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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NKAIN4 |
 Gene summary |
| Gene information | Gene symbol | NKAIN4 | Gene ID | 128414 |
| Gene name | sodium/potassium transporting ATPase interacting 4 | |
| Synonyms | C20orf58|FAM77A|bA261N11.2 | |
| Cytomap | 20q13.33 | |
| Type of gene | protein-coding | |
| Description | sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4Na+/K+ transporting ATPase interacting 4 | |
| Modification date | 20180529 | |
| UniProtAcc | Q8IVV8 | |
| Context | PubMed: NKAIN4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for NKAIN4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NKAIN4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NKAIN4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358620 | 20 | 61872741:61872858:61873890:61873975:61875375:61875436 | 61873890:61873975 | ENSG00000101198.10 | ENST00000470246.1,ENST00000370316.3,ENST00000466885.1,ENST00000370307.2 |
| exon_skip_358624 | 20 | 61873079:61873104:61873890:61873975:61875375:61875436 | 61873890:61873975 | ENSG00000101198.10 | ENST00000370317.3 |
| exon_skip_358629 | 20 | 61875423:61875436:61875821:61875895:61878929:61879122 | 61875821:61875895 | ENSG00000101198.10 | ENST00000370317.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NKAIN4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358620 | 20 | 61872741:61872858:61873890:61873975:61875375:61875436 | 61873890:61873975 | ENSG00000101198.10 | ENST00000370316.3,ENST00000466885.1,ENST00000470246.1,ENST00000370307.2 |
| exon_skip_358629 | 20 | 61875423:61875436:61875821:61875895:61878929:61879122 | 61875821:61875895 | ENSG00000101198.10 | ENST00000370317.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NKAIN4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370316 | 61873890 | 61873975 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370316 | 61873890 | 61873975 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NKAIN4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for NKAIN4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-FD-A3B3-01 | exon_skip_358624 exon_skip_358620 | 61873891 | 61873975 | 61873940 | 61873941 | Frame_Shift_Del | AG | - | p.L189fs |
| BLCA | TCGA-FD-A3B3-01 | exon_skip_358624 exon_skip_358620 | 61873891 | 61873975 | 61873940 | 61873941 | Frame_Shift_Del | AG | - | p.Y190fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CHLA06ATRT_SOFT_TISSUE | 61873891 | 61873975 | 61873913 | 61873913 | Missense_Mutation | G | C | p.L199V |
| MCC26_SKIN | 61873891 | 61873975 | 61873951 | 61873951 | Missense_Mutation | G | A | p.P186L |
| NCIH1694_LUNG | 61873891 | 61873975 | 61873969 | 61873969 | Missense_Mutation | A | T | p.F180Y |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NKAIN4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NKAIN4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NKAIN4 |
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RelatedDrugs for NKAIN4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NKAIN4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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