRII-aigG Fc receptor II-a
	Modification date	20180527
	UniProtAcc	P12318
	Context	PubMed: FCGR2A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for FCGR2A from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for FCGR2A

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for FCGR2A

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_13330	1	161475776:161475797:161476123:161476381:161479609:161479689	161476123:161476381	ENSG00000143226.9	ENST00000271450.6
exon_skip_13331	1	161475776:161475797:161476123:161476497:161479609:161479689	161476123:161476497	ENSG00000143226.9	ENST00000536731.1
exon_skip_13332	1	161475776:161475797:161476126:161476381:161479609:161479689	161476126:161476381	ENSG00000143226.9	ENST00000367972.4,ENST00000467654.1
exon_skip_13333	1	161475776:161475797:161476126:161476497:161479609:161479689	161476126:161476497	ENSG00000143226.9	ENST00000483665.2
exon_skip_13335	1	161479609:161479864:161480623:161480746:161483684:161483722	161480623:161480746	ENSG00000143226.9	ENST00000367972.4,ENST00000271450.6,ENST00000483665.2
exon_skip_13339	1	161480630:161480746:161483684:161483722:161487764:161487927	161483684:161483722	ENSG00000143226.9	ENST00000367972.4,ENST00000271450.6,ENST00000483665.2
exon_skip_13342	1	161480630:161480746:161487764:161487927:161489378:161489450	161487764:161487927	ENSG00000143226.9	ENST00000467525.1
exon_skip_13356	1	161487764:161487927:161489378:161489450:161489591:161489781	161489378:161489450	ENSG00000143226.9	ENST00000491841.1
exon_skip_13357	1	161487764:161487927:161489378:161489503:161493079:161493226	161489378:161489503	ENSG00000143226.9	ENST00000467525.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for FCGR2A

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_13330	1	161475776:161475797:161476123:161476381:161479609:161479689	161476123:161476381	ENSG00000143226.9	ENST00000271450.6
exon_skip_13331	1	161475776:161475797:161476123:161476497:161479609:161479689	161476123:161476497	ENSG00000143226.9	ENST00000536731.1
exon_skip_13332	1	161475776:161475797:161476126:161476381:161479609:161479689	161476126:161476381	ENSG00000143226.9	ENST00000367972.4,ENST00000467654.1
exon_skip_13333	1	161475776:161475797:161476126:161476497:161479609:161479689	161476126:161476497	ENSG00000143226.9	ENST00000483665.2
exon_skip_13335	1	161479609:161479864:161480623:161480746:161483684:161483722	161480623:161480746	ENSG00000143226.9	ENST00000367972.4,ENST00000271450.6,ENST00000483665.2
exon_skip_13339	1	161480630:161480746:161483684:161483722:161487764:161487927	161483684:161483722	ENSG00000143226.9	ENST00000367972.4,ENST00000271450.6,ENST00000483665.2
exon_skip_13342	1	161480630:161480746:161487764:161487927:161489378:161489450	161487764:161487927	ENSG00000143226.9	ENST00000467525.1
exon_skip_13356	1	161487764:161487927:161489378:161489450:161489591:161489781	161489378:161489450	ENSG00000143226.9	ENST00000491841.1
exon_skip_13357	1	161487764:161487927:161489378:161489503:161493079:161493226	161489378:161489503	ENSG00000143226.9	ENST00000467525.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for FCGR2A

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000271450	161483684	161483722	Frame-shift
ENST00000271450	161476123	161476381	In-frame
ENST00000271450	161480623	161480746	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000271450	161483684	161483722	Frame-shift
ENST00000271450	161476123	161476381	In-frame
ENST00000271450	161480623	161480746	In-frame

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Infer the effects of exon skipping event on protein functional features for FCGR2A

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000271450	2429	317	161476123	161476381	145	402	35	121
ENST00000271450	2429	317	161480623	161480746	658	780	206	247

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000271450	2429	317	161476123	161476381	145	402	35	121
ENST00000271450	2429	317	161480623	161480746	658	780	206	247

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P12318	35	121	35	35	Alternative sequence	ID=VSP_036865;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P12318	35	121	42	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	50	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	57	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	68	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	73	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	80	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FCG
P12318	35	121	87	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	100	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	107	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1H9V
P12318	35	121	115	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	34	317	Chain	ID=PRO_0000015145;Note=Low affinity immunoglobulin gamma Fc region receptor II-a
P12318	35	121	62	104	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PDB:1FCG,ECO:0000269\|PubMed:10331870,ECO:0000269\|PubMed:11397093,ECO:0000269\|PubMed:19011614;Dbxref=PMID:10331870,PMID:11397093,PMID:19011614
P12318	35	121	39	118	Domain	Note=Ig-like C2-type 1
P12318	35	121	97	97	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:10397151;Dbxref=PMID:10397151
P12318	35	121	96	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	63	63	Natural variant	ID=VAR_054857;Note=Q->R;Dbxref=dbSNP:rs9427398
P12318	35	121	34	217	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P12318	206	247	34	317	Chain	ID=PRO_0000015145;Note=Low affinity immunoglobulin gamma Fc region receptor II-a
P12318	206	247	218	218	Natural variant	ID=VAR_054859;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15489334;Dbxref=dbSNP:rs17851834,PMID:15489334
P12318	206	247	34	217	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P12318	206	247	241	317	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
P12318	206	247	218	240	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P12318	35	121	35	35	Alternative sequence	ID=VSP_036865;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P12318	35	121	42	47	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	50	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	57	64	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	68	71	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	73	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	80	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1FCG
P12318	35	121	87	93	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	100	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	107	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1H9V
P12318	35	121	115	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	34	317	Chain	ID=PRO_0000015145;Note=Low affinity immunoglobulin gamma Fc region receptor II-a
P12318	35	121	62	104	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PDB:1FCG,ECO:0000269\|PubMed:10331870,ECO:0000269\|PubMed:11397093,ECO:0000269\|PubMed:19011614;Dbxref=PMID:10331870,PMID:11397093,PMID:19011614
P12318	35	121	39	118	Domain	Note=Ig-like C2-type 1
P12318	35	121	97	97	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:10397151;Dbxref=PMID:10397151
P12318	35	121	96	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RY4
P12318	35	121	63	63	Natural variant	ID=VAR_054857;Note=Q->R;Dbxref=dbSNP:rs9427398
P12318	35	121	34	217	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P12318	206	247	34	317	Chain	ID=PRO_0000015145;Note=Low affinity immunoglobulin gamma Fc region receptor II-a
P12318	206	247	218	218	Natural variant	ID=VAR_054859;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15489334;Dbxref=dbSNP:rs17851834,PMID:15489334
P12318	206	247	34	217	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P12318	206	247	241	317	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
P12318	206	247	218	240	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255

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SNVs in the skipped exons for FCGR2A

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-G3-A3CJ-01	exon_skip_13332 exon_skip_13330	161476124	161476381	161476156	161476156	Frame_Shift_Del	C	-	p.P48fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_13331 exon_skip_13333	161476124	161476497	161476156	161476156	Frame_Shift_Del	C	-	p.P48fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_13332 exon_skip_13330	161476127	161476381	161476156	161476156	Frame_Shift_Del	C	-	p.P48fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_13331 exon_skip_13333	161476127	161476497	161476156	161476156	Frame_Shift_Del	C	-	p.P48fs
BLCA	TCGA-UY-A78K-01	exon_skip_13332 exon_skip_13330	161476124	161476381	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
BLCA	TCGA-UY-A78K-01	exon_skip_13331 exon_skip_13333	161476124	161476497	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
BLCA	TCGA-UY-A78K-01	exon_skip_13332 exon_skip_13330	161476127	161476381	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
BLCA	TCGA-UY-A78K-01	exon_skip_13331 exon_skip_13333	161476127	161476497	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
SKCM	TCGA-D3-A5GS-06	exon_skip_13332 exon_skip_13330	161476124	161476381	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
SKCM	TCGA-D3-A5GS-06	exon_skip_13332 exon_skip_13330	161476124	161476381	161476237	161476237	Nonsense_Mutation	C	T	p.Q74X
SKCM	TCGA-D3-A5GS-06	exon_skip_13331 exon_skip_13333	161476124	161476497	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
SKCM	TCGA-D3-A5GS-06	exon_skip_13331 exon_skip_13333	161476124	161476497	161476237	161476237	Nonsense_Mutation	C	T	p.Q74X
SKCM	TCGA-D3-A5GS-06	exon_skip_13332 exon_skip_13330	161476127	161476381	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
SKCM	TCGA-D3-A5GS-06	exon_skip_13332 exon_skip_13330	161476127	161476381	161476237	161476237	Nonsense_Mutation	C	T	p.Q74X
SKCM	TCGA-D3-A5GS-06	exon_skip_13331 exon_skip_13333	161476127	161476497	161476237	161476237	Nonsense_Mutation	C	T	p.Q74*
SKCM	TCGA-D3-A5GS-06	exon_skip_13331 exon_skip_13333	161476127	161476497	161476237	161476237	Nonsense_Mutation	C	T	p.Q74X

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
NCIH196_LUNG	161476124	161476497	161476138	161476138	Missense_Mutation	G	T	p.A41S
NCIH196_LUNG	161476127	161476381	161476138	161476138	Missense_Mutation	G	T	p.A41S
NCIH196_LUNG	161476127	161476497	161476138	161476138	Missense_Mutation	G	T	p.A41S
NCIH196_LUNG	161476124	161476381	161476138	161476138	Missense_Mutation	G	T	p.A41S
KALS1_CENTRAL_NERVOUS_SYSTEM	161476124	161476497	161476214	161476214	Missense_Mutation	G	A	p.R66H
KALS1_CENTRAL_NERVOUS_SYSTEM	161476127	161476381	161476214	161476214	Missense_Mutation	G	A	p.R66H
KALS1_CENTRAL_NERVOUS_SYSTEM	161476127	161476497	161476214	161476214	Missense_Mutation	G	A	p.R66H
KALS1_CENTRAL_NERVOUS_SYSTEM	161476124	161476381	161476214	161476214	Missense_Mutation	G	A	p.R66H
SNUC4_LARGE_INTESTINE	161476124	161476497	161476228	161476228	Missense_Mutation	G	A	p.D71N
SNUC4_LARGE_INTESTINE	161476127	161476381	161476228	161476228	Missense_Mutation	G	A	p.D71N
SNUC4_LARGE_INTESTINE	161476127	161476497	161476228	161476228	Missense_Mutation	G	A	p.D71N
SNUC4_LARGE_INTESTINE	161476124	161476381	161476228	161476228	Missense_Mutation	G	A	p.D71N
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	161476124	161476497	161476372	161476372	Missense_Mutation	G	A	p.V119M
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	161476127	161476381	161476372	161476372	Missense_Mutation	G	A	p.V119M
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	161476127	161476497	161476372	161476372	Missense_Mutation	G	A	p.V119M
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	161476124	161476381	161476372	161476372	Missense_Mutation	G	A	p.V119M
COLO684_ENDOMETRIUM	161480624	161480746	161480633	161480633	Missense_Mutation	T	C	p.M210T
EB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	161480624	161480746	161480678	161480678	Missense_Mutation	C	G	p.A225G
OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	161480624	161480746	161480678	161480678	Missense_Mutation	C	G	p.A225G
MFE296_ENDOMETRIUM	161483685	161483722	161483712	161483712	Missense_Mutation	C	T	p.A257V
JHH6_LIVER	161487765	161487927	161487774	161487774	Missense_Mutation	C	T	p.R264C
CCK81_LARGE_INTESTINE	161487765	161487927	161487774	161487774	Missense_Mutation	C	T	p.R264C
GAK_SKIN	161487765	161487927	161487774	161487774	Missense_Mutation	C	T	p.R264C
OVKATE_OVARY	161487765	161487927	161487774	161487774	Missense_Mutation	C	T	p.R264C
OVSAHO_OVARY	161487765	161487927	161487840	161487840	Missense_Mutation	G	A	p.G286S
L33_PANCREAS	161487765	161487927	161487882	161487882	Missense_Mutation	G	A	p.D300N
OVCAR5_OVARY	161487765	161487927	161487882	161487882	Missense_Mutation	G	A	p.D300N
HT55_LARGE_INTESTINE	161487765	161487927	161487929	161487929	Missense_Mutation	T	A	p.S315R
VMRCLCD_LUNG	161487765	161487927	161487766	161487766	Splice_Site	C	A	p.P261Q

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCGR2A

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_13335	1	161479609:161479864:161480623:161480746:161483684:161483722	161480623:161480746	ENST00000367972.4,ENST00000271450.6,ENST00000483665.2	GBM	rs11810143	chr1:161480649	A/G	1.98e-07
exon_skip_13331	1	161475776:161475797:161476123:161476497:161479609:161479689	161476123:161476497	ENST00000536731.1	GBM	rs9427397	chr1:161476204	C/T	9.64e-09
exon_skip_13331	1	161475776:161475797:161476123:161476497:161479609:161479689	161476123:161476497	ENST00000536731.1	GBM	rs9427398	chr1:161476205	A/G	1.15e-08
exon_skip_13332	1	161475776:161475797:161476126:161476381:161479609:161479689	161476126:161476381	ENST00000367972.4,ENST00000467654.1	GBM	rs9427397	chr1:161476204	C/T	9.64e-09
exon_skip_13332	1	161475776:161475797:161476126:161476381:161479609:161479689	161476126:161476381	ENST00000367972.4,ENST00000467654.1	GBM	rs9427398	chr1:161476205	A/G	1.15e-08
exon_skip_13333	1	161475776:161475797:161476126:161476497:161479609:161479689	161476126:161476497	ENST00000483665.2	GBM	rs9427397	chr1:161476204	C/T	9.64e-09
exon_skip_13333	1	161475776:161475797:161476126:161476497:161479609:161479689	161476126:161476497	ENST00000483665.2	GBM	rs9427398	chr1:161476205	A/G	1.15e-08
exon_skip_13330	1	161475776:161475797:161476123:161476381:161479609:161479689	161476123:161476381	ENST00000271450.6	GBM	rs9427397	chr1:161476204	C/T	9.64e-09
exon_skip_13330	1	161475776:161475797:161476123:161476381:161479609:161479689	161476123:161476381	ENST00000271450.6	GBM	rs9427398	chr1:161476205	A/G	1.15e-08

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCGR2A

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCGR2A

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RelatedDrugs for FCGR2A

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	P12318	DB00002	Cetuximab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved
	P12318	DB00054	Abciximab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved
	P12318	DB00005	Etanercept	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00056	Gemtuzumab ozogamicin	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00072	Trastuzumab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00074	Basiliximab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00075	Muromonab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00078	Ibritumomab tiuxetan	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00081	Tositumomab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00087	Alemtuzumab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00095	Efalizumab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00108	Natalizumab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00110	Palivizumab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00112	Bevacizumab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB11767	Sarilumab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational
	P12318	DB00092	Alefacept	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational\|withdrawn
	P12318	DB06607	Catumaxomab	Low affinity immunoglobulin gamma Fc region receptor II-a	biotech	approved\|investigational\|withdrawn

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RelatedDiseases for FCGR2A

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
FCGR2A	C0003873	Rheumatoid Arthritis	2	CTD_human
FCGR2A	C0009324	Ulcerative Colitis	2	CTD_human
FCGR2A	C0026691	Mucocutaneous Lymph Node Syndrome	2	CTD_human
FCGR2A	C0024141	Lupus Erythematosus, Systemic	1	CTD_human
FCGR2A	C0036341	Schizophrenia	1	PSYGENET
FCGR2A	C0040034	Thrombocytopenia	1	CTD_human
FCGR2A	C0040053	Thrombosis	1	CTD_human
FCGR2A	C1527336	Sjogren's Syndrome	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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