ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for DCP1B

Gene summary

Gene information	Gene symbol	DCP1B
	Gene ID	196513
	Gene name	decapping mRNA 1B
	Synonyms	DCP1
	Cytomap	12p13.33
	Type of gene	protein-coding
	Description	mRNA-decapping enzyme 1BDCP1 decapping enzyme homolog Bdecapping enzyme hDcp1b
	Modification date	20180526
	UniProtAcc	Q8IZD4
	Context	PubMed: DCP1B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for DCP1B from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for DCP1B

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for DCP1B

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_89239	12	2055317:2055452:2058251:2058500:2061581:2062454	2058251:2058500	ENSG00000151065.9	ENST00000280665.6,ENST00000397173.4,ENST00000543381.1
exon_skip_89240	12	2061942:2062454:2064597:2064726:2074723:2074859	2064597:2064726	ENSG00000151065.9	ENST00000280665.6,ENST00000397173.4,ENST00000543381.1,ENST00000536665.1,ENST00000540622.1
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENSG00000151065.9	ENST00000397173.4,ENST00000543381.1
exon_skip_89243	12	2102429:2102557:2107100:2107141:2113447:2113593	2107100:2107141	ENSG00000151065.9	ENST00000535873.1,ENST00000397173.4,ENST00000543381.1,ENST00000537725.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for DCP1B

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_89239	12	2055317:2055452:2058251:2058500:2061581:2062454	2058251:2058500	ENSG00000151065.9	ENST00000280665.6,ENST00000543381.1,ENST00000397173.4
exon_skip_89240	12	2061942:2062454:2064597:2064726:2074723:2074859	2064597:2064726	ENSG00000151065.9	ENST00000280665.6,ENST00000543381.1,ENST00000397173.4,ENST00000540622.1,ENST00000536665.1
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENSG00000151065.9	ENST00000543381.1,ENST00000397173.4
exon_skip_89243	12	2102429:2102557:2107100:2107141:2113447:2113593	2107100:2107141	ENSG00000151065.9	ENST00000543381.1,ENST00000397173.4,ENST00000537725.1,ENST00000535873.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for DCP1B

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

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Infer the effects of exon skipping event on protein functional features for DCP1B

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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SNVs in the skipped exons for DCP1B

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A3A0-01	exon_skip_89239	2058252	2058500	2058325	2058325	Frame_Shift_Del	G	-	p.P567fs
LIHC	TCGA-DD-A3A0-01	exon_skip_89239	2058252	2058500	2058444	2058444	Frame_Shift_Del	G	-	p.P527fs
HNSC	TCGA-CV-A6K1-01	exon_skip_89240	2064598	2064726	2064701	2064701	Frame_Shift_Del	T	-	p.K183fs
LUAD	TCGA-86-A4JF-01	exon_skip_89240	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.N183fs
KIRC	TCGA-A3-3380-01	exon_skip_89240	2064598	2064726	2064624	2064624	Nonsense_Mutation	G	A	p.Q209*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
NCIH250_LUNG	2064598	2064726	2064671	2064671	Frame_Shift_Del	T	-	p.N193fs
SNUC4_LARGE_INTESTINE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
A204_SOFT_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
CAL12T_LUNG	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
HCC827GR5_LUNG	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
HS834T_FIBROBLAST	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
HS940T_FIBROBLAST	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
IGR1_SKIN	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
JHOM2B_OVARY	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
JHUEM3_ENDOMETRIUM	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
JM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
LN319_CENTRAL_NERVOUS_SYSTEM	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
MALME3M_SKIN	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
MUTZ3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
NCIH1836_LUNG	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
NCIH1838_LUNG	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
NCIH508_LARGE_INTESTINE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
NCIH596_LUNG	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
NUDUL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
RERFLCAD2_LUNG	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
SF126_CENTRAL_NERVOUS_SYSTEM	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
SNU216_STOMACH	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
SNU449_LIVER	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
TE159T_FIBROBLAST	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
U118MG_CENTRAL_NERVOUS_SYSTEM	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
ZR7530_BREAST	2064598	2064726	2064700	2064701	Frame_Shift_Ins	-	T	p.K183fs
SNU245_BILIARY_TRACT	2058252	2058500	2058277	2058277	Missense_Mutation	T	C	p.Q583R
PACADD137_PANCREAS	2058252	2058500	2058383	2058383	Missense_Mutation	C	G	p.V548L
D245MG_CENTRAL_NERVOUS_SYSTEM	2058252	2058500	2058434	2058434	Missense_Mutation	C	T	p.A531T
253J_URINARY_TRACT	2058252	2058500	2058481	2058481	Missense_Mutation	A	T	p.I515N
253JBV_URINARY_TRACT	2058252	2058500	2058481	2058481	Missense_Mutation	A	T	p.I515N
MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2058252	2058500	2058485	2058485	Missense_Mutation	G	A	p.R514C
OVK18_OVARY	2064598	2064726	2064681	2064681	Missense_Mutation	T	C	p.I190V
AU565_BREAST	2058252	2058500	2058407	2058407	Nonsense_Mutation	C	A	p.E540*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCP1B

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	ESCA	rs11062046	chr12:2100324	A/C	4.07e-04
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	BRCA	rs11062046	chr12:2100324	A/C	1.64e-26
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	KIRC	rs11062046	chr12:2100324	A/C	1.55e-20
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	OV	rs11062046	chr12:2100324	A/C	7.73e-15
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	PCPG	rs11062046	chr12:2100324	A/C	8.95e-04
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	PAAD	rs11062046	chr12:2100324	A/C	1.86e-04
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	PRAD	rs11062046	chr12:2100324	A/C	3.29e-09
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	TGCT	rs11062046	chr12:2100324	A/C	3.19e-07
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	STAD	rs11062046	chr12:2100324	A/C	2.21e-11
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	THCA	rs11062046	chr12:2100324	A/C	4.47e-21
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	THCA	rs11062046	chr12:2100324	A/C	1.87e-03
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	THCA	rs11062046	chr12:2100324	A/C	1.87e-03
exon_skip_89242	12	2077009:2077076:2100286:2100412:2102429:2102557	2100286:2100412	ENST00000397173.4,ENST00000543381.1	UVM	rs11062046	chr12:2100324	A/C	8.94e-06

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCP1B

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCP1B

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RelatedDrugs for DCP1B

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DCP1B

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for DCP1B

Exon skipping events across known transcript of Ensembl for DCP1B from UCSC genome browser

Gene isoform structures and expression levels for DCP1B

Exon skipping events with PSIs in TCGA for DCP1B

Exon skipping events with PSIs in GTEx for DCP1B

Open reading frame (ORF) annotation in the exon skipping event for DCP1B

Infer the effects of exon skipping event on protein functional features for DCP1B

SNVs in the skipped exons for DCP1B

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCP1B

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCP1B

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCP1B

RelatedDrugs for DCP1B

RelatedDiseases for DCP1B