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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAB31 |
 Gene summary |
| Gene information | Gene symbol | RAB31 | Gene ID | 11031 |
| Gene name | RAB31, member RAS oncogene family | |
| Synonyms | Rab22B | |
| Cytomap | 18p11.22 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Rab-31ras-related protein Rab-22B | |
| Modification date | 20180523 | |
| UniProtAcc | Q13636 | |
| Context | PubMed: RAB31 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RAB31 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAB31 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAB31 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_295632 | 18 | 9708319:9708441:9775274:9775354:9792150:9792232 | 9775274:9775354 | ENSG00000168461.8 | ENST00000581109.1 |
| exon_skip_295634 | 18 | 9708319:9708441:9792150:9792232:9814016:9814088 | 9792150:9792232 | ENSG00000168461.8 | ENST00000578734.1 |
| exon_skip_295639 | 18 | 9775283:9775354:9792150:9792232:9814016:9814088 | 9792150:9792232 | ENSG00000168461.8 | ENST00000578921.1 |
| exon_skip_295641 | 18 | 9792150:9792232:9814016:9814088:9815112:9815219 | 9814016:9814088 | ENSG00000168461.8 | ENST00000578921.1,ENST00000578734.1,ENST00000578737.1 |
| exon_skip_295644 | 18 | 9792150:9792232:9845578:9845688:9859224:9859283 | 9845578:9845688 | ENSG00000168461.8 | ENST00000581109.1 |
| exon_skip_295649 | 18 | 9815112:9815219:9845578:9845688:9859224:9859283 | 9845578:9845688 | ENSG00000168461.8 | ENST00000578921.1,ENST00000578734.1,ENST00000583921.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAB31 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_295632 | 18 | 9708319:9708441:9775274:9775354:9792150:9792232 | 9775274:9775354 | ENSG00000168461.8 | ENST00000581109.1 |
| exon_skip_295634 | 18 | 9708319:9708441:9792150:9792232:9814016:9814088 | 9792150:9792232 | ENSG00000168461.8 | ENST00000578734.1 |
| exon_skip_295639 | 18 | 9775283:9775354:9792150:9792232:9814016:9814088 | 9792150:9792232 | ENSG00000168461.8 | ENST00000578921.1 |
| exon_skip_295641 | 18 | 9792150:9792232:9814016:9814088:9815112:9815219 | 9814016:9814088 | ENSG00000168461.8 | ENST00000578921.1,ENST00000578734.1,ENST00000578737.1 |
| exon_skip_295644 | 18 | 9792150:9792232:9845578:9845688:9859224:9859283 | 9845578:9845688 | ENSG00000168461.8 | ENST00000581109.1 |
| exon_skip_295649 | 18 | 9815112:9815219:9845578:9845688:9859224:9859283 | 9845578:9845688 | ENSG00000168461.8 | ENST00000578921.1,ENST00000578734.1,ENST00000583921.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAB31 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000578921 | 9792150 | 9792232 | Frame-shift |
| ENST00000578921 | 9845578 | 9845688 | Frame-shift |
| ENST00000578921 | 9814016 | 9814088 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000578921 | 9792150 | 9792232 | Frame-shift |
| ENST00000578921 | 9845578 | 9845688 | Frame-shift |
| ENST00000578921 | 9814016 | 9814088 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RAB31 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000578921 | 4072 | 194 | 9814016 | 9814088 | 443 | 514 | 67 | 91 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000578921 | 4072 | 194 | 9814016 | 9814088 | 443 | 514 | 67 | 91 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13636 | 67 | 91 | 79 | 86 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
| Q13636 | 67 | 91 | 1 | 194 | Chain | ID=PRO_0000121232;Note=Ras-related protein Rab-31 |
| Q13636 | 67 | 91 | 65 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
| Q13636 | 67 | 91 | 72 | 75 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
| Q13636 | 67 | 91 | 91 | 106 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13636 | 67 | 91 | 79 | 86 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
| Q13636 | 67 | 91 | 1 | 194 | Chain | ID=PRO_0000121232;Note=Ras-related protein Rab-31 |
| Q13636 | 67 | 91 | 65 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
| Q13636 | 67 | 91 | 72 | 75 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
| Q13636 | 67 | 91 | 91 | 106 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FG5 |
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SNVs in the skipped exons for RAB31 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_295649 exon_skip_295644 | 9845579 | 9845688 | 9845586 | 9845586 | Frame_Shift_Del | C | - | p.P130fs |
| STAD | TCGA-BR-8368-01 | exon_skip_295649 exon_skip_295644 | 9845579 | 9845688 | 9845647 | 9845648 | Frame_Shift_Ins | - | A | p.A150fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNUC2A_LARGE_INTESTINE | 9845579 | 9845688 | 9845648 | 9845648 | Frame_Shift_Del | A | - | p.A150fs |
| SNUC2B_LARGE_INTESTINE | 9845579 | 9845688 | 9845648 | 9845648 | Frame_Shift_Del | A | - | p.A150fs |
| SKUT1_SOFT_TISSUE | 9792151 | 9792232 | 9792230 | 9792230 | Missense_Mutation | C | T | p.R67W |
| HCC2218_BREAST | 9814017 | 9814088 | 9814032 | 9814032 | Missense_Mutation | C | T | p.P73S |
| A431_SKIN | 9814017 | 9814088 | 9814024 | 9814024 | Nonsense_Mutation | C | A | p.S70* |
| MZ7MEL_SKIN | 9814017 | 9814088 | 9814044 | 9814044 | Nonsense_Mutation | C | T | p.R77* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAB31 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB31 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB31 |
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RelatedDrugs for RAB31 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB31 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RAB31 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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