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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for IPO7 |
 Gene summary |
| Gene information | Gene symbol | IPO7 | Gene ID | 10527 |
| Gene name | importin 7 | |
| Synonyms | Imp7|RANBP7 | |
| Cytomap | 11p15.4 | |
| Type of gene | protein-coding | |
| Description | importin-7RAN-binding protein 7 | |
| Modification date | 20180523 | |
| UniProtAcc | O95373 | |
| Context | PubMed: IPO7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for IPO7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for IPO7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for IPO7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_56842 | 11 | 9406199:9406394:9413744:9413867:9430032:9430186 | 9413744:9413867 | ENSG00000205339.5 | ENST00000533233.1 |
| exon_skip_56847 | 11 | 9431615:9431633:9435801:9435958:9438605:9438695 | 9435801:9435958 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56849 | 11 | 9435801:9435958:9438605:9438695:9441957:9442052 | 9438605:9438695 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56851 | 11 | 9445332:9445423:9446460:9446537:9446692:9446809 | 9446460:9446537 | ENSG00000205339.5 | ENST00000379719.3,ENST00000530037.1 |
| exon_skip_56852 | 11 | 9446692:9446809:9450086:9450176:9450577:9450743 | 9450086:9450176 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56856 | 11 | 9451220:9451381:9452421:9452550:9455116:9455183 | 9452421:9452550 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56857 | 11 | 9452421:9452550:9455116:9455183:9455267:9455393 | 9455116:9455183 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56862 | 11 | 9455116:9455183:9455267:9455393:9456480:9456578 | 9455267:9455393 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56865 | 11 | 9457817:9457913:9459300:9459521:9459626:9459832 | 9459300:9459521 | ENSG00000205339.5 | ENST00000379719.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for IPO7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_56842 | 11 | 9406199:9406394:9413744:9413867:9430032:9430186 | 9413744:9413867 | ENSG00000205339.5 | ENST00000533233.1 |
| exon_skip_56847 | 11 | 9431615:9431633:9435801:9435958:9438605:9438695 | 9435801:9435958 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56849 | 11 | 9435801:9435958:9438605:9438695:9441957:9442052 | 9438605:9438695 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56851 | 11 | 9445332:9445423:9446460:9446537:9446692:9446809 | 9446460:9446537 | ENSG00000205339.5 | ENST00000379719.3,ENST00000530037.1 |
| exon_skip_56852 | 11 | 9446692:9446809:9450086:9450176:9450577:9450743 | 9450086:9450176 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56856 | 11 | 9451220:9451381:9452421:9452550:9455116:9455183 | 9452421:9452550 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56857 | 11 | 9452421:9452550:9455116:9455183:9455267:9455393 | 9455116:9455183 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56862 | 11 | 9455116:9455183:9455267:9455393:9456480:9456578 | 9455267:9455393 | ENSG00000205339.5 | ENST00000379719.3 |
| exon_skip_56865 | 11 | 9457817:9457913:9459300:9459521:9459626:9459832 | 9459300:9459521 | ENSG00000205339.5 | ENST00000379719.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for IPO7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000379719 | 9435801 | 9435958 | Frame-shift |
| ENST00000379719 | 9446460 | 9446537 | Frame-shift |
| ENST00000379719 | 9455116 | 9455183 | Frame-shift |
| ENST00000379719 | 9459300 | 9459521 | Frame-shift |
| ENST00000379719 | 9438605 | 9438695 | In-frame |
| ENST00000379719 | 9450086 | 9450176 | In-frame |
| ENST00000379719 | 9452421 | 9452550 | In-frame |
| ENST00000379719 | 9455267 | 9455393 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000379719 | 9435801 | 9435958 | Frame-shift |
| ENST00000379719 | 9446460 | 9446537 | Frame-shift |
| ENST00000379719 | 9455116 | 9455183 | Frame-shift |
| ENST00000379719 | 9459300 | 9459521 | Frame-shift |
| ENST00000379719 | 9438605 | 9438695 | In-frame |
| ENST00000379719 | 9450086 | 9450176 | In-frame |
| ENST00000379719 | 9452421 | 9452550 | In-frame |
| ENST00000379719 | 9455267 | 9455393 | In-frame |
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Infer the effects of exon skipping event on protein functional features for IPO7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000379719 | 6208 | 1038 | 9438605 | 9438695 | 779 | 868 | 212 | 242 |
| ENST00000379719 | 6208 | 1038 | 9450086 | 9450176 | 1478 | 1567 | 445 | 475 |
| ENST00000379719 | 6208 | 1038 | 9452421 | 9452550 | 1895 | 2023 | 584 | 627 |
| ENST00000379719 | 6208 | 1038 | 9455267 | 9455393 | 2091 | 2216 | 649 | 691 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000379719 | 6208 | 1038 | 9438605 | 9438695 | 779 | 868 | 212 | 242 |
| ENST00000379719 | 6208 | 1038 | 9450086 | 9450176 | 1478 | 1567 | 445 | 475 |
| ENST00000379719 | 6208 | 1038 | 9452421 | 9452550 | 1895 | 2023 | 584 | 627 |
| ENST00000379719 | 6208 | 1038 | 9455267 | 9455393 | 2091 | 2216 | 649 | 691 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95373 | 212 | 242 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
| O95373 | 445 | 475 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
| O95373 | 584 | 627 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
| O95373 | 649 | 691 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95373 | 212 | 242 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
| O95373 | 445 | 475 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
| O95373 | 584 | 627 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
| O95373 | 649 | 691 | 1 | 1038 | Chain | ID=PRO_0000120750;Note=Importin-7 |
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SNVs in the skipped exons for IPO7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
IPO7_LIHC_exon_skip_56847_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-4R-AA8I-01 | exon_skip_56847 | 9435802 | 9435958 | 9435806 | 9435806 | Frame_Shift_Del | A | - | p.Y161X |
| LIHC | TCGA-BC-A112-01 | exon_skip_56847 | 9435802 | 9435958 | 9435805 | 9435806 | Frame_Shift_Ins | - | A | p.*K161fs |
| BLCA | TCGA-G2-A2EO-01 | exon_skip_56847 | 9435802 | 9435958 | 9435956 | 9435956 | Nonsense_Mutation | C | T | p.Q212* |
| BLCA | TCGA-4Z-AA7W-01 | exon_skip_56852 | 9450087 | 9450176 | 9450105 | 9450105 | Nonsense_Mutation | C | T | p.Q452* |
| HNSC | TCGA-RS-A6TO-01 | exon_skip_56862 | 9455268 | 9455393 | 9455312 | 9455312 | Nonsense_Mutation | C | T | p.Q665* |
| STAD | TCGA-BR-4362-01 | exon_skip_56852 | 9450087 | 9450176 | 9450086 | 9450087 | Splice_Site | - | A | . |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_56862 | 9455268 | 9455393 | 9455267 | 9455267 | Splice_Site | G | T | e18-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-BC-A112-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_56847 | |
| Skipped exon start: 9435802 | |
| Skipped exon end: 9435958 | |
| Mutation start: 9435805 | |
| Mutation end: 9435806 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: A | |
| AAchange: p.*K161fs | |
exon_skip_114200_LIHC_TCGA-BC-A112-01.png | |
exon_skip_131894_LIHC_TCGA-BC-A112-01.png | |
exon_skip_135820_LIHC_TCGA-BC-A112-01.png | |
exon_skip_138911_LIHC_TCGA-BC-A112-01.png | |
exon_skip_141587_LIHC_TCGA-BC-A112-01.png | |
exon_skip_142606_LIHC_TCGA-BC-A112-01.png | |
exon_skip_146695_LIHC_TCGA-BC-A112-01.png | |
exon_skip_146697_LIHC_TCGA-BC-A112-01.png | |
exon_skip_152962_LIHC_TCGA-BC-A112-01.png | |
exon_skip_155765_LIHC_TCGA-BC-A112-01.png | |
exon_skip_1757_LIHC_TCGA-BC-A112-01.png | |
exon_skip_1879_LIHC_TCGA-BC-A112-01.png | |
exon_skip_1881_LIHC_TCGA-BC-A112-01.png | |
exon_skip_266_LIHC_TCGA-BC-A112-01.png | |
exon_skip_284527_LIHC_TCGA-BC-A112-01.png | |
exon_skip_286998_LIHC_TCGA-BC-A112-01.png | |
exon_skip_293546_LIHC_TCGA-BC-A112-01.png | |
exon_skip_293549_LIHC_TCGA-BC-A112-01.png | |
exon_skip_306900_LIHC_TCGA-BC-A112-01.png | |
exon_skip_311841_LIHC_TCGA-BC-A112-01.png | |
exon_skip_325884_LIHC_TCGA-BC-A112-01.png | |
exon_skip_326432_LIHC_TCGA-BC-A112-01.png | |
exon_skip_32825_LIHC_TCGA-BC-A112-01.png | |
exon_skip_331787_LIHC_TCGA-BC-A112-01.png | |
exon_skip_337208_LIHC_TCGA-BC-A112-01.png | |
exon_skip_337747_LIHC_TCGA-BC-A112-01.png | |
exon_skip_339045_LIHC_TCGA-BC-A112-01.png | |
exon_skip_344031_LIHC_TCGA-BC-A112-01.png | |
exon_skip_35548_LIHC_TCGA-BC-A112-01.png | |
exon_skip_35556_LIHC_TCGA-BC-A112-01.png | |
exon_skip_359720_LIHC_TCGA-BC-A112-01.png | |
exon_skip_37056_LIHC_TCGA-BC-A112-01.png | |
exon_skip_37483_LIHC_TCGA-BC-A112-01.png | |
exon_skip_37491_LIHC_TCGA-BC-A112-01.png | |
exon_skip_375724_LIHC_TCGA-BC-A112-01.png | |
exon_skip_378789_LIHC_TCGA-BC-A112-01.png | |
exon_skip_386291_LIHC_TCGA-BC-A112-01.png | |
exon_skip_41850_LIHC_TCGA-BC-A112-01.png | |
exon_skip_435931_LIHC_TCGA-BC-A112-01.png | |
exon_skip_436296_LIHC_TCGA-BC-A112-01.png | |
exon_skip_438393_LIHC_TCGA-BC-A112-01.png | |
exon_skip_443977_LIHC_TCGA-BC-A112-01.png | |
exon_skip_444190_LIHC_TCGA-BC-A112-01.png | |
exon_skip_44538_LIHC_TCGA-BC-A112-01.png | |
exon_skip_449944_LIHC_TCGA-BC-A112-01.png | |
exon_skip_458520_LIHC_TCGA-BC-A112-01.png | |
exon_skip_460075_LIHC_TCGA-BC-A112-01.png | |
exon_skip_472635_LIHC_TCGA-BC-A112-01.png | |
exon_skip_489149_LIHC_TCGA-BC-A112-01.png | |
exon_skip_492152_LIHC_TCGA-BC-A112-01.png | |
exon_skip_49506_LIHC_TCGA-BC-A112-01.png | |
exon_skip_5044_LIHC_TCGA-BC-A112-01.png | |
exon_skip_512559_LIHC_TCGA-BC-A112-01.png | |
exon_skip_514460_LIHC_TCGA-BC-A112-01.png | |
exon_skip_514990_LIHC_TCGA-BC-A112-01.png | |
exon_skip_55171_LIHC_TCGA-BC-A112-01.png | |
exon_skip_55175_LIHC_TCGA-BC-A112-01.png | |
exon_skip_56847_LIHC_TCGA-BC-A112-01.png | |
exon_skip_57586_LIHC_TCGA-BC-A112-01.png | |
exon_skip_57892_LIHC_TCGA-BC-A112-01.png | |
exon_skip_58035_LIHC_TCGA-BC-A112-01.png | |
exon_skip_6399_LIHC_TCGA-BC-A112-01.png | |
exon_skip_77132_LIHC_TCGA-BC-A112-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LOVO_LARGE_INTESTINE | 9459301 | 9459521 | 9459480 | 9459480 | Frame_Shift_Del | T | - | p.H816fs |
| MCAS_OVARY | 9435802 | 9435958 | 9435805 | 9435806 | Frame_Shift_Ins | - | A | p.K162fs |
| NCIH460_LUNG | 9452422 | 9452550 | 9452524 | 9452525 | In_Frame_Ins | - | TTAGTG | p.621_622insSV |
| HTCC3_THYROID | 9435802 | 9435958 | 9435822 | 9435822 | Missense_Mutation | G | A | p.R167Q |
| C33A_CERVIX | 9446461 | 9446537 | 9446482 | 9446482 | Missense_Mutation | C | G | p.S388C |
| SNU1040_LARGE_INTESTINE | 9450087 | 9450176 | 9450166 | 9450166 | Missense_Mutation | T | C | p.M472T |
| NCIH661_LUNG | 9455117 | 9455183 | 9455148 | 9455148 | Missense_Mutation | A | T | p.Q638L |
| HCT116_LARGE_INTESTINE | 9455268 | 9455393 | 9455295 | 9455295 | Missense_Mutation | C | T | p.A659V |
| CORL88_LUNG | 9459301 | 9459521 | 9459430 | 9459430 | Missense_Mutation | A | T | p.T800S |
| KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 9459301 | 9459521 | 9459440 | 9459440 | Missense_Mutation | A | G | p.N803S |
| IGROV1_OVARY | 9459301 | 9459521 | 9459446 | 9459446 | Missense_Mutation | G | A | p.R805H |
| YT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 9438606 | 9438695 | 9438657 | 9438657 | Nonsense_Mutation | G | T | p.E230* |
| FUOV1_OVARY | 9450087 | 9450176 | 9450098 | 9450098 | Nonsense_Mutation | T | A | p.Y449* |
| HCET_UPPER_AERODIGESTIVE_TRACT | 9452422 | 9452550 | 9452437 | 9452437 | Nonsense_Mutation | C | T | p.Q590* |
| PCI6A_UPPER_AERODIGESTIVE_TRACT | 9455268 | 9455393 | 9455276 | 9455276 | Nonsense_Mutation | G | T | p.E653* |
| MRKNU1_BREAST | 9455268 | 9455393 | 9455366 | 9455366 | Nonsense_Mutation | C | T | p.Q683* |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 9459301 | 9459521 | 9459378 | 9459378 | Nonsense_Mutation | T | A | p.C782* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IPO7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IPO7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IPO7 |
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RelatedDrugs for IPO7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| IPO7 | C0019693 | HIV Infections | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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