|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for FCHO2 |
 Gene summary |
| Gene information | Gene symbol | FCHO2 | Gene ID | 115548 |
| Gene name | FCH domain only 2 | |
| Synonyms | - | |
| Cytomap | 5q13.2 | |
| Type of gene | protein-coding | |
| Description | F-BAR domain only protein 2FCH domain only protein 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q0JRZ9 | |
| Context | PubMed: FCHO2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Exon skipping events across known transcript of Ensembl for FCHO2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for FCHO2 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for FCHO2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_435571 | 5 | 72251897:72251956:72264324:72264416:72285253:72285328 | 72264324:72264416 | ENSG00000157107.9 | ENST00000341845.6,ENST00000512348.1,ENST00000287761.6 |
| exon_skip_435572 | 5 | 72264324:72264416:72285253:72285328:72286304:72286446 | 72285253:72285328 | ENSG00000157107.9 | ENST00000341845.6,ENST00000512348.1,ENST00000287761.6,ENST00000430046.2 |
| exon_skip_435573 | 5 | 72286304:72286446:72286538:72286691:72302271:72302376 | 72286538:72286691 | ENSG00000157107.9 | ENST00000507345.2,ENST00000341845.6,ENST00000512348.1,ENST00000287761.6,ENST00000430046.2 |
| exon_skip_435574 | 5 | 72286538:72286691:72302271:72302376:72311452:72311551 | 72302271:72302376 | ENSG00000157107.9 | ENST00000507345.2,ENST00000341845.6,ENST00000287761.6,ENST00000430046.2 |
| exon_skip_435575 | 5 | 72286538:72286691:72302271:72302376:72313038:72313109 | 72302271:72302376 | ENSG00000157107.9 | ENST00000512348.1 |
| exon_skip_435580 | 5 | 72302271:72302376:72311452:72311551:72313038:72313109 | 72311452:72311551 | ENSG00000157107.9 | ENST00000507345.2,ENST00000341845.6,ENST00000287761.6,ENST00000430046.2 |
| exon_skip_435581 | 5 | 72302271:72302376:72313038:72313135:72330483:72330528 | 72313038:72313135 | ENSG00000157107.9 | ENST00000512348.1 |
| exon_skip_435582 | 5 | 72332969:72333042:72337117:72337142:72347175:72347233 | 72337117:72337142 | ENSG00000157107.9 | ENST00000341845.6,ENST00000512348.1,ENST00000430046.2 |
| exon_skip_435584 | 5 | 72354259:72354351:72359667:72359771:72364476:72364606 | 72359667:72359771 | ENSG00000157107.9 | ENST00000508431.1,ENST00000341845.6,ENST00000512348.1,ENST00000430046.2 |
| exon_skip_435591 | 5 | 72373164:72373320:72374006:72374139:72377609:72377809 | 72374006:72374139 | ENSG00000157107.9 | ENST00000341845.6,ENST00000512348.1,ENST00000430046.2 |
| exon_skip_435595 | 5 | 72374006:72374139:72377609:72377809:72378587:72378652 | 72377609:72377809 | ENSG00000157107.9 | ENST00000341845.6,ENST00000512348.1,ENST00000430046.2 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for FCHO2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_435571 | 5 | 72251897:72251956:72264324:72264416:72285253:72285328 | 72264324:72264416 | ENSG00000157107.9 | ENST00000341845.6,ENST00000512348.1,ENST00000287761.6 |
| exon_skip_435572 | 5 | 72264324:72264416:72285253:72285328:72286304:72286446 | 72285253:72285328 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000512348.1,ENST00000287761.6 |
| exon_skip_435573 | 5 | 72286304:72286446:72286538:72286691:72302271:72302376 | 72286538:72286691 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000507345.2,ENST00000512348.1,ENST00000287761.6 |
| exon_skip_435574 | 5 | 72286538:72286691:72302271:72302376:72311452:72311551 | 72302271:72302376 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000507345.2,ENST00000287761.6 |
| exon_skip_435575 | 5 | 72286538:72286691:72302271:72302376:72313038:72313109 | 72302271:72302376 | ENSG00000157107.9 | ENST00000512348.1 |
| exon_skip_435580 | 5 | 72302271:72302376:72311452:72311551:72313038:72313109 | 72311452:72311551 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000507345.2,ENST00000287761.6 |
| exon_skip_435581 | 5 | 72302271:72302376:72313038:72313135:72330483:72330528 | 72313038:72313135 | ENSG00000157107.9 | ENST00000512348.1 |
| exon_skip_435582 | 5 | 72332969:72333042:72337117:72337142:72347175:72347233 | 72337117:72337142 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000512348.1 |
| exon_skip_435584 | 5 | 72354259:72354351:72359667:72359771:72364476:72364606 | 72359667:72359771 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000512348.1,ENST00000508431.1 |
| exon_skip_435591 | 5 | 72373164:72373320:72374006:72374139:72377609:72377809 | 72374006:72374139 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000512348.1 |
| exon_skip_435595 | 5 | 72374006:72374139:72377609:72377809:72378587:72378652 | 72377609:72377809 | ENSG00000157107.9 | ENST00000430046.2,ENST00000341845.6,ENST00000512348.1 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for FCHO2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000430046 | 72337117 | 72337142 | Frame-shift |
| ENST00000430046 | 72359667 | 72359771 | Frame-shift |
| ENST00000430046 | 72374006 | 72374139 | Frame-shift |
| ENST00000430046 | 72377609 | 72377809 | Frame-shift |
| ENST00000430046 | 72285253 | 72285328 | In-frame |
| ENST00000430046 | 72286538 | 72286691 | In-frame |
| ENST00000430046 | 72302271 | 72302376 | In-frame |
| ENST00000430046 | 72311452 | 72311551 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000430046 | 72337117 | 72337142 | Frame-shift |
| ENST00000430046 | 72359667 | 72359771 | Frame-shift |
| ENST00000430046 | 72374006 | 72374139 | Frame-shift |
| ENST00000430046 | 72377609 | 72377809 | Frame-shift |
| ENST00000430046 | 72285253 | 72285328 | In-frame |
| ENST00000430046 | 72286538 | 72286691 | In-frame |
| ENST00000430046 | 72302271 | 72302376 | In-frame |
| ENST00000430046 | 72311452 | 72311551 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for FCHO2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000430046 | 4998 | 810 | 72285253 | 72285328 | 242 | 316 | 42 | 66 |
| ENST00000430046 | 4998 | 810 | 72286538 | 72286691 | 459 | 611 | 114 | 165 |
| ENST00000430046 | 4998 | 810 | 72302271 | 72302376 | 612 | 716 | 165 | 200 |
| ENST00000430046 | 4998 | 810 | 72311452 | 72311551 | 717 | 815 | 200 | 233 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000430046 | 4998 | 810 | 72285253 | 72285328 | 242 | 316 | 42 | 66 |
| ENST00000430046 | 4998 | 810 | 72286538 | 72286691 | 459 | 611 | 114 | 165 |
| ENST00000430046 | 4998 | 810 | 72302271 | 72302376 | 612 | 716 | 165 | 200 |
| ENST00000430046 | 4998 | 810 | 72311452 | 72311551 | 717 | 815 | 200 | 233 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q0JRZ9 | 42 | 66 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 42 | 66 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 42 | 66 | 17 | 61 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 42 | 66 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
| Q0JRZ9 | 114 | 165 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 114 | 165 | 87 | 156 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q0JRZ9 | 114 | 165 | 147 | 147 | Disulfide bond | Note=Interchain (with C-273);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17540576;Dbxref=PMID:17540576 |
| Q0JRZ9 | 114 | 165 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 114 | 165 | 73 | 118 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 114 | 165 | 120 | 156 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 114 | 165 | 160 | 244 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 114 | 165 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
| Q0JRZ9 | 165 | 200 | 200 | 232 | Alternative sequence | ID=VSP_044812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q0JRZ9 | 165 | 200 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 165 | 200 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 165 | 200 | 160 | 244 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 165 | 200 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
| Q0JRZ9 | 200 | 233 | 200 | 232 | Alternative sequence | ID=VSP_044812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q0JRZ9 | 200 | 233 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 200 | 233 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 200 | 233 | 160 | 244 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 200 | 233 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q0JRZ9 | 42 | 66 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 42 | 66 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 42 | 66 | 17 | 61 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 42 | 66 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
| Q0JRZ9 | 114 | 165 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 114 | 165 | 87 | 156 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q0JRZ9 | 114 | 165 | 147 | 147 | Disulfide bond | Note=Interchain (with C-273);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17540576;Dbxref=PMID:17540576 |
| Q0JRZ9 | 114 | 165 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 114 | 165 | 73 | 118 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 114 | 165 | 120 | 156 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 114 | 165 | 160 | 244 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 114 | 165 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
| Q0JRZ9 | 165 | 200 | 200 | 232 | Alternative sequence | ID=VSP_044812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q0JRZ9 | 165 | 200 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 165 | 200 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 165 | 200 | 160 | 244 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 165 | 200 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
| Q0JRZ9 | 200 | 233 | 200 | 232 | Alternative sequence | ID=VSP_044812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q0JRZ9 | 200 | 233 | 1 | 810 | Chain | ID=PRO_0000266005;Note=F-BAR domain only protein 2 |
| Q0JRZ9 | 200 | 233 | 3 | 250 | Domain | Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 |
| Q0JRZ9 | 200 | 233 | 160 | 244 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2V0O |
| Q0JRZ9 | 200 | 233 | 3 | 274 | Region | Note=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation |
Top |
SNVs in the skipped exons for FCHO2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-G4-6586-01 | exon_skip_435571 | 72264325 | 72264416 | 72264329 | 72264330 | Frame_Shift_Del | AA | - | p.13_13del |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_435571 | 72264325 | 72264416 | 72264329 | 72264329 | Frame_Shift_Del | A | - | p.E13fs |
| HNSC | TCGA-CV-7250-01 | exon_skip_435581 | 72313039 | 72313135 | 72313079 | 72313086 | Frame_Shift_Del | TTGAAAGT | - | p.VES247fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_435581 | 72313039 | 72313135 | 72313110 | 72313110 | Frame_Shift_Del | A | - | p.S257fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_435581 | 72313039 | 72313135 | 72313125 | 72313125 | Frame_Shift_Del | G | - | p.K262fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_435584 | 72359668 | 72359771 | 72359732 | 72359732 | Frame_Shift_Del | A | - | p.P470fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_435591 | 72374007 | 72374139 | 72374077 | 72374077 | Frame_Shift_Del | A | - | p.K641fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_435591 | 72374007 | 72374139 | 72374098 | 72374098 | Frame_Shift_Del | C | - | p.P647fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_435591 | 72374007 | 72374139 | 72374106 | 72374106 | Frame_Shift_Del | T | - | p.A649fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_435595 | 72377610 | 72377809 | 72377661 | 72377661 | Frame_Shift_Del | A | - | p.K678fs |
| BLCA | TCGA-E7-A97P-01 | exon_skip_435595 | 72377610 | 72377809 | 72377796 | 72377797 | Frame_Shift_Del | CC | - | p.P724fs |
| COAD | TCGA-AZ-6598-01 | exon_skip_435571 | 72264325 | 72264416 | 72264328 | 72264329 | Frame_Shift_Ins | - | A | p.E13fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_435584 | 72359668 | 72359771 | 72359766 | 72359767 | Frame_Shift_Ins | - | A | p.N482fs |
| KIRC | TCGA-A3-A8OV-01 | exon_skip_435575 exon_skip_435574 | 72302272 | 72302376 | 72302307 | 72302307 | Nonsense_Mutation | T | G | p.Y177X |
| SKCM | TCGA-W3-A828-06 | exon_skip_435580 | 72311453 | 72311551 | 72311459 | 72311459 | Nonsense_Mutation | C | T | p.Q203* |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_435595 | 72377610 | 72377809 | 72377614 | 72377614 | Nonsense_Mutation | C | A | p.S662* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LNCAPCLONEFGC_PROSTATE | 72264325 | 72264416 | 72264329 | 72264329 | Frame_Shift_Del | A | - | p.E13fs |
| MDAPCA2B_PROSTATE | 72264325 | 72264416 | 72264329 | 72264329 | Frame_Shift_Del | A | - | p.E13fs |
| CAL51_BREAST | 72264325 | 72264416 | 72264329 | 72264329 | Frame_Shift_Del | A | - | p.E13fs |
| CCK81_LARGE_INTESTINE | 72264325 | 72264416 | 72264329 | 72264329 | Frame_Shift_Del | A | - | p.E13fs |
| 2313287_STOMACH | 72264325 | 72264416 | 72264329 | 72264329 | Frame_Shift_Del | A | - | p.E13fs |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 72264325 | 72264416 | 72264329 | 72264329 | Frame_Shift_Del | A | - | p.E13fs |
| OVMIU_OVARY | 72286539 | 72286691 | 72286549 | 72286550 | Missense_Mutation | AA | TT | p.E118V |
| NCIH630_LARGE_INTESTINE | 72286539 | 72286691 | 72286651 | 72286651 | Missense_Mutation | G | A | p.R152H |
| BC3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 72359668 | 72359771 | 72359682 | 72359682 | Missense_Mutation | C | T | p.P454S |
| HEC151_ENDOMETRIUM | 72374007 | 72374139 | 72374083 | 72374083 | Missense_Mutation | C | A | p.L642M |
| NCIH441_LUNG | 72377610 | 72377809 | 72377626 | 72377626 | Missense_Mutation | T | C | p.I666T |
| HUG1N_STOMACH | 72377610 | 72377809 | 72377685 | 72377685 | Missense_Mutation | C | T | p.L686F |
| HSC2_UPPER_AERODIGESTIVE_TRACT | 72377610 | 72377809 | 72377698 | 72377698 | Missense_Mutation | A | G | p.Y690C |
| HEC6_ENDOMETRIUM | 72377610 | 72377809 | 72377710 | 72377710 | Missense_Mutation | C | T | p.P694L |
| CP66MEL_SKIN | 72377610 | 72377809 | 72377754 | 72377754 | Missense_Mutation | G | A | p.V709M |
| JHUEM7_ENDOMETRIUM | 72286539 | 72286691 | 72286680 | 72286680 | Nonsense_Mutation | G | T | p.E162* |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCHO2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCHO2 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCHO2 |
Top |
RelatedDrugs for FCHO2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FCHO2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|