ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for GLRX3

Gene summary

Gene information	Gene symbol	GLRX3
	Gene ID	10539
	Gene name	glutaredoxin 3
	Synonyms	GLRX4\|GRX3\|GRX4\|PICOT\|TXNL2\|TXNL3
	Cytomap	10q26.3
	Type of gene	protein-coding
	Description	glutaredoxin-3PKC-interacting cousin of thioredoxinPKC-theta-interacting proteinPKCq-interacting proteinglutaredoxin 4testicular tissue protein Li 75thioredoxin-like protein 2
	Modification date	20180522
	UniProtAcc	O76003
	Context	PubMed: GLRX3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GLRX3	GO:0044571	[2Fe-2S] cluster assembly	27519415
GLRX3	GO:0097428	protein maturation by iron-sulfur cluster transfer	27519415

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Exon skipping events across known transcript of Ensembl for GLRX3 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for GLRX3

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for GLRX3

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_46113	10	131934662:131934776:131943474:131943583:131958258:131958333	131943474:131943583	ENSG00000108010.7	ENST00000481034.1,ENST00000368644.1
exon_skip_46116	10	131943474:131943583:131958258:131958333:131959059:131959137	131958258:131958333	ENSG00000108010.7	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENSG00000108010.7	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1
exon_skip_46133	10	131973130:131973170:131973260:131973353:131977605:131977684	131973260:131973353	ENSG00000108010.7	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1
exon_skip_46138	10	131973260:131973353:131977605:131977684:131978376:131978585	131977605:131977684	ENSG00000108010.7	ENST00000481034.1,ENST00000368644.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for GLRX3

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_46113	10	131934662:131934776:131943474:131943583:131958258:131958333	131943474:131943583	ENSG00000108010.7	ENST00000368644.1,ENST00000481034.1
exon_skip_46116	10	131943474:131943583:131958258:131958333:131959059:131959137	131958258:131958333	ENSG00000108010.7	ENST00000331244.5,ENST00000368644.1,ENST00000481034.1
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENSG00000108010.7	ENST00000331244.5,ENST00000368644.1,ENST00000481034.1
exon_skip_46133	10	131973130:131973170:131973260:131973353:131977605:131977684	131973260:131973353	ENSG00000108010.7	ENST00000331244.5,ENST00000368644.1,ENST00000481034.1
exon_skip_46138	10	131973260:131973353:131977605:131977684:131978376:131978585	131977605:131977684	ENSG00000108010.7	ENST00000368644.1,ENST00000481034.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for GLRX3

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000368644	131977605	131977684	3UTR-3CDS
ENST00000368644	131943474	131943583	Frame-shift
ENST00000331244	131967696	131967754	Frame-shift
ENST00000368644	131967696	131967754	Frame-shift
ENST00000331244	131958258	131958333	In-frame
ENST00000368644	131958258	131958333	In-frame
ENST00000331244	131973260	131973353	In-frame
ENST00000368644	131973260	131973353	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000368644	131977605	131977684	3UTR-3CDS
ENST00000368644	131943474	131943583	Frame-shift
ENST00000331244	131967696	131967754	Frame-shift
ENST00000368644	131967696	131967754	Frame-shift
ENST00000331244	131958258	131958333	In-frame
ENST00000368644	131958258	131958333	In-frame
ENST00000331244	131973260	131973353	In-frame
ENST00000368644	131973260	131973353	In-frame

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Infer the effects of exon skipping event on protein functional features for GLRX3

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000331244	1279	335	131958258	131958333	224	298	67	92
ENST00000368644	1339	335	131958258	131958333	224	298	67	92
ENST00000331244	1279	335	131973260	131973353	887	979	288	319
ENST00000368644	1339	335	131973260	131973353	887	979	288	319

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000331244	1279	335	131958258	131958333	224	298	67	92
ENST00000368644	1339	335	131958258	131958333	224	298	67	92
ENST00000331244	1279	335	131973260	131973353	887	979	288	319
ENST00000368644	1339	335	131973260	131973353	887	979	288	319

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O76003	67	92	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	84	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	84	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	67	92	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	67	92	2	117	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00691
O76003	67	92	2	117	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00691
O76003	67	92	74	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	74	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	67	67	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
O76003	67	92	67	67	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
O76003	67	92	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	288	319	304	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	304	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	288	319	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	288	319	237	335	Domain	Note=Glutaredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00686
O76003	288	319	237	335	Domain	Note=Glutaredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00686
O76003	288	319	287	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	287	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	315	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	315	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	299	300	Mutagenesis	Note=Loss of 2Fe-2S-binding and interaction with BOLA2%3B when associated with S-261. WP->DA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27519415;Dbxref=PMID:27519415
O76003	288	319	299	300	Mutagenesis	Note=Loss of 2Fe-2S-binding and interaction with BOLA2%3B when associated with S-261. WP->DA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27519415;Dbxref=PMID:27519415

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O76003	67	92	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	63	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	84	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	84	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	67	92	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	67	92	2	117	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00691
O76003	67	92	2	117	Domain	Note=Thioredoxin;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00691
O76003	67	92	74	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	74	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	67	67	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
O76003	67	92	67	67	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
O76003	67	92	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	67	92	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WZ9
O76003	288	319	304	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	304	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	288	319	2	335	Chain	ID=PRO_0000120019;Note=Glutaredoxin-3
O76003	288	319	237	335	Domain	Note=Glutaredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00686
O76003	288	319	237	335	Domain	Note=Glutaredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00686
O76003	288	319	287	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	287	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	315	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	315	323	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YAN
O76003	288	319	299	300	Mutagenesis	Note=Loss of 2Fe-2S-binding and interaction with BOLA2%3B when associated with S-261. WP->DA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27519415;Dbxref=PMID:27519415
O76003	288	319	299	300	Mutagenesis	Note=Loss of 2Fe-2S-binding and interaction with BOLA2%3B when associated with S-261. WP->DA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27519415;Dbxref=PMID:27519415

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SNVs in the skipped exons for GLRX3

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

GLRX3_LUAD_exon_skip_46116_psi_boxplot.png
boxplot

GLRX3_STAD_exon_skip_46116_psi_boxplot.png
boxplot

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
STAD	TCGA-BR-6852-01	exon_skip_46116	131958259	131958333	131958325	131958325	Frame_Shift_Del	T	-	p.L89fs
COAD	TCGA-CA-6718-01	exon_skip_46113	131943475	131943583	131943557	131943557	Nonsense_Mutation	G	T	p.E59X
STAD	TCGA-BR-8680-01	exon_skip_46113	131943475	131943583	131943557	131943557	Nonsense_Mutation	G	T	p.E59*
STAD	TCGA-BR-8680-01	exon_skip_46113	131943475	131943583	131943557	131943557	Nonsense_Mutation	G	T	p.E59X
UCEC	TCGA-BS-A0UF-01	exon_skip_46113	131943475	131943583	131943557	131943557	Nonsense_Mutation	G	T	p.E59*
STAD	TCGA-BR-8059-01	exon_skip_46116	131958259	131958333	131958297	131958297	Nonsense_Mutation	T	A	p.Y80*
STAD	TCGA-BR-8059-01	exon_skip_46116	131958259	131958333	131958297	131958297	Nonsense_Mutation	T	A	p.Y80X
UCEC	TCGA-AX-A05Z-01	exon_skip_46138	131977606	131977684	131977615	131977615	Nonsense_Mutation	G	T	p.E323*
UCEC	TCGA-D1-A17Q-01	exon_skip_46138	131977606	131977684	131977648	131977648	Nonsense_Mutation	G	T	p.E334*
LUAD	TCGA-44-2656-01	exon_skip_46116	131958259	131958333	131958334	131958334	Splice_Site	G	T	p.K92_splice

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons	Mutation description
	Sample: TCGA-44-2656-01
	Cancer type: LUAD
	ESID: exon_skip_46116
	Skipped exon start: 131958259
	Skipped exon end: 131958333
	Mutation start: 131958334
	Mutation end: 131958334
	Mutation type: Splice_Site
	Reference seq: G
	Mutation seq: T
	AAchange: p.K92_splice
exon_skip_106588_LUAD_TCGA-44-2656-01.png
exon_skip_10918_LUAD_TCGA-44-2656-01.png
exon_skip_134787_LUAD_TCGA-44-2656-01.png
exon_skip_291076_LUAD_TCGA-44-2656-01.png
exon_skip_347690_LUAD_TCGA-44-2656-01.png
exon_skip_353194_LUAD_TCGA-44-2656-01.png
exon_skip_374468_LUAD_TCGA-44-2656-01.png
exon_skip_374469_LUAD_TCGA-44-2656-01.png
exon_skip_3814_LUAD_TCGA-44-2656-01.png
exon_skip_3815_LUAD_TCGA-44-2656-01.png
exon_skip_390105_LUAD_TCGA-44-2656-01.png
exon_skip_451924_LUAD_TCGA-44-2656-01.png
exon_skip_451926_LUAD_TCGA-44-2656-01.png
exon_skip_46116_LUAD_TCGA-44-2656-01.png
exon_skip_48232_LUAD_TCGA-44-2656-01.png
exon_skip_503611_LUAD_TCGA-44-2656-01.png
exon_skip_506466_LUAD_TCGA-44-2656-01.png

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LN235_CENTRAL_NERVOUS_SYSTEM	131943475	131943583	131943503	131943503	Missense_Mutation	C	T	p.P41S
RL952_ENDOMETRIUM	131943475	131943583	131943526	131943526	Missense_Mutation	G	C	p.Q48H
HCC2108_LUNG	131943475	131943583	131943552	131943552	Missense_Mutation	C	G	p.A57G
MORCPR_LUNG	131943475	131943583	131943552	131943552	Missense_Mutation	C	G	p.A57G
BICR18_UPPER_AERODIGESTIVE_TRACT	131943475	131943583	131943561	131943561	Missense_Mutation	T	A	p.L60H
BICR18_UPPER_AERODIGESTIVE_TRACT	131943475	131943583	131943568	131943568	Missense_Mutation	A	T	p.Q62H
EJM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	131943475	131943583	131943573	131943573	Missense_Mutation	C	T	p.S64L
SNU8_OVARY	131958259	131958333	131958264	131958264	Missense_Mutation	A	T	p.E69D
SNU8_OVARY	131958259	131958333	131958274	131958274	Missense_Mutation	G	A	p.V73I
639V_URINARY_TRACT	131973261	131973353	131973295	131973295	Missense_Mutation	C	T	p.P300L
SNGM_ENDOMETRIUM	131977606	131977684	131977640	131977640	Missense_Mutation	T	G	p.L331R

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GLRX3

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	COAD	rs17297984	chr10:131967693	A/T	5.39e-05
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	BLCA	rs17297984	chr10:131967693	A/T	2.21e-03
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	HNSC	rs17297984	chr10:131967693	A/T	1.06e-03
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	BRCA	rs17297984	chr10:131967693	A/T	9.82e-04
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	BRCA	rs17297984	chr10:131967693	A/T	2.26e-03
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	KIRC	rs17297984	chr10:131967693	A/T	2.47e-04
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	LUAD	rs17297984	chr10:131967693	A/T	4.14e-07
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	LUAD	rs17297984	chr10:131967693	A/T	8.45e-05
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	LUSC	rs17297984	chr10:131967693	A/T	4.81e-05
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	READ	rs17297984	chr10:131967693	A/T	1.12e-04
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	READ	rs17297984	chr10:131967693	A/T	2.43e-04
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	PCPG	rs17297984	chr10:131967693	A/T	3.36e-04
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	PRAD	rs17297984	chr10:131967693	A/T	2.30e-06
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	PRAD	rs17297984	chr10:131967693	A/T	2.24e-03
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	THCA	rs17297984	chr10:131967693	A/T	2.20e-08
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	THCA	rs17297984	chr10:131967693	A/T	5.51e-04
exon_skip_46125	10	131965182:131965244:131967696:131967754:131969847:131969900	131967696:131967754	ENST00000481034.1,ENST00000331244.5,ENST00000368644.1	THCA	rs17297984	chr10:131967693	A/T	1.69e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GLRX3

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GLRX3

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RelatedDrugs for GLRX3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GLRX3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GLRX3	C0018800	Cardiomegaly	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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