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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ADAM28 |
 Gene summary |
| Gene information | Gene symbol | ADAM28 | Gene ID | 10863 |
| Gene name | ADAM metallopeptidase domain 28 | |
| Synonyms | ADAM 28|MDC-L|MDCL|eMDC II|eMDCII | |
| Cytomap | 8p21.2 | |
| Type of gene | protein-coding | |
| Description | disintegrin and metalloproteinase domain-containing protein 28epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein IImetalloproteinase-like, dis | |
| Modification date | 20180519 | |
| UniProtAcc | Q9UKQ2 | |
| Context | PubMed: ADAM28 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ADAM28 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ADAM28 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ADAM28 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_482265 | 8 | 24151623:24151708:24157486:24157590:24166153:24166281 | 24157486:24157590 | ENSG00000042980.8 | ENST00000523379.1 |
| exon_skip_482266 | 8 | 24151623:24151708:24157486:24157590:24167406:24167483 | 24157486:24157590 | ENSG00000042980.8 | ENST00000397649.3,ENST00000437154.2,ENST00000540823.1,ENST00000520448.1 |
| exon_skip_482270 | 8 | 24157490:24157590:24166153:24166281:24167406:24167483 | 24166153:24166281 | ENSG00000042980.8 | ENST00000523379.1 |
| exon_skip_482271 | 8 | 24157486:24157590:24167406:24167483:24167675:24167754 | 24167406:24167483 | ENSG00000042980.8 | ENST00000523440.1,ENST00000397649.3,ENST00000437154.2,ENST00000540823.1,ENST00000520448.1,ENST00000265769.4 |
| exon_skip_482272 | 8 | 24167675:24167754:24168873:24168950:24170900:24171093 | 24168873:24168950 | ENSG00000042980.8 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 |
| exon_skip_482273 | 8 | 24167675:24167754:24168873:24168950:24177748:24177820 | 24168873:24168950 | ENSG00000042980.8 | ENST00000540823.1 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENSG00000042980.8 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 |
| exon_skip_482277 | 8 | 24170900:24171093:24177748:24177820:24178730:24178802 | 24177748:24177820 | ENSG00000042980.8 | ENST00000437154.2,ENST00000265769.4 |
| exon_skip_482285 | 8 | 24201018:24201097:24207376:24207485:24208744:24208799 | 24207376:24207485 | ENSG00000042980.8 | ENST00000518326.1,ENST00000521629.1,ENST00000265769.4 |
| exon_skip_482286 | 8 | 24201018:24201101:24207376:24207485:24208744:24208799 | 24207376:24207485 | ENSG00000042980.8 | ENST00000397649.3,ENST00000520448.1 |
| exon_skip_482289 | 8 | 24208744:24208823:24209499:24209565:24211282:24211345 | 24209499:24209565 | ENSG00000042980.8 | ENST00000397649.3,ENST00000520448.1,ENST00000265769.4 |
| exon_skip_482290 | 8 | 24208744:24208823:24209499:24209565:24211896:24211985 | 24209499:24209565 | ENSG00000042980.8 | ENST00000521629.1 |
| exon_skip_482295 | 8 | 24209499:24209565:24211282:24211345:24211896:24211985 | 24211282:24211345 | ENSG00000042980.8 | ENST00000397649.3,ENST00000520448.1,ENST00000265769.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ADAM28 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_482270 | 8 | 24157490:24157590:24166153:24166281:24167406:24167483 | 24166153:24166281 | ENSG00000042980.8 | ENST00000523379.1 |
| exon_skip_482271 | 8 | 24157486:24157590:24167406:24167483:24167675:24167754 | 24167406:24167483 | ENSG00000042980.8 | ENST00000265769.4,ENST00000520448.1,ENST00000540823.1,ENST00000397649.3,ENST00000437154.2,ENST00000523440.1 |
| exon_skip_482272 | 8 | 24167675:24167754:24168873:24168950:24170900:24171093 | 24168873:24168950 | ENSG00000042980.8 | ENST00000265769.4,ENST00000520448.1,ENST00000397649.3,ENST00000437154.2 |
| exon_skip_482273 | 8 | 24167675:24167754:24168873:24168950:24177748:24177820 | 24168873:24168950 | ENSG00000042980.8 | ENST00000540823.1 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENSG00000042980.8 | ENST00000265769.4,ENST00000520448.1,ENST00000397649.3,ENST00000437154.2 |
| exon_skip_482285 | 8 | 24201018:24201097:24207376:24207485:24208744:24208799 | 24207376:24207485 | ENSG00000042980.8 | ENST00000265769.4,ENST00000521629.1,ENST00000518326.1 |
| exon_skip_482289 | 8 | 24208744:24208823:24209499:24209565:24211282:24211345 | 24209499:24209565 | ENSG00000042980.8 | ENST00000265769.4,ENST00000520448.1,ENST00000397649.3 |
| exon_skip_482290 | 8 | 24208744:24208823:24209499:24209565:24211896:24211985 | 24209499:24209565 | ENSG00000042980.8 | ENST00000521629.1 |
| exon_skip_482295 | 8 | 24209499:24209565:24211282:24211345:24211896:24211985 | 24211282:24211345 | ENSG00000042980.8 | ENST00000265769.4,ENST00000520448.1,ENST00000397649.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ADAM28 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265769 | 24167406 | 24167483 | Frame-shift |
| ENST00000265769 | 24168873 | 24168950 | Frame-shift |
| ENST00000265769 | 24170900 | 24171093 | Frame-shift |
| ENST00000265769 | 24207376 | 24207485 | Frame-shift |
| ENST00000265769 | 24177748 | 24177820 | In-frame |
| ENST00000265769 | 24209499 | 24209565 | In-frame |
| ENST00000265769 | 24211282 | 24211345 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265769 | 24167406 | 24167483 | Frame-shift |
| ENST00000265769 | 24168873 | 24168950 | Frame-shift |
| ENST00000265769 | 24170900 | 24171093 | Frame-shift |
| ENST00000265769 | 24207376 | 24207485 | Frame-shift |
| ENST00000265769 | 24209499 | 24209565 | In-frame |
| ENST00000265769 | 24211282 | 24211345 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ADAM28 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265769 | 7069 | 775 | 24177748 | 24177820 | 687 | 758 | 192 | 216 |
| ENST00000265769 | 7069 | 775 | 24209499 | 24209565 | 2289 | 2354 | 726 | 748 |
| ENST00000265769 | 7069 | 775 | 24211282 | 24211345 | 2355 | 2417 | 748 | 769 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265769 | 7069 | 775 | 24209499 | 24209565 | 2289 | 2354 | 726 | 748 |
| ENST00000265769 | 7069 | 775 | 24211282 | 24211345 | 2355 | 2417 | 748 | 769 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UKQ2 | 192 | 216 | 199 | 775 | Chain | ID=PRO_0000029129;Note=Disintegrin and metalloproteinase domain-containing protein 28 |
| Q9UKQ2 | 192 | 216 | 204 | 399 | Domain | Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Q9UKQ2 | 192 | 216 | 19 | 198 | Propeptide | ID=PRO_0000029128;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9UKQ2 | 192 | 216 | 199 | 665 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UKQ2 | 726 | 748 | 541 | 775 | Alternative sequence | ID=VSP_005487;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10506182;Dbxref=PMID:10506182 |
| Q9UKQ2 | 726 | 748 | 199 | 775 | Chain | ID=PRO_0000029129;Note=Disintegrin and metalloproteinase domain-containing protein 28 |
| Q9UKQ2 | 726 | 748 | 687 | 775 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UKQ2 | 748 | 769 | 541 | 775 | Alternative sequence | ID=VSP_005487;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10506182;Dbxref=PMID:10506182 |
| Q9UKQ2 | 748 | 769 | 199 | 775 | Chain | ID=PRO_0000029129;Note=Disintegrin and metalloproteinase domain-containing protein 28 |
| Q9UKQ2 | 748 | 769 | 765 | 765 | Natural variant | ID=VAR_024596;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10506182,ECO:0000269|PubMed:10587367,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs7814768,PMID:10506182,PMID:10587367,PMID:15 |
| Q9UKQ2 | 748 | 769 | 687 | 775 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UKQ2 | 726 | 748 | 541 | 775 | Alternative sequence | ID=VSP_005487;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10506182;Dbxref=PMID:10506182 |
| Q9UKQ2 | 726 | 748 | 199 | 775 | Chain | ID=PRO_0000029129;Note=Disintegrin and metalloproteinase domain-containing protein 28 |
| Q9UKQ2 | 726 | 748 | 687 | 775 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UKQ2 | 748 | 769 | 541 | 775 | Alternative sequence | ID=VSP_005487;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10506182;Dbxref=PMID:10506182 |
| Q9UKQ2 | 748 | 769 | 199 | 775 | Chain | ID=PRO_0000029129;Note=Disintegrin and metalloproteinase domain-containing protein 28 |
| Q9UKQ2 | 748 | 769 | 765 | 765 | Natural variant | ID=VAR_024596;Note=V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10506182,ECO:0000269|PubMed:10587367,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs7814768,PMID:10506182,PMID:10587367,PMID:15 |
| Q9UKQ2 | 748 | 769 | 687 | 775 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for ADAM28 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-G4-6588-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167473 | Frame_Shift_Del | A | - | p.L72fs |
| GBM | TCGA-19-5951-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167473 | Frame_Shift_Del | A | - | p.K73fs |
| PRAD | TCGA-KK-A59V-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167473 | Frame_Shift_Del | A | - | p.K74fs |
| STAD | TCGA-BR-4280-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167473 | Frame_Shift_Del | A | - | p.L72fs |
| STAD | TCGA-D7-A6EY-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Del | AA | - | p.K74fs |
| STAD | TCGA-HU-A4GQ-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167473 | Frame_Shift_Del | A | - | p.L72fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_482275 | 24170901 | 24171093 | 24170994 | 24170994 | Frame_Shift_Del | C | - | p.N159fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_482275 | 24170901 | 24171093 | 24170994 | 24170994 | Frame_Shift_Del | C | - | p.N159fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_482275 | 24170901 | 24171093 | 24171002 | 24171002 | Frame_Shift_Del | A | - | p.E162fs |
| STAD | TCGA-VQ-A8DL-01 | exon_skip_482277 | 24177749 | 24177820 | 24177792 | 24177799 | Frame_Shift_Del | AATATTAT | - | p.207_209del |
| STAD | TCGA-VQ-A8DL-01 | exon_skip_482277 | 24177749 | 24177820 | 24177792 | 24177799 | Frame_Shift_Del | AATATTAT | - | p.EYY207fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_482295 | 24211283 | 24211345 | 24211304 | 24211304 | Frame_Shift_Del | C | - | p.P757fs |
| ACC | TCGA-OR-A5LJ-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.L72fs |
| ACC | TCGA-OR-A5LJ-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.LK72fs |
| COAD | TCGA-AA-3555-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.L72fs |
| COAD | TCGA-CM-6171-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.L72fs |
| HNSC | TCGA-T3-A92N-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.LK72fs |
| PAAD | TCGA-IB-7651-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.LK72fs |
| STAD | TCGA-R5-A7ZI-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.LK72fs |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.LK72fs |
| UCEC | TCGA-BS-A0TJ-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.L72fs |
| UCEC | TCGA-D1-A17H-01 | exon_skip_482271 | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | A | p.L72fs |
| STAD | TCGA-BR-4368-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Ins | - | A | p.L72fs |
| STAD | TCGA-BR-6452-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Ins | - | A | p.L72fs |
| STAD | TCGA-BR-6566-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Ins | - | A | p.L72fs |
| STAD | TCGA-BR-8372-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Ins | - | A | p.L72fs |
| STAD | TCGA-BR-8487-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Ins | - | A | p.L72fs |
| STAD | TCGA-CG-4306-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Ins | - | A | p.L72fs |
| STAD | TCGA-HU-A4G8-01 | exon_skip_482271 | 24167407 | 24167483 | 24167473 | 24167474 | Frame_Shift_Ins | - | A | p.L72fs |
| THCA | TCGA-DO-A1JZ-01 | exon_skip_482285 exon_skip_482286 | 24207377 | 24207485 | 24207413 | 24207414 | Frame_Shift_Ins | - | G | p.G676fs |
| HNSC | TCGA-CN-6021-01 | exon_skip_482272 exon_skip_482273 | 24168874 | 24168950 | 24168892 | 24168892 | Nonsense_Mutation | G | T | p.G109* |
| UCEC | TCGA-AP-A051-01 | exon_skip_482272 exon_skip_482273 | 24168874 | 24168950 | 24168892 | 24168892 | Nonsense_Mutation | G | T | p.G109* |
| SKCM | TCGA-EE-A29S-06 | exon_skip_482277 | 24177749 | 24177820 | 24177770 | 24177770 | Nonsense_Mutation | C | T | p.Q200* |
| SKCM | TCGA-EE-A29S-06 | exon_skip_482277 | 24177749 | 24177820 | 24177770 | 24177770 | Nonsense_Mutation | C | T | p.Q200X |
| LGG | TCGA-TQ-A7RV-01 | exon_skip_482271 | 24167407 | 24167483 | 24167482 | 24167485 | Splice_Site | AAGT | - | p.76_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MFE319_ENDOMETRIUM | 24167407 | 24167483 | 24167472 | 24167473 | Frame_Shift_Ins | - | AA | p.K73fs |
| SNGM_ENDOMETRIUM | 24157487 | 24157590 | 24157508 | 24157508 | Missense_Mutation | C | A | p.P23H |
| SNUC5_LARGE_INTESTINE | 24167407 | 24167483 | 24167461 | 24167461 | Missense_Mutation | G | A | p.V69M |
| A704_KIDNEY | 24168874 | 24168950 | 24168905 | 24168905 | Missense_Mutation | A | G | p.N113S |
| MIAPACA2_PANCREAS | 24168874 | 24168950 | 24168919 | 24168919 | Missense_Mutation | G | A | p.D118N |
| TT_OESOPHAGUS | 24168874 | 24168950 | 24168925 | 24168925 | Missense_Mutation | A | G | p.S120G |
| KURAMOCHI_OVARY | 24168874 | 24168950 | 24168938 | 24168938 | Missense_Mutation | G | T | p.C124F |
| IGR1_SKIN | 24170901 | 24171093 | 24170962 | 24170962 | Missense_Mutation | G | A | p.D149N |
| NUGC3_STOMACH | 24170901 | 24171093 | 24171049 | 24171049 | Missense_Mutation | C | G | p.H178D |
| HCC2998_LARGE_INTESTINE | 24170901 | 24171093 | 24171052 | 24171052 | Missense_Mutation | G | A | p.D179N |
| HCC1569_BREAST | 24177749 | 24177820 | 24177753 | 24177753 | Missense_Mutation | T | C | p.L194S |
| CHSA0011_BONE | 24207377 | 24207485 | 24207416 | 24207416 | Missense_Mutation | T | C | p.V677A |
| SW1088_CENTRAL_NERVOUS_SYSTEM | 24211283 | 24211345 | 24211301 | 24211301 | Missense_Mutation | C | T | p.L755F |
| LN464_CENTRAL_NERVOUS_SYSTEM | 24157487 | 24157590 | 24157519 | 24157519 | Nonsense_Mutation | A | T | p.K27* |
| ACN_AUTONOMIC_GANGLIA | 24157487 | 24157590 | 24157519 | 24157519 | Nonsense_Mutation | A | T | p.K27* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ADAM28 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | ESCA | rs6996616 | chr8:24171051 | C/T | 5.17e-05 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | ESCA | rs6996616 | chr8:24171051 | C/T | 5.17e-05 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | ESCA | rs6996616 | chr8:24171051 | C/T | 1.11e-04 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | BRCA | rs6996616 | chr8:24171051 | C/T | 4.34e-06 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | BRCA | rs6996616 | chr8:24171051 | C/T | 9.03e-06 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LAML | rs6996616 | chr8:24171051 | C/T | 9.68e-07 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LGG | rs6996616 | chr8:24171051 | C/T | 2.08e-04 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LGG | rs6996616 | chr8:24171051 | C/T | 2.08e-04 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | KIRC | rs6996616 | chr8:24171051 | C/T | 1.40e-05 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LUAD | rs6996616 | chr8:24171051 | C/T | 1.44e-04 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LUAD | rs6996616 | chr8:24171051 | C/T | 2.93e-04 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LUAD | rs6996616 | chr8:24171051 | C/T | 6.33e-04 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LUSC | rs6996616 | chr8:24171051 | C/T | 7.07e-05 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LUSC | rs6996616 | chr8:24171051 | C/T | 7.07e-05 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | LUSC | rs6996616 | chr8:24171051 | C/T | 2.27e-03 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | PAAD | rs6996616 | chr8:24171051 | C/T | 3.46e-04 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | STAD | rs6996616 | chr8:24171051 | C/T | 4.81e-07 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | STAD | rs6996616 | chr8:24171051 | C/T | 1.29e-03 |
| exon_skip_482275 | 8 | 24168873:24168950:24170900:24171093:24177748:24177815 | 24170900:24171093 | ENST00000397649.3,ENST00000437154.2,ENST00000520448.1,ENST00000265769.4 | STAD | rs6996616 | chr8:24171051 | C/T | 1.29e-03 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ADAM28 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ADAM28 |
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RelatedDrugs for ADAM28 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9UKQ2 | DB03088 | Pidolic Acid | Disintegrin and metalloproteinase domain-containing protein 28 | small molecule | approved|investigational |
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RelatedDiseases for ADAM28 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ADAM28 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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