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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF234 |
 Gene summary |
| Gene information | Gene symbol | ZNF234 | Gene ID | 10780 |
| Gene name | zinc finger protein 234 | |
| Synonyms | HZF4|ZNF269 | |
| Cytomap | 19q13.31 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 234C2-H2 type zinc finger proteinHomo sapiens zinc finger 234zinc finger protein 234, partial sequencezinc finger protein 269zinc finger protein 4zinc finger protein HZF4 | |
| Modification date | 20180523 | |
| UniProtAcc | Q14588 | |
| Context | PubMed: ZNF234 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF234 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF234 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF234 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307781 | 19 | 44646466:44646520:44648709:44648800:44652923:44652964 | 44648709:44648800 | ENSG00000263002.3 | ENST00000590795.1,ENST00000592437.1,ENST00000426739.2 |
| exon_skip_307782 | 19 | 44652923:44653050:44653923:44654129:44654565:44654658 | 44653923:44654129 | ENSG00000263002.3 | ENST00000590795.1 |
| exon_skip_307784 | 19 | 44652923:44653050:44654565:44654658:44660404:44660507 | 44654565:44654658 | ENSG00000263002.3 | ENST00000592437.1,ENST00000426739.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF234 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307781 | 19 | 44646466:44646520:44648709:44648800:44652923:44652964 | 44648709:44648800 | ENSG00000263002.3 | ENST00000592437.1,ENST00000426739.2,ENST00000590795.1 |
| exon_skip_307782 | 19 | 44652923:44653050:44653923:44654129:44654565:44654658 | 44653923:44654129 | ENSG00000263002.3 | ENST00000590795.1 |
| exon_skip_307784 | 19 | 44652923:44653050:44654565:44654658:44660404:44660507 | 44654565:44654658 | ENSG00000263002.3 | ENST00000592437.1,ENST00000426739.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF234 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000426739 | 44648709 | 44648800 | 5CDS-5UTR |
| ENST00000592437 | 44648709 | 44648800 | 5CDS-5UTR |
| ENST00000426739 | 44654565 | 44654658 | In-frame |
| ENST00000592437 | 44654565 | 44654658 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000426739 | 44648709 | 44648800 | 5CDS-5UTR |
| ENST00000592437 | 44648709 | 44648800 | 5CDS-5UTR |
| ENST00000426739 | 44654565 | 44654658 | In-frame |
| ENST00000592437 | 44654565 | 44654658 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF234 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000426739 | 3262 | 700 | 44654565 | 44654658 | 401 | 493 | 47 | 78 |
| ENST00000592437 | 2309 | 700 | 44654565 | 44654658 | 332 | 424 | 47 | 78 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000426739 | 3262 | 700 | 44654565 | 44654658 | 401 | 493 | 47 | 78 |
| ENST00000592437 | 2309 | 700 | 44654565 | 44654658 | 332 | 424 | 47 | 78 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14588 | 47 | 78 | 1 | 700 | Chain | ID=PRO_0000047473;Note=Zinc finger protein 234 |
| Q14588 | 47 | 78 | 1 | 700 | Chain | ID=PRO_0000047473;Note=Zinc finger protein 234 |
| Q14588 | 47 | 78 | 8 | 90 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Q14588 | 47 | 78 | 8 | 90 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14588 | 47 | 78 | 1 | 700 | Chain | ID=PRO_0000047473;Note=Zinc finger protein 234 |
| Q14588 | 47 | 78 | 1 | 700 | Chain | ID=PRO_0000047473;Note=Zinc finger protein 234 |
| Q14588 | 47 | 78 | 8 | 90 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Q14588 | 47 | 78 | 8 | 90 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
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SNVs in the skipped exons for ZNF234 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-P3-A6T2-01 | exon_skip_307784 | 44654566 | 44654658 | 44654608 | 44654608 | Frame_Shift_Del | A | - | p.E62fs |
| STAD | TCGA-BR-8487-01 | exon_skip_307784 | 44654566 | 44654658 | 44654608 | 44654608 | Frame_Shift_Del | A | - | p.E62fs |
| UVM | TCGA-WC-A88A-01 | exon_skip_307784 | 44654566 | 44654658 | 44654608 | 44654608 | Frame_Shift_Del | A | - | p.E62fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| GP2D_LARGE_INTESTINE | 44654566 | 44654658 | 44654608 | 44654608 | Frame_Shift_Del | A | - | p.E62fs |
| GP5D_LARGE_INTESTINE | 44654566 | 44654658 | 44654608 | 44654608 | Frame_Shift_Del | A | - | p.E62fs |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 44654566 | 44654658 | 44654608 | 44654608 | Frame_Shift_Del | A | - | p.E62fs |
| HCC2998_LARGE_INTESTINE | 44648710 | 44648800 | 44648797 | 44648797 | Missense_Mutation | C | A | p.F4L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF234 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF234 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF234 |
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RelatedDrugs for ZNF234 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF234 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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