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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CLPX |
 Gene summary |
| Gene information | Gene symbol | CLPX | Gene ID | 10845 |
| Gene name | caseinolytic mitochondrial matrix peptidase chaperone subunit | |
| Synonyms | - | |
| Cytomap | 15q22.31 | |
| Type of gene | protein-coding | |
| Description | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrialClpX caseinolytic peptidase X homologClpX caseinolytic protease X homologenergy-dependent regulator of proteolysis | |
| Modification date | 20180523 | |
| UniProtAcc | O76031 | |
| Context | PubMed: CLPX [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CLPX | GO:0046034 | ATP metabolic process | 22710082 |
| CLPX | GO:0051603 | proteolysis involved in cellular protein catabolic process | 16115876 |
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Exon skipping events across known transcript of Ensembl for CLPX from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CLPX |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CLPX |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_128485 | 15 | 65442851:65443251:65444767:65444874:65445884:65445977 | 65444767:65444874 | ENSG00000166855.5 | ENST00000300107.3,ENST00000559152.1 |
| exon_skip_128486 | 15 | 65444767:65444874:65445884:65445977:65447119:65447419 | 65445884:65445977 | ENSG00000166855.5 | ENST00000300107.3,ENST00000559152.1 |
| exon_skip_128488 | 15 | 65448029:65448194:65449115:65449270:65450083:65450248 | 65449115:65449270 | ENSG00000166855.5 | ENST00000559152.1 |
| exon_skip_128489 | 15 | 65448029:65448194:65449181:65449270:65450083:65450248 | 65449181:65449270 | ENSG00000166855.5 | ENST00000300107.3 |
| exon_skip_128491 | 15 | 65451024:65451089:65454941:65454983:65456366:65456526 | 65454941:65454983 | ENSG00000166855.5 | ENST00000558958.1,ENST00000300107.3,ENST00000559152.1 |
| exon_skip_128494 | 15 | 65454941:65454983:65456366:65456526:65458968:65459123 | 65456366:65456526 | ENSG00000166855.5 | ENST00000558958.1,ENST00000300107.3,ENST00000559152.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CLPX |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_128485 | 15 | 65442851:65443251:65444767:65444874:65445884:65445977 | 65444767:65444874 | ENSG00000166855.5 | ENST00000300107.3,ENST00000559152.1 |
| exon_skip_128486 | 15 | 65444767:65444874:65445884:65445977:65447119:65447419 | 65445884:65445977 | ENSG00000166855.5 | ENST00000300107.3,ENST00000559152.1 |
| exon_skip_128488 | 15 | 65448029:65448194:65449115:65449270:65450083:65450248 | 65449115:65449270 | ENSG00000166855.5 | ENST00000559152.1 |
| exon_skip_128489 | 15 | 65448029:65448194:65449181:65449270:65450083:65450248 | 65449181:65449270 | ENSG00000166855.5 | ENST00000300107.3 |
| exon_skip_128491 | 15 | 65451024:65451089:65454941:65454983:65456366:65456526 | 65454941:65454983 | ENSG00000166855.5 | ENST00000300107.3,ENST00000559152.1,ENST00000558958.1 |
| exon_skip_128494 | 15 | 65454941:65454983:65456366:65456526:65458968:65459123 | 65456366:65456526 | ENSG00000166855.5 | ENST00000300107.3,ENST00000559152.1,ENST00000558958.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CLPX |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300107 | 65444767 | 65444874 | Frame-shift |
| ENST00000300107 | 65449181 | 65449270 | Frame-shift |
| ENST00000300107 | 65456366 | 65456526 | Frame-shift |
| ENST00000300107 | 65445884 | 65445977 | In-frame |
| ENST00000300107 | 65454941 | 65454983 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300107 | 65444767 | 65444874 | Frame-shift |
| ENST00000300107 | 65449181 | 65449270 | Frame-shift |
| ENST00000300107 | 65456366 | 65456526 | Frame-shift |
| ENST00000300107 | 65445884 | 65445977 | In-frame |
| ENST00000300107 | 65454941 | 65454983 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CLPX |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000300107 | 4712 | 633 | 65454941 | 65454983 | 863 | 904 | 224 | 238 |
| ENST00000300107 | 4712 | 633 | 65445884 | 65445977 | 1801 | 1893 | 537 | 568 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000300107 | 4712 | 633 | 65454941 | 65454983 | 863 | 904 | 224 | 238 |
| ENST00000300107 | 4712 | 633 | 65445884 | 65445977 | 1801 | 1893 | 537 | 568 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O76031 | 224 | 238 | 57 | 633 | Chain | ID=PRO_0000005518;Note=ATP-dependent Clp protease ATP-binding subunit clpX-like%2C mitochondrial |
| O76031 | 537 | 568 | 57 | 633 | Chain | ID=PRO_0000005518;Note=ATP-dependent Clp protease ATP-binding subunit clpX-like%2C mitochondrial |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O76031 | 224 | 238 | 57 | 633 | Chain | ID=PRO_0000005518;Note=ATP-dependent Clp protease ATP-binding subunit clpX-like%2C mitochondrial |
| O76031 | 537 | 568 | 57 | 633 | Chain | ID=PRO_0000005518;Note=ATP-dependent Clp protease ATP-binding subunit clpX-like%2C mitochondrial |
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SNVs in the skipped exons for CLPX |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-CM-6162-01 | exon_skip_128486 | 65445885 | 65445977 | 65445920 | 65445920 | Nonsense_Mutation | G | A | p.R557X |
| UCEC | TCGA-AP-A0LM-01 | exon_skip_128494 | 65456367 | 65456526 | 65456367 | 65456367 | Nonsense_Mutation | C | A | p.E225* |
| HNSC | TCGA-UF-A7JA-01 | exon_skip_128494 | 65456367 | 65456526 | 65456381 | 65456381 | Nonsense_Mutation | G | C | p.S220* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH630_LARGE_INTESTINE | 65444768 | 65444874 | 65444786 | 65444786 | Frame_Shift_Del | T | - | p.K598fs |
| SNUC1_LARGE_INTESTINE | 65444768 | 65444874 | 65444855 | 65444855 | Missense_Mutation | G | T | p.P575Q |
| IGROV1_OVARY | 65445885 | 65445977 | 65445958 | 65445958 | Missense_Mutation | T | G | p.E544A |
| BV173_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 65454942 | 65454983 | 65454947 | 65454947 | Missense_Mutation | A | C | p.F237C |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 65456367 | 65456526 | 65456396 | 65456396 | Missense_Mutation | A | G | p.V215A |
| MCC13_SKIN | 65456367 | 65456526 | 65456420 | 65456420 | Missense_Mutation | G | A | p.A207V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLPX |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLPX |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLPX |
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RelatedDrugs for CLPX |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLPX |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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