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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CENPC |
 Gene summary |
| Gene information | Gene symbol | CENPC | Gene ID | 1060 |
| Gene name | centromere protein C | |
| Synonyms | CENP-C|CENPC1|MIF2|hcp-4 | |
| Cytomap | 4q13.2 | |
| Type of gene | protein-coding | |
| Description | centromere protein CCENP-C 1centromere autoantigen Ccentromere autoantigen C1centromere protein C 1interphase centromere complex protein 7 | |
| Modification date | 20180523 | |
| UniProtAcc | Q03188 | |
| Context | PubMed: CENPC [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for CENPC from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CENPC |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CENPC |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429768 | 4 | 68338199:68338393:68340605:68340696:68355684:68355839 | 68340605:68340696 | ENSG00000145241.6 | ENST00000513216.1,ENST00000273853.6,ENST00000506882.1 |
| exon_skip_429770 | 4 | 68357897:68357993:68358468:68358715:68359601:68359706 | 68358468:68358715 | ENSG00000145241.6 | ENST00000513216.1,ENST00000515140.1 |
| exon_skip_429771 | 4 | 68357897:68357993:68358586:68358715:68359601:68359706 | 68358586:68358715 | ENSG00000145241.6 | ENST00000273853.6,ENST00000506882.1 |
| exon_skip_429774 | 4 | 68359601:68359706:68360876:68360930:68370922:68371002 | 68360876:68360930 | ENSG00000145241.6 | ENST00000513216.1,ENST00000273853.6,ENST00000510189.1,ENST00000506882.1 |
| exon_skip_429777 | 4 | 68374531:68374823:68376390:68376743:68378119:68378287 | 68376390:68376743 | ENSG00000145241.6 | ENST00000506882.1 |
| exon_skip_429781 | 4 | 68405557:68405652:68406697:68406768:68409866:68409913 | 68406697:68406768 | ENSG00000145241.6 | ENST00000273853.6,ENST00000510189.1,ENST00000506882.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CENPC |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429768 | 4 | 68338199:68338393:68340605:68340696:68355684:68355839 | 68340605:68340696 | ENSG00000145241.6 | ENST00000273853.6,ENST00000513216.1,ENST00000506882.1 |
| exon_skip_429770 | 4 | 68357897:68357993:68358468:68358715:68359601:68359706 | 68358468:68358715 | ENSG00000145241.6 | ENST00000513216.1,ENST00000515140.1 |
| exon_skip_429771 | 4 | 68357897:68357993:68358586:68358715:68359601:68359706 | 68358586:68358715 | ENSG00000145241.6 | ENST00000273853.6,ENST00000506882.1 |
| exon_skip_429774 | 4 | 68359601:68359706:68360876:68360930:68370922:68371002 | 68360876:68360930 | ENSG00000145241.6 | ENST00000273853.6,ENST00000513216.1,ENST00000506882.1,ENST00000510189.1 |
| exon_skip_429777 | 4 | 68374531:68374823:68376390:68376743:68378119:68378287 | 68376390:68376743 | ENSG00000145241.6 | ENST00000506882.1 |
| exon_skip_429781 | 4 | 68405557:68405652:68406697:68406768:68409866:68409913 | 68406697:68406768 | ENSG00000145241.6 | ENST00000273853.6,ENST00000506882.1,ENST00000510189.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CENPC |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273853 | 68340605 | 68340696 | Frame-shift |
| ENST00000273853 | 68406697 | 68406768 | Frame-shift |
| ENST00000273853 | 68358586 | 68358715 | In-frame |
| ENST00000273853 | 68360876 | 68360930 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273853 | 68340605 | 68340696 | Frame-shift |
| ENST00000273853 | 68406697 | 68406768 | Frame-shift |
| ENST00000273853 | 68358586 | 68358715 | In-frame |
| ENST00000273853 | 68360876 | 68360930 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CENPC |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000273853 | 3902 | 943 | 68360876 | 68360930 | 2383 | 2436 | 710 | 728 |
| ENST00000273853 | 3902 | 943 | 68358586 | 68358715 | 2542 | 2670 | 763 | 806 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000273853 | 3902 | 943 | 68360876 | 68360930 | 2383 | 2436 | 710 | 728 |
| ENST00000273853 | 3902 | 943 | 68358586 | 68358715 | 2542 | 2670 | 763 | 806 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q03188 | 710 | 728 | 543 | 943 | Alternative sequence | ID=VSP_057281;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q03188 | 710 | 728 | 1 | 943 | Chain | ID=PRO_0000089474;Note=Centromere protein C |
| Q03188 | 710 | 728 | 727 | 727 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q03188 | 710 | 728 | 710 | 710 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692 |
| Q03188 | 763 | 806 | 543 | 943 | Alternative sequence | ID=VSP_057281;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q03188 | 763 | 806 | 1 | 943 | Chain | ID=PRO_0000089474;Note=Centromere protein C |
| Q03188 | 763 | 806 | 763 | 763 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231 |
| Q03188 | 763 | 806 | 773 | 773 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231 |
| Q03188 | 763 | 806 | 780 | 798 | Motif | Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q03188 | 710 | 728 | 543 | 943 | Alternative sequence | ID=VSP_057281;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q03188 | 710 | 728 | 1 | 943 | Chain | ID=PRO_0000089474;Note=Centromere protein C |
| Q03188 | 710 | 728 | 727 | 727 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q03188 | 710 | 728 | 710 | 710 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692 |
| Q03188 | 763 | 806 | 543 | 943 | Alternative sequence | ID=VSP_057281;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q03188 | 763 | 806 | 1 | 943 | Chain | ID=PRO_0000089474;Note=Centromere protein C |
| Q03188 | 763 | 806 | 763 | 763 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:19690332,PMID:20068231 |
| Q03188 | 763 | 806 | 773 | 773 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231 |
| Q03188 | 763 | 806 | 780 | 798 | Motif | Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for CENPC |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_429768 | 68340606 | 68340696 | 68340651 | 68340651 | Frame_Shift_Del | T | - | p.T906fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_429770 | 68358469 | 68358715 | 68358627 | 68358627 | Frame_Shift_Del | T | - | p.K793fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_429771 | 68358587 | 68358715 | 68358627 | 68358627 | Frame_Shift_Del | T | - | p.K793fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_429770 | 68358469 | 68358715 | 68358639 | 68358639 | Frame_Shift_Del | T | - | p.K789fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_429771 | 68358587 | 68358715 | 68358639 | 68358639 | Frame_Shift_Del | T | - | p.K789fs |
| BLCA | TCGA-G2-A2EC-01 | exon_skip_429770 | 68358469 | 68358715 | 68358626 | 68358627 | Frame_Shift_Ins | - | T | p.S794fs |
| BLCA | TCGA-G2-A2EC-01 | exon_skip_429771 | 68358587 | 68358715 | 68358626 | 68358627 | Frame_Shift_Ins | - | T | p.S794fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| C4I_CERVIX | 68358469 | 68358715 | 68358673 | 68358673 | Missense_Mutation | G | A | p.S778L |
| C4I_CERVIX | 68358587 | 68358715 | 68358673 | 68358673 | Missense_Mutation | G | A | p.S778L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CENPC |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CENPC |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CENPC |
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RelatedDrugs for CENPC |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CENPC |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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