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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CSNK1G2 |
 Gene summary |
| Gene information | Gene symbol | CSNK1G2 | Gene ID | 1455 |
| Gene name | casein kinase 1 gamma 2 | |
| Synonyms | CK1g2 | |
| Cytomap | 19p13.3 | |
| Type of gene | protein-coding | |
| Description | casein kinase I isoform gamma-2casein kinase ICKI-gamma 2casein kinase 1 isoform gamma-2 | |
| Modification date | 20180523 | |
| UniProtAcc | P78368 | |
| Context | PubMed: CSNK1G2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CSNK1G2 | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
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Exon skipping events across known transcript of Ensembl for CSNK1G2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CSNK1G2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CSNK1G2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_300710 | 19 | 1959236:1959302:1968789:1968904:1969506:1969958 | 1968789:1968904 | ENSG00000133275.11 | ENST00000589350.1 |
| exon_skip_300712 | 19 | 1969824:1969958:1978303:1978344:1978440:1978510 | 1978303:1978344 | ENSG00000133275.11 | ENST00000255641.8 |
| exon_skip_300714 | 19 | 1978473:1978510:1978600:1978749:1978857:1979092 | 1978600:1978749 | ENSG00000133275.11 | ENST00000590106.1,ENST00000255641.8,ENST00000589385.1 |
| exon_skip_300720 | 19 | 1978911:1979092:1979161:1979247:1979317:1979401 | 1979161:1979247 | ENSG00000133275.11 | ENST00000255641.8,ENST00000585959.1,ENST00000589385.1 |
| exon_skip_300723 | 19 | 1979493:1979642:1979750:1979834:1979909:1980016 | 1979750:1979834 | ENSG00000133275.11 | ENST00000255641.8 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CSNK1G2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_300710 | 19 | 1959236:1959302:1968789:1968904:1969506:1969958 | 1968789:1968904 | ENSG00000133275.11 | ENST00000589350.1 |
| exon_skip_300712 | 19 | 1969824:1969958:1978303:1978344:1978440:1978510 | 1978303:1978344 | ENSG00000133275.11 | ENST00000255641.8 |
| exon_skip_300714 | 19 | 1978473:1978510:1978600:1978749:1978857:1979092 | 1978600:1978749 | ENSG00000133275.11 | ENST00000255641.8,ENST00000589385.1,ENST00000590106.1 |
| exon_skip_300720 | 19 | 1978911:1979092:1979161:1979247:1979317:1979401 | 1979161:1979247 | ENSG00000133275.11 | ENST00000255641.8,ENST00000589385.1,ENST00000585959.1 |
| exon_skip_300723 | 19 | 1979493:1979642:1979750:1979834:1979909:1980016 | 1979750:1979834 | ENSG00000133275.11 | ENST00000255641.8 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CSNK1G2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255641 | 1978303 | 1978344 | Frame-shift |
| ENST00000255641 | 1978600 | 1978749 | Frame-shift |
| ENST00000255641 | 1979161 | 1979247 | Frame-shift |
| ENST00000255641 | 1979750 | 1979834 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255641 | 1978303 | 1978344 | Frame-shift |
| ENST00000255641 | 1978600 | 1978749 | Frame-shift |
| ENST00000255641 | 1979161 | 1979247 | Frame-shift |
| ENST00000255641 | 1979750 | 1979834 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CSNK1G2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000255641 | 2895 | 415 | 1979750 | 1979834 | 1498 | 1581 | 334 | 362 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000255641 | 2895 | 415 | 1979750 | 1979834 | 1498 | 1581 | 334 | 362 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P78368 | 334 | 362 | 1 | 415 | Chain | ID=PRO_0000192842;Note=Casein kinase I isoform gamma-2 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P78368 | 334 | 362 | 1 | 415 | Chain | ID=PRO_0000192842;Note=Casein kinase I isoform gamma-2 |
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SNVs in the skipped exons for CSNK1G2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-E7-A4IJ-01 | exon_skip_300714 | 1978601 | 1978749 | 1978612 | 1978612 | Nonsense_Mutation | C | T | p.Q104* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1978304 | 1978344 | 1978312 | 1978312 | Missense_Mutation | C | T | p.L66F |
| MEWO_SKIN | 1978304 | 1978344 | 1978312 | 1978312 | Missense_Mutation | C | G | p.L66V |
| HEC59_ENDOMETRIUM | 1978304 | 1978344 | 1978316 | 1978316 | Missense_Mutation | A | G | p.Y67C |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1978601 | 1978749 | 1978648 | 1978648 | Missense_Mutation | G | A | p.A116T |
| NCIH630_LARGE_INTESTINE | 1978601 | 1978749 | 1978705 | 1978705 | Missense_Mutation | C | T | p.R135W |
| JHUEM7_ENDOMETRIUM | 1978601 | 1978749 | 1978730 | 1978730 | Missense_Mutation | T | C | p.L143P |
| SNU175_LARGE_INTESTINE | 1979162 | 1979247 | 1979171 | 1979171 | Missense_Mutation | G | A | p.R231H |
| MCC13_SKIN | 1979162 | 1979247 | 1979182 | 1979182 | Missense_Mutation | C | A | p.L235M |
| TOV21G_OVARY | 1979162 | 1979247 | 1979206 | 1979206 | Missense_Mutation | A | G | p.M243V |
| HEC1B_ENDOMETRIUM | 1979751 | 1979834 | 1979776 | 1979776 | Missense_Mutation | C | T | p.T343I |
| SKUT1_SOFT_TISSUE | 1979162 | 1979247 | 1979247 | 1979247 | Splice_Site | G | T | p.K256N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSNK1G2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CSNK1G2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CSNK1G2 |
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RelatedDrugs for CSNK1G2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CSNK1G2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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