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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAP3K8 |
 Gene summary |
| Gene information | Gene symbol | MAP3K8 | Gene ID | 1326 |
| Gene name | mitogen-activated protein kinase kinase kinase 8 | |
| Synonyms | AURA2|COT|EST|ESTF|MEKK8|TPL2|Tpl-2|c-COT | |
| Cytomap | 10p11.23 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 8Ewing sarcoma transformantaugmented in rheumatoid arthritis 2cot (cancer Osaka thyroid) oncogeneproto-oncogene c-Cotproto-oncogene serine/threoine protein kinasetumor progression locus 2 | |
| Modification date | 20180523 | |
| UniProtAcc | P41279 | |
| Context | PubMed: MAP3K8 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MAP3K8 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAP3K8 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAP3K8 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_40316 | 10 | 30723172:30723307:30726104:30726335:30727844:30728203 | 30726104:30726335 | ENSG00000107968.5 | ENST00000375322.2 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENSG00000107968.5 | ENST00000415139.1,ENST00000542547.1 |
| exon_skip_40325 | 10 | 30739186:30739448:30740566:30740673:30747012:30747165 | 30740566:30740673 | ENSG00000107968.5 | ENST00000263056.1,ENST00000375321.1,ENST00000542547.1 |
| exon_skip_40326 | 10 | 30740566:30740673:30747012:30747165:30748183:30748430 | 30747012:30747165 | ENSG00000107968.5 | ENST00000263056.1,ENST00000375321.1,ENST00000542547.1 |
| exon_skip_40327 | 10 | 30747012:30747165:30748183:30748430:30749634:30749765 | 30748183:30748430 | ENSG00000107968.5 | ENST00000263056.1,ENST00000375321.1,ENST00000542547.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAP3K8 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_40316 | 10 | 30723172:30723307:30726104:30726335:30727844:30728203 | 30726104:30726335 | ENSG00000107968.5 | ENST00000375322.2 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENSG00000107968.5 | ENST00000542547.1,ENST00000415139.1 |
| exon_skip_40325 | 10 | 30739186:30739448:30740566:30740673:30747012:30747165 | 30740566:30740673 | ENSG00000107968.5 | ENST00000263056.1,ENST00000542547.1,ENST00000375321.1 |
| exon_skip_40326 | 10 | 30740566:30740673:30747012:30747165:30748183:30748430 | 30747012:30747165 | ENSG00000107968.5 | ENST00000263056.1,ENST00000542547.1,ENST00000375321.1 |
| exon_skip_40327 | 10 | 30747012:30747165:30748183:30748430:30749634:30749765 | 30748183:30748430 | ENSG00000107968.5 | ENST00000263056.1,ENST00000542547.1,ENST00000375321.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAP3K8 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000542547 | 30727844 | 30728203 | 5CDS-5UTR |
| ENST00000263056 | 30740566 | 30740673 | Frame-shift |
| ENST00000375321 | 30740566 | 30740673 | Frame-shift |
| ENST00000542547 | 30740566 | 30740673 | Frame-shift |
| ENST00000263056 | 30748183 | 30748430 | Frame-shift |
| ENST00000375321 | 30748183 | 30748430 | Frame-shift |
| ENST00000542547 | 30748183 | 30748430 | Frame-shift |
| ENST00000263056 | 30747012 | 30747165 | In-frame |
| ENST00000375321 | 30747012 | 30747165 | In-frame |
| ENST00000542547 | 30747012 | 30747165 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000542547 | 30727844 | 30728203 | 5CDS-5UTR |
| ENST00000263056 | 30740566 | 30740673 | Frame-shift |
| ENST00000375321 | 30740566 | 30740673 | Frame-shift |
| ENST00000542547 | 30740566 | 30740673 | Frame-shift |
| ENST00000263056 | 30748183 | 30748430 | Frame-shift |
| ENST00000375321 | 30748183 | 30748430 | Frame-shift |
| ENST00000542547 | 30748183 | 30748430 | Frame-shift |
| ENST00000263056 | 30747012 | 30747165 | In-frame |
| ENST00000375321 | 30747012 | 30747165 | In-frame |
| ENST00000542547 | 30747012 | 30747165 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP3K8 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263056 | 3113 | 467 | 30747012 | 30747165 | 1570 | 1722 | 291 | 342 |
| ENST00000375321 | 2535 | 467 | 30747012 | 30747165 | 991 | 1143 | 291 | 342 |
| ENST00000542547 | 1699 | 467 | 30747012 | 30747165 | 1152 | 1304 | 291 | 342 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263056 | 3113 | 467 | 30747012 | 30747165 | 1570 | 1722 | 291 | 342 |
| ENST00000375321 | 2535 | 467 | 30747012 | 30747165 | 991 | 1143 | 291 | 342 |
| ENST00000542547 | 1699 | 467 | 30747012 | 30747165 | 1152 | 1304 | 291 | 342 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41279 | 291 | 342 | 1 | 467 | Chain | ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8 |
| P41279 | 291 | 342 | 1 | 467 | Chain | ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8 |
| P41279 | 291 | 342 | 1 | 467 | Chain | ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8 |
| P41279 | 291 | 342 | 138 | 388 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P41279 | 291 | 342 | 138 | 388 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P41279 | 291 | 342 | 138 | 388 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P41279 | 291 | 342 | 291 | 293 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 291 | 293 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 291 | 293 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 296 | 300 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 296 | 300 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 296 | 300 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 307 | 322 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 307 | 322 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 307 | 322 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 340 | 346 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 340 | 346 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 340 | 346 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 326 | 330 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 326 | 330 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 326 | 330 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41279 | 291 | 342 | 1 | 467 | Chain | ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8 |
| P41279 | 291 | 342 | 1 | 467 | Chain | ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8 |
| P41279 | 291 | 342 | 1 | 467 | Chain | ID=PRO_0000024350;Note=Mitogen-activated protein kinase kinase kinase 8 |
| P41279 | 291 | 342 | 138 | 388 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P41279 | 291 | 342 | 138 | 388 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P41279 | 291 | 342 | 138 | 388 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P41279 | 291 | 342 | 291 | 293 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 291 | 293 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 291 | 293 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 296 | 300 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 296 | 300 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 296 | 300 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 307 | 322 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 307 | 322 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 307 | 322 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 340 | 346 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 340 | 346 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 340 | 346 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 326 | 330 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 326 | 330 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
| P41279 | 291 | 342 | 326 | 330 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Y85 |
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SNVs in the skipped exons for MAP3K8 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_40319 | 30727845 | 30728203 | 30727989 | 30727989 | Frame_Shift_Del | T | - | p.V41fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_40325 | 30740567 | 30740673 | 30740592 | 30740592 | Frame_Shift_Del | A | - | p.T264fs |
| LIHC | TCGA-BC-A3KG-01 | exon_skip_40327 | 30748184 | 30748430 | 30748322 | 30748322 | Frame_Shift_Del | A | - | p.N389fs |
| BLCA | TCGA-E7-A97Q-01 | exon_skip_40319 | 30727845 | 30728203 | 30728018 | 30728018 | Nonsense_Mutation | C | T | p.Q51* |
| LUAD | TCGA-49-6745-01 | exon_skip_40325 | 30740567 | 30740673 | 30740626 | 30740626 | Nonsense_Mutation | C | T | p.Q276* |
| ESCA | TCGA-JY-A6FH-01 | exon_skip_40325 | 30740567 | 30740673 | 30740566 | 30740566 | Splice_Site | G | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30748184 | 30748430 | 30748200 | 30748201 | Frame_Shift_Ins | - | A | p.P349fs |
| NCIH1793_LUNG | 30727845 | 30728203 | 30727883 | 30727883 | Missense_Mutation | A | C | p.T6P |
| JSC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30727845 | 30728203 | 30727931 | 30727931 | Missense_Mutation | A | C | p.N22H |
| CORL279_LUNG | 30727845 | 30728203 | 30727965 | 30727965 | Missense_Mutation | T | G | p.L33R |
| SW48_LARGE_INTESTINE | 30727845 | 30728203 | 30727986 | 30727986 | Missense_Mutation | C | T | p.A40V |
| SNU1033_LARGE_INTESTINE | 30727845 | 30728203 | 30728036 | 30728036 | Missense_Mutation | G | A | p.D57N |
| SQ1_LUNG | 30727845 | 30728203 | 30728081 | 30728081 | Missense_Mutation | T | C | p.W72R |
| 769P_KIDNEY | 30727845 | 30728203 | 30728082 | 30728082 | Missense_Mutation | G | T | p.W72L |
| BT474_BREAST | 30740567 | 30740673 | 30740612 | 30740612 | Missense_Mutation | T | A | p.F271Y |
| HEC151_ENDOMETRIUM | 30740567 | 30740673 | 30740659 | 30740659 | Missense_Mutation | C | A | p.L287I |
| HCT116_LARGE_INTESTINE | 30748184 | 30748430 | 30748217 | 30748217 | Missense_Mutation | G | A | p.A354T |
| HS939T_SKIN | 30748184 | 30748430 | 30748283 | 30748283 | Missense_Mutation | C | T | p.R376C |
| OUMS23_LARGE_INTESTINE | 30748184 | 30748430 | 30748310 | 30748310 | Missense_Mutation | C | T | p.H385Y |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30748184 | 30748430 | 30748347 | 30748347 | Missense_Mutation | G | A | p.R397H |
| ML1_THYROID | 30748184 | 30748430 | 30748354 | 30748354 | Missense_Mutation | G | C | p.Q399H |
| NCIH660_PROSTATE | 30748184 | 30748430 | 30748359 | 30748359 | Missense_Mutation | T | G | p.L401R |
| HEC108_ENDOMETRIUM | 30748184 | 30748430 | 30748379 | 30748379 | Missense_Mutation | C | T | p.R408C |
| SNU1040_LARGE_INTESTINE | 30748184 | 30748430 | 30748379 | 30748379 | Missense_Mutation | C | T | p.R408C |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30740567 | 30740673 | 30740662 | 30740662 | Nonsense_Mutation | C | T | p.R288* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP3K8 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | COAD | rs1042058 | chr10:30728101 | T/C | 3.42e-12 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | COAD | rs1042058 | chr10:30728101 | T/C | 3.42e-12 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | BLCA | rs1042058 | chr10:30728101 | T/C | 4.73e-09 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | BLCA | rs1042058 | chr10:30728101 | T/C | 4.74e-09 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | HNSC | rs1042058 | chr10:30728101 | T/C | 1.24e-10 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | HNSC | rs1042058 | chr10:30728101 | T/C | 1.24e-10 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | KIRP | rs1042058 | chr10:30728101 | T/C | 1.20e-05 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | KIRP | rs1042058 | chr10:30728101 | T/C | 1.20e-05 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LGG | rs1042058 | chr10:30728101 | T/C | 8.58e-08 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LGG | rs1042058 | chr10:30728101 | T/C | 8.58e-08 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | KIRC | rs1042058 | chr10:30728101 | T/C | 1.25e-18 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | KIRC | rs1042058 | chr10:30728101 | T/C | 1.25e-18 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LUAD | rs1042058 | chr10:30728101 | T/C | 1.67e-06 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LUAD | rs1042058 | chr10:30728101 | T/C | 1.67e-06 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LIHC | rs1042058 | chr10:30728101 | T/C | 1.97e-04 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LIHC | rs1042058 | chr10:30728101 | T/C | 1.97e-04 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LUSC | rs1042058 | chr10:30728101 | T/C | 8.94e-12 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | LUSC | rs1042058 | chr10:30728101 | T/C | 8.94e-12 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | OV | rs1042058 | chr10:30728101 | T/C | 8.57e-09 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | OV | rs1042058 | chr10:30728101 | T/C | 8.57e-09 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | READ | rs1042058 | chr10:30728101 | T/C | 1.88e-04 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | READ | rs1042058 | chr10:30728101 | T/C | 1.88e-04 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | PAAD | rs1042058 | chr10:30728101 | T/C | 3.64e-09 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | PAAD | rs1042058 | chr10:30728101 | T/C | 3.64e-09 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | PRAD | rs1042058 | chr10:30728101 | T/C | 2.02e-10 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | PRAD | rs1042058 | chr10:30728101 | T/C | 2.64e-09 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | SARC | rs1042058 | chr10:30728101 | T/C | 2.56e-06 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | SARC | rs1042058 | chr10:30728101 | T/C | 2.56e-06 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | TGCT | rs1042058 | chr10:30728101 | T/C | 4.40e-04 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | TGCT | rs1042058 | chr10:30728101 | T/C | 4.40e-04 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | STAD | rs1042058 | chr10:30728101 | T/C | 6.53e-06 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | STAD | rs1042058 | chr10:30728101 | T/C | 6.53e-06 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | THCA | rs1042058 | chr10:30728101 | T/C | 1.39e-12 |
| exon_skip_40319 | 10 | 30723172:30723307:30727844:30728203:30736710:30736878 | 30727844:30728203 | ENST00000415139.1,ENST00000542547.1 | THCA | rs1042058 | chr10:30728101 | T/C | 1.39e-12 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K8 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K8 |
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RelatedDrugs for MAP3K8 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP3K8 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAP3K8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| MAP3K8 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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