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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLC26A7 |
 Gene summary |
| Gene information | Gene symbol | SLC26A7 | Gene ID | 115111 |
| Gene name | solute carrier family 26 member 7 | |
| Synonyms | SUT2 | |
| Cytomap | 8q21.3 | |
| Type of gene | protein-coding | |
| Description | anion exchange transportersolute carrier family 26 (anion exchanger), member 7sulfate anion transporter | |
| Modification date | 20180523 | |
| UniProtAcc | Q8TE54 | |
| Context | PubMed: SLC26A7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC26A7 | GO:0006820 | anion transport | 11834742 |
| SLC26A7 | GO:0006821 | chloride transport | 1183472 |
| SLC26A7 | GO:0008272 | sulfate transport | 1183472 |
| SLC26A7 | GO:0019532 | oxalate transport | 1183472 |
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Exon skipping events across known transcript of Ensembl for SLC26A7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC26A7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC26A7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_484562 | 8 | 92261846:92262072:92301363:92301474:92307758:92307931 | 92301363:92301474 | ENSG00000147606.4 | ENST00000523719.1,ENST00000276609.3,ENST00000522862.1,ENST00000309536.2,ENST00000522181.1 |
| exon_skip_484568 | 8 | 92307851:92307931:92330443:92330608:92346522:92346675 | 92330443:92330608 | ENSG00000147606.4 | ENST00000523719.1,ENST00000276609.3,ENST00000309536.2,ENST00000520818.1,ENST00000522181.1 |
| exon_skip_484569 | 8 | 92330443:92330608:92346522:92346675:92352631:92352779 | 92346522:92346675 | ENSG00000147606.4 | ENST00000522181.1 |
| exon_skip_484570 | 8 | 92346522:92346675:92350377:92350460:92352631:92352704 | 92350377:92350460 | ENSG00000147606.4 | ENST00000523719.1,ENST00000276609.3,ENST00000309536.2,ENST00000520818.1 |
| exon_skip_484573 | 8 | 92352631:92352779:92355580:92355694:92364037:92364115 | 92355580:92355694 | ENSG00000147606.4 | ENST00000523719.1,ENST00000276609.3,ENST00000309536.2,ENST00000522181.1 |
| exon_skip_484585 | 8 | 92355580:92355694:92364037:92364115:92365128:92365224 | 92364037:92364115 | ENSG00000147606.4 | ENST00000523719.1,ENST00000520249.1,ENST00000276609.3,ENST00000309536.2,ENST00000522181.1 |
| exon_skip_484594 | 8 | 92375699:92375766:92378807:92378945:92382012:92382061 | 92378807:92378945 | ENSG00000147606.4 | ENST00000523719.1,ENST00000520249.1,ENST00000517930.1,ENST00000276609.3,ENST00000309536.2,ENST00000522181.1 |
| exon_skip_484596 | 8 | 92378819:92378945:92382012:92382061:92401565:92401666 | 92382012:92382061 | ENSG00000147606.4 | ENST00000523719.1,ENST00000520249.1,ENST00000517930.1,ENST00000276609.3,ENST00000309536.2,ENST00000522181.1 |
| exon_skip_484598 | 8 | 92406024:92406079:92406163:92406267:92407289:92407877 | 92406163:92406267 | ENSG00000147606.4 | ENST00000523719.1,ENST00000520249.1,ENST00000276609.3,ENST00000522181.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC26A7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_484562 | 8 | 92261846:92262072:92301363:92301474:92307758:92307931 | 92301363:92301474 | ENSG00000147606.4 | ENST00000522181.1,ENST00000522862.1,ENST00000523719.1,ENST00000276609.3,ENST00000309536.2 |
| exon_skip_484568 | 8 | 92307851:92307931:92330443:92330608:92346522:92346675 | 92330443:92330608 | ENSG00000147606.4 | ENST00000522181.1,ENST00000523719.1,ENST00000276609.3,ENST00000309536.2,ENST00000520818.1 |
| exon_skip_484569 | 8 | 92330443:92330608:92346522:92346675:92352631:92352779 | 92346522:92346675 | ENSG00000147606.4 | ENST00000522181.1 |
| exon_skip_484570 | 8 | 92346522:92346675:92350377:92350460:92352631:92352704 | 92350377:92350460 | ENSG00000147606.4 | ENST00000523719.1,ENST00000276609.3,ENST00000309536.2,ENST00000520818.1 |
| exon_skip_484573 | 8 | 92352631:92352779:92355580:92355694:92364037:92364115 | 92355580:92355694 | ENSG00000147606.4 | ENST00000522181.1,ENST00000523719.1,ENST00000276609.3,ENST00000309536.2 |
| exon_skip_484594 | 8 | 92375699:92375766:92378807:92378945:92382012:92382061 | 92378807:92378945 | ENSG00000147606.4 | ENST00000522181.1,ENST00000523719.1,ENST00000276609.3,ENST00000309536.2,ENST00000520249.1,ENST00000517930.1 |
| exon_skip_484596 | 8 | 92378819:92378945:92382012:92382061:92401565:92401666 | 92382012:92382061 | ENSG00000147606.4 | ENST00000522181.1,ENST00000523719.1,ENST00000276609.3,ENST00000309536.2,ENST00000520249.1,ENST00000517930.1 |
| exon_skip_484598 | 8 | 92406024:92406079:92406163:92406267:92407289:92407877 | 92406163:92406267 | ENSG00000147606.4 | ENST00000522181.1,ENST00000523719.1,ENST00000276609.3,ENST00000520249.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC26A7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276609 | 92350377 | 92350460 | Frame-shift |
| ENST00000523719 | 92350377 | 92350460 | Frame-shift |
| ENST00000276609 | 92382012 | 92382061 | Frame-shift |
| ENST00000523719 | 92382012 | 92382061 | Frame-shift |
| ENST00000276609 | 92406163 | 92406267 | Frame-shift |
| ENST00000523719 | 92406163 | 92406267 | Frame-shift |
| ENST00000276609 | 92301363 | 92301474 | In-frame |
| ENST00000523719 | 92301363 | 92301474 | In-frame |
| ENST00000276609 | 92330443 | 92330608 | In-frame |
| ENST00000523719 | 92330443 | 92330608 | In-frame |
| ENST00000276609 | 92355580 | 92355694 | In-frame |
| ENST00000523719 | 92355580 | 92355694 | In-frame |
| ENST00000276609 | 92364037 | 92364115 | In-frame |
| ENST00000523719 | 92364037 | 92364115 | In-frame |
| ENST00000276609 | 92378807 | 92378945 | In-frame |
| ENST00000523719 | 92378807 | 92378945 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276609 | 92350377 | 92350460 | Frame-shift |
| ENST00000523719 | 92350377 | 92350460 | Frame-shift |
| ENST00000276609 | 92382012 | 92382061 | Frame-shift |
| ENST00000523719 | 92382012 | 92382061 | Frame-shift |
| ENST00000276609 | 92406163 | 92406267 | Frame-shift |
| ENST00000523719 | 92406163 | 92406267 | Frame-shift |
| ENST00000276609 | 92301363 | 92301474 | In-frame |
| ENST00000523719 | 92301363 | 92301474 | In-frame |
| ENST00000276609 | 92330443 | 92330608 | In-frame |
| ENST00000523719 | 92330443 | 92330608 | In-frame |
| ENST00000276609 | 92355580 | 92355694 | In-frame |
| ENST00000523719 | 92355580 | 92355694 | In-frame |
| ENST00000276609 | 92378807 | 92378945 | In-frame |
| ENST00000523719 | 92378807 | 92378945 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC26A7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276609 | 5280 | 656 | 92301363 | 92301474 | 433 | 543 | 64 | 101 |
| ENST00000523719 | 2919 | 656 | 92301363 | 92301474 | 466 | 576 | 64 | 101 |
| ENST00000276609 | 5280 | 656 | 92330443 | 92330608 | 717 | 881 | 159 | 214 |
| ENST00000523719 | 2919 | 656 | 92330443 | 92330608 | 750 | 914 | 159 | 214 |
| ENST00000276609 | 5280 | 656 | 92355580 | 92355694 | 1266 | 1379 | 342 | 380 |
| ENST00000523719 | 2919 | 656 | 92355580 | 92355694 | 1299 | 1412 | 342 | 380 |
| ENST00000276609 | 5280 | 656 | 92364037 | 92364115 | 1380 | 1457 | 380 | 406 |
| ENST00000523719 | 2919 | 656 | 92364037 | 92364115 | 1413 | 1490 | 380 | 406 |
| ENST00000276609 | 5280 | 656 | 92378807 | 92378945 | 1728 | 1865 | 496 | 542 |
| ENST00000523719 | 2919 | 656 | 92378807 | 92378945 | 1761 | 1898 | 496 | 542 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276609 | 5280 | 656 | 92301363 | 92301474 | 433 | 543 | 64 | 101 |
| ENST00000523719 | 2919 | 656 | 92301363 | 92301474 | 466 | 576 | 64 | 101 |
| ENST00000276609 | 5280 | 656 | 92330443 | 92330608 | 717 | 881 | 159 | 214 |
| ENST00000523719 | 2919 | 656 | 92330443 | 92330608 | 750 | 914 | 159 | 214 |
| ENST00000276609 | 5280 | 656 | 92355580 | 92355694 | 1266 | 1379 | 342 | 380 |
| ENST00000523719 | 2919 | 656 | 92355580 | 92355694 | 1299 | 1412 | 342 | 380 |
| ENST00000276609 | 5280 | 656 | 92378807 | 92378945 | 1728 | 1865 | 496 | 542 |
| ENST00000523719 | 2919 | 656 | 92378807 | 92378945 | 1761 | 1898 | 496 | 542 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TE54 | 64 | 101 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 64 | 101 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 64 | 101 | 1 | 75 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 1 | 75 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 97 | 144 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 97 | 144 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 76 | 96 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 76 | 96 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 159 | 214 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 159 | 214 | 166 | 166 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 166 | 166 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 188 | 202 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 188 | 202 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 145 | 165 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 145 | 165 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 167 | 187 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 167 | 187 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 203 | 223 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 203 | 223 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 342 | 380 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 342 | 380 | 328 | 343 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 328 | 343 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 365 | 383 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 365 | 383 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 344 | 364 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 344 | 364 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 380 | 406 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 380 | 406 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 380 | 406 | 381 | 381 | Natural variant | ID=VAR_053667;Note=V->G;Dbxref=dbSNP:rs34921316 |
| Q8TE54 | 380 | 406 | 381 | 381 | Natural variant | ID=VAR_053667;Note=V->G;Dbxref=dbSNP:rs34921316 |
| Q8TE54 | 380 | 406 | 365 | 383 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 380 | 406 | 365 | 383 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 380 | 406 | 384 | 404 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 380 | 406 | 384 | 404 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 380 | 406 | 405 | 425 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 380 | 406 | 405 | 425 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 496 | 542 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 496 | 542 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 496 | 542 | 492 | 641 | Domain | Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198 |
| Q8TE54 | 496 | 542 | 492 | 641 | Domain | Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198 |
| Q8TE54 | 496 | 542 | 521 | 521 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8TE54 | 496 | 542 | 521 | 521 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8TE54 | 496 | 542 | 470 | 656 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 496 | 542 | 470 | 656 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TE54 | 64 | 101 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 64 | 101 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 64 | 101 | 1 | 75 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 1 | 75 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 97 | 144 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 97 | 144 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 76 | 96 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 64 | 101 | 76 | 96 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 159 | 214 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 159 | 214 | 166 | 166 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 166 | 166 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 188 | 202 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 188 | 202 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 145 | 165 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 145 | 165 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 167 | 187 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 167 | 187 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 203 | 223 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 159 | 214 | 203 | 223 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 342 | 380 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 342 | 380 | 328 | 343 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 328 | 343 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 365 | 383 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 365 | 383 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 344 | 364 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 342 | 380 | 344 | 364 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 496 | 542 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 496 | 542 | 1 | 656 | Chain | ID=PRO_0000320681;Note=Anion exchange transporter |
| Q8TE54 | 496 | 542 | 492 | 641 | Domain | Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198 |
| Q8TE54 | 496 | 542 | 492 | 641 | Domain | Note=STAS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00198 |
| Q8TE54 | 496 | 542 | 521 | 521 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8TE54 | 496 | 542 | 521 | 521 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8TE54 | 496 | 542 | 470 | 656 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TE54 | 496 | 542 | 470 | 656 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for SLC26A7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_484562 | 92301364 | 92301474 | 92301379 | 92301379 | Frame_Shift_Del | T | - | p.V70fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_484568 | 92330444 | 92330608 | 92330529 | 92330529 | Frame_Shift_Del | C | - | p.T188fs |
| LUAD | TCGA-78-7152-01 | exon_skip_484569 | 92346523 | 92346675 | 92346585 | 92346585 | Frame_Shift_Del | G | - | p.L235fs |
| LUAD | TCGA-78-7152-01 | exon_skip_484569 | 92346523 | 92346675 | 92346585 | 92346585 | Frame_Shift_Del | G | - | p.L236fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_484569 | 92346523 | 92346675 | 92346653 | 92346653 | Frame_Shift_Del | T | - | p.V258fs |
| BLCA | TCGA-XF-AAMX-01 | exon_skip_484569 | 92346523 | 92346675 | 92346658 | 92346658 | Frame_Shift_Del | C | - | p.P260fs |
| HNSC | TCGA-CQ-7068-01 | exon_skip_484570 | 92350378 | 92350460 | 92350418 | 92350418 | Frame_Shift_Del | A | - | p.E279fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_484573 | 92355581 | 92355694 | 92355612 | 92355612 | Frame_Shift_Del | T | - | p.V353fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_484573 | 92355581 | 92355694 | 92355620 | 92355620 | Frame_Shift_Del | T | - | p.F358fs |
| STAD | TCGA-BR-4292-01 | exon_skip_484598 | 92406164 | 92406267 | 92406218 | 92406218 | Frame_Shift_Del | T | - | p.I629fs |
| STAD | TCGA-BR-4361-01 | exon_skip_484598 | 92406164 | 92406267 | 92406218 | 92406218 | Frame_Shift_Del | T | - | p.I629fs |
| STAD | TCGA-BR-A4QL-01 | exon_skip_484598 | 92406164 | 92406267 | 92406218 | 92406218 | Frame_Shift_Del | T | - | p.I629fs |
| STAD | TCGA-FP-A4BE-01 | exon_skip_484594 | 92378808 | 92378945 | 92378866 | 92378867 | Frame_Shift_Ins | - | A | p.A516fs |
| STAD | TCGA-FP-A4BE-01 | exon_skip_484594 | 92378808 | 92378945 | 92378867 | 92378868 | Frame_Shift_Ins | - | A | p.A516fs |
| PRAD | TCGA-EJ-7125-01 | exon_skip_484598 | 92406164 | 92406267 | 92406217 | 92406218 | Frame_Shift_Ins | - | T | p.F629fs |
| STAD | TCGA-CD-A48A-01 | exon_skip_484598 | 92406164 | 92406267 | 92406217 | 92406218 | Frame_Shift_Ins | - | T | p.I629fs |
| STAD | TCGA-CD-A48A-01 | exon_skip_484598 | 92406164 | 92406267 | 92406218 | 92406219 | Frame_Shift_Ins | - | T | p.I629fs |
| LIHC | TCGA-DD-AAE3-01 | exon_skip_484568 | 92330444 | 92330608 | 92330492 | 92330492 | Nonsense_Mutation | G | T | p.E176X |
| UCEC | TCGA-AP-A0LM-01 | exon_skip_484569 | 92346523 | 92346675 | 92346559 | 92346559 | Nonsense_Mutation | C | T | p.R227* |
| COAD | TCGA-AZ-4315-01 | exon_skip_484570 | 92350378 | 92350460 | 92350435 | 92350435 | Nonsense_Mutation | G | T | p.E285X |
| LUAD | TCGA-44-3918-01 | exon_skip_484585 | 92364038 | 92364115 | 92364058 | 92364058 | Nonsense_Mutation | C | A | p.C387* |
| LUSC | TCGA-56-6546-01 | exon_skip_484594 | 92378808 | 92378945 | 92378879 | 92378879 | Nonsense_Mutation | T | A | p.Y520* |
| LUAD | TCGA-86-A4JF-01 | exon_skip_484598 | 92406164 | 92406267 | 92406193 | 92406193 | Nonsense_Mutation | G | T | p.G621* |
| COAD | TCGA-CA-6717-01 | exon_skip_484562 | 92301364 | 92301474 | 92301363 | 92301363 | Splice_Site | G | T | . |
| LIHC | TCGA-DD-AAEB-01 | exon_skip_484569 | 92346523 | 92346675 | 92346676 | 92346676 | Splice_Site | G | T | . |
| OV | TCGA-24-1427-01 | exon_skip_484570 | 92350378 | 92350460 | 92350462 | 92350462 | Splice_Site | T | G | e6+2 |
| UCEC | TCGA-B5-A0JV-01 | exon_skip_484585 | 92364038 | 92364115 | 92364037 | 92364037 | Splice_Site | G | A | p.V381_splice |
| PAAD | TCGA-HZ-A77Q-01 | exon_skip_484585 | 92364038 | 92364115 | 92364116 | 92364116 | Splice_Site | G | C | . |
| SKCM | TCGA-BF-A3DJ-01 | exon_skip_484598 | 92406164 | 92406267 | 92406163 | 92406163 | Splice_Site | G | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LNCAPCLONEFGC_PROSTATE | 92406164 | 92406267 | 92406217 | 92406218 | Frame_Shift_Ins | - | T | p.I629fs |
| SKUT1_SOFT_TISSUE | 92406164 | 92406267 | 92406217 | 92406218 | Frame_Shift_Ins | - | T | p.I629fs |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 92406164 | 92406267 | 92406217 | 92406218 | Frame_Shift_Ins | - | T | p.I629fs |
| EN_ENDOMETRIUM | 92406164 | 92406267 | 92406217 | 92406218 | Frame_Shift_Ins | - | T | p.I629fs |
| RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 92301364 | 92301474 | 92301378 | 92301378 | Missense_Mutation | G | A | p.V70I |
| HCC2450_LUNG | 92301364 | 92301474 | 92301385 | 92301385 | Missense_Mutation | C | T | p.S72L |
| SKUT1_SOFT_TISSUE | 92301364 | 92301474 | 92301469 | 92301469 | Missense_Mutation | C | T | p.A100V |
| NCIH510_LUNG | 92330444 | 92330608 | 92330454 | 92330454 | Missense_Mutation | T | C | p.F163S |
| SNU175_LARGE_INTESTINE | 92330444 | 92330608 | 92330475 | 92330475 | Missense_Mutation | C | T | p.A170V |
| NCIH1435_LUNG | 92330444 | 92330608 | 92330529 | 92330529 | Missense_Mutation | C | A | p.T188N |
| SISO_CERVIX | 92330444 | 92330608 | 92330558 | 92330558 | Missense_Mutation | C | A | p.L198I |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 92330444 | 92330608 | 92330558 | 92330558 | Missense_Mutation | C | A | p.L198I |
| NCCSTCK140_STOMACH | 92330444 | 92330608 | 92330565 | 92330565 | Missense_Mutation | G | A | p.G200E |
| HS944T_SKIN | 92330444 | 92330608 | 92330604 | 92330604 | Missense_Mutation | T | C | p.F213S |
| NCIH2066_LUNG | 92346523 | 92346675 | 92346533 | 92346533 | Missense_Mutation | A | T | p.Y218F |
| MCC13_SKIN | 92346523 | 92346675 | 92346565 | 92346565 | Missense_Mutation | G | A | p.E229K |
| NCIH250_LUNG | 92346523 | 92346675 | 92346629 | 92346629 | Missense_Mutation | A | T | p.Q250L |
| HEC108_ENDOMETRIUM | 92346523 | 92346675 | 92346644 | 92346644 | Missense_Mutation | T | G | p.I255S |
| HCC2998_LARGE_INTESTINE | 92355581 | 92355694 | 92355585 | 92355585 | Missense_Mutation | T | G | p.F344C |
| RKO_LARGE_INTESTINE | 92355581 | 92355694 | 92355630 | 92355630 | Missense_Mutation | G | A | p.C359Y |
| GP5D_LARGE_INTESTINE | 92364038 | 92364115 | 92364057 | 92364057 | Missense_Mutation | G | A | p.C387Y |
| SNUC4_LARGE_INTESTINE | 92378808 | 92378945 | 92378866 | 92378866 | Missense_Mutation | C | T | p.A516V |
| SW480_LARGE_INTESTINE | 92378808 | 92378945 | 92378874 | 92378874 | Missense_Mutation | T | A | p.F519I |
| SW620_LARGE_INTESTINE | 92378808 | 92378945 | 92378874 | 92378874 | Missense_Mutation | T | A | p.F519I |
| TUHR10TKB_KIDNEY | 92378808 | 92378945 | 92378887 | 92378887 | Missense_Mutation | T | C | p.L523S |
| CAKI1_KIDNEY | 92378808 | 92378945 | 92378926 | 92378926 | Missense_Mutation | C | G | p.P536R |
| NCIH358_LUNG | 92382013 | 92382061 | 92382016 | 92382016 | Missense_Mutation | G | A | p.E544K |
| MEWO_SKIN | 92406164 | 92406267 | 92406194 | 92406194 | Missense_Mutation | G | A | p.G621E |
| PK1_PANCREAS | 92406164 | 92406267 | 92406217 | 92406217 | Missense_Mutation | A | T | p.I629F |
| KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 92406164 | 92406267 | 92406242 | 92406242 | Missense_Mutation | C | A | p.A637E |
| NCIH510_LUNG | 92355581 | 92355694 | 92355673 | 92355673 | Nonsense_Mutation | C | A | p.Y373* |
| MCC13_SKIN | 92378808 | 92378945 | 92378808 | 92378808 | Splice_Site | G | A | p.E497K |
| CP66MEL_SKIN | 92378808 | 92378945 | 92378808 | 92378808 | Splice_Site | G | A | p.E497K |
| NCIH1573_LUNG | 92378808 | 92378945 | 92378944 | 92378944 | Splice_Site | A | T | p.K542M |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC26A7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC26A7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC26A7 |
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RelatedDrugs for SLC26A7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC26A7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLC26A7 | C0036341 | Schizophrenia | 1 | CTD_human |
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