|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for CSNK1G3 |
 Gene summary |
| Gene information | Gene symbol | CSNK1G3 | Gene ID | 1456 |
| Gene name | casein kinase 1 gamma 3 | |
| Synonyms | CKI-gamma 3|CSNK1G3L | |
| Cytomap | 5q23.2 | |
| Type of gene | protein-coding | |
| Description | casein kinase I isoform gamma-3casein kinase I | |
| Modification date | 20180523 | |
| UniProtAcc | Q9Y6M4 | |
| Context | PubMed: CSNK1G3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CSNK1G3 | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
Top |
Exon skipping events across known transcript of Ensembl for CSNK1G3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for CSNK1G3 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for CSNK1G3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_437012 | 5 | 122847953:122848264:122881110:122881535:122888800:122888841 | 122881110:122881535 | ENSG00000151292.13 | ENST00000345990.4,ENST00000395411.1 |
| exon_skip_437015 | 5 | 122847953:122848264:122888800:122888841:122893188:122893258 | 122888800:122888841 | ENSG00000151292.13 | ENST00000512718.3 |
| exon_skip_437018 | 5 | 122881327:122881535:122888800:122888841:122893188:122893258 | 122888800:122888841 | ENSG00000151292.13 | ENST00000345990.4,ENST00000521364.1,ENST00000361991.2,ENST00000395411.1,ENST00000395412.1,ENST00000510842.2,ENST00000360683.2 |
| exon_skip_437021 | 5 | 122909086:122909235:122911422:122911657:122923761:122923847 | 122911422:122911657 | ENSG00000151292.13 | ENST00000345990.4,ENST00000521364.1,ENST00000361991.2,ENST00000395411.1,ENST00000512718.3,ENST00000511130.2,ENST00000395412.1,ENST00000510842.2,ENST00000360683.2 |
| exon_skip_437024 | 5 | 122927012:122927108:122930732:122930828:122940417:122940524 | 122930732:122930828 | ENSG00000151292.13 | ENST00000361991.2,ENST00000395411.1,ENST00000395412.1,ENST00000360683.2 |
| exon_skip_437025 | 5 | 122940417:122940524:122941032:122941056:122950035:122950149 | 122941032:122941056 | ENSG00000151292.13 | ENST00000345990.4,ENST00000521364.1,ENST00000512718.3,ENST00000511130.2,ENST00000395412.1,ENST00000510842.2,ENST00000360683.2 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for CSNK1G3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_437012 | 5 | 122847953:122848264:122881110:122881535:122888800:122888841 | 122881110:122881535 | ENSG00000151292.13 | ENST00000395411.1,ENST00000345990.4 |
| exon_skip_437015 | 5 | 122847953:122848264:122888800:122888841:122893188:122893258 | 122888800:122888841 | ENSG00000151292.13 | ENST00000512718.3 |
| exon_skip_437018 | 5 | 122881327:122881535:122888800:122888841:122893188:122893258 | 122888800:122888841 | ENSG00000151292.13 | ENST00000395412.1,ENST00000395411.1,ENST00000345990.4,ENST00000521364.1,ENST00000510842.2,ENST00000361991.2,ENST00000360683.2 |
| exon_skip_437021 | 5 | 122909086:122909235:122911422:122911657:122923761:122923847 | 122911422:122911657 | ENSG00000151292.13 | ENST00000395412.1,ENST00000395411.1,ENST00000345990.4,ENST00000511130.2,ENST00000512718.3,ENST00000521364.1,ENST00000510842.2,ENST00000361991.2,ENST00000360683.2 |
| exon_skip_437024 | 5 | 122927012:122927108:122930732:122930828:122940417:122940524 | 122930732:122930828 | ENSG00000151292.13 | ENST00000395412.1,ENST00000395411.1,ENST00000361991.2,ENST00000360683.2 |
| exon_skip_437025 | 5 | 122940417:122940524:122941032:122941056:122950035:122950149 | 122941032:122941056 | ENSG00000151292.13 | ENST00000395412.1,ENST00000345990.4,ENST00000511130.2,ENST00000512718.3,ENST00000521364.1,ENST00000510842.2,ENST00000360683.2 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for CSNK1G3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361991 | 122888800 | 122888841 | Frame-shift |
| ENST00000361991 | 122911422 | 122911657 | Frame-shift |
| ENST00000361991 | 122930732 | 122930828 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361991 | 122888800 | 122888841 | Frame-shift |
| ENST00000361991 | 122911422 | 122911657 | Frame-shift |
| ENST00000361991 | 122930732 | 122930828 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for CSNK1G3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000361991 | 2441 | 447 | 122930732 | 122930828 | 1117 | 1212 | 362 | 394 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000361991 | 2441 | 447 | 122930732 | 122930828 | 1117 | 1212 | 362 | 394 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y6M4 | 362 | 394 | 363 | 394 | Alternative sequence | ID=VSP_010256;Note=In isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q9Y6M4 | 362 | 394 | 1 | 447 | Chain | ID=PRO_0000192846;Note=Casein kinase I isoform gamma-3 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y6M4 | 362 | 394 | 363 | 394 | Alternative sequence | ID=VSP_010256;Note=In isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q9Y6M4 | 362 | 394 | 1 | 447 | Chain | ID=PRO_0000192846;Note=Casein kinase I isoform gamma-3 |
Top |
SNVs in the skipped exons for CSNK1G3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
CSNK1G3_STAD_exon_skip_437025_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_437012 | 122881111 | 122881535 | 122881495 | 122881495 | Frame_Shift_Del | A | - | p.G46fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_437024 | 122930733 | 122930828 | 122930775 | 122930775 | Frame_Shift_Del | C | - | p.P377fs |
| BLCA | TCGA-GV-A3QH-01 | exon_skip_437012 | 122881111 | 122881535 | 122881389 | 122881389 | Nonsense_Mutation | C | G | p.S11* |
| DLBC | TCGA-GS-A9TZ-01 | exon_skip_437012 | 122881111 | 122881535 | 122881389 | 122881389 | Nonsense_Mutation | C | G | p.S11X |
| BLCA | TCGA-XF-AAMG-01 | exon_skip_437012 | 122881111 | 122881535 | 122881418 | 122881418 | Nonsense_Mutation | C | T | p.R21* |
| BRCA | TCGA-D8-A1JM-01 | exon_skip_437012 | 122881111 | 122881535 | 122881422 | 122881422 | Nonsense_Mutation | C | A | p.S22* |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_437012 | 122881111 | 122881535 | 122881529 | 122881529 | Nonsense_Mutation | C | T | p.R58* |
| STAD | TCGA-BR-4292-01 | exon_skip_437025 | 122941033 | 122941056 | 122941058 | 122941058 | Splice_Site | T | C | . |
| STAD | TCGA-MX-A5UJ-01 | exon_skip_437025 | 122941033 | 122941056 | 122941058 | 122941058 | Splice_Site | T | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-MX-A5UJ-01 |
| Cancer type: STAD | |
| ESID: exon_skip_437025 | |
| Skipped exon start: 122941033 | |
| Skipped exon end: 122941056 | |
| Mutation start: 122941058 | |
| Mutation end: 122941058 | |
| Mutation type: Splice_Site | |
| Reference seq: T | |
| Mutation seq: C | |
| AAchange: . | |
exon_skip_135418_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_25303_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_302981_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_322889_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_322890_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_370065_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_437025_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_439048_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_442836_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_443160_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_458347_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_461292_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_474340_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_69055_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_77217_STAD_TCGA-MX-A5UJ-01.png | |
exon_skip_83002_STAD_TCGA-MX-A5UJ-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC265_ENDOMETRIUM | 122881111 | 122881535 | 122881495 | 122881495 | Frame_Shift_Del | A | - | p.G46fs |
| HEC6_ENDOMETRIUM | 122881111 | 122881535 | 122881495 | 122881495 | Frame_Shift_Del | A | - | p.G46fs |
| IGROV1_OVARY | 122881111 | 122881535 | 122881495 | 122881495 | Frame_Shift_Del | A | - | p.G46fs |
| KM12_LARGE_INTESTINE | 122881111 | 122881535 | 122881495 | 122881495 | Frame_Shift_Del | A | - | p.G46fs |
| MFE319_ENDOMETRIUM | 122881111 | 122881535 | 122881495 | 122881495 | Frame_Shift_Del | A | - | p.G46fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 122881111 | 122881535 | 122881363 | 122881363 | Missense_Mutation | A | T | p.E2D |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 122881111 | 122881535 | 122881363 | 122881363 | Missense_Mutation | A | T | p.E2D |
| LNCAPCLONEFGC_PROSTATE | 122881111 | 122881535 | 122881532 | 122881532 | Missense_Mutation | T | A | p.L59I |
| JHUEM7_ENDOMETRIUM | 122888801 | 122888841 | 122888809 | 122888809 | Missense_Mutation | T | G | p.L63V |
| SW620_LARGE_INTESTINE | 122888801 | 122888841 | 122888813 | 122888813 | Missense_Mutation | A | T | p.Y64F |
| KP1N_PANCREAS | 122911423 | 122911657 | 122911433 | 122911433 | Missense_Mutation | T | G | p.M150R |
| CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 122911423 | 122911657 | 122911438 | 122911438 | Missense_Mutation | T | A | p.Y152N |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 122911423 | 122911657 | 122911453 | 122911453 | Missense_Mutation | A | G | p.N157D |
| HEC251_ENDOMETRIUM | 122911423 | 122911657 | 122911521 | 122911521 | Missense_Mutation | A | C | p.Q179H |
| SNU1040_LARGE_INTESTINE | 122911423 | 122911657 | 122911578 | 122911578 | Missense_Mutation | G | T | p.K198N |
| SNU81_LARGE_INTESTINE | 122911423 | 122911657 | 122911616 | 122911616 | Missense_Mutation | G | A | p.G211E |
| HCC1438_LUNG | 122930733 | 122930828 | 122930746 | 122930746 | Missense_Mutation | G | T | p.R367M |
| DV90_LUNG | 122930733 | 122930828 | 122930796 | 122930796 | Missense_Mutation | C | A | p.L384I |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSNK1G3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CSNK1G3 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CSNK1G3 |
Top |
RelatedDrugs for CSNK1G3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CSNK1G3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|