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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RNF145 |
 Gene summary |
| Gene information | Gene symbol | RNF145 | Gene ID | 153830 |
| Gene name | ring finger protein 145 | |
| Synonyms | - | |
| Cytomap | 5q33.3 | |
| Type of gene | protein-coding | |
| Description | RING finger protein 145 | |
| Modification date | 20180522 | |
| UniProtAcc | Q96MT1 | |
| Context | PubMed: RNF145 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RNF145 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RNF145 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RNF145 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_445968 | 5 | 158584831:158585434:158585847:158586043:158588273:158588368 | 158585847:158586043 | ENSG00000145860.7 | ENST00000519985.1 |
| exon_skip_445971 | 5 | 158589939:158590087:158595880:158596063:158596686:158596827 | 158595880:158596063 | ENSG00000145860.7 | ENST00000274542.2,ENST00000521606.2,ENST00000520638.1,ENST00000518802.1,ENST00000519865.1,ENST00000424310.2 |
| exon_skip_445972 | 5 | 158589939:158590087:158595999:158596063:158596686:158596827 | 158595999:158596063 | ENSG00000145860.7 | ENST00000521266.1 |
| exon_skip_445973 | 5 | 158596686:158596827:158600990:158601166:158603639:158603875 | 158600990:158601166 | ENSG00000145860.7 | ENST00000274542.2,ENST00000521606.2,ENST00000520638.1,ENST00000518802.1,ENST00000519865.1,ENST00000424310.2 |
| exon_skip_445982 | 5 | 158600990:158601166:158603639:158603875:158608967:158609059 | 158603639:158603875 | ENSG00000145860.7 | ENST00000274542.2,ENST00000521606.2,ENST00000520638.1,ENST00000518802.1,ENST00000519865.1,ENST00000424310.2 |
| exon_skip_445985 | 5 | 158603639:158603875:158608967:158609059:158621723:158621832 | 158608967:158609059 | ENSG00000145860.7 | ENST00000274542.2,ENST00000521606.2,ENST00000520638.1,ENST00000518802.1,ENST00000519865.1,ENST00000424310.2 |
| exon_skip_445988 | 5 | 158608967:158609059:158621723:158621832:158630441:158630664 | 158621723:158621832 | ENSG00000145860.7 | ENST00000274542.2,ENST00000521606.2,ENST00000520638.1,ENST00000518802.1,ENST00000519865.1,ENST00000520548.1,ENST00000424310.2 |
| exon_skip_445989 | 5 | 158621723:158621832:158630441:158630664:158636238:158636559 | 158630441:158630664 | ENSG00000145860.7 | ENST00000424310.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RNF145 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_445968 | 5 | 158584831:158585434:158585847:158586043:158588273:158588368 | 158585847:158586043 | ENSG00000145860.7 | ENST00000519985.1 |
| exon_skip_445971 | 5 | 158589939:158590087:158595880:158596063:158596686:158596827 | 158595880:158596063 | ENSG00000145860.7 | ENST00000274542.2,ENST00000519865.1,ENST00000424310.2,ENST00000521606.2,ENST00000518802.1,ENST00000520638.1 |
| exon_skip_445972 | 5 | 158589939:158590087:158595999:158596063:158596686:158596827 | 158595999:158596063 | ENSG00000145860.7 | ENST00000521266.1 |
| exon_skip_445973 | 5 | 158596686:158596827:158600990:158601166:158603639:158603875 | 158600990:158601166 | ENSG00000145860.7 | ENST00000274542.2,ENST00000519865.1,ENST00000424310.2,ENST00000521606.2,ENST00000518802.1,ENST00000520638.1 |
| exon_skip_445982 | 5 | 158600990:158601166:158603639:158603875:158608967:158609059 | 158603639:158603875 | ENSG00000145860.7 | ENST00000274542.2,ENST00000519865.1,ENST00000424310.2,ENST00000521606.2,ENST00000518802.1,ENST00000520638.1 |
| exon_skip_445985 | 5 | 158603639:158603875:158608967:158609059:158621723:158621832 | 158608967:158609059 | ENSG00000145860.7 | ENST00000274542.2,ENST00000519865.1,ENST00000424310.2,ENST00000521606.2,ENST00000518802.1,ENST00000520638.1 |
| exon_skip_445988 | 5 | 158608967:158609059:158621723:158621832:158630441:158630664 | 158621723:158621832 | ENSG00000145860.7 | ENST00000274542.2,ENST00000519865.1,ENST00000424310.2,ENST00000521606.2,ENST00000518802.1,ENST00000520638.1,ENST00000520548.1 |
| exon_skip_445989 | 5 | 158621723:158621832:158630441:158630664:158636238:158636559 | 158630441:158630664 | ENSG00000145860.7 | ENST00000424310.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RNF145 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000424310 | 158630441 | 158630664 | 3UTR-3CDS |
| ENST00000424310 | 158600990 | 158601166 | Frame-shift |
| ENST00000519865 | 158600990 | 158601166 | Frame-shift |
| ENST00000424310 | 158603639 | 158603875 | Frame-shift |
| ENST00000519865 | 158603639 | 158603875 | Frame-shift |
| ENST00000424310 | 158608967 | 158609059 | Frame-shift |
| ENST00000519865 | 158608967 | 158609059 | Frame-shift |
| ENST00000424310 | 158621723 | 158621832 | Frame-shift |
| ENST00000519865 | 158621723 | 158621832 | Frame-shift |
| ENST00000424310 | 158595880 | 158596063 | In-frame |
| ENST00000519865 | 158595880 | 158596063 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000424310 | 158630441 | 158630664 | 3UTR-3CDS |
| ENST00000424310 | 158600990 | 158601166 | Frame-shift |
| ENST00000519865 | 158600990 | 158601166 | Frame-shift |
| ENST00000424310 | 158603639 | 158603875 | Frame-shift |
| ENST00000519865 | 158603639 | 158603875 | Frame-shift |
| ENST00000424310 | 158608967 | 158609059 | Frame-shift |
| ENST00000519865 | 158608967 | 158609059 | Frame-shift |
| ENST00000424310 | 158621723 | 158621832 | Frame-shift |
| ENST00000519865 | 158621723 | 158621832 | Frame-shift |
| ENST00000424310 | 158595880 | 158596063 | In-frame |
| ENST00000519865 | 158595880 | 158596063 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RNF145 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000424310 | 3630 | 663 | 158595880 | 158596063 | 1299 | 1481 | 313 | 373 |
| ENST00000519865 | 3495 | 663 | 158595880 | 158596063 | 1164 | 1346 | 313 | 373 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000424310 | 3630 | 663 | 158595880 | 158596063 | 1299 | 1481 | 313 | 373 |
| ENST00000519865 | 3495 | 663 | 158595880 | 158596063 | 1164 | 1346 | 313 | 373 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96MT1 | 313 | 373 | 1 | 663 | Chain | ID=PRO_0000294024;Note=RING finger protein 145 |
| Q96MT1 | 313 | 373 | 1 | 663 | Chain | ID=PRO_0000294024;Note=RING finger protein 145 |
| Q96MT1 | 313 | 373 | 316 | 336 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96MT1 | 313 | 373 | 316 | 336 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96MT1 | 313 | 373 | 340 | 360 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96MT1 | 313 | 373 | 340 | 360 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96MT1 | 313 | 373 | 1 | 663 | Chain | ID=PRO_0000294024;Note=RING finger protein 145 |
| Q96MT1 | 313 | 373 | 1 | 663 | Chain | ID=PRO_0000294024;Note=RING finger protein 145 |
| Q96MT1 | 313 | 373 | 316 | 336 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96MT1 | 313 | 373 | 316 | 336 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96MT1 | 313 | 373 | 340 | 360 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96MT1 | 313 | 373 | 340 | 360 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for RNF145 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_445968 | 158585848 | 158586043 | 158585855 | 158585855 | Frame_Shift_Del | A | - | p.F605fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_445968 | 158585848 | 158586043 | 158585923 | 158585923 | Frame_Shift_Del | G | - | p.Q583fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_445973 | 158600991 | 158601166 | 158600999 | 158600999 | Frame_Shift_Del | A | - | p.F263fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_445985 | 158608968 | 158609059 | 158609032 | 158609032 | Frame_Shift_Del | A | - | p.F107fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_445988 | 158621724 | 158621832 | 158621763 | 158621763 | Frame_Shift_Del | A | - | p.L85fs |
| LIHC | TCGA-DD-A3A1-01 | exon_skip_445989 | 158630442 | 158630664 | 158630583 | 158630583 | Frame_Shift_Del | G | - | p.L15fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_445989 | 158630442 | 158630664 | 158630583 | 158630583 | Frame_Shift_Del | G | - | p.L15fs |
| COAD | TCGA-AA-3663-01 | exon_skip_445989 | 158630442 | 158630664 | 158630630 | 158630631 | Frame_Shift_Del | TT | - | p.27_27del |
| COAD | TCGA-AY-6197-01 | exon_skip_445989 | 158630442 | 158630664 | 158630630 | 158630630 | Frame_Shift_Del | T | - | p.N27fs |
| LIHC | TCGA-EP-A12J-01 | exon_skip_445989 | 158630442 | 158630664 | 158630630 | 158630630 | Frame_Shift_Del | T | - | p.N28fs |
| THCA | TCGA-DJ-A1QL-01 | exon_skip_445989 | 158630442 | 158630664 | 158630630 | 158630630 | Frame_Shift_Del | T | - | p.N28fs |
| KICH | TCGA-KN-8427-01 | exon_skip_445989 | 158630442 | 158630664 | 158630641 | 158630641 | Frame_Shift_Del | C | - | p.K10fs |
| CESC | TCGA-EA-A410-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630643 | Frame_Shift_Del | TT | - | p.K23fs |
| ESCA | TCGA-L5-A43J-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630642 | Frame_Shift_Del | T | - | p.K25fs |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630642 | Frame_Shift_Del | T | - | p.K25fs |
| KIRC | TCGA-B0-5094-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630642 | Frame_Shift_Del | T | - | p.K26fs |
| KIRC | TCGA-BP-4992-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630642 | Frame_Shift_Del | T | - | p.K26fs |
| PAAD | TCGA-2J-AAB9-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630642 | Frame_Shift_Del | T | - | p.K26fs |
| PAAD | TCGA-IB-A7LX-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630642 | Frame_Shift_Del | T | - | p.K26fs |
| PRAD | TCGA-G9-7521-01 | exon_skip_445989 | 158630442 | 158630664 | 158630642 | 158630642 | Frame_Shift_Del | T | - | p.K26fs |
| KIRC | TCGA-B0-5713-01 | exon_skip_445973 | 158600991 | 158601166 | 158601127 | 158601128 | Frame_Shift_Ins | - | GGACATT | p.L251fs |
| KIRC | TCGA-B0-5713-01 | exon_skip_445973 | 158600991 | 158601166 | 158601127 | 158601128 | Frame_Shift_Ins | - | GGACATT | p.V221fs |
| LIHC | TCGA-DD-AADD-01 | exon_skip_445982 | 158603640 | 158603875 | 158603773 | 158603774 | Frame_Shift_Ins | - | CAAGG | p.V193fs |
| COAD | TCGA-AD-6964-01 | exon_skip_445988 | 158621724 | 158621832 | 158621762 | 158621763 | Frame_Shift_Ins | - | A | p.L113fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_445989 | 158630442 | 158630664 | 158630612 | 158630613 | Frame_Shift_Ins | - | C | p.E5fs |
| BLCA | TCGA-E7-A677-01 | exon_skip_445989 | 158630442 | 158630664 | 158630629 | 158630630 | Frame_Shift_Ins | - | T | p.N27fs |
| ESCA | TCGA-LN-A4A2-01 | exon_skip_445989 | 158630442 | 158630664 | 158630641 | 158630642 | Frame_Shift_Ins | - | T | p.K26fs |
| SKCM | TCGA-W3-AA1V-06 | exon_skip_445982 | 158603640 | 158603875 | 158603642 | 158603642 | Nonsense_Mutation | G | A | p.Q207* |
| LIHC | TCGA-BC-A10Z-01 | exon_skip_445982 | 158603640 | 158603875 | 158603765 | 158603765 | Nonsense_Mutation | C | A | p.E166* |
| LIHC | TCGA-BC-A10Z-01 | exon_skip_445982 | 158603640 | 158603875 | 158603765 | 158603765 | Nonsense_Mutation | C | A | p.E196X |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_445988 | 158621724 | 158621832 | 158621768 | 158621768 | Nonsense_Mutation | A | T | p.Y113X |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_445988 | 158621724 | 158621832 | 158621768 | 158621768 | Nonsense_Mutation | A | T | p.Y83* |
| HNSC | TCGA-CV-7568-01 | exon_skip_445989 | 158630442 | 158630664 | 158630511 | 158630511 | Nonsense_Mutation | G | A | p.Q39* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 158585848 | 158586043 | 158586003 | 158586003 | Frame_Shift_Del | A | - | p.F556fs |
| CW2_LARGE_INTESTINE | 158603640 | 158603875 | 158603813 | 158603813 | Frame_Shift_Del | A | - | p.S150fs |
| SNU1040_LARGE_INTESTINE | 158621724 | 158621832 | 158621763 | 158621763 | Frame_Shift_Del | A | - | p.L85fs |
| NCIH2347_LUNG | 158585848 | 158586043 | 158585842 | 158585842 | Missense_Mutation | C | T | p.E610K |
| WM983B_SKIN | 158585848 | 158586043 | 158585928 | 158585928 | Missense_Mutation | G | A | p.S581F |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 158585848 | 158586043 | 158585946 | 158585946 | Missense_Mutation | T | C | p.H575R |
| PECAPJ15_UPPER_AERODIGESTIVE_TRACT | 158585848 | 158586043 | 158585985 | 158585985 | Missense_Mutation | T | G | p.K562T |
| PECAPJ49_UPPER_AERODIGESTIVE_TRACT | 158585848 | 158586043 | 158586021 | 158586021 | Missense_Mutation | G | A | p.T550M |
| CROAP3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 158585848 | 158586043 | 158586024 | 158586024 | Missense_Mutation | A | C | p.I549S |
| CW2_LARGE_INTESTINE | 158585848 | 158586043 | 158586028 | 158586028 | Missense_Mutation | C | T | p.V548M |
| NCIH524_LUNG | 158595881 | 158596063 | 158595961 | 158595961 | Missense_Mutation | G | C | p.F347L |
| MCC13_SKIN | 158596000 | 158596063 | 158595998 | 158595998 | Missense_Mutation | A | G | p.V335A |
| MCC13_SKIN | 158595881 | 158596063 | 158595998 | 158595998 | Missense_Mutation | A | G | p.V335A |
| ECC10_STOMACH | 158596000 | 158596063 | 158596037 | 158596037 | Missense_Mutation | A | G | p.L322S |
| ECC10_STOMACH | 158595881 | 158596063 | 158596037 | 158596037 | Missense_Mutation | A | G | p.L322S |
| TM31_CENTRAL_NERVOUS_SYSTEM | 158600991 | 158601166 | 158601058 | 158601058 | Missense_Mutation | A | G | p.Y244H |
| HCC1569_BREAST | 158603640 | 158603875 | 158603713 | 158603713 | Missense_Mutation | A | G | p.V183A |
| JHUEM3_ENDOMETRIUM | 158603640 | 158603875 | 158603756 | 158603756 | Missense_Mutation | C | T | p.V169I |
| KYSE410_OESOPHAGUS | 158603640 | 158603875 | 158603756 | 158603756 | Missense_Mutation | C | T | p.V169I |
| CORL95_LUNG | 158603640 | 158603875 | 158603864 | 158603864 | Missense_Mutation | C | A | p.V133L |
| MZ7MEL_SKIN | 158603640 | 158603875 | 158603864 | 158603864 | Missense_Mutation | C | T | p.V133M |
| KM12_LARGE_INTESTINE | 158608968 | 158609059 | 158608989 | 158608989 | Missense_Mutation | G | A | p.R122W |
| HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 158608968 | 158609059 | 158608989 | 158608989 | Missense_Mutation | G | A | p.R122W |
| SNU81_LARGE_INTESTINE | 158621724 | 158621832 | 158621800 | 158621800 | Missense_Mutation | G | A | p.P73S |
| HCC2998_LARGE_INTESTINE | 158630442 | 158630664 | 158630477 | 158630477 | Missense_Mutation | T | C | p.Q50R |
| CAL78_BONE | 158630442 | 158630664 | 158630529 | 158630529 | Missense_Mutation | A | C | p.S33A |
| BCP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 158621724 | 158621832 | 158621782 | 158621782 | Nonsense_Mutation | G | A | p.Q79* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RNF145 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RNF145 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RNF145 |
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RelatedDrugs for RNF145 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF145 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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