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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for DAPK1

check button Gene summary
Gene informationGene symbol

DAPK1

Gene ID

1612

Gene namedeath associated protein kinase 1
SynonymsDAPK|ROCO3
Cytomap

9q21.33

Type of geneprotein-coding
Descriptiondeath-associated protein kinase 1DAP kinase 1
Modification date20180523
UniProtAcc

P53355

ContextPubMed: DAPK1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
DAPK1

GO:0006468

protein phosphorylation

10629061

DAPK1

GO:0017148

negative regulation of translation

18995835

DAPK1

GO:0035556

intracellular signal transduction

10629061

DAPK1

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

16132846

DAPK1

GO:0046777

protein autophosphorylation

10629061|12730201

DAPK1

GO:0071346

cellular response to interferon-gamma

18995835


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Exon skipping events across known transcript of Ensembl for DAPK1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for DAPK1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for DAPK1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_496796990113920:90114054:90219868:90220090:90252857:9025294290219868:90220090ENSG00000196730.8ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000496522.1,ENST00000358077.5,ENST00000472284.1,ENST00000491893.1,ENST00000489291.1
exon_skip_496798990219868:90220090:90252857:90252996:90254268:9025439890252857:90252996ENSG00000196730.8ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000491893.1,ENST00000489291.1
exon_skip_496799990254352:90254398:90254564:90254613:90254703:9025473090254564:90254613ENSG00000196730.8ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000491893.1
exon_skip_496800990256883:90256973:90258290:90258383:90260809:9026092990258290:90258383ENSG00000196730.8ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000491893.1,ENST00000489291.1
exon_skip_496801990260809:90260929:90261375:90261474:90262219:9026231890261375:90261474ENSG00000196730.8ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000491893.1,ENST00000489291.1
exon_skip_496806990266441:90266639:90272943:90273042:90283511:9028358990272943:90273042ENSG00000196730.8ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000491893.1,ENST00000489291.1
exon_skip_496807990296318:90296541:90301465:90301654:90311921:9031211990301465:90301654ENSG00000196730.8ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000489291.1
exon_skip_496810990301465:90301654:90311921:90312119:90313570:9031370990311921:90312119ENSG00000196730.8ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000489291.1
exon_skip_496812990311921:90312119:90313570:90313709:90315031:9031513290313570:90313709ENSG00000196730.8ENST00000469640.2,ENST00000408954.3,ENST00000358077.5,ENST00000472284.1,ENST00000489291.1
exon_skip_496813990315031:90315152:90316750:90316825:90317943:9031812790316750:90316825ENSG00000196730.8ENST00000469640.2

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for DAPK1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_496796990113920:90114054:90219868:90220090:90252857:9025294290219868:90220090ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000496522.1,ENST00000491893.1,ENST00000489291.1
exon_skip_496798990219868:90220090:90252857:90252996:90254268:9025439890252857:90252996ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000491893.1,ENST00000489291.1
exon_skip_496799990254352:90254398:90254564:90254613:90254703:9025473090254564:90254613ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000491893.1
exon_skip_496800990256883:90256973:90258290:90258383:90260809:9026092990258290:90258383ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000491893.1,ENST00000489291.1
exon_skip_496801990260809:90260929:90261375:90261474:90262219:9026231890261375:90261474ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469067.1,ENST00000469640.2,ENST00000408954.3,ENST00000491893.1,ENST00000489291.1
exon_skip_496806990266441:90266639:90272943:90273042:90283511:9028358990272943:90273042ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469640.2,ENST00000408954.3,ENST00000491893.1,ENST00000489291.1
exon_skip_496807990296318:90296541:90301465:90301654:90311921:9031211990301465:90301654ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469640.2,ENST00000408954.3,ENST00000489291.1
exon_skip_496810990301465:90301654:90311921:90312119:90313570:9031370990311921:90312119ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469640.2,ENST00000408954.3,ENST00000489291.1
exon_skip_496812990311921:90312119:90313570:90313709:90315031:9031513290313570:90313709ENSG00000196730.8ENST00000358077.5,ENST00000472284.1,ENST00000469640.2,ENST00000408954.3,ENST00000489291.1
exon_skip_496813990315031:90315152:90316750:90316825:90317943:9031812790316750:90316825ENSG00000196730.8ENST00000469640.2

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for DAPK1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003580779025285790252996Frame-shift
ENST000004089549025285790252996Frame-shift
ENST000004722849025285790252996Frame-shift
ENST000003580779025456490254613Frame-shift
ENST000004089549025456490254613Frame-shift
ENST000004722849025456490254613Frame-shift
ENST000003580779031357090313709Frame-shift
ENST000004089549031357090313709Frame-shift
ENST000004722849031357090313709Frame-shift
ENST000003580779021986890220090In-frame
ENST000004089549021986890220090In-frame
ENST000004722849021986890220090In-frame
ENST000003580779025829090258383In-frame
ENST000004089549025829090258383In-frame
ENST000004722849025829090258383In-frame
ENST000003580779026137590261474In-frame
ENST000004089549026137590261474In-frame
ENST000004722849026137590261474In-frame
ENST000003580779027294390273042In-frame
ENST000004089549027294390273042In-frame
ENST000004722849027294390273042In-frame
ENST000003580779030146590301654In-frame
ENST000004089549030146590301654In-frame
ENST000004722849030146590301654In-frame
ENST000003580779031192190312119In-frame
ENST000004089549031192190312119In-frame
ENST000004722849031192190312119In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003580779025285790252996Frame-shift
ENST000004089549025285790252996Frame-shift
ENST000004722849025285790252996Frame-shift
ENST000003580779025456490254613Frame-shift
ENST000004089549025456490254613Frame-shift
ENST000004722849025456490254613Frame-shift
ENST000003580779031357090313709Frame-shift
ENST000004089549031357090313709Frame-shift
ENST000004722849031357090313709Frame-shift
ENST000003580779021986890220090In-frame
ENST000004089549021986890220090In-frame
ENST000004722849021986890220090In-frame
ENST000003580779025829090258383In-frame
ENST000004089549025829090258383In-frame
ENST000004722849025829090258383In-frame
ENST000003580779026137590261474In-frame
ENST000004089549026137590261474In-frame
ENST000004722849026137590261474In-frame
ENST000003580779027294390273042In-frame
ENST000004089549027294390273042In-frame
ENST000004722849027294390273042In-frame
ENST000003580779030146590301654In-frame
ENST000004089549030146590301654In-frame
ENST000004722849030146590301654In-frame
ENST000003580779031192190312119In-frame
ENST000004089549031192190312119In-frame
ENST000004722849031192190312119In-frame

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Infer the effects of exon skipping event on protein functional features for DAPK1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003580775760143090219868902200902464672194
ENST000004089545909143090219868902200903986192194
ENST000004722845776143090219868902200902634842194
ENST0000035807757601430902582909025838311021194306337
ENST0000040895459091430902582909025838312541346306337
ENST0000047228457761430902582909025838311191211306337
ENST0000035807757601430902613759026147413151413377410
ENST0000040895459091430902613759026147414671565377410
ENST0000047228457761430902613759026147413321430377410
ENST0000035807757601430902729439027304220082106608641
ENST0000040895459091430902729439027304221602258608641
ENST0000047228457761430902729439027304220252123608641
ENST0000035807757601430903014659030165424082596741804
ENST0000040895459091430903014659030165425602748741804
ENST0000047228457761430903014659030165424252613741804
ENST0000035807757601430903119219031211925972794804870
ENST0000040895459091430903119219031211927492946804870
ENST0000047228457761430903119219031211926142811804870

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003580775760143090219868902200902464672194
ENST000004089545909143090219868902200903986192194
ENST000004722845776143090219868902200902634842194
ENST0000035807757601430902582909025838311021194306337
ENST0000040895459091430902582909025838312541346306337
ENST0000047228457761430902582909025838311191211306337
ENST0000035807757601430902613759026147413151413377410
ENST0000040895459091430902613759026147414671565377410
ENST0000047228457761430902613759026147413321430377410
ENST0000035807757601430902729439027304220082106608641
ENST0000040895459091430902729439027304221602258608641
ENST0000047228457761430902729439027304220252123608641
ENST0000035807757601430903014659030165424082596741804
ENST0000040895459091430903014659030165425602748741804
ENST0000047228457761430903014659030165424252613741804
ENST0000035807757601430903119219031211925972794804870
ENST0000040895459091430903119219031211927492946804870
ENST0000047228457761430903119219031211926142811804870

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521944242Binding siteNote=ATP
P5335521944242Binding siteNote=ATP
P5335521944242Binding siteNote=ATP
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521941927Nucleotide bindingNote=ATP
P5335521941927Nucleotide bindingNote=ATP
P5335521941927Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337267334RegionNote=Calmodulin-binding
P53355306337267334RegionNote=Calmodulin-binding
P53355306337267334RegionNote=Calmodulin-binding
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355377410378407RepeatNote=ANK 1
P53355377410378407RepeatNote=ANK 1
P53355377410378407RepeatNote=ANK 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641609638RepeatNote=ANK 8
P53355608641609638RepeatNote=ANK 8
P53355608641609638RepeatNote=ANK 8
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521944242Binding siteNote=ATP
P5335521944242Binding siteNote=ATP
P5335521944242Binding siteNote=ATP
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521941927Nucleotide bindingNote=ATP
P5335521941927Nucleotide bindingNote=ATP
P5335521941927Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337267334RegionNote=Calmodulin-binding
P53355306337267334RegionNote=Calmodulin-binding
P53355306337267334RegionNote=Calmodulin-binding
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355377410378407RepeatNote=ANK 1
P53355377410378407RepeatNote=ANK 1
P53355377410378407RepeatNote=ANK 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641609638RepeatNote=ANK 8
P53355608641609638RepeatNote=ANK 8
P53355608641609638RepeatNote=ANK 8
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758


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SNVs in the skipped exons for DAPK1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-AADG-01exon_skip_496796
90219869902200909021988890219888Frame_Shift_DelA-p.V27fs
STADTCGA-CG-5723-01exon_skip_496798
90252858902529969025290390252904Frame_Shift_DelTT-p.110_110del
STADTCGA-CG-5723-01exon_skip_496798
90252858902529969025290390252904Frame_Shift_DelTT-p.S110fs
KIRCTCGA-B0-5400-01exon_skip_496798
90252858902529969025292690252933Frame_Shift_DelAATTTCTC-p.118_120del
LIHCTCGA-DD-A3A0-01exon_skip_496807
90301466903016549030157790301577Frame_Shift_DelC-p.A779fs
STADTCGA-HU-A4GP-01exon_skip_496810
90311922903121199031211190312111Frame_Shift_DelA-p.E868fs
LIHCTCGA-DD-A3A0-01exon_skip_496813
90316751903168259031676090316760Frame_Shift_DelC-p.P961fs
LGGTCGA-DU-6392-01exon_skip_496806
90272944902730429027295090272950Nonsense_MutationCTp.R611*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE90219869902200909021994590219947In_Frame_DelAGG-p.R48del
OPM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE90219869902200909021994590219947In_Frame_DelAGG-p.R48del
NCIH1944_LUNG90219869902200909021987990219879Missense_MutationGCp.A25P
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE90219869902200909021989790219897Missense_MutationCTp.R31C
KM12_LARGE_INTESTINE90219869902200909021992490219924Missense_MutationGAp.A40T
HCT15_LARGE_INTESTINE90219869902200909021993690219936Missense_MutationAGp.I44V
TE10_OESOPHAGUS90219869902200909021994690219946Missense_MutationGTp.R47M
HEC59_ENDOMETRIUM90219869902200909021996190219961Missense_MutationGAp.S52N
LK2_LUNG90219869902200909021996790219967Missense_MutationGTp.R54L
GP2D_LARGE_INTESTINE90219869902200909022003390220033Missense_MutationTCp.V76A
GP5D_LARGE_INTESTINE90219869902200909022003390220033Missense_MutationTCp.V76A
EN_ENDOMETRIUM90219869902200909022005390220053Missense_MutationTCp.Y83H
EN_ENDOMETRIUM90219869902200909022007490220074Missense_MutationAGp.I90V
HEC251_ENDOMETRIUM90252858902529969025294390252943Missense_MutationCAp.L124I
KMS34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE90258291902583839025833790258337Missense_MutationTAp.F322Y
TOV21G_OVARY90261376902614749026138390261383Missense_MutationCTp.T380I
HEC251_ENDOMETRIUM90261376902614749026145290261452Missense_MutationCTp.S403L
BT16_SOFT_TISSUE90261376902614749026145690261456Missense_MutationACp.R404S
NB10_AUTONOMIC_GANGLIA90261376902614749026145690261456Missense_MutationACp.R404S
SNUC2A_LARGE_INTESTINE90272944902730429027298090272980Missense_MutationGAp.G621R
SNUC2B_LARGE_INTESTINE90272944902730429027298090272980Missense_MutationGAp.G621R
OC316_OVARY90272944902730429027299990272999Missense_MutationGAp.R627Q
OC314_OVARY90272944902730429027299990272999Missense_MutationGAp.R627Q
LB647SCLC_LUNG90301466903016549030151390301513Missense_MutationGTp.V758L
NCIH1436_LUNG90311922903121199031206490312064Missense_MutationATp.Q852H
RD_SOFT_TISSUE90313571903137099031362790313627Missense_MutationGAp.D890N
JHUEM7_ENDOMETRIUM90313571903137099031364090313640Missense_MutationTCp.V894A
SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE90258291902583839025829190258291Splice_SiteCAp.Q307K

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DAPK1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DAPK1


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DAPK1


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RelatedDrugs for DAPK1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P53355DB12010FostamatinibDeath-associated protein kinase 1small moleculeapproved|investigational

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RelatedDiseases for DAPK1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
DAPK1C0001418Adenocarcinoma1CTD_human
DAPK1C0006118Brain Neoplasms1CTD_human
DAPK1C0007131Non-Small Cell Lung Carcinoma1CTD_human
DAPK1C0007134Renal Cell Carcinoma1CTD_human
DAPK1C0007138Carcinoma, Transitional Cell1CTD_human
DAPK1C0009759Conjunctival Diseases1CTD_human
DAPK1C0010606Adenoid Cystic Carcinoma1CTD_human
DAPK1C0023467Leukemia, Myelocytic, Acute1CTD_human
DAPK1C0024121Lung Neoplasms1CTD_human
DAPK1C0027627Neoplasm Metastasis1CTD_human
DAPK1C0031117Peripheral Neuropathy1CTD_human
DAPK1C0035242Respiratory Tract Diseases1CTD_human
DAPK1C0036095Salivary Gland Neoplasms1CTD_human
DAPK1C0085183Neoplasms, Second Primary1CTD_human
DAPK1C3463824MYELODYSPLASTIC SYNDROME1CTD_human
DAPK1C3495559Juvenile arthritis1CTD_human