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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DUSP5 |
 Gene summary |
| Gene information | Gene symbol | DUSP5 | Gene ID | 1847 |
| Gene name | dual specificity phosphatase 5 | |
| Synonyms | DUSP|HVH3 | |
| Cytomap | 10q25.2 | |
| Type of gene | protein-coding | |
| Description | dual specificity protein phosphatase 5VH1-like phosphatase 3dual specificity protein phosphatase hVH3serine/threonine specific protein phosphatase | |
| Modification date | 20180527 | |
| UniProtAcc | Q16690 | |
| Context | PubMed: DUSP5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DUSP5 | GO:0016311 | dephosphorylation | 24531476 |
| DUSP5 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 7961985 |
| DUSP5 | GO:0035970 | peptidyl-threonine dephosphorylation | 7961985 |
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Exon skipping events across known transcript of Ensembl for DUSP5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DUSP5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DUSP5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_45011 | 10 | 112262504:112262627:112263190:112263248:112266692:112266912 | 112263190:112263248 | ENSG00000138166.5 | ENST00000468749.1 |
| exon_skip_45012 | 10 | 112262504:112262627:112266692:112266912:112269777:112270195 | 112266692:112266912 | ENSG00000138166.5 | ENST00000369583.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DUSP5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_45011 | 10 | 112262504:112262627:112263190:112263248:112266692:112266912 | 112263190:112263248 | ENSG00000138166.5 | ENST00000468749.1 |
| exon_skip_45012 | 10 | 112262504:112262627:112266692:112266912:112269777:112270195 | 112266692:112266912 | ENSG00000138166.5 | ENST00000369583.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DUSP5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369583 | 112266692 | 112266912 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369583 | 112266692 | 112266912 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DUSP5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for DUSP5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-BA-6871-01 | exon_skip_45012 | 112266693 | 112266912 | 112266854 | 112266854 | Frame_Shift_Del | G | - | p.V230fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MERO82_LUNG | 112266693 | 112266912 | 112266804 | 112266804 | Missense_Mutation | C | T | p.R214W |
| 786O_KIDNEY | 112266693 | 112266912 | 112266837 | 112266837 | Missense_Mutation | T | C | p.Y225H |
| NUGC3_STOMACH | 112266693 | 112266912 | 112266868 | 112266868 | Missense_Mutation | C | T | p.T235M |
| CORL95_LUNG | 112266693 | 112266912 | 112266894 | 112266894 | Nonsense_Mutation | G | T | p.E244* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DUSP5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DUSP5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DUSP5 |
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RelatedDrugs for DUSP5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DUSP5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DUSP5 | C0020538 | Hypertensive disease | 1 | CTD_human |
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