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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SENP5 |
 Gene summary |
| Gene information | Gene symbol | SENP5 | Gene ID | 205564 |
| Gene name | SUMO specific peptidase 5 | |
| Synonyms | - | |
| Cytomap | 3q29 | |
| Type of gene | protein-coding | |
| Description | sentrin-specific protease 5SUMO1/sentrin specific peptidase 5SUMO1/sentrin specific protease 5sentrin/SUMO-specific protease SENP5 | |
| Modification date | 20180523 | |
| UniProtAcc | Q96HI0 | |
| Context | PubMed: SENP5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SENP5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SENP5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SENP5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_380755 | 3 | 196594815:196594944:196612021:196613565:196626536:196626642 | 196612021:196613565 | ENSG00000119231.6 | ENST00000323460.5 |
| exon_skip_380758 | 3 | 196626909:196626933:196627235:196627283:196630403:196630481 | 196627235:196627283 | ENSG00000119231.6 | ENST00000419026.1,ENST00000323460.5,ENST00000489744.1,ENST00000445299.2 |
| exon_skip_380760 | 3 | 196630403:196630481:196650284:196650422:196654666:196654750 | 196650284:196650422 | ENSG00000119231.6 | ENST00000419026.1,ENST00000323460.5 |
| exon_skip_380763 | 3 | 196630403:196630481:196654666:196654750:196656503:196656554 | 196654666:196654750 | ENSG00000119231.6 | ENST00000445299.2 |
| exon_skip_380766 | 3 | 196650288:196650422:196654666:196654750:196656503:196656554 | 196654666:196654750 | ENSG00000119231.6 | ENST00000419026.1,ENST00000323460.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SENP5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_380755 | 3 | 196594815:196594944:196612021:196613565:196626536:196626642 | 196612021:196613565 | ENSG00000119231.6 | ENST00000323460.5 |
| exon_skip_380758 | 3 | 196626909:196626933:196627235:196627283:196630403:196630481 | 196627235:196627283 | ENSG00000119231.6 | ENST00000445299.2,ENST00000323460.5,ENST00000419026.1,ENST00000489744.1 |
| exon_skip_380760 | 3 | 196630403:196630481:196650284:196650422:196654666:196654750 | 196650284:196650422 | ENSG00000119231.6 | ENST00000323460.5,ENST00000419026.1 |
| exon_skip_380763 | 3 | 196630403:196630481:196654666:196654750:196656503:196656554 | 196654666:196654750 | ENSG00000119231.6 | ENST00000445299.2 |
| exon_skip_380766 | 3 | 196650288:196650422:196654666:196654750:196656503:196656554 | 196654666:196654750 | ENSG00000119231.6 | ENST00000323460.5,ENST00000419026.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SENP5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323460 | 196612021 | 196613565 | 5CDS-5UTR |
| ENST00000323460 | 196627235 | 196627283 | In-frame |
| ENST00000323460 | 196650284 | 196650422 | In-frame |
| ENST00000323460 | 196654666 | 196654750 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323460 | 196612021 | 196613565 | 5CDS-5UTR |
| ENST00000323460 | 196627235 | 196627283 | In-frame |
| ENST00000323460 | 196650284 | 196650422 | In-frame |
| ENST00000323460 | 196654666 | 196654750 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SENP5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000323460 | 6325 | 755 | 196627235 | 196627283 | 2008 | 2055 | 586 | 602 |
| ENST00000323460 | 6325 | 755 | 196650284 | 196650422 | 2134 | 2271 | 628 | 674 |
| ENST00000323460 | 6325 | 755 | 196654666 | 196654750 | 2272 | 2355 | 674 | 702 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000323460 | 6325 | 755 | 196627235 | 196627283 | 2008 | 2055 | 586 | 602 |
| ENST00000323460 | 6325 | 755 | 196650284 | 196650422 | 2134 | 2271 | 628 | 674 |
| ENST00000323460 | 6325 | 755 | 196654666 | 196654750 | 2272 | 2355 | 674 | 702 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96HI0 | 586 | 602 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 586 | 602 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 628 | 674 | 646 | 646 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 663 | 663 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 628 | 674 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 628 | 674 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 674 | 702 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 674 | 702 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 674 | 702 | 567 | 724 | Region | Note=Protease |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96HI0 | 586 | 602 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 586 | 602 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 628 | 674 | 646 | 646 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 663 | 663 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 628 | 674 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 628 | 674 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 674 | 702 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 674 | 702 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 674 | 702 | 567 | 724 | Region | Note=Protease |
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SNVs in the skipped exons for SENP5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_380755 | 196612022 | 196613565 | 196612143 | 196612143 | Frame_Shift_Del | T | - | p.F31fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_380755 | 196612022 | 196613565 | 196612452 | 196612452 | Frame_Shift_Del | A | - | p.K134fs |
| KIRP | TCGA-A4-A5Y1-01 | exon_skip_380755 | 196612022 | 196613565 | 196612951 | 196612952 | Frame_Shift_Ins | - | T | p.S300fs |
| KIRP | TCGA-GL-A9DD-01 | exon_skip_380755 | 196612022 | 196613565 | 196613001 | 196613001 | Nonsense_Mutation | A | T | p.K317X |
| GBM | TCGA-28-5218-01 | exon_skip_380755 | 196612022 | 196613565 | 196613120 | 196613120 | Nonsense_Mutation | G | A | p.W356* |
| LUAD | TCGA-50-5930-01 | exon_skip_380758 | 196627236 | 196627283 | 196627254 | 196627254 | Nonsense_Mutation | G | T | p.E593* |
| HNSC | TCGA-CN-A6V1-01 | exon_skip_380760 | 196650285 | 196650422 | 196650379 | 196650379 | Nonsense_Mutation | C | G | p.S660* |
| UCS | TCGA-ND-A4WC-01 | exon_skip_380760 | 196650285 | 196650422 | 196650379 | 196650379 | Nonsense_Mutation | C | A | p.S660* |
| UCS | TCGA-ND-A4WC-01 | exon_skip_380760 | 196650285 | 196650422 | 196650379 | 196650379 | Nonsense_Mutation | C | A | p.S660X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UWB1289_OVARY | 196612022 | 196613565 | 196612239 | 196612239 | Frame_Shift_Del | G | - | p.A63fs |
| NCIH1703_LUNG | 196654667 | 196654750 | 196654700 | 196654701 | Frame_Shift_Ins | - | A | p.E686fs |
| SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196654667 | 196654750 | 196654700 | 196654701 | Frame_Shift_Ins | - | A | p.E686fs |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196612022 | 196613565 | 196612077 | 196612077 | Missense_Mutation | T | C | p.W9R |
| SKMEL30_SKIN | 196612022 | 196613565 | 196612277 | 196612278 | Missense_Mutation | CC | TT | p.L76F |
| SKMEL30_SKIN | 196612022 | 196613565 | 196612278 | 196612278 | Missense_Mutation | C | T | p.L76F |
| MDAMB231_BREAST | 196612022 | 196613565 | 196612295 | 196612295 | Missense_Mutation | G | T | p.K81N |
| NCIH650_LUNG | 196612022 | 196613565 | 196612435 | 196612435 | Missense_Mutation | A | G | p.H128R |
| NCIH2342_LUNG | 196612022 | 196613565 | 196612504 | 196612504 | Missense_Mutation | A | T | p.Q151L |
| MCF7_BREAST | 196612022 | 196613565 | 196612576 | 196612576 | Missense_Mutation | A | G | p.Q175R |
| SYO1_SOFT_TISSUE | 196612022 | 196613565 | 196612648 | 196612648 | Missense_Mutation | G | C | p.C199S |
| KYSE520_OESOPHAGUS | 196612022 | 196613565 | 196612648 | 196612648 | Missense_Mutation | G | C | p.C199S |
| KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196612022 | 196613565 | 196612648 | 196612648 | Missense_Mutation | G | C | p.C199S |
| TE15_OESOPHAGUS | 196612022 | 196613565 | 196612648 | 196612648 | Missense_Mutation | G | C | p.C199S |
| NCIH524_LUNG | 196612022 | 196613565 | 196612782 | 196612782 | Missense_Mutation | A | G | p.R244G |
| MDAMB330_BREAST | 196612022 | 196613565 | 196612820 | 196612820 | Missense_Mutation | G | C | p.K256N |
| SNU1040_LARGE_INTESTINE | 196612022 | 196613565 | 196612870 | 196612870 | Missense_Mutation | G | A | p.G273E |
| KYSE50_OESOPHAGUS | 196612022 | 196613565 | 196612879 | 196612879 | Missense_Mutation | A | C | p.Q276P |
| OC316_OVARY | 196612022 | 196613565 | 196612939 | 196612939 | Missense_Mutation | C | A | p.P296H |
| OC314_OVARY | 196612022 | 196613565 | 196612939 | 196612939 | Missense_Mutation | C | A | p.P296H |
| FUOV1_OVARY | 196612022 | 196613565 | 196612956 | 196612956 | Missense_Mutation | C | G | p.R302G |
| YD15_SALIVARY_GLAND | 196612022 | 196613565 | 196612957 | 196612957 | Missense_Mutation | G | T | p.R302L |
| VMCUB1_URINARY_TRACT | 196612022 | 196613565 | 196612977 | 196612977 | Missense_Mutation | G | T | p.D309Y |
| HCC2108_LUNG | 196612022 | 196613565 | 196613005 | 196613005 | Missense_Mutation | G | A | p.G318E |
| MORCPR_LUNG | 196612022 | 196613565 | 196613005 | 196613005 | Missense_Mutation | G | A | p.G318E |
| NCIH292_LUNG | 196612022 | 196613565 | 196613037 | 196613037 | Missense_Mutation | A | C | p.K329Q |
| HCC15_LUNG | 196612022 | 196613565 | 196613119 | 196613119 | Missense_Mutation | G | T | p.W356L |
| CHL1_SKIN | 196612022 | 196613565 | 196613151 | 196613151 | Missense_Mutation | G | A | p.E367K |
| HMCB_SKIN | 196612022 | 196613565 | 196613151 | 196613151 | Missense_Mutation | G | A | p.E367K |
| KMOE2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196612022 | 196613565 | 196613160 | 196613160 | Missense_Mutation | G | C | p.E370Q |
| CW2_LARGE_INTESTINE | 196612022 | 196613565 | 196613169 | 196613169 | Missense_Mutation | C | T | p.H373Y |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196612022 | 196613565 | 196613275 | 196613275 | Missense_Mutation | A | G | p.D408G |
| SNUC2B_LARGE_INTESTINE | 196612022 | 196613565 | 196613332 | 196613332 | Missense_Mutation | G | T | p.G427V |
| IALM_LUNG | 196612022 | 196613565 | 196613383 | 196613383 | Missense_Mutation | A | T | p.E444V |
| TE12_OESOPHAGUS | 196612022 | 196613565 | 196613385 | 196613385 | Missense_Mutation | G | A | p.D445N |
| SNU175_LARGE_INTESTINE | 196612022 | 196613565 | 196613389 | 196613389 | Missense_Mutation | G | A | p.G446E |
| OV7_OVARY | 196612022 | 196613565 | 196613413 | 196613413 | Missense_Mutation | G | A | p.S454N |
| NCC021_KIDNEY | 196612022 | 196613565 | 196613432 | 196613432 | Missense_Mutation | C | A | p.H460Q |
| HCC2450_LUNG | 196612022 | 196613565 | 196613448 | 196613448 | Missense_Mutation | C | G | p.P466A |
| RKO_LARGE_INTESTINE | 196650285 | 196650422 | 196650310 | 196650310 | Missense_Mutation | T | C | p.L637P |
| L1236_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196650285 | 196650422 | 196650315 | 196650315 | Missense_Mutation | A | T | p.I639F |
| HEC108_ENDOMETRIUM | 196650285 | 196650422 | 196650400 | 196650400 | Missense_Mutation | T | C | p.I667T |
| IM95_STOMACH | 196612022 | 196613565 | 196613388 | 196613388 | Nonsense_Mutation | G | T | p.G446* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SENP5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_380755 | 3 | 196594815:196594944:196612021:196613565:196626536:196626642 | 196612021:196613565 | ENST00000323460.5 | BRCA | rs34533379 | chr3:196613075 | C/T | 5.50e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SENP5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SENP5 |
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RelatedDrugs for SENP5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SENP5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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