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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DPP4 |
 Gene summary |
| Gene information | Gene symbol | DPP4 | Gene ID | 1803 |
| Gene name | dipeptidyl peptidase 4 | |
| Synonyms | ADABP|ADCP2|CD26|DPPIV|TP103 | |
| Cytomap | 2q24.2 | |
| Type of gene | protein-coding | |
| Description | dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) | |
| Modification date | 20180519 | |
| UniProtAcc | P27487 | |
| Context | PubMed: DPP4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DPP4 | GO:0001666 | response to hypoxia | 16670267 |
| DPP4 | GO:0006508 | proteolysis | 27198182 |
| DPP4 | GO:0008284 | positive regulation of cell proliferation | 17549790 |
| DPP4 | GO:0010716 | negative regulation of extracellular matrix disassembly | 16651416 |
| DPP4 | GO:0031295 | T cell costimulation | 10900005|17287217 |
| DPP4 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 11772392 |
| DPP4 | GO:0042110 | T cell activation | 7594462 |
| DPP4 | GO:0043542 | endothelial cell migration | 16651416 |
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Exon skipping events across known transcript of Ensembl for DPP4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DPP4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DPP4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_344399 | 2 | 162849792:162849894:162851470:162851544:162851809:162851882 | 162851470:162851544 | ENSG00000197635.5 | ENST00000360534.3,ENST00000434918.2 |
| exon_skip_344401 | 2 | 162862254:162862319:162865071:162865171:162865750:162865805 | 162865071:162865171 | ENSG00000197635.5 | ENST00000490286.1,ENST00000494507.1,ENST00000360534.3,ENST00000434918.2,ENST00000491591.1 |
| exon_skip_344402 | 2 | 162875238:162875360:162875732:162875786:162876738:162876806 | 162875732:162875786 | ENSG00000197635.5 | ENST00000490286.1,ENST00000360534.3,ENST00000434918.2,ENST00000468903.1 |
| exon_skip_344403 | 2 | 162881313:162881449:162888544:162888775:162890050:162890159 | 162888544:162888775 | ENSG00000197635.5 | ENST00000434918.2 |
| exon_skip_344406 | 2 | 162894883:162894932:162895458:162895531:162902041:162902122 | 162895458:162895531 | ENSG00000197635.5 | ENST00000461836.1,ENST00000416189.1 |
| exon_skip_344408 | 2 | 162895497:162895531:162895641:162895694:162902041:162902122 | 162895641:162895694 | ENSG00000197635.5 | ENST00000490286.1,ENST00000497461.1,ENST00000360534.3,ENST00000434918.2,ENST00000413651.1 |
| exon_skip_344410 | 2 | 162902041:162902122:162903211:162903315:162903424:162903516 | 162903211:162903315 | ENSG00000197635.5 | ENST00000497461.1,ENST00000413651.1,ENST00000416189.1 |
| exon_skip_344413 | 2 | 162903424:162903516:162903912:162904008:162929908:162929973 | 162903912:162904008 | ENSG00000197635.5 | ENST00000434918.2 |
| exon_skip_344414 | 2 | 162903424:162903516:162903912:162904011:162929908:162929973 | 162903912:162904011 | ENSG00000197635.5 | ENST00000490286.1,ENST00000497461.1,ENST00000360534.3,ENST00000461836.1,ENST00000413651.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DPP4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_344399 | 2 | 162849792:162849894:162851470:162851544:162851809:162851882 | 162851470:162851544 | ENSG00000197635.5 | ENST00000360534.3,ENST00000434918.2 |
| exon_skip_344401 | 2 | 162862254:162862319:162865071:162865171:162865750:162865805 | 162865071:162865171 | ENSG00000197635.5 | ENST00000360534.3,ENST00000434918.2,ENST00000491591.1,ENST00000490286.1,ENST00000494507.1 |
| exon_skip_344402 | 2 | 162875238:162875360:162875732:162875786:162876738:162876806 | 162875732:162875786 | ENSG00000197635.5 | ENST00000360534.3,ENST00000434918.2,ENST00000490286.1,ENST00000468903.1 |
| exon_skip_344403 | 2 | 162881313:162881449:162888544:162888775:162890050:162890159 | 162888544:162888775 | ENSG00000197635.5 | ENST00000434918.2 |
| exon_skip_344406 | 2 | 162894883:162894932:162895458:162895531:162902041:162902122 | 162895458:162895531 | ENSG00000197635.5 | ENST00000416189.1,ENST00000461836.1 |
| exon_skip_344408 | 2 | 162895497:162895531:162895641:162895694:162902041:162902122 | 162895641:162895694 | ENSG00000197635.5 | ENST00000360534.3,ENST00000434918.2,ENST00000490286.1,ENST00000497461.1,ENST00000413651.1 |
| exon_skip_344410 | 2 | 162902041:162902122:162903211:162903315:162903424:162903516 | 162903211:162903315 | ENSG00000197635.5 | ENST00000416189.1,ENST00000497461.1,ENST00000413651.1 |
| exon_skip_344413 | 2 | 162903424:162903516:162903912:162904008:162929908:162929973 | 162903912:162904008 | ENSG00000197635.5 | ENST00000434918.2 |
| exon_skip_344414 | 2 | 162903424:162903516:162903912:162904011:162929908:162929973 | 162903912:162904011 | ENSG00000197635.5 | ENST00000360534.3,ENST00000490286.1,ENST00000497461.1,ENST00000461836.1,ENST00000413651.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DPP4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360534 | 162851470 | 162851544 | Frame-shift |
| ENST00000360534 | 162865071 | 162865171 | Frame-shift |
| ENST00000360534 | 162895641 | 162895694 | Frame-shift |
| ENST00000360534 | 162875732 | 162875786 | In-frame |
| ENST00000360534 | 162903912 | 162904011 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360534 | 162851470 | 162851544 | Frame-shift |
| ENST00000360534 | 162865071 | 162865171 | Frame-shift |
| ENST00000360534 | 162895641 | 162895694 | Frame-shift |
| ENST00000360534 | 162875732 | 162875786 | In-frame |
| ENST00000360534 | 162903912 | 162904011 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DPP4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360534 | 3921 | 766 | 162903912 | 162904011 | 656 | 754 | 31 | 64 |
| ENST00000360534 | 3921 | 766 | 162875732 | 162875786 | 1806 | 1859 | 415 | 432 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360534 | 3921 | 766 | 162903912 | 162904011 | 656 | 754 | 31 | 64 |
| ENST00000360534 | 3921 | 766 | 162875732 | 162875786 | 1806 | 1859 | 415 | 432 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P27487 | 31 | 64 | 40 | 42 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VJM |
| P27487 | 31 | 64 | 60 | 62 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 31 | 64 | 64 | 72 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 31 | 64 | 1 | 766 | Chain | ID=PRO_0000027213;Note=Dipeptidyl peptidase 4 membrane form |
| P27487 | 31 | 64 | 39 | 766 | Chain | ID=PRO_0000027214;Note=Dipeptidyl peptidase 4 soluble form |
| P27487 | 31 | 64 | 45 | 50 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 31 | 64 | 29 | 766 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P27487 | 415 | 432 | 412 | 420 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 415 | 432 | 429 | 435 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 415 | 432 | 1 | 766 | Chain | ID=PRO_0000027213;Note=Dipeptidyl peptidase 4 membrane form |
| P27487 | 415 | 432 | 39 | 766 | Chain | ID=PRO_0000027214;Note=Dipeptidyl peptidase 4 soluble form |
| P27487 | 415 | 432 | 422 | 424 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 415 | 432 | 29 | 766 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P27487 | 31 | 64 | 40 | 42 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VJM |
| P27487 | 31 | 64 | 60 | 62 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 31 | 64 | 64 | 72 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 31 | 64 | 1 | 766 | Chain | ID=PRO_0000027213;Note=Dipeptidyl peptidase 4 membrane form |
| P27487 | 31 | 64 | 39 | 766 | Chain | ID=PRO_0000027214;Note=Dipeptidyl peptidase 4 soluble form |
| P27487 | 31 | 64 | 45 | 50 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 31 | 64 | 29 | 766 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P27487 | 415 | 432 | 412 | 420 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 415 | 432 | 429 | 435 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 415 | 432 | 1 | 766 | Chain | ID=PRO_0000027213;Note=Dipeptidyl peptidase 4 membrane form |
| P27487 | 415 | 432 | 39 | 766 | Chain | ID=PRO_0000027214;Note=Dipeptidyl peptidase 4 soluble form |
| P27487 | 415 | 432 | 422 | 424 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4A5S |
| P27487 | 415 | 432 | 29 | 766 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for DPP4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-BC-A3KG-01 | exon_skip_344399 | 162851471 | 162851544 | 162851476 | 162851476 | Frame_Shift_Del | C | - | p.A732fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_344399 | 162851471 | 162851544 | 162851503 | 162851503 | Frame_Shift_Del | G | - | p.L723fs |
| UCS | TCGA-N5-A4RV-01 | exon_skip_344401 | 162865072 | 162865171 | 162865080 | 162865089 | Frame_Shift_Del | TCCCACCGGG | - | p.657_660del |
| UCS | TCGA-N5-A4RV-01 | exon_skip_344401 | 162865072 | 162865171 | 162865080 | 162865089 | Frame_Shift_Del | TCCCACCGGG | - | p.SRWE657fs |
| COAD | TCGA-AZ-4615-01 | exon_skip_344413 | 162903913 | 162904008 | 162903954 | 162903954 | Frame_Shift_Del | T | - | p.N51fs |
| COAD | TCGA-AZ-4615-01 | exon_skip_344414 | 162903913 | 162904011 | 162903954 | 162903954 | Frame_Shift_Del | T | - | p.N51fs |
| PRAD | TCGA-V1-A9OA-01 | exon_skip_344401 | 162865072 | 162865171 | 162865117 | 162865118 | Frame_Shift_Ins | - | G | p.LV647fs |
| LUSC | TCGA-60-2724-01 | exon_skip_344399 | 162851471 | 162851544 | 162851470 | 162851470 | Splice_Site | C | T | p.M733_splice |
| PAAD | TCGA-IB-7651-01 | exon_skip_344401 | 162865072 | 162865171 | 162865071 | 162865071 | Splice_Site | C | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| TUHR14TKB_KIDNEY | 162895642 | 162895694 | 162895667 | 162895667 | Frame_Shift_Del | A | - | p.Y132fs |
| SW684_SOFT_TISSUE | 162865072 | 162865171 | 162865089 | 162865089 | Missense_Mutation | G | A | p.S657F |
| DMS273_LUNG | 162875733 | 162875786 | 162875771 | 162875771 | Missense_Mutation | A | T | p.N420K |
| SNB75_CENTRAL_NERVOUS_SYSTEM | 162895459 | 162895531 | 162895470 | 162895470 | Missense_Mutation | C | A | p.G161C |
| SNU81_LARGE_INTESTINE | 162895642 | 162895694 | 162895661 | 162895661 | Missense_Mutation | T | G | p.I134L |
| SNU1_STOMACH | 162903913 | 162904008 | 162903987 | 162903987 | Missense_Mutation | C | T | p.R40H |
| SNU1_STOMACH | 162903913 | 162904011 | 162903987 | 162903987 | Missense_Mutation | C | T | p.R40H |
| D263MG_CENTRAL_NERVOUS_SYSTEM | 162903913 | 162904008 | 162903977 | 162903977 | Nonsense_Mutation | G | T | p.Y43* |
| D263MG_CENTRAL_NERVOUS_SYSTEM | 162903913 | 162904011 | 162903977 | 162903977 | Nonsense_Mutation | G | T | p.Y43* |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 162865072 | 162865171 | 162865170 | 162865170 | Splice_Site | G | A | p.S630L |
| KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 162895459 | 162895531 | 162895531 | 162895531 | Splice_Site | C | T | p.R140R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DPP4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DPP4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DPP4 |
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RelatedDrugs for DPP4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P27487 | DB01076 | Atorvastatin | Dipeptidyl peptidase 4 | small molecule | approved | |
| P27487 | DB06203 | Alogliptin | Dipeptidyl peptidase 4 | small molecule | approved | |
| P27487 | DB06335 | Saxagliptin | Dipeptidyl peptidase 4 | small molecule | approved | |
| P27487 | DB08882 | Linagliptin | Dipeptidyl peptidase 4 | small molecule | approved | |
| P27487 | DB01261 | Sitagliptin | Dipeptidyl peptidase 4 | small molecule | approved|investigational | |
| P27487 | DB04876 | Vildagliptin | Dipeptidyl peptidase 4 | small molecule | approved|investigational |
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RelatedDiseases for DPP4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DPP4 | C0011570 | Mental Depression | 2 | PSYGENET |
| DPP4 | C0011581 | Depressive disorder | 2 | PSYGENET |
| DPP4 | C0033687 | Proteinuria | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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