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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CCNY |
 Gene summary |
| Gene information | Gene symbol | CCNY | Gene ID | 219771 |
| Gene name | cyclin Y | |
| Synonyms | C10orf9|CBCP1|CCNX|CFP1 | |
| Cytomap | 10p11.21 | |
| Type of gene | protein-coding | |
| Description | cyclin-Ycyc-Ycyclin box protein 1cyclin fold protein 1cyclin-Xcyclin-box carrying protein 1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8ND76 | |
| Context | PubMed: CCNY [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CCNY | GO:0000086 | G2/M transition of mitotic cell cycle | 20059949 |
| CCNY | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 19524571|20059949 |
| CCNY | GO:0060828 | regulation of canonical Wnt signaling pathway | 20059949 |
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Exon skipping events across known transcript of Ensembl for CCNY from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CCNY |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CCNY |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_40497 | 10 | 35625979:35626135:35683743:35683806:35772331:35772406 | 35683743:35683806 | ENSG00000108100.13 | ENST00000492478.1 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENSG00000108100.13 | ENST00000265375.9,ENST00000374704.4 |
| exon_skip_40507 | 10 | 35625979:35626135:35790428:35790463:35805450:35805503 | 35790428:35790463 | ENSG00000108100.13 | ENST00000339497.5 |
| exon_skip_40522 | 10 | 35772331:35772406:35790428:35790463:35805450:35805503 | 35790428:35790463 | ENSG00000108100.13 | ENST00000490012.2,ENST00000374706.1,ENST00000265375.9,ENST00000492478.1,ENST00000493157.2,ENST00000374704.4 |
| exon_skip_40536 | 10 | 35790428:35790463:35805450:35805551:35814891:35814927 | 35805450:35805551 | ENSG00000108100.13 | ENST00000339497.5,ENST00000374706.1,ENST00000265375.9,ENST00000492478.1,ENST00000493157.2,ENST00000374704.4 |
| exon_skip_40549 | 10 | 35805450:35805551:35814891:35814927:35818900:35818958 | 35814891:35814927 | ENSG00000108100.13 | ENST00000339497.5,ENST00000374706.1,ENST00000265375.9,ENST00000492478.1,ENST00000493157.2,ENST00000374704.4 |
| exon_skip_40557 | 10 | 35814891:35814927:35818900:35818958:35819051:35819171 | 35818900:35818958 | ENSG00000108100.13 | ENST00000339497.5,ENST00000374706.1,ENST00000265375.9,ENST00000492478.1,ENST00000374704.4 |
| exon_skip_40559 | 10 | 35814891:35814927:35819051:35819171:35841946:35842111 | 35819051:35819171 | ENSG00000108100.13 | ENST00000465416.1 |
| exon_skip_40560 | 10 | 35819123:35819171:35841946:35842113:35854950:35855056 | 35841946:35842113 | ENSG00000108100.13 | ENST00000339497.5,ENST00000374706.1,ENST00000265375.9,ENST00000497692.1,ENST00000465416.1,ENST00000374704.4 |
| exon_skip_40561 | 10 | 35841946:35842113:35854950:35855113:35857981:35860840 | 35854950:35855113 | ENSG00000108100.13 | ENST00000339497.5,ENST00000374706.1,ENST00000265375.9,ENST00000374704.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CCNY |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_40497 | 10 | 35625979:35626135:35683743:35683806:35772331:35772406 | 35683743:35683806 | ENSG00000108100.13 | ENST00000492478.1 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENSG00000108100.13 | ENST00000374704.4,ENST00000265375.9 |
| exon_skip_40507 | 10 | 35625979:35626135:35790428:35790463:35805450:35805503 | 35790428:35790463 | ENSG00000108100.13 | ENST00000339497.5 |
| exon_skip_40521 | 10 | 35723040:35723148:35744284:35744391:35772331:35772406 | 35744284:35744391 | ENSG00000108100.13 | ENST00000493157.2 |
| exon_skip_40522 | 10 | 35772331:35772406:35790428:35790463:35805450:35805503 | 35790428:35790463 | ENSG00000108100.13 | ENST00000490012.2,ENST00000374706.1,ENST00000493157.2,ENST00000374704.4,ENST00000265375.9,ENST00000492478.1 |
| exon_skip_40536 | 10 | 35790428:35790463:35805450:35805551:35814891:35814927 | 35805450:35805551 | ENSG00000108100.13 | ENST00000374706.1,ENST00000493157.2,ENST00000374704.4,ENST00000339497.5,ENST00000265375.9,ENST00000492478.1 |
| exon_skip_40549 | 10 | 35805450:35805551:35814891:35814927:35818900:35818958 | 35814891:35814927 | ENSG00000108100.13 | ENST00000374706.1,ENST00000493157.2,ENST00000374704.4,ENST00000339497.5,ENST00000265375.9,ENST00000492478.1 |
| exon_skip_40557 | 10 | 35814891:35814927:35818900:35818958:35819051:35819171 | 35818900:35818958 | ENSG00000108100.13 | ENST00000374706.1,ENST00000374704.4,ENST00000339497.5,ENST00000265375.9,ENST00000492478.1 |
| exon_skip_40559 | 10 | 35814891:35814927:35819051:35819171:35841946:35842111 | 35819051:35819171 | ENSG00000108100.13 | ENST00000465416.1 |
| exon_skip_40560 | 10 | 35819123:35819171:35841946:35842113:35854950:35855056 | 35841946:35842113 | ENSG00000108100.13 | ENST00000374706.1,ENST00000374704.4,ENST00000339497.5,ENST00000265375.9,ENST00000465416.1,ENST00000497692.1 |
| exon_skip_40561 | 10 | 35841946:35842113:35854950:35855113:35857981:35860840 | 35854950:35855113 | ENSG00000108100.13 | ENST00000374706.1,ENST00000374704.4,ENST00000339497.5,ENST00000265375.9 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CCNY |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374704 | 35790428 | 35790463 | Frame-shift |
| ENST00000374704 | 35805450 | 35805551 | Frame-shift |
| ENST00000374704 | 35818900 | 35818958 | Frame-shift |
| ENST00000374704 | 35841946 | 35842113 | Frame-shift |
| ENST00000374704 | 35854950 | 35855113 | Frame-shift |
| ENST00000374704 | 35772331 | 35772406 | In-frame |
| ENST00000374704 | 35814891 | 35814927 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374704 | 35790428 | 35790463 | Frame-shift |
| ENST00000374704 | 35805450 | 35805551 | Frame-shift |
| ENST00000374704 | 35818900 | 35818958 | Frame-shift |
| ENST00000374704 | 35841946 | 35842113 | Frame-shift |
| ENST00000374704 | 35854950 | 35855113 | Frame-shift |
| ENST00000374704 | 35772331 | 35772406 | In-frame |
| ENST00000374704 | 35814891 | 35814927 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CCNY |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374704 | 3977 | 341 | 35772331 | 35772406 | 335 | 409 | 51 | 76 |
| ENST00000374704 | 3977 | 341 | 35814891 | 35814927 | 546 | 581 | 122 | 133 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374704 | 3977 | 341 | 35772331 | 35772406 | 335 | 409 | 51 | 76 |
| ENST00000374704 | 3977 | 341 | 35814891 | 35814927 | 546 | 581 | 122 | 133 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CCNY |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
CCNY_ESCA_exon_skip_40536_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_40557 | 35818901 | 35818958 | 35818930 | 35818930 | Frame_Shift_Del | T | - | p.I144fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_40557 | 35818901 | 35818958 | 35818949 | 35818949 | Frame_Shift_Del | C | - | p.H150fs |
| BLCA | TCGA-BT-A2LB-01 | exon_skip_40560 | 35841947 | 35842113 | 35842099 | 35842100 | Frame_Shift_Del | CA | - | p.I244fs |
| BLCA | TCGA-BT-A2LB-01 | exon_skip_40560 | 35841947 | 35842113 | 35842099 | 35842100 | Frame_Shift_Del | CA | - | p.T245fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_40561 | 35854951 | 35855113 | 35855072 | 35855072 | Frame_Shift_Del | C | - | p.P290fs |
| ESCA | TCGA-LN-A49U-01 | exon_skip_40536 | 35805451 | 35805551 | 35805450 | 35805450 | Splice_Site | G | A | . |
| ESCA | TCGA-LN-A49U-01 | exon_skip_40536 | 35805451 | 35805551 | 35805450 | 35805450 | Splice_Site | G | A | e4-1 |
| GBM | TCGA-06-0124-01 | exon_skip_40559 | 35819052 | 35819171 | 35819172 | 35819172 | Splice_Site | G | A | p.L193_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-LN-A49U-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_40536 | |
| Skipped exon start: 35805451 | |
| Skipped exon end: 35805551 | |
| Mutation start: 35805450 | |
| Mutation end: 35805450 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: . | |
| Sample: TCGA-LN-A49U-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_40536 | |
| Skipped exon start: 35805451 | |
| Skipped exon end: 35805551 | |
| Mutation start: 35805450 | |
| Mutation end: 35805450 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: e4-1 | |
exon_skip_339155_ESCA_TCGA-LN-A49U-01.png | |
exon_skip_40536_ESCA_TCGA-LN-A49U-01.png | |
exon_skip_452826_ESCA_TCGA-LN-A49U-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC1_ENDOMETRIUM | 35772332 | 35772406 | 35772343 | 35772343 | Missense_Mutation | G | A | p.E56K |
| HEC1B_ENDOMETRIUM | 35772332 | 35772406 | 35772343 | 35772343 | Missense_Mutation | G | A | p.E56K |
| NCIH3255_LUNG | 35790429 | 35790463 | 35790449 | 35790449 | Missense_Mutation | C | G | p.L84V |
| NCIH510_LUNG | 35805451 | 35805551 | 35805509 | 35805509 | Missense_Mutation | A | T | p.D108V |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 35805451 | 35805551 | 35805541 | 35805541 | Missense_Mutation | A | G | p.T119A |
| RERFLCFM_LUNG | 35814892 | 35814927 | 35814921 | 35814921 | Missense_Mutation | A | G | p.K132R |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 35819052 | 35819171 | 35819106 | 35819106 | Missense_Mutation | T | G | p.Y172D |
| HT115_LARGE_INTESTINE | 35819052 | 35819171 | 35819118 | 35819118 | Missense_Mutation | C | T | p.R176W |
| LNCAPCLONEFGC_PROSTATE | 35819052 | 35819171 | 35819146 | 35819146 | Missense_Mutation | C | T | p.T185M |
| NCIH2110_LUNG | 35841947 | 35842113 | 35842048 | 35842048 | Missense_Mutation | G | C | p.W227C |
| BFTC905_URINARY_TRACT | 35854951 | 35855113 | 35854976 | 35854976 | Missense_Mutation | G | A | p.E258K |
| SBC5_LUNG | 35854951 | 35855113 | 35855019 | 35855019 | Missense_Mutation | C | T | p.A272V |
| HCC1195_LUNG | 35854951 | 35855113 | 35855088 | 35855088 | Missense_Mutation | G | T | p.S295I |
| LOVO_LARGE_INTESTINE | 35814892 | 35814927 | 35814927 | 35814927 | Splice_Site | G | T | p.R134M |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CCNY |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | ACC | rs3802509 | chr10:35772402 | G/A | 2.62e-04 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | CESC | rs3802509 | chr10:35772402 | G/A | 1.00e-13 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | COAD | rs3802509 | chr10:35772402 | G/A | 4.91e-17 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | BLCA | rs3802509 | chr10:35772402 | G/A | 1.46e-21 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | ESCA | rs3802509 | chr10:35772402 | G/A | 3.45e-19 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | HNSC | rs3802509 | chr10:35772402 | G/A | 4.97e-30 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | BRCA | rs3802509 | chr10:35772402 | G/A | 4.01e-143 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | LAML | rs3802509 | chr10:35772402 | G/A | 7.85e-11 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | KIRP | rs3802509 | chr10:35772402 | G/A | 7.52e-14 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | LGG | rs3802509 | chr10:35772402 | G/A | 1.21e-57 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | KIRC | rs3802509 | chr10:35772402 | G/A | 1.79e-68 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | LUAD | rs3802509 | chr10:35772402 | G/A | 5.30e-35 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | MESO | rs3802509 | chr10:35772402 | G/A | 8.91e-06 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | LIHC | rs3802509 | chr10:35772402 | G/A | 8.97e-18 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | LUSC | rs3802509 | chr10:35772402 | G/A | 4.85e-48 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | OV | rs3802509 | chr10:35772402 | G/A | 3.40e-29 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | READ | rs3802509 | chr10:35772402 | G/A | 3.23e-08 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | PCPG | rs3802509 | chr10:35772402 | G/A | 2.15e-08 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | PAAD | rs3802509 | chr10:35772402 | G/A | 7.92e-18 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | PRAD | rs3802509 | chr10:35772402 | G/A | 1.52e-28 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | SARC | rs3802509 | chr10:35772402 | G/A | 1.45e-12 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | THYM | rs3802509 | chr10:35772402 | G/A | 3.72e-07 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | TGCT | rs3802509 | chr10:35772402 | G/A | 5.24e-06 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | SKCM | rs3802509 | chr10:35772402 | G/A | 3.60e-10 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | STAD | rs3802509 | chr10:35772402 | G/A | 1.44e-38 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | THCA | rs3802509 | chr10:35772402 | G/A | 1.25e-39 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | UVM | rs3802509 | chr10:35772402 | G/A | 1.33e-06 |
| exon_skip_40501 | 10 | 35625979:35626135:35772331:35772406:35790428:35790463 | 35772331:35772406 | ENST00000265375.9,ENST00000374704.4 | UCEC | rs3802509 | chr10:35772402 | G/A | 8.81e-11 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CCNY |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CCNY |
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RelatedDrugs for CCNY |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNY |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CCNY | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| CCNY | C0010346 | Crohn Disease | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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