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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF420 |
 Gene summary |
| Gene information | Gene symbol | ZNF420 | Gene ID | 147923 |
| Gene name | zinc finger protein 420 | |
| Synonyms | APAK | |
| Cytomap | 19q13.12 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 420ATM and p53-associated KZNF protein | |
| Modification date | 20180522 | |
| UniProtAcc | Q8TAQ5 | |
| Context | PubMed: ZNF420 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF420 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF420 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF420 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_306233 | 19 | 37498760:37498984:37571246:37571290:37579940:37580029 | 37571246:37571290 | ENSG00000197050.6 | ENST00000587029.1 |
| exon_skip_306236 | 19 | 37569381:37569472:37571246:37571290:37579940:37580029 | 37571246:37571290 | ENSG00000197050.6 | ENST00000587082.1,ENST00000337995.3,ENST00000304239.7,ENST00000589461.1 |
| exon_skip_306239 | 19 | 37571246:37571290:37579940:37580029:37581896:37582023 | 37579940:37580029 | ENSG00000197050.6 | ENST00000587082.1,ENST00000587029.1,ENST00000337995.3,ENST00000304239.7,ENST00000589461.1 |
| exon_skip_306242 | 19 | 37579940:37580029:37581896:37582023:37586932:37587017 | 37581896:37582023 | ENSG00000197050.6 | ENST00000587082.1 |
| exon_skip_306243 | 19 | 37579940:37580029:37581896:37582023:37618029:37618041 | 37581896:37582023 | ENSG00000197050.6 | ENST00000587029.1,ENST00000337995.3,ENST00000304239.7,ENST00000589245.1 |
| exon_skip_306246 | 19 | 37581896:37582023:37586932:37587017:37602501:37602589 | 37586932:37587017 | ENSG00000197050.6 | ENST00000587082.1 |
| exon_skip_306248 | 19 | 37581896:37582023:37602501:37602613:37618029:37618041 | 37602501:37602613 | ENSG00000197050.6 | ENST00000589461.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF420 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_306233 | 19 | 37498760:37498984:37571246:37571290:37579940:37580029 | 37571246:37571290 | ENSG00000197050.6 | ENST00000587029.1 |
| exon_skip_306236 | 19 | 37569381:37569472:37571246:37571290:37579940:37580029 | 37571246:37571290 | ENSG00000197050.6 | ENST00000589461.1,ENST00000587082.1,ENST00000304239.7,ENST00000337995.3 |
| exon_skip_306239 | 19 | 37571246:37571290:37579940:37580029:37581896:37582023 | 37579940:37580029 | ENSG00000197050.6 | ENST00000587029.1,ENST00000589461.1,ENST00000587082.1,ENST00000304239.7,ENST00000337995.3 |
| exon_skip_306242 | 19 | 37579940:37580029:37581896:37582023:37586932:37587017 | 37581896:37582023 | ENSG00000197050.6 | ENST00000587082.1 |
| exon_skip_306243 | 19 | 37579940:37580029:37581896:37582023:37618029:37618041 | 37581896:37582023 | ENSG00000197050.6 | ENST00000587029.1,ENST00000304239.7,ENST00000589245.1,ENST00000337995.3 |
| exon_skip_306246 | 19 | 37581896:37582023:37586932:37587017:37602501:37602589 | 37586932:37587017 | ENSG00000197050.6 | ENST00000587082.1 |
| exon_skip_306248 | 19 | 37581896:37582023:37602501:37602613:37618029:37618041 | 37602501:37602613 | ENSG00000197050.6 | ENST00000589461.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF420 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337995 | 37579940 | 37580029 | 5CDS-5UTR |
| ENST00000337995 | 37571246 | 37571290 | 5UTR-5UTR |
| ENST00000337995 | 37581896 | 37582023 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337995 | 37579940 | 37580029 | 5CDS-5UTR |
| ENST00000337995 | 37571246 | 37571290 | 5UTR-5UTR |
| ENST00000337995 | 37581896 | 37582023 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZNF420 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZNF420 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| READ | TCGA-F5-6814-01 | exon_skip_306242 exon_skip_306243 | 37581897 | 37582023 | 37581901 | 37581901 | Nonsense_Mutation | T | G | p.L5X |
| UCS | TCGA-ND-A4WC-01 | exon_skip_306242 exon_skip_306243 | 37581897 | 37582023 | 37581896 | 37581896 | Splice_Site | G | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JHOS2_OVARY | 37581897 | 37582023 | 37581908 | 37581908 | Missense_Mutation | G | A | p.M7I |
| HCC2998_LARGE_INTESTINE | 37581897 | 37582023 | 37581932 | 37581932 | Missense_Mutation | C | A | p.F15L |
| KYSE510_OESOPHAGUS | 37581897 | 37582023 | 37581939 | 37581939 | Missense_Mutation | G | A | p.E18K |
| LS411N_LARGE_INTESTINE | 37581897 | 37582023 | 37581955 | 37581955 | Missense_Mutation | T | C | p.L23P |
| HUH6_LIVER | 37581897 | 37582023 | 37581977 | 37581977 | Missense_Mutation | G | T | p.L30F |
| HUH6CLONE5_LIVER | 37581897 | 37582023 | 37581977 | 37581977 | Missense_Mutation | G | T | p.L30F |
| OACP4C_OESOPHAGUS | 37581897 | 37582023 | 37581991 | 37581991 | Missense_Mutation | T | A | p.M35K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF420 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF420 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF420 |
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RelatedDrugs for ZNF420 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF420 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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