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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAB35 |
 Gene summary |
| Gene information | Gene symbol | RAB35 | Gene ID | 11021 |
| Gene name | RAB35, member RAS oncogene family | |
| Synonyms | H-ray|RAB1C|RAY | |
| Cytomap | 12q24.23 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Rab-35GTP-binding protein RAYras-related protein rab-1c (GTP-binding protein ray) | |
| Modification date | 20180526 | |
| UniProtAcc | Q15286 | |
| Context | PubMed: RAB35 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RAB35 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAB35 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAB35 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_97217 | 12 | 120535069:120535177:120536614:120536739:120536833:120536894 | 120536614:120536739 | ENSG00000111737.7 | ENST00000229340.5,ENST00000544304.1,ENST00000538903.1,ENST00000543364.1 |
| exon_skip_97220 | 12 | 120541629:120541753:120546220:120546271:120554402:120554540 | 120546220:120546271 | ENSG00000111737.7 | ENST00000534951.1,ENST00000540803.1,ENST00000538903.1 |
| exon_skip_97222 | 12 | 120546220:120546271:120546395:120546507:120554402:120554540 | 120546395:120546507 | ENSG00000111737.7 | ENST00000544304.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAB35 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_97217 | 12 | 120535069:120535177:120536614:120536739:120536833:120536894 | 120536614:120536739 | ENSG00000111737.7 | ENST00000229340.5,ENST00000544304.1,ENST00000538903.1,ENST00000543364.1 |
| exon_skip_97220 | 12 | 120541629:120541753:120546220:120546271:120554402:120554540 | 120546220:120546271 | ENSG00000111737.7 | ENST00000534951.1,ENST00000538903.1,ENST00000540803.1 |
| exon_skip_97222 | 12 | 120546220:120546271:120546395:120546507:120554402:120554540 | 120546395:120546507 | ENSG00000111737.7 | ENST00000544304.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAB35 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000229340 | 120536614 | 120536739 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000229340 | 120536614 | 120536739 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for RAB35 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RAB35 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_97220 | 120546221 | 120546271 | 120546240 | 120546240 | Frame_Shift_Del | A | - | p.F28fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 120536615 | 120536739 | 120536622 | 120536622 | Missense_Mutation | A | G | p.V157A |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 120536615 | 120536739 | 120536641 | 120536641 | Missense_Mutation | C | T | p.A151T |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 120536615 | 120536739 | 120536641 | 120536641 | Missense_Mutation | C | T | p.A151T |
| SNU1040_LARGE_INTESTINE | 120536615 | 120536739 | 120536695 | 120536695 | Missense_Mutation | C | T | p.E133K |
| HCT116_LARGE_INTESTINE | 120546221 | 120546271 | 120546245 | 120546245 | Missense_Mutation | G | A | p.R27C |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAB35 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB35 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB35 |
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RelatedDrugs for RAB35 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB35 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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