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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZCWPW2 |
 Gene summary |
| Gene information | Gene symbol | ZCWPW2 | Gene ID | 152098 |
| Gene name | zinc finger CW-type and PWWP domain containing 2 | |
| Synonyms | ZCW2 | |
| Cytomap | 3p24.1 | |
| Type of gene | protein-coding | |
| Description | zinc finger CW-type PWWP domain protein 2zinc finger CW-type and PWWP domain 2zinc finger, CW type with PWWP domain 2 | |
| Modification date | 20180519 | |
| UniProtAcc | Q504Y3 | |
| Context | PubMed: ZCWPW2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZCWPW2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZCWPW2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZCWPW2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_372297 | 3 | 28390639:28390694:28431988:28432108:28454546:28454891 | 28431988:28432108 | ENSG00000206559.3 | ENST00000383768.2 |
| exon_skip_372304 | 3 | 28476714:28476760:28519779:28519878:28520304:28520422 | 28519779:28519878 | ENSG00000206559.3 | ENST00000419130.1 |
| exon_skip_372305 | 3 | 28476714:28476760:28520304:28520422:28533617:28533664 | 28520304:28520422 | ENSG00000206559.3 | ENST00000383768.2,ENST00000421010.1 |
| exon_skip_372311 | 3 | 28520304:28520422:28533617:28533664:28555554:28555613 | 28533617:28533664 | ENSG00000206559.3 | ENST00000419130.1,ENST00000383768.2,ENST00000421010.1 |
| exon_skip_372314 | 3 | 28533617:28533664:28555554:28555613:28557044:28557112 | 28555554:28555613 | ENSG00000206559.3 | ENST00000419130.1,ENST00000383768.2,ENST00000421010.1 |
| exon_skip_372317 | 3 | 28555554:28555613:28557044:28557112:28562482:28562607 | 28557044:28557112 | ENSG00000206559.3 | ENST00000419130.1,ENST00000383768.2,ENST00000457897.1,ENST00000421010.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZCWPW2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_372297 | 3 | 28390639:28390694:28431988:28432108:28454546:28454891 | 28431988:28432108 | ENSG00000206559.3 | ENST00000383768.2 |
| exon_skip_372304 | 3 | 28476714:28476760:28519779:28519878:28520304:28520422 | 28519779:28519878 | ENSG00000206559.3 | ENST00000419130.1 |
| exon_skip_372305 | 3 | 28476714:28476760:28520304:28520422:28533617:28533664 | 28520304:28520422 | ENSG00000206559.3 | ENST00000383768.2,ENST00000421010.1 |
| exon_skip_372311 | 3 | 28520304:28520422:28533617:28533664:28555554:28555613 | 28533617:28533664 | ENSG00000206559.3 | ENST00000383768.2,ENST00000421010.1,ENST00000419130.1 |
| exon_skip_372314 | 3 | 28533617:28533664:28555554:28555613:28557044:28557112 | 28555554:28555613 | ENSG00000206559.3 | ENST00000383768.2,ENST00000421010.1,ENST00000419130.1 |
| exon_skip_372317 | 3 | 28555554:28555613:28557044:28557112:28562482:28562607 | 28557044:28557112 | ENSG00000206559.3 | ENST00000383768.2,ENST00000421010.1,ENST00000419130.1,ENST00000457897.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZCWPW2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000383768 | 28431988 | 28432108 | 5UTR-5UTR |
| ENST00000383768 | 28520304 | 28520422 | Frame-shift |
| ENST00000383768 | 28533617 | 28533664 | Frame-shift |
| ENST00000383768 | 28555554 | 28555613 | Frame-shift |
| ENST00000383768 | 28557044 | 28557112 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000383768 | 28431988 | 28432108 | 5UTR-5UTR |
| ENST00000383768 | 28520304 | 28520422 | Frame-shift |
| ENST00000383768 | 28533617 | 28533664 | Frame-shift |
| ENST00000383768 | 28555554 | 28555613 | Frame-shift |
| ENST00000383768 | 28557044 | 28557112 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZCWPW2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZCWPW2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_372314 | 28555555 | 28555613 | 28555567 | 28555567 | Frame_Shift_Del | A | - | p.K224fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_372317 | 28557045 | 28557112 | 28557099 | 28557099 | Frame_Shift_Del | A | - | p.S257fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_372317 | 28557045 | 28557112 | 28557110 | 28557110 | Frame_Shift_Del | G | - | p.R261fs |
| LGG | TCGA-DU-5870-02 | exon_skip_372314 | 28555555 | 28555613 | 28555576 | 28555577 | Frame_Shift_Ins | - | C | p.*227fs |
| COAD | TCGA-G4-6323-01 | exon_skip_372305 | 28520305 | 28520422 | 28520395 | 28520395 | Nonsense_Mutation | G | T | p.E195X |
| HNSC | TCGA-CV-5432-01 | exon_skip_372305 | 28520305 | 28520422 | 28520395 | 28520395 | Nonsense_Mutation | G | T | p.E195* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SW684_SOFT_TISSUE | 28520305 | 28520422 | 28520320 | 28520320 | Missense_Mutation | A | C | p.N170H |
| LU165_LUNG | 28520305 | 28520422 | 28520333 | 28520334 | Missense_Mutation | GG | TT | p.W174F |
| A427_LUNG | 28533618 | 28533664 | 28533633 | 28533633 | Missense_Mutation | A | T | p.H209L |
| LS411N_LARGE_INTESTINE | 28520305 | 28520422 | 28520422 | 28520422 | Splice_Site | G | A | p.D204N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZCWPW2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZCWPW2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZCWPW2 |
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RelatedDrugs for ZCWPW2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZCWPW2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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