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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for METTL15 |
 Gene summary |
| Gene information | Gene symbol | METTL15 | Gene ID | 196074 |
| Gene name | methyltransferase like 15 | |
| Synonyms | METT5D1 | |
| Cytomap | 11p14.1 | |
| Type of gene | protein-coding | |
| Description | probable methyltransferase-like protein 15methyltransferase 5 domain containing 1methyltransferase 5 domain-containing protein 1probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1putative S-adenosyl-L-methionine-dependent methyltransf | |
| Modification date | 20180523 | |
| UniProtAcc | A6NJ78 | |
| Context | PubMed: METTL15 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for METTL15 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for METTL15 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for METTL15 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_57523 | 11 | 28131861:28131948:28134864:28135151:28232608:28232745 | 28134864:28135151 | ENSG00000169519.15 | ENST00000406787.3,ENST00000407364.3,ENST00000342303.5,ENST00000303459.6 |
| exon_skip_57524 | 11 | 28134864:28135151:28143688:28143727:28145408:28145469 | 28143688:28143727 | ENSG00000169519.15 | ENST00000437814.1 |
| exon_skip_57528 | 11 | 28134864:28135151:28145408:28145469:28147056:28147134 | 28145408:28145469 | ENSG00000169519.15 | ENST00000403099.1 |
| exon_skip_57533 | 11 | 28134864:28135151:28232608:28232745:28311752:28311944 | 28232608:28232745 | ENSG00000169519.15 | ENST00000406787.3,ENST00000407364.3,ENST00000342303.5,ENST00000303459.6 |
| exon_skip_57535 | 11 | 28143688:28143727:28145408:28145469:28147056:28147134 | 28145408:28145469 | ENSG00000169519.15 | ENST00000437814.1 |
| exon_skip_57539 | 11 | 28232608:28232745:28311752:28311944:28318299:28318478 | 28311752:28311944 | ENSG00000169519.15 | ENST00000407364.3,ENST00000342303.5,ENST00000303459.6,ENST00000451385.2 |
| exon_skip_57540 | 11 | 28232608:28232745:28311752:28311944:28318343:28318478 | 28311752:28311944 | ENSG00000169519.15 | ENST00000406787.3 |
| exon_skip_57545 | 11 | 28311752:28311944:28318299:28318478:28351942:28352176 | 28318299:28318478 | ENSG00000169519.15 | ENST00000407364.3,ENST00000451385.2 |
| exon_skip_57546 | 11 | 28311752:28311944:28318343:28318478:28351942:28352176 | 28318343:28318478 | ENSG00000169519.15 | ENST00000406787.3 |
| exon_skip_57547 | 11 | 28318343:28318478:28349641:28349712:28351942:28352176 | 28349641:28349712 | ENSG00000169519.15 | ENST00000342303.5,ENST00000303459.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for METTL15 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_57523 | 11 | 28131861:28131948:28134864:28135151:28232608:28232745 | 28134864:28135151 | ENSG00000169519.15 | ENST00000406787.3,ENST00000342303.5,ENST00000407364.3,ENST00000303459.6 |
| exon_skip_57524 | 11 | 28134864:28135151:28143688:28143727:28145408:28145469 | 28143688:28143727 | ENSG00000169519.15 | ENST00000437814.1 |
| exon_skip_57528 | 11 | 28134864:28135151:28145408:28145469:28147056:28147134 | 28145408:28145469 | ENSG00000169519.15 | ENST00000403099.1 |
| exon_skip_57533 | 11 | 28134864:28135151:28232608:28232745:28311752:28311944 | 28232608:28232745 | ENSG00000169519.15 | ENST00000406787.3,ENST00000342303.5,ENST00000407364.3,ENST00000303459.6 |
| exon_skip_57535 | 11 | 28143688:28143727:28145408:28145469:28147056:28147134 | 28145408:28145469 | ENSG00000169519.15 | ENST00000437814.1 |
| exon_skip_57539 | 11 | 28232608:28232745:28311752:28311944:28318299:28318478 | 28311752:28311944 | ENSG00000169519.15 | ENST00000342303.5,ENST00000451385.2,ENST00000407364.3,ENST00000303459.6 |
| exon_skip_57540 | 11 | 28232608:28232745:28311752:28311944:28318343:28318478 | 28311752:28311944 | ENSG00000169519.15 | ENST00000406787.3 |
| exon_skip_57545 | 11 | 28311752:28311944:28318299:28318478:28351942:28352176 | 28318299:28318478 | ENSG00000169519.15 | ENST00000451385.2,ENST00000407364.3 |
| exon_skip_57546 | 11 | 28311752:28311944:28318343:28318478:28351942:28352176 | 28318343:28318478 | ENSG00000169519.15 | ENST00000406787.3 |
| exon_skip_57547 | 11 | 28318343:28318478:28349641:28349712:28351942:28352176 | 28349641:28349712 | ENSG00000169519.15 | ENST00000342303.5,ENST00000303459.6 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for METTL15 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407364 | 28134864 | 28135151 | 5CDS-5UTR |
| ENST00000407364 | 28232608 | 28232745 | Frame-shift |
| ENST00000407364 | 28318299 | 28318478 | Frame-shift |
| ENST00000407364 | 28311752 | 28311944 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407364 | 28134864 | 28135151 | 5CDS-5UTR |
| ENST00000407364 | 28232608 | 28232745 | Frame-shift |
| ENST00000407364 | 28318299 | 28318478 | Frame-shift |
| ENST00000407364 | 28311752 | 28311944 | In-frame |
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Infer the effects of exon skipping event on protein functional features for METTL15 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000407364 | 4259 | 407 | 28311752 | 28311944 | 760 | 951 | 136 | 199 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000407364 | 4259 | 407 | 28311752 | 28311944 | 760 | 951 | 136 | 199 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| A6NJ78 | 136 | 199 | 100 | 407 | Alternative sequence | ID=VSP_028971;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| A6NJ78 | 136 | 199 | 146 | 146 | Binding site | Note=S-adenosyl-L-methionine%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| A6NJ78 | 136 | 199 | 169 | 169 | Binding site | Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| A6NJ78 | 136 | 199 | 176 | 176 | Binding site | Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| A6NJ78 | 136 | 199 | 1 | 407 | Chain | ID=PRO_0000308332;Note=Probable methyltransferase-like protein 15 |
| A6NJ78 | 136 | 199 | 149 | 149 | Natural variant | ID=VAR_036802;Note=A->T;Dbxref=dbSNP:rs11823114 |
| A6NJ78 | 136 | 199 | 191 | 191 | Sequence conflict | Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| A6NJ78 | 136 | 199 | 194 | 194 | Sequence conflict | Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| A6NJ78 | 136 | 199 | 100 | 407 | Alternative sequence | ID=VSP_028971;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| A6NJ78 | 136 | 199 | 146 | 146 | Binding site | Note=S-adenosyl-L-methionine%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| A6NJ78 | 136 | 199 | 169 | 169 | Binding site | Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| A6NJ78 | 136 | 199 | 176 | 176 | Binding site | Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| A6NJ78 | 136 | 199 | 1 | 407 | Chain | ID=PRO_0000308332;Note=Probable methyltransferase-like protein 15 |
| A6NJ78 | 136 | 199 | 149 | 149 | Natural variant | ID=VAR_036802;Note=A->T;Dbxref=dbSNP:rs11823114 |
| A6NJ78 | 136 | 199 | 191 | 191 | Sequence conflict | Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| A6NJ78 | 136 | 199 | 194 | 194 | Sequence conflict | Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for METTL15 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KICH | TCGA-KL-8339-01 | exon_skip_57533 | 28232609 | 28232745 | 28232627 | 28232627 | Frame_Shift_Del | T | - | p.F97fs |
| KICH | TCGA-KL-8339-01 | exon_skip_57533 | 28232609 | 28232745 | 28232627 | 28232627 | Frame_Shift_Del | T | - | p.T96fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_57533 | 28232609 | 28232745 | 28232635 | 28232635 | Frame_Shift_Del | G | - | p.S99fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_57533 | 28232609 | 28232745 | 28232647 | 28232647 | Frame_Shift_Del | A | - | p.T103fs |
| LIHC | TCGA-BC-A3KG-01 | exon_skip_57533 | 28232609 | 28232745 | 28232710 | 28232710 | Frame_Shift_Del | T | - | p.A124fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_57540 exon_skip_57539 | 28311753 | 28311944 | 28311894 | 28311894 | Frame_Shift_Del | T | - | p.G183fs |
| LUAD | TCGA-95-7039-01 | exon_skip_57546 | 28318300 | 28318478 | 28318438 | 28318438 | Frame_Shift_Del | C | - | p.Y246fs |
| LUAD | TCGA-95-7039-01 | exon_skip_57546 | 28318344 | 28318478 | 28318438 | 28318438 | Frame_Shift_Del | C | - | p.Y246fs |
| UCEC | TCGA-D1-A101-01 | exon_skip_57540 exon_skip_57539 | 28311753 | 28311944 | 28311757 | 28311757 | Nonsense_Mutation | C | T | p.Q138* |
| HNSC | TCGA-CV-7090-01 | exon_skip_57546 | 28318300 | 28318478 | 28318421 | 28318421 | Nonsense_Mutation | C | T | p.Q241* |
| HNSC | TCGA-CV-7090-01 | exon_skip_57546 | 28318344 | 28318478 | 28318421 | 28318421 | Nonsense_Mutation | C | T | p.Q241* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| M14_SKIN | 28134865 | 28135151 | 28134894 | 28134894 | Missense_Mutation | C | T | p.P5S |
| MDAMB435S_SKIN | 28134865 | 28135151 | 28134894 | 28134894 | Missense_Mutation | C | T | p.P5S |
| SH4_SKIN | 28134865 | 28135151 | 28135066 | 28135066 | Missense_Mutation | A | G | p.D62G |
| KMBC2_URINARY_TRACT | 28134865 | 28135151 | 28135101 | 28135101 | Missense_Mutation | C | T | p.P74S |
| LS411N_LARGE_INTESTINE | 28134865 | 28135151 | 28135120 | 28135120 | Missense_Mutation | T | C | p.V80A |
| LN428_CENTRAL_NERVOUS_SYSTEM | 28134865 | 28135151 | 28135122 | 28135122 | Missense_Mutation | G | T | p.V81F |
| AN3CA_ENDOMETRIUM | 28232609 | 28232745 | 28232694 | 28232694 | Missense_Mutation | A | T | p.D119V |
| CAL29_URINARY_TRACT | 28232609 | 28232745 | 28232711 | 28232711 | Missense_Mutation | T | C | p.Y125H |
| HARA_LUNG | 28311753 | 28311944 | 28311756 | 28311756 | Missense_Mutation | A | T | p.K137N |
| NCIH1930_LUNG | 28311753 | 28311944 | 28311775 | 28311775 | Missense_Mutation | G | T | p.G144C |
| HEC108_ENDOMETRIUM | 28311753 | 28311944 | 28311836 | 28311836 | Missense_Mutation | A | G | p.D164G |
| SISO_CERVIX | 28311753 | 28311944 | 28311849 | 28311850 | Missense_Mutation | GG | TT | p.168_169MD>IY |
| SNU1040_LARGE_INTESTINE | 28311753 | 28311944 | 28311905 | 28311905 | Missense_Mutation | G | A | p.R187Q |
| KYSE140_OESOPHAGUS | 28318300 | 28318478 | 28318314 | 28318314 | Missense_Mutation | C | T | p.P205L |
| MM127_SKIN | 28318300 | 28318478 | 28318427 | 28318427 | Missense_Mutation | C | T | p.R243C |
| MM127_SKIN | 28318344 | 28318478 | 28318427 | 28318427 | Missense_Mutation | C | T | p.R243C |
| AN3CA_ENDOMETRIUM | 28318300 | 28318478 | 28318427 | 28318427 | Missense_Mutation | C | T | p.R243C |
| AN3CA_ENDOMETRIUM | 28318344 | 28318478 | 28318427 | 28318427 | Missense_Mutation | C | T | p.R243C |
| HEC108_ENDOMETRIUM | 28318300 | 28318478 | 28318464 | 28318464 | Missense_Mutation | C | T | p.A255V |
| HEC108_ENDOMETRIUM | 28318344 | 28318478 | 28318464 | 28318464 | Missense_Mutation | C | T | p.A255V |
| UMUC5_URINARY_TRACT | 28232609 | 28232745 | 28232745 | 28232745 | Splice_Site | C | T | p.P136L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for METTL15 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_57523 | 11 | 28131861:28131948:28134864:28135151:28232608:28232745 | 28134864:28135151 | ENST00000406787.3,ENST00000407364.3,ENST00000342303.5,ENST00000303459.6 | BLCA | rs60970073 | chr11:28134974 | C/A | 3.14e-06 |
| exon_skip_57523 | 11 | 28131861:28131948:28134864:28135151:28232608:28232745 | 28134864:28135151 | ENST00000406787.3,ENST00000407364.3,ENST00000342303.5,ENST00000303459.6 | BRCA | rs60970073 | chr11:28134974 | C/A | 2.34e-04 |
| exon_skip_57523 | 11 | 28131861:28131948:28134864:28135151:28232608:28232745 | 28134864:28135151 | ENST00000406787.3,ENST00000407364.3,ENST00000342303.5,ENST00000303459.6 | LGG | rs60970073 | chr11:28134974 | C/A | 3.11e-03 |
| exon_skip_57523 | 11 | 28131861:28131948:28134864:28135151:28232608:28232745 | 28134864:28135151 | ENST00000406787.3,ENST00000407364.3,ENST00000342303.5,ENST00000303459.6 | PRAD | rs60970073 | chr11:28134974 | C/A | 2.41e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for METTL15 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for METTL15 |
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RelatedDrugs for METTL15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for METTL15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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