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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FBXO41 |
 Gene summary |
| Gene information | Gene symbol | FBXO41 | Gene ID | 150726 |
| Gene name | F-box protein 41 | |
| Synonyms | FBX41 | |
| Cytomap | 2p13.2 | |
| Type of gene | protein-coding | |
| Description | F-box only protein 41 | |
| Modification date | 20180519 | |
| UniProtAcc | Q8TF61 | |
| Context | PubMed: FBXO41 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for FBXO41 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FBXO41 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FBXO41 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_340050 | 2 | 73490340:73490436:73490805:73490958:73491065:73491181 | 73490805:73490958 | ENSG00000163013.7 | ENST00000520530.2,ENST00000521871.1,ENST00000295133.5 |
| exon_skip_340051 | 2 | 73492610:73492768:73493020:73493094:73493584:73493806 | 73493020:73493094 | ENSG00000163013.7 | ENST00000520530.2,ENST00000521871.1,ENST00000295133.5,ENST00000519873.1 |
| exon_skip_340058 | 2 | 73493584:73493810:73495853:73496896:73511287:73511438 | 73495853:73496896 | ENSG00000163013.7 | ENST00000520530.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FBXO41 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_340050 | 2 | 73490340:73490436:73490805:73490958:73491065:73491181 | 73490805:73490958 | ENSG00000163013.7 | ENST00000295133.5,ENST00000521871.1,ENST00000520530.2 |
| exon_skip_340051 | 2 | 73492610:73492768:73493020:73493094:73493584:73493806 | 73493020:73493094 | ENSG00000163013.7 | ENST00000295133.5,ENST00000521871.1,ENST00000520530.2,ENST00000519873.1 |
| exon_skip_340058 | 2 | 73493584:73493810:73495853:73496896:73511287:73511438 | 73495853:73496896 | ENSG00000163013.7 | ENST00000520530.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FBXO41 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000520530 | 73495853 | 73496896 | 3UTR-3CDS |
| ENST00000295133 | 73493020 | 73493094 | Frame-shift |
| ENST00000520530 | 73493020 | 73493094 | Frame-shift |
| ENST00000521871 | 73493020 | 73493094 | Frame-shift |
| ENST00000295133 | 73490805 | 73490958 | In-frame |
| ENST00000520530 | 73490805 | 73490958 | In-frame |
| ENST00000521871 | 73490805 | 73490958 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000520530 | 73495853 | 73496896 | 3UTR-3CDS |
| ENST00000295133 | 73493020 | 73493094 | Frame-shift |
| ENST00000520530 | 73493020 | 73493094 | Frame-shift |
| ENST00000521871 | 73493020 | 73493094 | Frame-shift |
| ENST00000295133 | 73490805 | 73490958 | In-frame |
| ENST00000520530 | 73490805 | 73490958 | In-frame |
| ENST00000521871 | 73490805 | 73490958 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FBXO41 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000520530 | 3310 | 875 | 73490805 | 73490958 | 2212 | 2364 | 641 | 691 |
| ENST00000521871 | 7353 | 875 | 73490805 | 73490958 | 2339 | 2491 | 641 | 691 |
| ENST00000295133 | 7128 | 875 | 73490805 | 73490958 | 2106 | 2258 | 702 | 752 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000520530 | 3310 | 875 | 73490805 | 73490958 | 2212 | 2364 | 641 | 691 |
| ENST00000521871 | 7353 | 875 | 73490805 | 73490958 | 2339 | 2491 | 641 | 691 |
| ENST00000295133 | 7128 | 875 | 73490805 | 73490958 | 2106 | 2258 | 702 | 752 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TF61 | 641 | 691 | 1 | 875 | Chain | ID=PRO_0000119940;Note=F-box only protein 41 |
| Q8TF61 | 641 | 691 | 1 | 875 | Chain | ID=PRO_0000119940;Note=F-box only protein 41 |
| Q8TF61 | 702 | 752 | 1 | 875 | Chain | ID=PRO_0000119940;Note=F-box only protein 41 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TF61 | 641 | 691 | 1 | 875 | Chain | ID=PRO_0000119940;Note=F-box only protein 41 |
| Q8TF61 | 641 | 691 | 1 | 875 | Chain | ID=PRO_0000119940;Note=F-box only protein 41 |
| Q8TF61 | 702 | 752 | 1 | 875 | Chain | ID=PRO_0000119940;Note=F-box only protein 41 |
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SNVs in the skipped exons for FBXO41 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_340050 | 73490806 | 73490958 | 73490910 | 73490910 | Frame_Shift_Del | C | - | p.G657fs |
| STAD | TCGA-BR-7707-01 | exon_skip_340050 | 73490806 | 73490958 | 73490910 | 73490910 | Frame_Shift_Del | C | - | p.N658fs |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_340050 | 73490806 | 73490958 | 73490910 | 73490910 | Frame_Shift_Del | C | - | p.G657fs |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_340050 | 73490806 | 73490958 | 73490910 | 73490910 | Frame_Shift_Del | C | - | p.N658fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73496430 | 73496432 | In_Frame_Del | TGG | - | p.109_110HH>H |
| T3M10_LUNG | 73490806 | 73490958 | 73490840 | 73490840 | Missense_Mutation | A | G | p.C681R |
| SNU1105_CENTRAL_NERVOUS_SYSTEM | 73495854 | 73496896 | 73495927 | 73495927 | Missense_Mutation | C | T | p.V278M |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73495938 | 73495938 | Missense_Mutation | C | T | p.R274H |
| JHUEM7_ENDOMETRIUM | 73495854 | 73496896 | 73495941 | 73495941 | Missense_Mutation | G | A | p.S273F |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73495956 | 73495956 | Missense_Mutation | C | T | p.R268H |
| KHYG_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73495980 | 73495980 | Missense_Mutation | C | T | p.R260H |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73495992 | 73495992 | Missense_Mutation | G | A | p.A256V |
| HEC251_ENDOMETRIUM | 73495854 | 73496896 | 73495996 | 73495996 | Missense_Mutation | T | G | p.S255R |
| SNU719_STOMACH | 73495854 | 73496896 | 73496028 | 73496028 | Missense_Mutation | T | G | p.K244T |
| BFTC909_KIDNEY | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| FLO1_OESOPHAGUS | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| JHOS2_OVARY | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| L540_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| MC116_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| NCIH508_LARGE_INTESTINE | 73495854 | 73496896 | 73496082 | 73496082 | Missense_Mutation | A | C | p.V226G |
| NCIH1437_LUNG | 73495854 | 73496896 | 73496109 | 73496109 | Missense_Mutation | C | A | p.R217L |
| NCIH1975_LUNG | 73495854 | 73496896 | 73496149 | 73496149 | Missense_Mutation | G | T | p.R204S |
| LS411N_LARGE_INTESTINE | 73495854 | 73496896 | 73496170 | 73496170 | Missense_Mutation | C | T | p.A197T |
| HSC3_UPPER_AERODIGESTIVE_TRACT | 73495854 | 73496896 | 73496253 | 73496253 | Missense_Mutation | G | C | p.S169W |
| NCIH513_PLEURA | 73495854 | 73496896 | 73496253 | 73496253 | Missense_Mutation | G | C | p.S169W |
| MCC13_SKIN | 73495854 | 73496896 | 73496293 | 73496294 | Missense_Mutation | CC | TT | p.E156K |
| BEN_LUNG | 73495854 | 73496896 | 73496427 | 73496427 | Missense_Mutation | T | A | p.H111L |
| LS411N_LARGE_INTESTINE | 73495854 | 73496896 | 73496457 | 73496457 | Missense_Mutation | G | A | p.A101V |
| MKN7_STOMACH | 73495854 | 73496896 | 73496476 | 73496476 | Missense_Mutation | C | T | p.A95T |
| MFE319_ENDOMETRIUM | 73495854 | 73496896 | 73496500 | 73496500 | Missense_Mutation | T | C | p.T87A |
| SEKI_SKIN | 73495854 | 73496896 | 73496611 | 73496611 | Missense_Mutation | C | T | p.G50S |
| UACC893_BREAST | 73495854 | 73496896 | 73496671 | 73496671 | Missense_Mutation | C | G | p.E30Q |
| NCIH1651_LUNG | 73495854 | 73496896 | 73496165 | 73496165 | Nonsense_Mutation | G | C | p.Y198* |
| PLCPRF5_LIVER | 73493021 | 73493094 | 73493022 | 73493022 | Splice_Site | C | T | p.G402R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FBXO41 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FBXO41 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FBXO41 |
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RelatedDrugs for FBXO41 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXO41 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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