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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MERTK |
 Gene summary |
| Gene information | Gene symbol | MERTK | Gene ID | 10461 |
| Gene name | MER proto-oncogene, tyrosine kinase | |
| Synonyms | MER|RP38|Tyro12|c-Eyk|c-mer | |
| Cytomap | 2q13 | |
| Type of gene | protein-coding | |
| Description | tyrosine-protein kinase MerMER receptor tyrosine kinaseSTK kinasec-mer proto-oncogene tyrosine kinaseproto-oncogene c-Merreceptor tyrosine kinase MerTK | |
| Modification date | 20180523 | |
| UniProtAcc | Q12866 | |
| Context | PubMed: MERTK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MERTK | GO:0050766 | positive regulation of phagocytosis | 18395422 |
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Exon skipping events across known transcript of Ensembl for MERTK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MERTK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MERTK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_328644 | 2 | 112656240:112656373:112686696:112686881:112702536:112702637 | 112686696:112686881 | ENSG00000153208.12 | ENST00000439966.1 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENSG00000153208.12 | ENST00000421804.2 |
| exon_skip_328648 | 2 | 112704970:112705144:112722767:112722854:112725713:112725829 | 112722767:112722854 | ENSG00000153208.12 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 |
| exon_skip_328650 | 2 | 112732865:112733049:112740418:112740570:112751827:112751981 | 112740418:112740570 | ENSG00000153208.12 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 |
| exon_skip_328652 | 2 | 112740418:112740570:112751827:112751981:112754899:112755053 | 112751827:112751981 | ENSG00000153208.12 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 |
| exon_skip_328653 | 2 | 112754946:112755053:112758777:112758863:112760668:112760764 | 112758777:112758863 | ENSG00000153208.12 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000473065.1,ENST00000421804.2 |
| exon_skip_328654 | 2 | 112765959:112766052:112767524:112767643:112776989:112777099 | 112767524:112767643 | ENSG00000153208.12 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 |
| exon_skip_328657 | 2 | 112767524:112767643:112776989:112777099:112778998:112779158 | 112776989:112777099 | ENSG00000153208.12 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 |
| exon_skip_328663 | 2 | 112777004:112777099:112778180:112778231:112778998:112779158 | 112778180:112778231 | ENSG00000153208.12 | ENST00000449344.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MERTK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_328644 | 2 | 112656240:112656373:112686696:112686881:112702536:112702637 | 112686696:112686881 | ENSG00000153208.12 | ENST00000439966.1 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENSG00000153208.12 | ENST00000421804.2 |
| exon_skip_328648 | 2 | 112704970:112705144:112722767:112722854:112725713:112725829 | 112722767:112722854 | ENSG00000153208.12 | ENST00000295408.4,ENST00000421804.2,ENST00000409780.1,ENST00000439966.1 |
| exon_skip_328650 | 2 | 112732865:112733049:112740418:112740570:112751827:112751981 | 112740418:112740570 | ENSG00000153208.12 | ENST00000295408.4,ENST00000421804.2,ENST00000409780.1,ENST00000439966.1 |
| exon_skip_328652 | 2 | 112740418:112740570:112751827:112751981:112754899:112755053 | 112751827:112751981 | ENSG00000153208.12 | ENST00000295408.4,ENST00000421804.2,ENST00000409780.1,ENST00000439966.1 |
| exon_skip_328653 | 2 | 112754946:112755053:112758777:112758863:112760668:112760764 | 112758777:112758863 | ENSG00000153208.12 | ENST00000295408.4,ENST00000421804.2,ENST00000409780.1,ENST00000439966.1,ENST00000473065.1 |
| exon_skip_328654 | 2 | 112765959:112766052:112767524:112767643:112776989:112777099 | 112767524:112767643 | ENSG00000153208.12 | ENST00000295408.4,ENST00000421804.2,ENST00000409780.1,ENST00000439966.1 |
| exon_skip_328657 | 2 | 112767524:112767643:112776989:112777099:112778998:112779158 | 112776989:112777099 | ENSG00000153208.12 | ENST00000295408.4,ENST00000421804.2,ENST00000409780.1,ENST00000439966.1 |
| exon_skip_328663 | 2 | 112777004:112777099:112778180:112778231:112778998:112779158 | 112778180:112778231 | ENSG00000153208.12 | ENST00000449344.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MERTK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000421804 | 112686696 | 112687117 | Frame-shift |
| ENST00000295408 | 112740418 | 112740570 | Frame-shift |
| ENST00000421804 | 112740418 | 112740570 | Frame-shift |
| ENST00000295408 | 112751827 | 112751981 | Frame-shift |
| ENST00000421804 | 112751827 | 112751981 | Frame-shift |
| ENST00000295408 | 112758777 | 112758863 | Frame-shift |
| ENST00000421804 | 112758777 | 112758863 | Frame-shift |
| ENST00000295408 | 112767524 | 112767643 | Frame-shift |
| ENST00000421804 | 112767524 | 112767643 | Frame-shift |
| ENST00000295408 | 112776989 | 112777099 | Frame-shift |
| ENST00000421804 | 112776989 | 112777099 | Frame-shift |
| ENST00000295408 | 112722767 | 112722854 | In-frame |
| ENST00000421804 | 112722767 | 112722854 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000421804 | 112686696 | 112687117 | Frame-shift |
| ENST00000295408 | 112740418 | 112740570 | Frame-shift |
| ENST00000421804 | 112740418 | 112740570 | Frame-shift |
| ENST00000295408 | 112751827 | 112751981 | Frame-shift |
| ENST00000421804 | 112751827 | 112751981 | Frame-shift |
| ENST00000295408 | 112758777 | 112758863 | Frame-shift |
| ENST00000421804 | 112758777 | 112758863 | Frame-shift |
| ENST00000295408 | 112767524 | 112767643 | Frame-shift |
| ENST00000421804 | 112767524 | 112767643 | Frame-shift |
| ENST00000295408 | 112776989 | 112777099 | Frame-shift |
| ENST00000421804 | 112776989 | 112777099 | Frame-shift |
| ENST00000295408 | 112722767 | 112722854 | In-frame |
| ENST00000421804 | 112722767 | 112722854 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MERTK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000295408 | 3971 | 999 | 112722767 | 112722854 | 1015 | 1101 | 252 | 281 |
| ENST00000421804 | 3617 | 999 | 112722767 | 112722854 | 886 | 972 | 252 | 281 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000295408 | 3971 | 999 | 112722767 | 112722854 | 1015 | 1101 | 252 | 281 |
| ENST00000421804 | 3617 | 999 | 112722767 | 112722854 | 886 | 972 | 252 | 281 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q12866 | 252 | 281 | 21 | 999 | Chain | ID=PRO_0000024443;Note=Tyrosine-protein kinase Mer |
| Q12866 | 252 | 281 | 21 | 999 | Chain | ID=PRO_0000024443;Note=Tyrosine-protein kinase Mer |
| Q12866 | 252 | 281 | 218 | 262 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q12866 | 252 | 281 | 218 | 262 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q12866 | 252 | 281 | 197 | 273 | Domain | Note=Ig-like C2-type 2 |
| Q12866 | 252 | 281 | 197 | 273 | Domain | Note=Ig-like C2-type 2 |
| Q12866 | 252 | 281 | 274 | 274 | Sequence conflict | Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q12866 | 252 | 281 | 274 | 274 | Sequence conflict | Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q12866 | 252 | 281 | 21 | 505 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12866 | 252 | 281 | 21 | 505 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q12866 | 252 | 281 | 21 | 999 | Chain | ID=PRO_0000024443;Note=Tyrosine-protein kinase Mer |
| Q12866 | 252 | 281 | 21 | 999 | Chain | ID=PRO_0000024443;Note=Tyrosine-protein kinase Mer |
| Q12866 | 252 | 281 | 218 | 262 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q12866 | 252 | 281 | 218 | 262 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q12866 | 252 | 281 | 197 | 273 | Domain | Note=Ig-like C2-type 2 |
| Q12866 | 252 | 281 | 197 | 273 | Domain | Note=Ig-like C2-type 2 |
| Q12866 | 252 | 281 | 274 | 274 | Sequence conflict | Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q12866 | 252 | 281 | 274 | 274 | Sequence conflict | Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q12866 | 252 | 281 | 21 | 505 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12866 | 252 | 281 | 21 | 505 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for MERTK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
MERTK_KIRP_exon_skip_328654_psi_boxplot.png |
MERTK_LIHC_exon_skip_328654_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328644 | 112686697 | 112686881 | 112686743 | 112686743 | Frame_Shift_Del | G | - | p.P36fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328645 | 112686697 | 112687117 | 112686743 | 112686743 | Frame_Shift_Del | G | - | p.P36fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_328652 | 112751828 | 112751981 | 112751847 | 112751847 | Frame_Shift_Del | T | - | p.V439fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_328652 | 112751828 | 112751981 | 112751928 | 112751928 | Frame_Shift_Del | G | - | p.R466fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_328654 | 112767525 | 112767643 | 112767573 | 112767573 | Frame_Shift_Del | T | - | p.I670fs |
| UCEC | TCGA-D1-A17R-01 | exon_skip_328654 | 112767525 | 112767643 | 112767604 | 112767607 | Frame_Shift_Del | TACT | - | p.H680fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_328654 | 112767525 | 112767643 | 112767607 | 112767607 | Frame_Shift_Del | T | - | p.T681fs |
| BRCA | TCGA-A2-A0SW-01 | exon_skip_328654 | 112767525 | 112767643 | 112767613 | 112767631 | Frame_Shift_Del | ACTTTATTCCCGATTGGAG | - | p.L684fs |
| KIRC | TCGA-B8-4153-01 | exon_skip_328654 | 112767525 | 112767643 | 112767558 | 112767559 | Frame_Shift_Ins | - | A | p.P665fs |
| KIRC | TCGA-B8-4153-01 | exon_skip_328654 | 112767525 | 112767643 | 112767558 | 112767559 | Frame_Shift_Ins | - | A | p.Q665fs |
| SKCM | TCGA-EB-A5SG-06 | exon_skip_328644 | 112686697 | 112686881 | 112686787 | 112686787 | Nonsense_Mutation | T | A | p.L51* |
| SKCM | TCGA-EB-A5SG-06 | exon_skip_328644 | 112686697 | 112686881 | 112686787 | 112686787 | Nonsense_Mutation | T | A | p.L51X |
| SKCM | TCGA-EB-A5SG-06 | exon_skip_328645 | 112686697 | 112687117 | 112686787 | 112686787 | Nonsense_Mutation | T | A | p.L51* |
| SKCM | TCGA-EB-A5SG-06 | exon_skip_328645 | 112686697 | 112687117 | 112686787 | 112686787 | Nonsense_Mutation | T | A | p.L51X |
| LUAD | TCGA-97-7937-01 | exon_skip_328644 | 112686697 | 112686881 | 112686861 | 112686861 | Nonsense_Mutation | G | T | p.G76* |
| LUAD | TCGA-97-7937-01 | exon_skip_328645 | 112686697 | 112687117 | 112686861 | 112686861 | Nonsense_Mutation | G | T | p.G76* |
| KIRP | TCGA-4A-A93W-01 | exon_skip_328654 | 112767525 | 112767643 | 112767644 | 112767644 | Splice_Site | G | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-4A-A93W-01 |
| Cancer type: KIRP | |
| ESID: exon_skip_328654 | |
| Skipped exon start: 112767525 | |
| Skipped exon end: 112767643 | |
| Mutation start: 112767644 | |
| Mutation end: 112767644 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: C | |
| AAchange: . | |
exon_skip_328654_KIRP_TCGA-4A-A93W-01.png | |
exon_skip_83523_KIRP_TCGA-4A-A93W-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MELJUSO_SKIN | 112767525 | 112767643 | 112767569 | 112767575 | Frame_Shift_Del | GTAATTT | - | p.VIL669fs |
| JHUEM1_ENDOMETRIUM | 112686697 | 112686881 | 112686712 | 112686712 | Missense_Mutation | G | T | p.R26M |
| JHUEM1_ENDOMETRIUM | 112686697 | 112687117 | 112686712 | 112686712 | Missense_Mutation | G | T | p.R26M |
| RKO_LARGE_INTESTINE | 112686697 | 112687117 | 112686894 | 112686894 | Missense_Mutation | G | A | p.E87K |
| CALU1_LUNG | 112686697 | 112687117 | 112686913 | 112686913 | Missense_Mutation | C | T | p.P93L |
| SNU410_PANCREAS | 112686697 | 112687117 | 112687057 | 112687057 | Missense_Mutation | A | G | p.H141R |
| NCIH2110_LUNG | 112686697 | 112687117 | 112687101 | 112687101 | Missense_Mutation | A | G | p.I156V |
| NCIH661_LUNG | 112722768 | 112722854 | 112722830 | 112722830 | Missense_Mutation | A | G | p.K274E |
| KARPAS384_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 112751828 | 112751981 | 112751845 | 112751845 | Missense_Mutation | A | C | p.E438D |
| KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 112751828 | 112751981 | 112751936 | 112751936 | Missense_Mutation | G | T | p.V469F |
| ECC12_STOMACH | 112751828 | 112751981 | 112751936 | 112751936 | Missense_Mutation | G | T | p.V469F |
| H3118_UPPER_AERODIGESTIVE_TRACT | 112751828 | 112751981 | 112751936 | 112751936 | Missense_Mutation | G | T | p.V469F |
| JMSU1_URINARY_TRACT | 112751828 | 112751981 | 112751972 | 112751972 | Missense_Mutation | C | T | p.P481S |
| MM383_SKIN | 112758778 | 112758863 | 112758846 | 112758846 | Missense_Mutation | G | A | p.R558Q |
| TE4_OESOPHAGUS | 112758778 | 112758863 | 112758855 | 112758855 | Missense_Mutation | A | G | p.E561G |
| COLO792_SKIN | 112767525 | 112767643 | 112767552 | 112767552 | Missense_Mutation | G | A | p.G663D |
| EFM192A_BREAST | 112767525 | 112767643 | 112767583 | 112767583 | Missense_Mutation | C | A | p.F673L |
| SW48_LARGE_INTESTINE | 112767525 | 112767643 | 112767593 | 112767593 | Missense_Mutation | G | A | p.G677R |
| HCC2998_LARGE_INTESTINE | 112767525 | 112767643 | 112767626 | 112767626 | Missense_Mutation | T | A | p.L688M |
| SW684_SOFT_TISSUE | 112776990 | 112777099 | 112776996 | 112776996 | Missense_Mutation | C | T | p.P696S |
| LB771HNC_UPPER_AERODIGESTIVE_TRACT | 112776990 | 112777099 | 112777032 | 112777032 | Missense_Mutation | G | T | p.A708S |
| HEC251_ENDOMETRIUM | 112776990 | 112777099 | 112777061 | 112777061 | Missense_Mutation | G | T | p.R717S |
| OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 112776990 | 112777099 | 112777075 | 112777075 | Missense_Mutation | G | A | p.R722Q |
| HCT116_LARGE_INTESTINE | 112776990 | 112777099 | 112777074 | 112777074 | Nonsense_Mutation | C | T | p.R722* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MERTK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_328652 | 2 | 112740418:112740570:112751827:112751981:112754899:112755053 | 112751827:112751981 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 | LGG | rs7604639 | chr2:112751928 | G/A | 3.55e-08 |
| exon_skip_328652 | 2 | 112740418:112740570:112751827:112751981:112754899:112755053 | 112751827:112751981 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 | KIRC | rs7604639 | chr2:112751928 | G/A | 3.18e-06 |
| exon_skip_328652 | 2 | 112740418:112740570:112751827:112751981:112754899:112755053 | 112751827:112751981 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 | LUSC | rs7604639 | chr2:112751928 | G/A | 3.06e-03 |
| exon_skip_328652 | 2 | 112740418:112740570:112751827:112751981:112754899:112755053 | 112751827:112751981 | ENST00000409780.1,ENST00000439966.1,ENST00000295408.4,ENST00000421804.2 | THCA | rs7604639 | chr2:112751928 | G/A | 2.55e-06 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENST00000421804.2 | LGG | rs13027171 | chr2:112686988 | G/A | 2.85e-13 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENST00000421804.2 | KIRC | rs13027171 | chr2:112686988 | G/A | 2.71e-04 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENST00000421804.2 | LUAD | rs13027171 | chr2:112686988 | G/A | 1.46e-03 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENST00000421804.2 | LUSC | rs13027171 | chr2:112686988 | G/A | 1.95e-12 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENST00000421804.2 | OV | rs13027171 | chr2:112686988 | G/A | 2.79e-06 |
| exon_skip_328645 | 2 | 112656240:112656373:112686696:112687117:112702536:112702637 | 112686696:112687117 | ENST00000421804.2 | THCA | rs13027171 | chr2:112686988 | G/A | 3.47e-08 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MERTK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MERTK |
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RelatedDrugs for MERTK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q12866 | DB12010 | Fostamatinib | Tyrosine-protein kinase Mer | small molecule | approved|investigational |
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RelatedDiseases for MERTK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MERTK | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| MERTK | C0034065 | Pulmonary Embolism | 1 | CTD_human |
| MERTK | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;HPO;ORPHANET |
| MERTK | C0040038 | Thromboembolism | 1 | CTD_human |
| MERTK | C0040053 | Thrombosis | 1 | CTD_human |
| MERTK | C3151228 | RETINITIS PIGMENTOSA 38 (disorder) | 1 | UNIPROT |
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