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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for DRAM2

check button Gene summary
Gene informationGene symbol

DRAM2

Gene ID

128338

Gene nameDNA damage regulated autophagy modulator 2
SynonymsCORD21|PRO180|TMEM77|WWFQ154
Cytomap

1p13.3

Type of geneprotein-coding
DescriptionDNA damage-regulated autophagy modulator protein 2damage regulated autophagy modulator 2transmembrane protein 77
Modification date20180523
UniProtAcc

Q6UX65

ContextPubMed: DRAM2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
DRAM2

GO:0010506

regulation of autophagy

19895784


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Exon skipping events across known transcript of Ensembl for DRAM2 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for DRAM2

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for DRAM2

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENSG00000156171.10ENST00000477769.1
exon_skip_291131111662498:111662581:111663137:111663315:111667363:111667503111663137:111663315ENSG00000156171.10ENST00000286692.4,ENST00000539140.1,ENST00000484310.1
exon_skip_291141111662498:111662581:111663137:111663315:111668848:111668916111663137:111663315ENSG00000156171.10ENST00000461449.1
exon_skip_291331111663291:111663315:111665237:111665265:111668848:111668916111665237:111665265ENSG00000156171.10ENST00000496430.2
exon_skip_291341111663291:111663315:111667363:111667503:111668848:111668916111667363:111667503ENSG00000156171.10ENST00000286692.4,ENST00000539140.1,ENST00000484310.1,ENST00000462092.1
exon_skip_291361111663291:111663315:111668848:111668916:111674045:111674190111668848:111668916ENSG00000156171.10ENST00000480600.2
exon_skip_291391111667363:111667503:111668848:111668916:111674045:111674190111668848:111668916ENSG00000156171.10ENST00000286692.4,ENST00000539140.1,ENST00000484310.1,ENST00000462092.1
exon_skip_291431111668848:111668916:111674045:111674190:111680144:111680208111674045:111674190ENSG00000156171.10ENST00000463682.1,ENST00000286692.4,ENST00000490780.1,ENST00000539140.1,ENST00000484310.1,ENST00000480600.2,ENST00000462092.1,ENST00000496430.2
exon_skip_291451111674045:111674190:111680144:111680208:111682122:111682142111680144:111680208ENSG00000156171.10ENST00000490780.1,ENST00000462092.1
exon_skip_291461111674045:111674190:111680144:111680208:111682659:111682684111680144:111680208ENSG00000156171.10ENST00000539140.1,ENST00000484310.1
exon_skip_291481111680144:111680208:111681687:111681745:111682122:111682142111681687:111681745ENSG00000156171.10ENST00000480600.2
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENSG00000156171.10ENST00000490780.1,ENST00000462092.1
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENSG00000156171.10ENST00000463682.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for DRAM2

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENSG00000156171.10ENST00000477769.1
exon_skip_291131111662498:111662581:111663137:111663315:111667363:111667503111663137:111663315ENSG00000156171.10ENST00000286692.4,ENST00000484310.1,ENST00000539140.1
exon_skip_291141111662498:111662581:111663137:111663315:111668848:111668916111663137:111663315ENSG00000156171.10ENST00000461449.1
exon_skip_291331111663291:111663315:111665237:111665265:111668848:111668916111665237:111665265ENSG00000156171.10ENST00000496430.2
exon_skip_291341111663291:111663315:111667363:111667503:111668848:111668916111667363:111667503ENSG00000156171.10ENST00000286692.4,ENST00000484310.1,ENST00000539140.1,ENST00000462092.1
exon_skip_291361111663291:111663315:111668848:111668916:111674045:111674190111668848:111668916ENSG00000156171.10ENST00000480600.2
exon_skip_291391111667363:111667503:111668848:111668916:111674045:111674190111668848:111668916ENSG00000156171.10ENST00000286692.4,ENST00000484310.1,ENST00000539140.1,ENST00000462092.1
exon_skip_291431111668848:111668916:111674045:111674190:111680144:111680208111674045:111674190ENSG00000156171.10ENST00000286692.4,ENST00000484310.1,ENST00000539140.1,ENST00000496430.2,ENST00000480600.2,ENST00000462092.1,ENST00000490780.1,ENST00000463682.1
exon_skip_291451111674045:111674190:111680144:111680208:111682122:111682142111680144:111680208ENSG00000156171.10ENST00000462092.1,ENST00000490780.1
exon_skip_291461111674045:111674190:111680144:111680208:111682659:111682684111680144:111680208ENSG00000156171.10ENST00000484310.1,ENST00000539140.1
exon_skip_291481111680144:111680208:111681687:111681745:111682122:111682142111681687:111681745ENSG00000156171.10ENST00000480600.2
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENSG00000156171.10ENST00000462092.1,ENST00000490780.1
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENSG00000156171.10ENST00000463682.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for DRAM2

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002866921116740451116741903UTR-3CDS
ENST000005391401116740451116741903UTR-3CDS
ENST000005391401116801441116802083UTR-3UTR
ENST00000286692111663137111663315Frame-shift
ENST00000539140111663137111663315Frame-shift
ENST00000286692111667363111667503Frame-shift
ENST00000539140111667363111667503Frame-shift
ENST00000286692111668848111668916Frame-shift
ENST00000539140111668848111668916Frame-shift

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002866921116740451116741903UTR-3CDS
ENST000005391401116740451116741903UTR-3CDS
ENST000005391401116801441116802083UTR-3UTR
ENST00000286692111663137111663315Frame-shift
ENST00000539140111663137111663315Frame-shift
ENST00000286692111667363111667503Frame-shift
ENST00000539140111667363111667503Frame-shift
ENST00000286692111668848111668916Frame-shift
ENST00000539140111668848111668916Frame-shift

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Infer the effects of exon skipping event on protein functional features for DRAM2

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for DRAM2

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A39Y-01exon_skip_29114
exon_skip_29113
111663138111663315111663306111663306Frame_Shift_DelG-p.L117fs
LIHCTCGA-DD-A1EG-01exon_skip_29139
exon_skip_29136
111668849111668916111668889111668889Frame_Shift_DelT-p.K53fs
CHOLTCGA-W5-AA2R-01exon_skip_29114
exon_skip_29113
111663138111663315111663216111663216Nonsense_MutationGAp.Q147*
UCECTCGA-AP-A054-01exon_skip_29114
exon_skip_29113
111663138111663315111663136111663136Splice_SiteAGe4+2

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
HEC6_ENDOMETRIUM111663138111663315111663242111663242Missense_MutationAGp.V138A
SNGM_ENDOMETRIUM111663138111663315111663249111663249Missense_MutationTCp.M136V
SNU175_LARGE_INTESTINE111663138111663315111663261111663261Missense_MutationCTp.G132S
NCIH1573_LUNG111667364111667503111667492111667492Missense_MutationTCp.I71V
HEC6_ENDOMETRIUM111674046111674190111674052111674052Missense_MutationTCp.Y42C
NCIH1355_LUNG111674046111674190111674061111674061Missense_MutationGCp.A39G
KNS42_CENTRAL_NERVOUS_SYSTEM111674046111674190111674152111674152Missense_MutationTCp.S9G

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DRAM2

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1BLCArs1043096chr1:111682307C/G1.17e-03
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1HNSCrs1043096chr1:111682307C/G3.90e-05
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1KIRPrs1043096chr1:111682307C/G1.25e-03
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1LGGrs1043096chr1:111682307C/G5.64e-06
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1KIRCrs1043096chr1:111682307C/G8.02e-04
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1LUADrs1043096chr1:111682307C/G3.43e-04
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1LIHCrs1043096chr1:111682307C/G6.78e-04
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1LUSCrs1043096chr1:111682307C/G8.64e-05
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1STADrs1043096chr1:111682307C/G9.29e-04
exon_skip_291631111680144:111680208:111682209:111682333:111682659:111682684111682209:111682333ENST00000463682.1THCArs1043096chr1:111682307C/G2.63e-05
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1CESCrs644081chr1:111662236C/T4.72e-05
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1COADrs644081chr1:111662236C/T1.19e-04
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1BLCArs644081chr1:111662236C/T2.50e-05
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1ESCArs644081chr1:111662236C/T1.09e-04
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1HNSCrs644081chr1:111662236C/T5.48e-10
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1BRCArs644081chr1:111662236C/T7.14e-16
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1KIRPrs644081chr1:111662236C/T1.75e-05
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1KIRCrs644081chr1:111662236C/T9.46e-10
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1LUADrs644081chr1:111662236C/T8.92e-08
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1LIHCrs644081chr1:111662236C/T3.34e-04
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1LUSCrs644081chr1:111662236C/T3.94e-07
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1OVrs644081chr1:111662236C/T1.65e-04
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1PCPGrs644081chr1:111662236C/T6.27e-04
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1PAADrs644081chr1:111662236C/T1.42e-04
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1PRADrs644081chr1:111662236C/T1.34e-05
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1STADrs644081chr1:111662236C/T3.32e-05
exon_skip_291061111661486:111661519:111662236:111662303:111662498:111662581111662236:111662303ENST00000477769.1THCArs644081chr1:111662236C/T8.89e-08
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1GBMrs3762374chr1:111682118C/T2.78e-44
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1CESCrs3762374chr1:111682118C/T7.76e-70
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1COADrs3762374chr1:111682118C/T3.41e-92
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1BLCArs3762374chr1:111682118C/T1.21e-105
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1ESCArs3762374chr1:111682118C/T5.51e-44
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1HNSCrs3762374chr1:111682118C/T2.31e-128
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1BRCArs3762374chr1:111682118C/T2.23e-308
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1KICHrs3762374chr1:111682118C/T1.39e-07
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1LAMLrs3762374chr1:111682118C/T1.09e-39
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1KIRPrs3762374chr1:111682118C/T1.11e-66
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1KIRCrs3762374chr1:111682118C/T5.77e-161
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1LUADrs3762374chr1:111682118C/T2.40e-168
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1LUSCrs3762374chr1:111682118C/T2.33e-145
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1OVrs3762374chr1:111682118C/T2.22e-91
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1READrs3762374chr1:111682118C/T2.01e-21
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1PAADrs3762374chr1:111682118C/T7.83e-51
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1PRADrs3762374chr1:111682118C/T5.79e-164
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1THYMrs3762374chr1:111682118C/T1.10e-36
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1TGCTrs3762374chr1:111682118C/T7.24e-53
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1SKCMrs3762374chr1:111682118C/T9.71e-29
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1STADrs3762374chr1:111682118C/T2.75e-104
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1THCArs3762374chr1:111682118C/T2.33e-187
exon_skip_291521111680144:111680208:111682122:111682288:111682659:111682684111682122:111682288ENST00000490780.1,ENST00000462092.1UCECrs3762374chr1:111682118C/T1.45e-63

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DRAM2


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DRAM2


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RelatedDrugs for DRAM2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DRAM2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource