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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for RABL2B

check button Gene summary
Gene informationGene symbol

RABL2B

Gene ID

11158

Gene nameRAB, member of RAS oncogene family like 2B
Synonyms-
Cytomap

22q13.33

Type of geneprotein-coding
Descriptionrab-like protein 2B
Modification date20180523
UniProtAcc

Q9UNT1

ContextPubMed: RABL2B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for RABL2B from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for RABL2B

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for RABL2B

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3709602251207468:51207552:51207852:51207980:51214199:5121426151207852:51207980ENSG00000079974.13ENST00000436958.1
exon_skip_3709652251207468:51207552:51207882:51207980:51214199:5121426151207882:51207980ENSG00000079974.13ENST00000425098.1
exon_skip_3709672251207882:51207977:51208332:51208444:51214199:5121426151208332:51208444ENSG00000079974.13ENST00000435118.1,ENST00000395593.3,ENST00000395598.3
exon_skip_3709692251207882:51207980:51208332:51208444:51214199:5121426151208332:51208444ENSG00000079974.13ENST00000354869.3,ENST00000395595.3
exon_skip_3709722251207882:51207980:51214199:51214279:51215097:5121517751214199:51214279ENSG00000079974.13ENST00000425098.1,ENST00000436958.1
exon_skip_3709782251208332:51208444:51214199:51214279:51215097:5121517751214199:51214279ENSG00000079974.13ENST00000354869.3,ENST00000435118.1,ENST00000395593.3,ENST00000395598.3,ENST00000464678.1,ENST00000395595.3
exon_skip_3709802251216379:51216409:51219040:51219146:51220615:5122077951219040:51219146ENSG00000079974.13ENST00000468451.1
exon_skip_3709822251216379:51216409:51220615:51220775:51221928:5122202851220615:51220775ENSG00000079974.13ENST00000464740.1,ENST00000395598.3,ENST00000395590.1
exon_skip_3709832251216379:51216409:51220615:51220779:51221928:5122202851220615:51220779ENSG00000079974.13ENST00000354869.3,ENST00000436958.1,ENST00000395591.1
exon_skip_3710022251220615:51220779:51221318:51221473:51221928:5122202851221318:51221473ENSG00000079974.13ENST00000395593.3
exon_skip_3710072251220615:51220779:51221466:51221714:51221928:5122202851221466:51221714ENSG00000079974.13ENST00000395595.3

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for RABL2B

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3709602251207468:51207552:51207852:51207980:51214199:5121426151207852:51207980ENSG00000079974.13ENST00000436958.1
exon_skip_3709652251207468:51207552:51207882:51207980:51214199:5121426151207882:51207980ENSG00000079974.13ENST00000425098.1
exon_skip_3709672251207882:51207977:51208332:51208444:51214199:5121426151208332:51208444ENSG00000079974.13ENST00000435118.1,ENST00000395593.3,ENST00000395598.3
exon_skip_3709692251207882:51207980:51208332:51208444:51214199:5121426151208332:51208444ENSG00000079974.13ENST00000354869.3,ENST00000395595.3
exon_skip_3709722251207882:51207980:51214199:51214279:51215097:5121517751214199:51214279ENSG00000079974.13ENST00000425098.1,ENST00000436958.1
exon_skip_3709782251208332:51208444:51214199:51214279:51215097:5121517751214199:51214279ENSG00000079974.13ENST00000435118.1,ENST00000354869.3,ENST00000395593.3,ENST00000395598.3,ENST00000395595.3,ENST00000464678.1
exon_skip_3709802251216379:51216409:51219040:51219146:51220615:5122077951219040:51219146ENSG00000079974.13ENST00000468451.1
exon_skip_3709822251216379:51216409:51220615:51220775:51221928:5122202851220615:51220775ENSG00000079974.13ENST00000395598.3,ENST00000395590.1,ENST00000464740.1
exon_skip_3709832251216379:51216409:51220615:51220779:51221928:5122202851220615:51220779ENSG00000079974.13ENST00000354869.3,ENST00000395591.1,ENST00000436958.1
exon_skip_3710022251220615:51220779:51221318:51221473:51221928:5122202851221318:51221473ENSG00000079974.13ENST00000395593.3
exon_skip_3710072251220615:51220779:51221466:51221714:51221928:5122202851221466:51221714ENSG00000079974.13ENST00000395595.3

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for RABL2B

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000039559851220615512207753UTR-3CDS
ENST000003955985120833251208444Frame-shift
ENST000004351185120833251208444Frame-shift
ENST000003955985121419951214279Frame-shift
ENST000004351185121419951214279Frame-shift

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000039559851220615512207753UTR-3CDS
ENST000003955985120833251208444Frame-shift
ENST000004351185120833251208444Frame-shift
ENST000003955985121419951214279Frame-shift
ENST000004351185121419951214279Frame-shift

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Infer the effects of exon skipping event on protein functional features for RABL2B

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for RABL2B

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A39Y-01exon_skip_370960
exon_skip_370965
51207853512079805120789551207895Frame_Shift_DelG-p.T165fs
LIHCTCGA-DD-A39Y-01exon_skip_370960
exon_skip_370965
51207883512079805120789551207895Frame_Shift_DelG-p.T165fs
LIHCTCGA-DD-A39Y-01exon_skip_370960
exon_skip_370965
51207853512079805120795751207957Frame_Shift_DelT-p.S145fs
LIHCTCGA-DD-A39Y-01exon_skip_370960
exon_skip_370965
51207883512079805120795751207957Frame_Shift_DelT-p.S145fs
LIHCTCGA-G3-A3CJ-01exon_skip_370960
exon_skip_370965
51207853512079805120795751207957Frame_Shift_DelT-p.S145fs
LIHCTCGA-G3-A3CJ-01exon_skip_370960
exon_skip_370965
51207883512079805120795751207957Frame_Shift_DelT-p.S145fs
STADTCGA-HU-A4GQ-01exon_skip_370960
exon_skip_370965
51207853512079805120795751207957Frame_Shift_DelT-p.S145fs
STADTCGA-HU-A4GQ-01exon_skip_370960
exon_skip_370965
51207883512079805120795751207957Frame_Shift_DelT-p.S145fs
LIHCTCGA-DD-A39Y-01exon_skip_370982
51220616512207755122070751220707Frame_Shift_DelT-p.T6fs
LIHCTCGA-DD-A39Y-01exon_skip_370983
51220616512207795122070751220707Frame_Shift_DelT-p.T6fs
HNSCTCGA-QK-A8Z7-01exon_skip_370960
exon_skip_370965
51207853512079805120795651207957Frame_Shift_Ins-Tp.L145fs
HNSCTCGA-QK-A8Z7-01exon_skip_370960
exon_skip_370965
51207883512079805120795651207957Frame_Shift_Ins-Tp.L145fs
ACCTCGA-OR-A5LL-01exon_skip_370967
exon_skip_370969
51208333512084445120839851208399Frame_Shift_Ins-Ap.W115fs

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
EN_ENDOMETRIUM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
EN_ENDOMETRIUM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
786O_KIDNEY51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
786O_KIDNEY51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
8MGBA_CENTRAL_NERVOUS_SYSTEM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
8MGBA_CENTRAL_NERVOUS_SYSTEM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
AGS_STOMACH51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
AGS_STOMACH51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
CAOV4_OVARY51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
CAOV4_OVARY51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
CAPAN2_PANCREAS51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
CAPAN2_PANCREAS51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
COLO741_SKIN51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
COLO741_SKIN51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
COV434_OVARY51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
COV434_OVARY51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
EKVX_LUNG51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
EKVX_LUNG51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
HS852T_SKIN51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
HS852T_SKIN51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
HT1080_SOFT_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
HT1080_SOFT_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
JHUEM3_ENDOMETRIUM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
JHUEM3_ENDOMETRIUM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
JHUEM7_ENDOMETRIUM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
JHUEM7_ENDOMETRIUM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
JK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
JK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KNS60_CENTRAL_NERVOUS_SYSTEM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KNS60_CENTRAL_NERVOUS_SYSTEM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KPNYN_AUTONOMIC_GANGLIA51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KPNYN_AUTONOMIC_GANGLIA51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KYSE410_OESOPHAGUS51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KYSE410_OESOPHAGUS51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KYSE510_OESOPHAGUS51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KYSE510_OESOPHAGUS51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MDAMB468_BREAST51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MDAMB468_BREAST51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MDST8_LARGE_INTESTINE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MDST8_LARGE_INTESTINE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MHHCALL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MHHCALL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH1373_LUNG51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH1373_LUNG51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH2066_LUNG51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH2066_LUNG51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH2228_LUNG51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH2228_LUNG51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH508_LARGE_INTESTINE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH508_LARGE_INTESTINE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH661_LUNG51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NCIH661_LUNG51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NIHOVCAR3_OVARY51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
NIHOVCAR3_OVARY51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
OC314_OVARY51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
OC314_OVARY51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
OE19_OESOPHAGUS51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
OE19_OESOPHAGUS51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
OELE_OVARY51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
OELE_OVARY51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
PL21_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
PL21_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SF172_CENTRAL_NERVOUS_SYSTEM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SF172_CENTRAL_NERVOUS_SYSTEM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SF767_CENTRAL_NERVOUS_SYSTEM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SF767_CENTRAL_NERVOUS_SYSTEM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SLR20_KIDNEY51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SLR20_KIDNEY51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU1105_CENTRAL_NERVOUS_SYSTEM51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU1105_CENTRAL_NERVOUS_SYSTEM51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU1214_UPPER_AERODIGESTIVE_TRACT51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU1214_UPPER_AERODIGESTIVE_TRACT51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU213_PANCREAS51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU213_PANCREAS51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU423_LIVER51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SNU423_LIVER51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SUPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SUPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SW1990_PANCREAS51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
SW1990_PANCREAS51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
TCCSUP_URINARY_TRACT51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
TCCSUP_URINARY_TRACT51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
TE11_OESOPHAGUS51207853512079805120795651207957Frame_Shift_Ins-Tp.S144fs
TE11_OESOPHAGUS51207883512079805120795651207957Frame_Shift_Ins-Tp.S144fs
KATOIII_STOMACH51207853512079805120795651207958In_Frame_DelCTT-p.143_144KS>N
KATOIII_STOMACH51207883512079805120795651207958In_Frame_DelCTT-p.143_144KS>N
SKNAS_AUTONOMIC_GANGLIA51207853512079805120791651207916Missense_MutationGCp.F157L
SKNAS_AUTONOMIC_GANGLIA51207883512079805120791651207916Missense_MutationGCp.F157L
SNU1040_LARGE_INTESTINE51208333512084445120834751208347Missense_MutationGAp.A132V
SNUC2B_LARGE_INTESTINE51208333512084445120835151208351Missense_MutationCAp.V131L
TOV21G_OVARY51208333512084445120837551208375Missense_MutationTCp.R123G
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE51214200512142795121422851214228Missense_MutationTCp.Y90C
HEC59_ENDOMETRIUM51220616512207755122065351220653Missense_MutationTCp.I24V
HEC59_ENDOMETRIUM51220616512207795122065351220653Missense_MutationTCp.I24V

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RABL2B

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RABL2B


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RABL2B


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RelatedDrugs for RABL2B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RABL2B

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource