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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for AKT1

check button Gene summary
Gene informationGene symbol

AKT1

Gene ID

207

Gene nameAKT serine/threonine kinase 1
SynonymsAKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA
Cytomap

14q32.33

Type of geneprotein-coding
DescriptionRAC-alpha serine/threonine-protein kinaseAKT1mPKB alphaRAC-PK-alphaprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alphaserine-threonine protein kinasev-akt murine thymoma viral oncogene homolog 1v-akt murine thymoma viral oncogene-l
Modification date20180527
UniProtAcc

P31749

ContextPubMed: AKT1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
AKT1

GO:0001934

positive regulation of protein phosphorylation

19057511

AKT1

GO:0006468

protein phosphorylation

11994271|14749367|23431171

AKT1

GO:0007173

epidermal growth factor receptor signaling pathway

20878056

AKT1

GO:0016310

phosphorylation

20333297

AKT1

GO:0018105

peptidyl-serine phosphorylation

16139227

AKT1

GO:0018107

peptidyl-threonine phosphorylation

20605787

AKT1

GO:0030307

positive regulation of cell growth

19203586

AKT1

GO:0031659

positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

18483258

AKT1

GO:0032079

positive regulation of endodeoxyribonuclease activity

20605787

AKT1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

AKT1

GO:0035556

intracellular signal transduction

14749367

AKT1

GO:0035655

interleukin-18-mediated signaling pathway

21321938

AKT1

GO:0043066

negative regulation of apoptotic process

19203586

AKT1

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

AKT1

GO:0048661

positive regulation of smooth muscle cell proliferation

21321938

AKT1

GO:0051091

positive regulation of DNA binding transcription factor activity

19057511

AKT1

GO:0070141

response to UV-A

18483258


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Exon skipping events across known transcript of Ensembl for AKT1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for AKT1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for AKT1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_11632514105237137:105237184:105238058:105238153:105238701:105238789105238058:105238153ENSG00000142208.11ENST00000554585.1
exon_skip_11632714105237137:105237184:105238701:105238789:105239214:105239330105238701:105238789ENSG00000142208.11ENST00000544168.1,ENST00000554848.1,ENST00000402615.2,ENST00000554192.1,ENST00000407796.2,ENST00000555458.1,ENST00000554581.1,ENST00000349310.3,ENST00000555528.1,ENST00000553506.1
exon_skip_11632914105238701:105238789:105239214:105239330:105239587:105239651105239214:105239330ENSG00000142208.11ENST00000554192.1
exon_skip_11633014105238701:105238789:105239214:105239429:105239587:105239651105239214:105239429ENSG00000142208.11ENST00000544168.1,ENST00000554848.1,ENST00000402615.2,ENST00000407796.2,ENST00000555458.1,ENST00000554581.1,ENST00000554585.1,ENST00000349310.3,ENST00000555528.1,ENST00000553506.1
exon_skip_11633214105239587:105239716:105239791:105239917:105240248:105240317105239791:105239917ENSG00000142208.11ENST00000544168.1,ENST00000554848.1,ENST00000402615.2,ENST00000407796.2,ENST00000554581.1,ENST00000349310.3,ENST00000555528.1
exon_skip_11633714105239791:105239917:105240248:105240317:105241274:105241340105240248:105240317ENSG00000142208.11ENST00000544168.1,ENST00000554848.1,ENST00000402615.2,ENST00000407796.2,ENST00000554581.1,ENST00000349310.3,ENST00000555528.1
exon_skip_11633914105241274:105241340:105241412:105241544:105241988:105242136105241412:105241544ENSG00000142208.11ENST00000544168.1,ENST00000554848.1,ENST00000402615.2,ENST00000407796.2,ENST00000554826.1,ENST00000554581.1,ENST00000349310.3,ENST00000555528.1
exon_skip_11634314105243007:105243107:105246424:105246553:105258934:105259057105246424:105246553ENSG00000142208.11ENST00000554848.1,ENST00000555926.1,ENST00000402615.2,ENST00000407796.2,ENST00000349310.3,ENST00000555528.1
exon_skip_11634714105246424:105246553:105258934:105259059:105261820:105261841105258934:105259059ENSG00000142208.11ENST00000407796.2
exon_skip_11635614105258934:105259059:105259463:105259547:105261820:105261841105259463:105259547ENSG00000142208.11ENST00000349310.3
exon_skip_11636214105258934:105259059:105259463:105259641:105261820:105261841105259463:105259641ENSG00000142208.11ENST00000555926.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for AKT1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_11632514105237137:105237184:105238058:105238153:105238701:105238789105238058:105238153ENSG00000142208.11ENST00000554585.1
exon_skip_11632714105237137:105237184:105238701:105238789:105239214:105239330105238701:105238789ENSG00000142208.11ENST00000554581.1,ENST00000407796.2,ENST00000349310.3,ENST00000553506.1,ENST00000402615.2,ENST00000555528.1,ENST00000555458.1,ENST00000554192.1,ENST00000544168.1,ENST00000554848.1
exon_skip_11632914105238701:105238789:105239214:105239330:105239587:105239651105239214:105239330ENSG00000142208.11ENST00000554192.1
exon_skip_11633014105238701:105238789:105239214:105239429:105239587:105239651105239214:105239429ENSG00000142208.11ENST00000554581.1,ENST00000407796.2,ENST00000349310.3,ENST00000553506.1,ENST00000402615.2,ENST00000555528.1,ENST00000555458.1,ENST00000544168.1,ENST00000554585.1,ENST00000554848.1
exon_skip_11633214105239587:105239716:105239791:105239917:105240248:105240317105239791:105239917ENSG00000142208.11ENST00000554581.1,ENST00000407796.2,ENST00000349310.3,ENST00000402615.2,ENST00000555528.1,ENST00000544168.1,ENST00000554848.1
exon_skip_11633714105239791:105239917:105240248:105240317:105241274:105241340105240248:105240317ENSG00000142208.11ENST00000554581.1,ENST00000407796.2,ENST00000349310.3,ENST00000402615.2,ENST00000555528.1,ENST00000544168.1,ENST00000554848.1
exon_skip_11633914105241274:105241340:105241412:105241544:105241988:105242136105241412:105241544ENSG00000142208.11ENST00000554581.1,ENST00000407796.2,ENST00000349310.3,ENST00000402615.2,ENST00000555528.1,ENST00000544168.1,ENST00000554848.1,ENST00000554826.1
exon_skip_11634314105243007:105243107:105246424:105246553:105258934:105259057105246424:105246553ENSG00000142208.11ENST00000407796.2,ENST00000349310.3,ENST00000402615.2,ENST00000555528.1,ENST00000554848.1,ENST00000555926.1
exon_skip_11634714105246424:105246553:105258934:105259059:105261820:105261841105258934:105259059ENSG00000142208.11ENST00000407796.2
exon_skip_11635614105258934:105259059:105259463:105259547:105261820:105261841105259463:105259547ENSG00000142208.11ENST00000349310.3
exon_skip_11636214105258934:105259059:105259463:105259641:105261820:105261841105259463:105259641ENSG00000142208.11ENST00000555926.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for AKT1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000004077961052589341052590593UTR-3CDS
ENST000003493101052594631052595473UTR-3UTR
ENST00000349310105238701105238789Frame-shift
ENST00000402615105238701105238789Frame-shift
ENST00000407796105238701105238789Frame-shift
ENST00000554581105238701105238789Frame-shift
ENST00000554848105238701105238789Frame-shift
ENST00000555528105238701105238789Frame-shift
ENST00000349310105239214105239429Frame-shift
ENST00000402615105239214105239429Frame-shift
ENST00000407796105239214105239429Frame-shift
ENST00000554581105239214105239429Frame-shift
ENST00000554848105239214105239429Frame-shift
ENST00000555528105239214105239429Frame-shift
ENST00000349310105239791105239917In-frame
ENST00000402615105239791105239917In-frame
ENST00000407796105239791105239917In-frame
ENST00000554581105239791105239917In-frame
ENST00000554848105239791105239917In-frame
ENST00000555528105239791105239917In-frame
ENST00000349310105240248105240317In-frame
ENST00000402615105240248105240317In-frame
ENST00000407796105240248105240317In-frame
ENST00000554581105240248105240317In-frame
ENST00000554848105240248105240317In-frame
ENST00000555528105240248105240317In-frame
ENST00000349310105241412105241544In-frame
ENST00000402615105241412105241544In-frame
ENST00000407796105241412105241544In-frame
ENST00000554581105241412105241544In-frame
ENST00000554848105241412105241544In-frame
ENST00000555528105241412105241544In-frame
ENST00000349310105246424105246553In-frame
ENST00000402615105246424105246553In-frame
ENST00000407796105246424105246553In-frame
ENST00000554848105246424105246553In-frame
ENST00000555528105246424105246553In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000004077961052589341052590593UTR-3CDS
ENST000003493101052594631052595473UTR-3UTR
ENST00000349310105238701105238789Frame-shift
ENST00000402615105238701105238789Frame-shift
ENST00000407796105238701105238789Frame-shift
ENST00000554581105238701105238789Frame-shift
ENST00000554848105238701105238789Frame-shift
ENST00000555528105238701105238789Frame-shift
ENST00000349310105239214105239429Frame-shift
ENST00000402615105239214105239429Frame-shift
ENST00000407796105239214105239429Frame-shift
ENST00000554581105239214105239429Frame-shift
ENST00000554848105239214105239429Frame-shift
ENST00000555528105239214105239429Frame-shift
ENST00000349310105239791105239917In-frame
ENST00000402615105239791105239917In-frame
ENST00000407796105239791105239917In-frame
ENST00000554581105239791105239917In-frame
ENST00000554848105239791105239917In-frame
ENST00000555528105239791105239917In-frame
ENST00000349310105240248105240317In-frame
ENST00000402615105240248105240317In-frame
ENST00000407796105240248105240317In-frame
ENST00000554581105240248105240317In-frame
ENST00000554848105240248105240317In-frame
ENST00000555528105240248105240317In-frame
ENST00000349310105241412105241544In-frame
ENST00000402615105241412105241544In-frame
ENST00000407796105241412105241544In-frame
ENST00000554581105241412105241544In-frame
ENST00000554848105241412105241544In-frame
ENST00000555528105241412105241544In-frame
ENST00000349310105246424105246553In-frame
ENST00000402615105246424105246553In-frame
ENST00000407796105246424105246553In-frame
ENST00000554848105246424105246553In-frame
ENST00000555528105246424105246553In-frame

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Infer the effects of exon skipping event on protein functional features for AKT1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000034931028834801052464241052465534786061558
ENST000004026153930480105246424105246553152816561558
ENST0000040779627274801052464241052465533224501558
ENST0000055484816124801052464241052465531993271558
ENST0000055552830834801052464241052465537008281558
ENST000003493102883480105241412105241544867998145189
ENST00000402615393048010524141210524154419172048145189
ENST000004077962727480105241412105241544711842145189
ENST00000554581393348010524141210524154419172048145189
ENST000005548481612480105241412105241544588719145189
ENST00000555528308348010524141210524154410891220145189
ENST00000349310288348010524024810524031710651133211234
ENST00000402615393048010524024810524031721152183211234
ENST000004077962727480105240248105240317909977211234
ENST00000554581393348010524024810524031721152183211234
ENST000005548481612480105240248105240317786854211234
ENST00000555528308348010524024810524031712871355211234
ENST00000349310288348010523979110523991711341259234276
ENST00000402615393048010523979110523991721842309234276
ENST0000040779627274801052397911052399179781103234276
ENST00000554581393348010523979110523991721842309234276
ENST000005548481612480105239791105239917855980234276
ENST00000555528308348010523979110523991713561481234276

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000034931028834801052464241052465534786061558
ENST000004026153930480105246424105246553152816561558
ENST0000040779627274801052464241052465533224501558
ENST0000055484816124801052464241052465531993271558
ENST0000055552830834801052464241052465537008281558
ENST000003493102883480105241412105241544867998145189
ENST00000402615393048010524141210524154419172048145189
ENST000004077962727480105241412105241544711842145189
ENST00000554581393348010524141210524154419172048145189
ENST000005548481612480105241412105241544588719145189
ENST00000555528308348010524141210524154410891220145189
ENST00000349310288348010524024810524031710651133211234
ENST00000402615393048010524024810524031721152183211234
ENST000004077962727480105240248105240317909977211234
ENST00000554581393348010524024810524031721152183211234
ENST000005548481612480105240248105240317786854211234
ENST00000555528308348010524024810524031712871355211234
ENST00000349310288348010523979110523991711341259234276
ENST00000402615393048010523979110523991721842309234276
ENST0000040779627274801052397911052399179781103234276
ENST00000554581393348010523979110523991721842309234276
ENST000005548481612480105239791105239917855980234276
ENST00000555528308348010523979110523991713561481234276

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305


Top

SNVs in the skipped exons for AKT1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
AKT1_LIHC_exon_skip_116330_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_116330
105239215105239429105239385105239385Frame_Shift_DelC-p.G334fs
LIHCTCGA-DD-A3A0-01exon_skip_116337
105240249105240317105240253105240253Frame_Shift_DelC-p.G233fs
LIHCTCGA-G3-A3CJ-01exon_skip_116337
105240249105240317105240253105240253Frame_Shift_DelC-p.G233fs
SKCMTCGA-ER-A193-06exon_skip_116343
105246425105246553105246461105246461Nonsense_MutationGAp.Q47*
SKCMTCGA-ER-A193-06exon_skip_116343
105246425105246553105246461105246461Nonsense_MutationGAp.Q47X

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
AKT1_105238701_105238789_105239214_105239429_105239587_105239651_TCGA-DD-A1EG-01Sample: TCGA-DD-A1EG-01
Cancer type: LIHC
ESID: exon_skip_116330
Skipped exon start: 105239215
Skipped exon end: 105239429
Mutation start: 105239385
Mutation end: 105239385
Mutation type: Frame_Shift_Del
Reference seq: C
Mutation seq: -
AAchange: p.G334fs
exon_skip_103075_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_100809_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_101656_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_10700_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_109033_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_110000_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_110381_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_110545_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_11218_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_11256_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_11259_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_11263_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_115462_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_115587_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_116330_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_121002_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_123667_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_12440_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_125045_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_129202_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_129996_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_130099_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_13071_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_131505_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_131697_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_133542_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_133548_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_134792_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_135418_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_135741_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_135763_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_135820_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_13608_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_138255_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_138373_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_138947_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_140996_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_141914_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_143553_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_143841_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_143843_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_144075_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_144116_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_144125_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_146762_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_146776_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_146807_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_14772_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_148738_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_148740_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_14897_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_14899_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_15042_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_150985_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_153494_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_155021_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_16928_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_17317_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_17318_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_17943_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_18708_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_19048_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_1906_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_87721_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_87_LIHC_TCGA-DD-A1EG-01.png
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exon_skip_99140_LIHC_TCGA-DD-A1EG-01.png
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check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
2313287_STOMACH105238702105238789105238745105238745Missense_MutationCTp.R406H
MESSA_SOFT_TISSUE105239215105239429105239351105239351Missense_MutationGAp.R346C
SNU175_LARGE_INTESTINE105239215105239429105239378105239378Missense_MutationCTp.V337M
GP5D_LARGE_INTESTINE105239792105239917105239805105239805Missense_MutationTCp.Y272C
DMS114_LUNG105239792105239917105239823105239823Missense_MutationGAp.S266L
ACCS_URINARY_TRACT105239792105239917105239825105239825Missense_MutationGCp.H265Q
OMC1_CERVIX105240249105240317105240290105240290Missense_MutationCTp.D221N
MFE319_ENDOMETRIUM105240249105240317105240308105240308Missense_MutationAGp.Y215H
KYSE30_OESOPHAGUS105246425105246553105246448105246448Missense_MutationGAp.P51L
KU1919_URINARY_TRACT105246425105246553105246455105246455Missense_MutationCTp.E49K
HEC50B_ENDOMETRIUM105246425105246553105246482105246482Missense_MutationCTp.E40K
SNU520_STOMACH105246425105246553105246532105246532Missense_MutationCTp.R23Q
KU1919_URINARY_TRACT105246425105246553105246551105246551Missense_MutationCTp.E17K
IHH4_THYROID105246425105246553105246551105246551Missense_MutationCTp.E17K
MDAMB361_BREAST105258935105259059105258974105258974Missense_MutationCTp.D3N
CHL1_SKIN105246425105246553105246425105246425Splice_SiteGAp.Q59*
SNU1040_LARGE_INTESTINE105246425105246553105246425105246425Splice_SiteGAp.Q59*
HMCB_SKIN105246425105246553105246425105246425Splice_SiteGAp.Q59*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AKT1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for AKT1


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for AKT1


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RelatedDrugs for AKT1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P31749DB01169Arsenic trioxideRAC-alpha serine/threonine-protein kinasesmall moleculeapproved|investigational

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RelatedDiseases for AKT1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
AKT1C0005586Bipolar Disorder5PSYGENET
AKT1C0011570Mental Depression5PSYGENET
AKT1C0011581Depressive disorder5PSYGENET
AKT1C0036341Schizophrenia4CTD_human
AKT1C0085261Proteus Syndrome4ORPHANET;UNIPROT
AKT1C0024121Lung Neoplasms3CTD_human
AKT1C0525045Mood Disorders2PSYGENET
AKT1C0919267ovarian neoplasm2CTD_human
AKT1C0007137Squamous cell carcinoma1CTD_human
AKT1C0014544Epilepsy1CTD_human;HPO
AKT1C0016059Fibrosis1CTD_human
AKT1C0018800Cardiomegaly1CTD_human
AKT1C0020507Hyperplasia1CTD_human
AKT1C0021368Inflammation1CTD_human
AKT1C0023487Acute Promyelocytic Leukemia1CTD_human
AKT1C0024809Marijuana Abuse1CTD_human
AKT1C0025286Meningioma1CTD_human;HPO
AKT1C0026846Muscular Atrophy1CTD_human
AKT1C0028754Obesity1CTD_human
AKT1C0030193Pain1CTD_human
AKT1C0032580Adenomatous Polyposis Coli1CTD_human
AKT1C0033578Prostatic Neoplasms1CTD_human
AKT1C0033941Psychoses, Substance-Induced1CTD_human
AKT1C0037286Skin Neoplasms1CTD_human
AKT1C0079772T-Cell Lymphoma1CTD_human
AKT1C0236733Amphetamine-Related Disorders1CTD_human
AKT1C0428791Aortic valve calcification1CTD_human
AKT1C0878544Cardiomyopathies1CTD_human
AKT1C1168401Squamous cell carcinoma of the head and neck1CTD_human
AKT1C1458155Mammary Neoplasms1CTD_human
AKT1C3554519COWDEN SYNDROME 61UNIPROT