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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLC9A6 |
 Gene summary |
| Gene information | Gene symbol | SLC9A6 | Gene ID | 10479 |
| Gene name | solute carrier family 9 member A6 | |
| Synonyms | MRSA|NHE6 | |
| Cytomap | Xq26.3 | |
| Type of gene | protein-coding | |
| Description | sodium/hydrogen exchanger 6Na(+)/H(+) exchanger 6solute carrier family 9 (sodium/hydrogen exchanger), member 6solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 | |
| Modification date | 20180523 | |
| UniProtAcc | Q92581 | |
| Context | PubMed: SLC9A6 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC9A6 | GO:0048675 | axon extension | 24035762 |
| SLC9A6 | GO:0048812 | neuron projection morphogenesis | 24035762 |
| SLC9A6 | GO:0097484 | dendrite extension | 24035762 |
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Exon skipping events across known transcript of Ensembl for SLC9A6 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC9A6 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC9A6 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_512489 | X | 135081014:135081127:135084266:135084372:135092600:135092742 | 135084266:135084372 | ENSG00000198689.5 | ENST00000370698.3,ENST00000370695.4,ENST00000370701.1 |
| exon_skip_512490 | X | 135095507:135095596:135098803:135098917:135104744:135104856 | 135098803:135098917 | ENSG00000198689.5 | ENST00000370698.3,ENST00000370695.4,ENST00000370701.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC9A6 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_512489 | X | 135081014:135081127:135084266:135084372:135092600:135092742 | 135084266:135084372 | ENSG00000198689.5 | ENST00000370701.1,ENST00000370698.3,ENST00000370695.4 |
| exon_skip_512490 | X | 135095507:135095596:135098803:135098917:135104744:135104856 | 135098803:135098917 | ENSG00000198689.5 | ENST00000370701.1,ENST00000370698.3,ENST00000370695.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC9A6 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370698 | 135084266 | 135084372 | Frame-shift |
| ENST00000370698 | 135098803 | 135098917 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370698 | 135084266 | 135084372 | Frame-shift |
| ENST00000370698 | 135098803 | 135098917 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC9A6 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370698 | 4602 | 669 | 135098803 | 135098917 | 1176 | 1289 | 380 | 418 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370698 | 4602 | 669 | 135098803 | 135098917 | 1176 | 1289 | 380 | 418 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SLC9A6 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-CV-6952-01 | exon_skip_512490 | 135098804 | 135098917 | 135098865 | 135098865 | Frame_Shift_Del | T | - | p.L401fs |
| HNSC | TCGA-CV-6952-01 | exon_skip_512490 | 135098804 | 135098917 | 135098865 | 135098865 | Frame_Shift_Del | T | - | p.L433fs |
| LUAD | TCGA-05-4398-01 | exon_skip_512489 | 135084267 | 135084372 | 135084373 | 135084373 | Splice_Site | G | T | p.S268_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC251_ENDOMETRIUM | 135098804 | 135098917 | 135098824 | 135098824 | Missense_Mutation | C | A | p.F387L |
| NCIH2110_LUNG | 135098804 | 135098917 | 135098847 | 135098847 | Missense_Mutation | C | T | p.S395F |
| NCIH2066_LUNG | 135098804 | 135098917 | 135098881 | 135098881 | Missense_Mutation | C | A | p.N406K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC9A6 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC9A6 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC9A6 |
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RelatedDrugs for SLC9A6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC9A6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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