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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STIP1 |
 Gene summary |
| Gene information | Gene symbol | STIP1 | Gene ID | 10963 |
| Gene name | stress induced phosphoprotein 1 | |
| Synonyms | HEL-S-94n|HOP|IEF-SSP-3521|P60|STI1|STI1L | |
| Cytomap | 11q13.1 | |
| Type of gene | protein-coding | |
| Description | stress-induced-phosphoprotein 1Hsp70/Hsp90-organizing proteinNY-REN-11 antigenepididymis secretory sperm binding protein Li 94nhsc70/Hsp90-organizing proteinrenal carcinoma antigen NY-REN-11transformation-sensitive protein IEF SSP 3521 | |
| Modification date | 20180523 | |
| UniProtAcc | P31948 | |
| Context | PubMed: STIP1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for STIP1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STIP1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STIP1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_60397 | 11 | 63960549:63960759:63961660:63961802:63961950:63962092 | 63961660:63961802 | ENSG00000168439.12 | ENST00000305218.4,ENST00000543847.1,ENST00000358794.5,ENST00000540501.1 |
| exon_skip_60400 | 11 | 63960549:63960759:63961732:63961802:63961950:63962092 | 63961732:63961802 | ENSG00000168439.12 | ENST00000538945.1 |
| exon_skip_60408 | 11 | 63964742:63964869:63964964:63965067:63965325:63965446 | 63964964:63965067 | ENSG00000168439.12 | ENST00000537479.1,ENST00000305218.4,ENST00000544739.1,ENST00000538497.1,ENST00000358794.5,ENST00000538945.1 |
| exon_skip_60410 | 11 | 63964964:63965067:63965325:63965446:63967411:63967480 | 63965325:63965446 | ENSG00000168439.12 | ENST00000537479.1,ENST00000305218.4,ENST00000538497.1,ENST00000358794.5,ENST00000538945.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STIP1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_60397 | 11 | 63960549:63960759:63961660:63961802:63961950:63962092 | 63961660:63961802 | ENSG00000168439.12 | ENST00000358794.5,ENST00000305218.4,ENST00000543847.1,ENST00000540501.1 |
| exon_skip_60400 | 11 | 63960549:63960759:63961732:63961802:63961950:63962092 | 63961732:63961802 | ENSG00000168439.12 | ENST00000538945.1 |
| exon_skip_60408 | 11 | 63964742:63964869:63964964:63965067:63965325:63965446 | 63964964:63965067 | ENSG00000168439.12 | ENST00000358794.5,ENST00000305218.4,ENST00000538945.1,ENST00000544739.1,ENST00000537479.1,ENST00000538497.1 |
| exon_skip_60410 | 11 | 63964964:63965067:63965325:63965446:63967411:63967480 | 63965325:63965446 | ENSG00000168439.12 | ENST00000358794.5,ENST00000305218.4,ENST00000538945.1,ENST00000537479.1,ENST00000538497.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STIP1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305218 | 63961660 | 63961802 | Frame-shift |
| ENST00000305218 | 63964964 | 63965067 | Frame-shift |
| ENST00000305218 | 63965325 | 63965446 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305218 | 63961660 | 63961802 | Frame-shift |
| ENST00000305218 | 63964964 | 63965067 | Frame-shift |
| ENST00000305218 | 63965325 | 63965446 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for STIP1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for STIP1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
STIP1_KIRC_exon_skip_60410_psi_boxplot.png |
STIP1_LUAD_exon_skip_60410_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_60397 | 63961661 | 63961802 | 63961672 | 63961672 | Frame_Shift_Del | A | - | p.R124fs |
| KIRC | TCGA-A3-3374-01 | exon_skip_60410 | 63965326 | 63965446 | 63965370 | 63965370 | Frame_Shift_Del | A | - | p.Y363fs |
| GBM | TCGA-76-6660-01 | exon_skip_60397 | 63961661 | 63961802 | 63961718 | 63961718 | Nonsense_Mutation | C | T | p.R93* |
| COAD | TCGA-AD-6895-01 | exon_skip_60408 | 63964965 | 63965067 | 63965011 | 63965011 | Nonsense_Mutation | T | A | p.C282X |
| CHOL | TCGA-W5-AA2X-01 | exon_skip_60408 | 63964965 | 63965067 | 63965024 | 63965024 | Nonsense_Mutation | G | T | p.E287X |
| READ | TCGA-AG-A002-01 | exon_skip_60408 | 63964965 | 63965067 | 63965024 | 63965024 | Nonsense_Mutation | G | T | p.E287X |
| STAD | TCGA-CG-5721-01 | exon_skip_60408 | 63964965 | 63965067 | 63965054 | 63965054 | Nonsense_Mutation | C | T | p.R297* |
| STAD | TCGA-CG-5721-01 | exon_skip_60408 | 63964965 | 63965067 | 63965054 | 63965054 | Nonsense_Mutation | C | T | p.R297X |
| LUAD | TCGA-49-4490-01 | exon_skip_60410 | 63965326 | 63965446 | 63965325 | 63965325 | Splice_Site | G | C | p.K301_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-49-4490-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_60410 | |
| Skipped exon start: 63965326 | |
| Skipped exon end: 63965446 | |
| Mutation start: 63965325 | |
| Mutation end: 63965325 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: C | |
| AAchange: p.K301_splice | |
exon_skip_60410_LUAD_TCGA-49-4490-01.png | |
 | Sample: TCGA-A3-3374-01 |
| Cancer type: KIRC | |
| ESID: exon_skip_60410 | |
| Skipped exon start: 63965326 | |
| Skipped exon end: 63965446 | |
| Mutation start: 63965370 | |
| Mutation end: 63965370 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: A | |
| Mutation seq: - | |
| AAchange: p.Y363fs | |
exon_skip_347690_KIRC_TCGA-A3-3374-01.png | |
exon_skip_353471_KIRC_TCGA-A3-3374-01.png | |
exon_skip_503611_KIRC_TCGA-A3-3374-01.png | |
exon_skip_60410_KIRC_TCGA-A3-3374-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH1435_LUNG | 63961661 | 63961802 | 63961724 | 63961724 | Frame_Shift_Del | T | - | p.Y95fs |
| JHUEM7_ENDOMETRIUM | 63961661 | 63961802 | 63961693 | 63961693 | Missense_Mutation | C | A | p.F84L |
| UOK101_KIDNEY | 63964965 | 63965067 | 63964980 | 63964980 | Missense_Mutation | A | G | p.K272R |
| HCC2108_LUNG | 63965326 | 63965446 | 63965352 | 63965352 | Missense_Mutation | A | G | p.Y310C |
| MORCPR_LUNG | 63965326 | 63965446 | 63965352 | 63965352 | Missense_Mutation | A | G | p.Y310C |
| HEC251_ENDOMETRIUM | 63965326 | 63965446 | 63965415 | 63965415 | Missense_Mutation | G | A | p.R331Q |
| TE441T_SOFT_TISSUE | 63961661 | 63961802 | 63961718 | 63961718 | Nonsense_Mutation | C | T | p.R93* |
| NCIH1703_LUNG | 63965326 | 63965446 | 63965327 | 63965327 | Splice_Site | G | A | p.A302T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STIP1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STIP1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STIP1 |
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RelatedDrugs for STIP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STIP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| STIP1 | C0011581 | Depressive disorder | 1 | PSYGENET |
| STIP1 | C0025202 | melanoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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